Review
Endocrinology & Metabolism
Xuejiao Wei, Yue Hou, Mengtuan Long, Lili Jiang, Yujun Du
Summary: Renal fibrosis is caused by renal tissue damage and repair response disorders, leading to chronic renal failure if not effectively blocked. HIF-1α plays an important role in renal fibrosis and glucose metabolism by regulating the expression of proteins related to aerobic glycolysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Savalan Babapoor- Farrokhran, Yu Qin, Miguel Flores- Bellver, Yueqi Niu, Imran A. Bhutto, Silvia Aparicio- Domingo, Chuanyu Guo, Murilo Rodrigues, Timothy Domashevich, Monika Deshpande, Haley Megarity, Rakesh Chopde, Charles G. Eberhart, Valeria Canto- Soler, Silvia Montaner, Akrit Sodhi
Summary: This study provides evidence that oxidative stress and hypoxia synergistically stimulate the accumulation of hypoxia-inducible factor in the retinal pigment epithelium, leading to the development of choroidal neovascularization in age-related macular degeneration patients. Adequate hypoxia-inducible factor expression is crucial for the protection of photoreceptors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Je Lin Sieow, Hweixian Leong Penny, Sin Yee Gun, Ling Qiao Tan, Kaibo Duan, Joe Poh Sheng Yeong, Angela Pang, Diana Lim, Han Chong Toh, Tony Kiat Hon Lim, Edgar Engleman, Olaf Rotzschke, Lai Guan Ng, Jinmao Chen, Suet Mien Tan, Siew Cheng Wong
Summary: A large number of neutrophils infiltrate tumors and contribute to the inflammatory tumor microenvironment. The metabolic status of these neutrophils and their role in tumor progression were investigated in a mouse model of pancreatic ductal adenocarcinoma (PDAC). Tumor-infiltrating neutrophils showed enhanced glycolytic activity compared to neutrophils from the bone marrow and blood of the same mouse. Deletion of hypoxia-inducible factor 1-alpha (HIF-1 alpha) in neutrophils reduced tumor burden and improved survival in the mouse model, indicating a potential target for metabolic modulation in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ji Young Kim, Eun Jung Lee, Yuri Ahn, Sujin Park, Yu Jeong Bae, Tae Gyun Kim, Sang Ho Oh
Summary: The study demonstrates that CTSL is a novel target gene of HIF-1 alpha and plays a role in melanosome degradation in melanocytes through lysosomal activity during autophagosome-lysosome fusion. Under autophagy-inducing starvation conditions, the expression of HIF-1 alpha and CTSL is upregulated in melan-a cells. Inhibition of conversion of pro-CTSL to mature CTSL leads to accumulation of certain proteins due to decreased lysosomal activity in the autophagic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Niya L. Morris, David N. Michael, Kathryn M. Crotty, Sarah S. Chang, Samantha M. Yeligar
Summary: This study investigated the effects of alcohol on the metabolism of alveolar macrophages, revealing that chronic alcohol exposure leads to a shift towards glycolysis in alveolar macrophages, resulting in reduced phagocytic capacity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sara da Silva-Ferreira, Claudio Duarte-Oliveira, Daniela Antunes, Catarina Barbosa-Matos, Ana Mendes-Frias, Egidio Torrado, Sandra Costa, Ricardo Silvestre, Cristina Cunha, Agostinho Carvalho
Summary: Chronic pulmonary aspergillosis is a devastating disease with increasing prevalence worldwide. The characteristic inflammation limits the effectiveness of antifungal therapies. The study shows that hypoxia-inducible factor 1 alpha (HIF-1 alpha) plays a central role in regulating neutrophil function and fungal infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dan Mircea Enescu, Sorin Viorel Parasca, Silviu Constantin Badoiu, Daniela Miricescu, Alexandra Ripszky Totan, Iulia-Ioana Stanescu-Spinu, Maria Greabu, Viorel Jinga
Summary: O-2 deprivation induces stress and oxidative stress. Hypoxia can occur in both physiological and pathological conditions, and severe burns may lead to acute kidney injury. HIFs play a crucial role in cellular responses to hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Milica Mandic, Kaitlyn Flear, Pearl Qiu, Yihang K. Pan, Steve F. Perry, Kathleen M. Gilmour
Summary: HIF-1α is important for hypoxic survival in zebrafish, particularly in relation to their ability to perform aquatic surface respiration (ASR). When zebrafish are prevented from accessing the surface during severe hypoxia, their survival is significantly compromised. However, when they are allowed to access the surface, there is no difference in survival between wild-type and HIF-1α knockout fish. ASR mitigates the negative effects of HIF-1α loss, with knockouts initiating ASR at a higher oxygen concentration and performing ASR for longer than wild-types.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Wenpeng Cao, Shan Lei, Zhirui Zeng, Chaolun Xiao, Baofei Sun, Peng Xie, Yumei Li, Daopeng Luo, Wenfeng Yu
Summary: This study identified TRAA2A as an important hypoxia-associated gene in pancreatic cancer, which is associated with tumor progression and metastasis. TRAA2A is regulated by hypoxia-inducible factor HIF1 alpha and promotes the proliferation and motility of pancreatic cancer cells via activation of the AKT pathway. Therefore, TRAA2A may serve as a novel molecular target for investigating the hypoxic response of pancreatic cancer cells.
Article
Neurosciences
Esra Aslan, Bahadir Demir, Hasan Ulusal, Sengul Sahin, Seyithan Taysi, Gulcin Elboga, Abdurrahman Altindag
Summary: This study aimed to measure the levels of sestrin-2 (SESN2) and hypoxia-inducible factor-1 alpha (HIF-1a) in major depressive disorder (MDD) and its subtypes. The results showed significantly lower levels of SESN2 and HIF-1a in MDD patients, which could contribute to the understanding of MDD etiology, objective assessment of disease severity, and identification of new treatment targets.
PSYCHOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Xijin Zhu, Renqing Dingkao, Nan Sun, Ling Han, Qunli Yu
Summary: This study found that nuclear accumulation of HIF-1α through the MAPK/ERK pathway promotes early postmortem metabolism under oxidative stress and regulates glycolysis. These findings contribute to a better understanding of postmortem metabolism and suggest HIF-1α as a potential target for controlling postmortem glycolysis.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Oncology
Liyun Yong, Shasha Tang, Haixin Yu, Hongyi Zhang, Yi Zhang, Yuan Wan, Fengfeng Cai
Summary: Breast cancer is the most common cancer in women, and drug resistance is a persistent clinical challenge. Hypoxia-inducible Factor-1 Alpha (HIF-1α) plays a crucial role in regulating cellular response to hypoxia and is closely associated with multidrug resistance in breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biology
Xu Zhang, Diming Wang, Jianxin Liu
Summary: HIF-1 alpha plays an important role in the response of dairy cows to heat stress. During moderate heat stress, respiratory rate, rectal temperature, and blood concentrations of HSP70 and HSP27 were higher, while oxygen saturation and hemoglobin concentration were lower compared to mild heat stress. Additionally, HIF-1 alpha concentration was higher during moderate heat stress, indicating its involvement in the response of lactating cows to heat stress. Further research confirmed these findings.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Mohammad Malekan, Mohammad Ali Ebrahimzadeh, Fateme Sheida
Summary: The adaptation to O2 loss is regulated by hypoxia-inducible factors such as HIF-1 alpha, which plays a crucial role in melanoma progression through various signaling pathways. Therefore, HIF-1 alpha serves as a diagnostic/prognostic biomarker and a potential target for therapy in melanoma.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Biomedical
S. M. Marza, K. Magyari, S. Bogdan, M. Moldovan, C. Pestean, A. Nagy, F. Tabaran, E. Licarete, S. Suarasan, A. Dreanca, L. Baia, I. Papuc
BIOMEDICAL MATERIALS
(2019)
Article
Instruments & Instrumentation
Alina Sesarman, Lucia Tefas, Bianca Sylvester, Emilia Licarete, Valentin Rauca, Lavinia Luput, Laura Patras, Sebastian Porav, Manuela Banciu, Alina Porfire
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2019)
Article
Nanoscience & Nanotechnology
Sorina Suarasan, Ana-Maria Craciun, Emilia Licarete, Monica Focsan, Klara Magyari, Simion Astilean
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Dentistry, Oral Surgery & Medicine
Alexandru Mester, Lidia Ciobanu, Marian Taulescu, Dragos Apostu, Ondine Lucaciu, Gabriela Adriana Filip, Vasile Feldrihan, Emilia Licarete, Aranka Ilea, Andra Piciu, Daniel Oltean-Dan, Iuliu Scurtu, Cristian Berce, Radu Septimiu Campian
JOURNAL OF PERIODONTOLOGY
(2019)
Article
Nanoscience & Nanotechnology
Alexandru-Milentie Hada, Monica Potara, Sorina Suarasan, Adriana Vulpoi, Timea Nagy-Simon, Emilia Licarete, Simion Astilean
Article
Materials Science, Ceramics
K. Magyari, Zs. Pap, Z. R. Toth, Zs. Kasa, E. Licarete, D. C. Vodnar, K. Hernadi, L. Baia
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2019)
Article
Chemistry, Physical
Diana Zaharie-Butucel, Monica Potara, Sorina Suarasan, Emilia Licarete, Simion Astilean
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2019)
Article
Oncology
Emilia Licarete, Valentin Florian Rauca, Lavinia Luput, Laura Patras, Alina Sesarman, Manuela Banciu
Article
Biochemistry & Molecular Biology
Alina Sesarman, Dana Muntean, Bianca Abrudan, Lucia Tefas, Bianca Sylvester, Emilia Licarete, Valentin Rauca, Lavinia Luput, Laura Patras, Manuela Banciu, Laurian Vlase, Alina Porfire
Summary: The study aimed to investigate the pharmacokinetic profile, tissue distribution, and adverse effects of long-circulating liposomes containing curcumin and doxorubicin. It demonstrated that the liposomal association of curcumin and doxorubicin effectively improved the pharmacokinetics and biodistribution of doxorubicin, limiting its side effects through curcumin-dependent antioxidant effects.
JOURNAL OF LIPOSOME RESEARCH
(2021)
Article
Oncology
Lavinia Luput, Alina Sesarman, Alina Porfire, Marcela Achim, Dana Muntean, Tibor Casian, Laura Patras, Valentin Florian Rauca, Denise Minerva Drotar, Ioana Stejerean, Ioan Tomuta, Laurian Vlase, Nicolae Dragos, Vlad Alexandru Toma, Emilia Licarete, Manuela Banciu
Article
Biochemistry & Molecular Biology
Emilia Licarete, Valentin Florian Rauca, Lavinia Luput, Denise Drotar, Ioana Stejerean, Laura Patras, Bogdan Dume, Vlad Alexandru Toma, Alina Porfire, Claudia Gherman, Alina Sesarman, Manuela Banciu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Sorin M. Marza, Klara Magyari, Sidonia Bogdan, Mirela Moldovan, Cosmin Pestean, Andras Nagy, Adrian Florin Gal, Flaviu Tabaran, Robert Cristian Purdoiu, Emilia Licarete, Sorina Suarasan, Lucian Baia, Ionel Papuc
Summary: The study showed that bioactive glass with spherical gold nanocages in Vaseline ointments can enhance skin healing and regeneration in rats, with great antibacterial activity to prevent bacterial infections. The incorporation of silver stabilized spherical gold nanocages influenced the wound healing process, leading to complete skin regeneration after two weeks in all groups of rats.
Article
Cell & Tissue Engineering
Flavia-Bianca Cristian, Alexandra Koeppel, Johannes Janssen, Jochen S. Utikal, Gudrun A. Rappold, Simone Berkel
STEM CELL RESEARCH
(2020)
Article
Multidisciplinary Sciences
Christine Unsicker, Flavia-Bianca Cristian, Manja von Hahn, Volker Eckstein, Gudrun A. Rappold, Simone Berkel
Summary: SHANK2 mutations impact cell morphology and neuronal differentiation. Cells with bi-allelicSHANK2 mutations show increased proliferation, decreased neurite outgrowth, alterations in downstream signaling of tyrosine kinase receptors, and changes in amyloid precursor protein expression.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Sabina-Madalina Vieriu, Adrian-Alexandru Somesan, Cristian Silvestru, Emilia Licarete, Manuela Banciu, Richard A. Varga
Summary: The study aims to evaluate the antiproliferative activity of various organotin(iv) compounds to better understand the structure-activity relationship. The novel organotin(iv) species synthesized show potential for pharmacological applications.
NEW JOURNAL OF CHEMISTRY
(2021)