FabH Mutations Confer Resistance to FabF-Directed Antibiotics in Staphylococcus aureus

Mechanisms of Self-Resistance in the Platensimycin- and Platencin-Producing Streptomyces platensis MA7327 and MA7339 Strains

(2014) Ryan M. Peterson et al.   CHEMISTRY & BIOLOGY

Structural insights into bacterial resistance to cerulenin

(2014) Felipe Trajtenberg et al.   FEBS Journal

Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway inStaphylococcus aureus

(2014) Joshua B. Parsons et al.   MOLECULAR MICROBIOLOGY

Perturbation of Staphylococcus aureus Gene Expression by the Enoyl-Acyl Carrier Protein Reductase Inhibitor AFN-1252

(2013) Joshua B. Parsons et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Staphylococcus aureus Fatty Acid Auxotrophs Do Not Proliferate in Mice

(2013) Joshua B. Parsons et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic Tools To Enhance the Study of Gene Function and Regulation in Staphylococcus aureus

(2013) Jeffrey L. Bose et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

AFN-1252 in vitro absorption studies and pharmacokinetics following microdosing in healthy subjects

(2013) Nachum Kaplan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Resistance to AFN-1252 Arises from Missense Mutations inStaphylococcus aureusEnoyl-acyl Carrier Protein Reductase (FabI)

(2013) Jiangwei Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial lipids: Metabolism and membrane homeostasis

(2013) Joshua B. Parsons et al.   PROGRESS IN LIPID RESEARCH

Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus

(2013) Daniela Albanesi et al.   PLoS Pathogens

The use of platensimycin and platencin to fight antibiotic resistance

(2013) Adil Allahverdiyev et al.   Infection and Drug Resistance

Mode of Action,In VitroActivity, andIn VivoEfficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor

(2012) Nachum Kaplan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

From Triclosan toward the Clinic: Discovery of Nonbiocidal, Potent FabI Inhibitors for the Treatment of Resistant Bacteria

(2012) Vincent Gerusz et al.   JOURNAL OF MEDICINAL CHEMISTRY

The MUT056399 Inhibitor of FabI Is a New Antistaphylococcal Compound

(2011) S. Escaich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

(2011) Joshua B Parsons et al.   CURRENT OPINION IN MICROBIOLOGY

Platensimycin and platencin: promising antibiotics for future application in human medicine

(2011) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

High-frequency transposition for determining antibacterial mode of action

(2011) Hao Wang et al.   Nature Chemical Biology

Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

(2011) J. B. Parsons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Role of Malonyl-ACP in Lipid Homeostasis,

(2010) Mariano A. Martinez et al.   BIOCHEMISTRY

Differences in Cold Adaptation of Bacillus subtilis under Anaerobic and Aerobic Conditions

(2010) J. Beranova et al.   JOURNAL OF BACTERIOLOGY

Brinster et al. reply

(2010) Sophie Brinster et al.   NATURE

Essentiality of FASII pathway for Staphylococcus aureus

(2010) Wendy Balemans et al.   NATURE

Expression ofVibrio harveyiAcyl-ACP Synthetase Allows Efficient Entry of Exogenous Fatty Acids into theEscherichia coliFatty Acid and Lipid A Synthetic Pathways

(2009) Yanfang Jiang et al.   BIOCHEMISTRY

Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme

(2009) Ketan S. Gajiwala et al.   FEBS LETTERS

Slow Onset Inhibition of Bacterial β-Ketoacyl-acyl Carrier Protein Synthases by Thiolactomycin

(2009) Carl A. Machutta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

(2009) Sophie Brinster et al.   NATURE

A malonyl-CoA-dependent switch in the bacterial response to a dysfunction of lipid metabolism

(2008) Gustavo E. Schujman et al.   MOLECULAR MICROBIOLOGY

Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic

(2008) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA