Article
Infectious Diseases
Yin-Ze Shi, Terutoyo Yoshida, Atushi Fujiwara, Issei Nishiki
Summary: This study identified a novel Lsa(D) gene that confers resistance to lincosamides-streptogramins A-pleuromutilins (LSAP) in clinically lincomycin-resistant L. garvieaeserotype II strains, but also found that some strains contain a specific mutation which results in susceptibility. The research provides valuable insights into antibiotic resistance mechanisms.
MICROBIAL DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Cristina Lagatolla, Jai W. Mehat, Roberto Marcello La Ragione, Roberto Luzzati, Stefano Di Bella
Summary: The combination of oritavancin and fosfomycin showed synergistic effect and increased drug susceptibility against vancomycin-resistant enterococci. It also showed promising results in reducing bacterial regrowth and restoring fosfomycin susceptibility.
Article
Agriculture, Dairy & Animal Science
Mohsen Hanifeh, Thomas Spillmann, Mirja Huhtinen, Yannes S. Sclivagnotis, Thomas Gronthal, Ulla Hynoenen
Summary: The study demonstrates that canine-derived Enterococcus faecalis and E. faecium strains adhere better to the duodenal mucosa of healthy beagles compared to chicken-derived strains, with canine E. faecalis showing the highest hydrophobicity levels. This suggests that both bacterial species and host origin may influence mucosal adhesion.
Article
Microbiology
Svetoslav Dimitrov Todorov, Richard Weeks, Igor Popov, Bernadette Dora Gombossy de Melo Franco, Michael Leonidas Chikindas
Summary: This study focuses on two strains of lactic acid bacteria that produce bacteriocin-like inhibitor substances (BLIS) active against Candida albicans. The BLIS showed antimicrobial activity against both Listeria monocytogenes and C. albicans. It was found that the adsorption levels of BLIS to C. albicans were influenced by factors such as temperature, pH, and the presence of a contraceptive.
Article
Microbiology
Zhong Chen, Yanpeng Xiong, Yuanyuan Tang, Yuxi Zhao, Junwen Chen, Jinxin Zheng, Yang Wu, Qiwen Deng, Di Qu, Zhijian Yu
Summary: Two thiazolidione derivatives (H2-60 and H2-81) can inhibit the growth and biofilm formation of E. faecium, especially when used in combination with daptomycin.
Article
Pharmacology & Pharmacy
Virginia Barreto Lordello, Andreia Bagliotti Meneguin, Sarah Raquel de Annunzio, Maria Pia Taranto, Marlus Chorilli, Carla Raquel Fontana, Daniela Cardoso Umbelino Cavallini
Summary: The orodispersible film developed in this study successfully delivered probiotic Enterococcus faecium CRL 183 into the oral cavity, demonstrating good antifungal activity against Candida albicans and reducing biofilm formation.
Article
Chemistry, Medicinal
Eman H. Zaghloul, Hatem M. Abuohashish, Amany S. El Sharkawy, Eman M. Abbas, Mohammed M. Ahmed, Salim S. Al-Rejaie
Summary: This study aimed to isolate a novel probiotic strain, Enterococcus faecium EA9, from marine shrimp samples and evaluate its probiotic potential through phenotypical and molecular identification. The study also assessed the antibacterial activity of EA9 against pathogenic bacteria and its effectiveness in improving liver and kidney function and reducing inflammation and oxidative stress in septic animals. The results showed that EA9 had high tolerance to low pH and elevated concentrations of bile salts, exhibited antibacterial properties, and demonstrated positive effects on the health of septic animals. The study concluded that EA9 is a promising marine probiotic with potential therapeutic applications.
Article
Biochemistry & Molecular Biology
Gabriela Krausova, Antonin Kana, Marek Vecka, Ivana Hyrslova, Barbora Stankova, Vera Kantorova, Iva Mrvikova, Martina Huttl, Hana Malinska
Summary: This study found that selenium-enriched LAB administration resulted in higher selenium concentrations in the liver and kidneys of rats, improving the antioxidant status of the animals. The effect of Se-enriched strains on the heart tissue was more pronounced, with potential benefits for the rats' antioxidant function.
Article
Food Science & Technology
Edibe Rabia Ozkan, Talha Demirci, Nihat Akin
Summary: Nine Enterococcus faecium isolates from Tulum cheese in Turkey were analyzed for probiotic potential through various tests, with one isolate showing promising probiotic properties and deemed worthy of further in vivo investigation.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
Ana Paula Marchi, Lauro Vieira Perdigao Neto, Marina Farrel Cortes, Victor Augusto Camarinha de Castro Lima, Roberta Cristina Ruedas Martins, Lucas Augusto Moyses Franco, Flavia Rossi, Vanderson Rocha, Anna S. Levin, Silvia Figueiredo Costa
Summary: This study characterized the genetic structure and mobile genetic elements of VRE isolates displaying a VanD-vanA phenotype, revealing different sequence types and gene mutations or inversions. Further studies are needed to fully understand the role of genetic variability and insertion elements in isolates with this profile.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Microbiology
Emine Dincer, Merih Kivanc
Summary: This study evaluated the probiotic potential of three Enterococcus faecium strains isolated from Turkish traditional dry-cured meat product, showing that the strains exhibit strong antimicrobial activity and tolerance to acidic conditions, making them promising probiotic candidates.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Microbiology
Pengfei She, Yangxia Wang, Yingjia Li, Linying Zhou, Shijia Li, Xianghai Zeng, Yaqian Liu, Lanlan Xu, Yong Wu
Summary: The study found that Bithionol has significant antimicrobial and antibiofilm effects against E. faecalis and vancomycin-resistant E. faecium, reducing bacterial load and showing potential as a therapeutic agent against resistant enterococcal infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Ashlan Kunz J. Coyne, Kyle Stamper, Amer El Ghali, Razieh Kebriaei, Biswajit Biswas, Melanie Wilson, Michael V. Deschenes, Truc T. Tran, Cesar A. Arias, Michael J. Rybak
Summary: Our study supports the additional benefit of standard-of-care antibiotics combined with a phage cocktail compared to antibiotic alone against a daptomycin-nonsusceptible (DNS) E. faecium isolate in a high-inoculum simulated endocardial vegetation ex vivo PK/PD model.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
Yingying Xiang, Chunlan Ma, Shuang Yin, Fei Song, Kunhao Qin, Yafang Ding, Xianghong Yang, Pengfei Song, Xiuling Ji, Yunlin Wei
Summary: This study investigated the resistance against Enterococcus faecalis infection using phage therapy and found that phage PEf771 showed significant antibacterial effect and prevention of infection.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ilona Trautmannsberger, Laura Kolberg, Melanie Meyer-Buehn, Johannes Huebner, Guido Werner, Robert Weber, Valerie Heselich, Sebastian Schroepf, Hans-Georg Muench, Ulrich von Both
Summary: This study aimed to investigate the dynamics and routes of transmission of VREfm infections in a German pediatric hospital, revealing a possible nosocomial spread as the cause for an unusual accumulation of cases. The findings highlight the importance of increasing efforts in hygiene measures, infection control, and antibiotic stewardship to combat VREfm transmission events.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Microbiology
Frederic Robin, Michel Auzou, Richard Bonnet, Romain Lebreuilly, Christophe Isnard, Vincent Cattoir, Francois Guerin
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Infectious Diseases
Mohamed Sassi, Francois Guerin, Leonie Lesec, Christophe Isnard, Marguerite Fines-Guyon, Vincent Cattoir, Jean-Christophe Giard
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Infectious Diseases
Christophe Isnard, Anne Dhalluin, Damasie Malandain, Quentin Bruey, Michel Auzou, Jocelyn Michon, Jean-Christophe Giard, Francois Guerin, Vincent Cattoir
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2018)
Article
Infectious Diseases
B. Pilmis, J. Lourtet-Hascoet, O. Barraud, C. Piau, C. Isnard, G. Hery-Arnaud, M. Amara, A. Merens, E. Farfour, E. Thomas, H. Jacquier, J-R Zahar, E. Bonnet, A. Le Monnier, V Cattoir, S. Corvec, D. BoutoillE, G. Pean de Ponfilly, S. Reissier
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2019)
Article
Infectious Diseases
J. Perron, A. Baldolli, C. Isnard, A. de La Blanchardiere, G. Saint-Lorant
MEDECINE ET MALADIES INFECTIEUSES
(2020)
Article
Infectious Diseases
Marion Le Marechal, Nelly Agrinier, Vincent Cattoir, Celine Pulcini, Olivier Belmonte, Beatrice Bercot, Anne Cady, Jocelyne Caillon, Christian Cattoen, Julie Cremniter, Olivier Dauwalder, Dominique Andre De Briel, Laurent Dortet, Anabele Dos Santos, Florence Doucet-Populaire, Veronique Dubois, Clarisse Dupin, Agnes Ferroni, Jenny Gallou, Pauline Garnier, Thomas Guillard, Jean-Louis Herrmann, Christophe Isnard, Herve Jacquier, Francoise Jaureguy, Marie Kempf, Luce Landraud, Jean-Philippe Lavigne, Cecile Le Brun, Florian Lorme, Alain Lozniewski, Jean-Luc Mainardi, Marie-Cecile Ploy, Isabelle Podglajen, Charlotte Pujol, Jerome Robert, Anne-Laure Roux, Raymond Ruimy, Frederic Schramm, Simon Sunder, Didier Tande, Anne Vachee, Frederic Wallet
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2019)
Article
Infectious Diseases
Agathe Capitaine, Paul-Louis Woerther, Michel Auzou, Elisabeth Chachaty, Francois Guerin, Jean-Christophe Giard, Vincent Cattoir, Christophe Isnard
MICROBIAL DRUG RESISTANCE
(2020)
Article
Pharmacology & Pharmacy
H. Benoist, A. de La Blanchardiere, A. Flatres, C. Isnard, P. Thibon, G. Saint-Lorant
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2020)
Article
Microbiology
Christophe Isnard, Sara B. Hernandez, Francois Guerin, Fanny Joalland, Didier Goux, Francois Gravey, Michel Auzou, David Enot, Pierrick Meignen, Jean-Christophe Giard, Felipe Cava, Vincent Cattoir
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Infectious Diseases
E. Farfour, N. Degand, E. Riverain, V Fihman, C. Le Brun, G. Pean de Ponfilly, A. Muggeo, A. Jousset, C. Piau, P. Lesprit, N. Chatelain, L. Dortet, A. Poisson, T. Guillard, A. Limelette, A. Mizrahi, A. Le Monnier, D. Fournier, A. Potron, P. Morand, F. Janvier, M-P Otto, P-L Woerther, J-W Decousser, S. Corvec, C. Plouzeau-Jayle, L. Broutin, N. Yin, G. Hery-Arnaud, C. Beauruelle, A. Grillon, M. Lecuru, E. Bille, S. Godreuil, H. Jean Pierre, M. Amara, A. Henry, J-R Zahar, E. Carbonelle, F. Jaureguy, A. Lomont, C. Isnard, V Cattoir, F. Canis, T. Diedrich, E. Flevin, A. Merens, H. Jacquier, E. Gyde
MEDECINE ET MALADIES INFECTIEUSES
(2020)
Article
Microbiology
Francois Guerin, Claire Lallement, Benoit Goudergues, Christophe Isnard, Maurizio Sanguinetti, Margherita Cacaci, Riccardo Torelli, Vincent Cattoir, Jean-Christophe Giard
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Infectious Diseases
Eric Farfour, Anne-Gaelle Si Larbi, Vincent Cattoir, Stephane Corvec, Thomas Guillard, Antoine Grillon, Christophe Isnard, Audrey Merens, Nicolas Degand, Typhaine Billard-Pomares, Damien Fournier, Emmanuelle Bille, Cecile Le Brun, Chloe Plouzeau, Emilie Flevin, Nicolas Yin, Paul-Louis Woerther, Julie Lourtet, Philippe Lesprit, Alban Le Monnier
Summary: Temocillin has been used in some European countries for several years, but only since 2015 in France. A study assessed the susceptibility of Enterobacterales strains isolated from blood culture 1 year before (2014) and 2 years after (2017) its use in France, showing that it remains highly active against this bacterial group, but there is a trend of increasing resistance.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Infectious Diseases
Clemence Beauruelle, Chloe Plouzeau, Antoine Grillon, Christophe Isnard, Stephane Corvec, Nicolas Degand, Herve Jacquier, Marlene Amara, Assaf Mizrahi, Tristan Diedrich, Caroline Piau, Eric Farfour, Lucas Bonzon, Cecile Le Brun, Violaine Walewski, Emmanuelle Bille, Laurent Dortet, Thomas Guillard, Nathalie Soismier, Ronan Le Guen, Philippe Morand, Gauthier Pean de Ponfilly, Alban Le Monnier, Genevieve Hery-Arnaud
Summary: Zoonotic species of Capnocytophaga genus, which belong to the oral microbiota of dogs and cats, can cause serious infections in humans, especially after animal bites. There have been few reported cases in France, and no multicenter study has been conducted. The aim of this study was to describe the French epidemiology of Capnocytophaga zoonosis.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Celine Vaesken, Paul Besnier, Claire Bernardeau, Rachid Garmi, Melanie Malherbe, Audrey Mouet, Jocelyn Michon, Alexandra Muzard, Christophe Isnard, Isaline Bazin, Guillaume Saint-Lorant
Summary: The study aims to improve the management of leeches from ordering to disposal to enhance patient care. The interdisciplinary protocol established allows for improved patient care management and ensures safer management of leeches for caregivers.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Article
Microbiology
Eric Farfour, Laurent Dortet, Thomas Guillard, Nicolas Chatelain, Agathe Poisson, Assaf Mizrahi, Damien Fournier, Remy A. Bonnin, Nicolas Degand, Philippe Morand, Frederic Janvier, Vincent Fihman, Stephane Corvec, Lauranne Broutin, Cecile Le Brun, Nicolas Yin, Genevieve Hery-Arnaud, Antoine Grillon, Emmanuelle Bille, Helene Jean-Pierre, Marlene Amara, Francoise Jaureguy, Christophe Isnard, Vincent Cattoir, Tristan Diedrich, Emilie Flevin, Audrey Merens, Herve Jacquier, Marc Vasse
Summary: There are some trends in antibiotic resistance among Enterobacterales isolates recovered from urinary tract samples in France. Certain carbapenem-sparing drugs remain highly active.