Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

The Kalimantacin/Batumin Biosynthesis Operon Encodes a Self-Resistance Isoform of the FabI Bacterial Target

(2010) Wesley Mattheus et al.   CHEMISTRY & BIOLOGY

Brinster et al. reply

(2010) Sophie Brinster et al.   NATURE

Essentiality of FASII pathway for Staphylococcus aureus

(2010) Wendy Balemans et al.   NATURE

AFN-1252, a FabI Inhibitor, Demonstrates a Staphylococcus-Specific Spectrum of Activity

(2009) J. A. Karlowsky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Expression ofVibrio harveyiAcyl-ACP Synthetase Allows Efficient Entry of Exogenous Fatty Acids into theEscherichia coliFatty Acid and Lipid A Synthetic Pathways

(2009) Yanfang Jiang et al.   BIOCHEMISTRY

Aquastatin A, a New Inhibitor of Enoyl-Acyl Carrier Protein Reductase from Sporothrix sp. FN611

(2009) Yun-Ju Kwon et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Macrolactin S, a New Antibacterial Agent with Fab G-inhibitory Activity from Bacillus sp. AT28

(2009) Mi-Jin Sohn et al.   JOURNAL OF ANTIBIOTICS

Acyl-Acyl Carrier Protein Regulates Transcription of Fatty Acid Biosynthetic Genes via the FabT Repressor inStreptococcus pneumoniae

(2009) Agoston Jerga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

(2009) Sophie Brinster et al.   NATURE

Waves of resistance: Staphylococcus aureus in the antibiotic era

(2009) Henry F. Chambers et al.   NATURE REVIEWS MICROBIOLOGY

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

(2009) J. Richard Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of FabI, an Enzyme Drug Target in the Bacterial Fatty Acid Biosynthesis Pathway

(2008) Hao Lu et al.   ACCOUNTS OF CHEMICAL RESEARCH

A malonyl-CoA-dependent switch in the bacterial response to a dysfunction of lipid metabolism

(2008) Gustavo E. Schujman et al.   MOLECULAR MICROBIOLOGY

Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic

(2008) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA