期刊
FRONTIERS IN MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.579806
关键词
drug repurposing; bithionol; antimicrobial; Enterococci; bacterial cell membrane
类别
资金
- Natural Science Foundation of Hunan Province [2019JJ80029]
- National Natural Science Foundation of China [82072350]
The study found that Bithionol has significant antimicrobial and antibiofilm effects against E. faecalis and vancomycin-resistant E. faecium, reducing bacterial load and showing potential as a therapeutic agent against resistant enterococcal infections.
Widespread antibiotic resistance has been reported in enterococcal pathogens that cause life-threatening infections. Enterococci species rapidly acquire resistance and the pace of new antibiotic development is slow. Drug repurposing is a promising approach in solving this problem. Bithionol (BT) is a clinically approved anthelminthic drug. In this study, we found that BT showed significant antimicrobial and antibiofilm effects against Enterococcus faecalis and vancomycin-resistant Entercococcus faecium in vitro, in a dose-dependent manner, by disrupting the integrity of the bacterial cell membranes. Moreover, BT effectively reduced the bacterial load in mouse organs when combined with conventional antibiotics in a peritonitis infection model. Thus, BT has shown potential as a therapeutic agent against E. faecalis- and vancomycin-resistant E. faecium-related infections.
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