Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia

Effects of Linezolid on Suppressing In Vivo Production of Staphylococcal Toxins and Improving Survival Outcomes in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia

(2013) Binh An Diep et al.   JOURNAL OF INFECTIOUS DISEASES

Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus α-Hemolysin

(2013) Davide Foletti et al.   JOURNAL OF MOLECULAR BIOLOGY

Staphylococcus aureus Alpha Toxin Suppresses Effective Innate and Adaptive Immune Responses in a Murine Dermonecrosis Model

(2013) Christine Tkaczyk et al.   PLoS One

Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue

(2013) Bryan Berube et al.   Toxins

Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency

(2012) C. Tkaczyk et al.   Clinical and Vaccine Immunology

Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa

(2012) Bruno François et al.   CRITICAL CARE MEDICINE

The potential use of toxin antibodies as a strategy for controlling acuteStaphylococcus aureusinfections

(2012) Gordon YC Cheung et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Host Response Signature to Staphylococcus aureus Alpha-Hemolysin Implicates Pulmonary Th17 Response

(2012) Karen M. Frank et al.   INFECTION AND IMMUNITY

Abscess Formation and Alpha-Hemolysin Induced Toxicity in a Mouse Model of Staphylococcus aureus Peritoneal Infection

(2012) Sabine Rauch et al.   INFECTION AND IMMUNITY

Efficacy of linezolid versus a pharmacodynamically optimized vancomycin therapy in an experimental pneumonia model caused by methicillin-resistant Staphylococcus aureus

(2012) F. Docobo-Perez et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of broadly protective human antibodies toPseudomonas aeruginosaexopolysaccharide Psl by phenotypic screening

(2012) Antonio DiGiandomenico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crosstalk between Human IgG Isotypes and Murine Effector Cells

(2012) M. B. Overdijk et al.   JOURNAL OF IMMUNOLOGY

Staphylococcus aureus α-Hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome

(2012) Chahnaz Kebaier et al.   JOURNAL OF INFECTIOUS DISEASES

ADAM10 Mediates Vascular Injury Induced by Staphylococcus aureus α-Hemolysin

(2012) Michael E. Powers et al.   JOURNAL OF INFECTIOUS DISEASES

Genetic Requirement for ADAM10 in Severe Staphylococcus aureus Skin Infection

(2012) Naoko Inoshima et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Clinical Impact of Antimicrobial Resistance in European Hospitals: Excess Mortality and Length of Hospital Stay Related to Methicillin-ResistantStaphylococcus aureusBloodstream Infections

(2011) Marlieke E. A. de Kraker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children: Executive Summary

(2011) Catherine Liu et al.   CLINICAL INFECTIOUS DISEASES

PcrV antibody–antibiotic combination improves survival in Pseudomonas aeruginosa-infected mice

(2011) Y. Song et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Comparative Analysis of USA300 Virulence Determinants in a Rabbit Model of Skin and Soft Tissue Infection

(2011) Scott D. Kobayashi et al.   JOURNAL OF INFECTIOUS DISEASES

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice

(2011) Ichiro Inoshima et al.   NATURE MEDICINE

Immunopathogenesis of Staphylococcus aureus pulmonary infection

(2011) Dane Parker et al.   Seminars in Immunopathology

Linezolid vs Glycopeptide Antibiotics for the Treatment of Suspected Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia

(2010) Allan J. Walkey et al.   CHEST

Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic

(2010) M. Z. David et al.   CLINICAL MICROBIOLOGY REVIEWS

Targeting of Alpha‐Hemolysin by Active or Passive Immunization Decreases Severity of USA300 Skin Infection in a Mouse Model

(2010) Adam D. Kennedy et al.   JOURNAL OF INFECTIOUS DISEASES

Treatment with Monoclonal Antibodies againstClostridium difficileToxins

(2010) Israel Lowy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury

(2010) B. A. Diep et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus  -hemolysin-mediated cellular injury

(2010) G. A. Wilke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lethal Antibody Enhancement of Dengue Disease in Mice Is Prevented by Fc Modification

(2010) Scott J. Balsitis et al.   PLoS Pathogens

Analysis of the Fc Gamma Receptor-Dependent Component of Neutralization Measured by Anthrax Toxin Neutralization Assays

(2009) A. Verma et al.   Clinical and Vaccine Immunology

Anti-Alpha-Hemolysin Monoclonal Antibodies Mediate Protection against Staphylococcus aureus Pneumonia

(2009) B. E. Ragle et al.   INFECTION AND IMMUNITY

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Comparison of Both Clinical Features and Mortality Risk Associated with Bacteremia due to Community-Acquired Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible S. aureus

(2008) J.-L. Wang et al.   CLINICAL INFECTIOUS DISEASES

Staphylococcus aureus Elicits Marked Alterations in the Airway Proteome during Early Pneumonia

(2008) C. L. Ventura et al.   INFECTION AND IMMUNITY

Vaccine protection againstStaphylococcus aureuspneumonia

(2008) Juliane Bubeck Wardenburg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

α‐Toxin Facilitates the Generation of CXC Chemokine Gradients and Stimulates Neutrophil Homing inStaphylococcus aureusPneumonia

(2008) Allison H. Bartlett et al.   JOURNAL OF INFECTIOUS DISEASES