Review
Oncology
Luigi Lorini, Francesco Perri, Stefania Vecchio, Liliana Belgioia, Marie Vinches, Irene Brana, Sharon Elad, Paolo Bossi
Summary: This paper reviews the confounding factors of oral mucositis related to head and neck cancer patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Marylin J. Dodd, Maria H. Cho, Bruce A. Cooper, Laurie MacPhail, Christine Miaskowski
Summary: This study aimed to compare the effectiveness of granulocyte macrophage colony stimulating factor (GM-CSF) mouthwash and Salt and Soda mouthwash in the prevention and treatment of radiation therapy-induced oral mucositis (OM). The results showed no significant differences between GM-CSF and Salt and Soda mouthwash in the occurrence and grades of OM during the prevention phase, as well as in functional status, pain, chewing, and swallowing during and after radiation therapy. Therefore, Salt and Soda mouthwash can be used instead of GM-CSF mouthwash to save costs.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
Review
Oncology
Catrina Davy, Sharron Heathcote
Summary: The author identified three interventions: benzydamine hydrochloride mouth rinse (BHM), honey and oral glutamine (OG). BHM studies had mostly favorable results but with overall low quality and poor tolerance. Honey had mostly favorable results but weak evidence supporting the intervention for mitigating radiation-induced oral mucositis.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Nutrition & Dietetics
Zalina Abu Zaid, May Kay Neoh, Zulfitri Azuan Mat Daud, Nor Baizura Md Yusop, Zuriati Ibrahim, Zuwariah Abdul Rahman, Norshariza Jamhuri, Aishah Zafirah Abdul Azim
Summary: This study aimed to evaluate the weight loss during and post-treatment among head and neck cancer patients. The study found that the average weight loss during treatment was 7.4%, and post-treatment weight loss was 2.1%. One month after treatment completion, patients showed significant improvements in nutrition status and muscle mass, but there was a decrease in oral nutritional supplement intake.
Review
Oncology
Patryk Gugnacki, Ewa Sierko
Summary: Human microbiome research is rapidly expanding in various medical and public health disciplines, showing potential in oncology for investigating the impact of oral microbiome on oncogenesis and treatment side effects. Studies indicate that the human microbiome can have oncogenic effects through various mechanisms, and that the oral microbiome plays a role in the development of head and neck cancer and radiation-induced oral mucositis. Further research is needed to better understand the structure and dynamics of the oral microbiome to develop personalized preventive measures and treatments.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Biochemistry & Molecular Biology
Huiwen Xiao, Yao Fan, Yuan Li, Jiali Dong, Shuqin Zhang, Bin Wang, Jia Liu, Xingzhong Liu, Saijun Fan, Jian Guan, Ming Cui
Summary: Oral mucositis is a common complication in NOALC patients undergoing radiotherapy, and oral microbiota transplantation can alleviate the symptoms. The gut microbiota also plays a role in oral mucositis progression. Additionally, specific oral microorganisms like Lactobacillaceae could potentially serve as biomarkers for predicting NOALC prognosis after radiotherapy.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Oncology
Carlos J. Roldan, David I. Rosenthal, Dhanalakshmi Koyyalagunta, Lei Feng, Keith Warner
Summary: Severe pain from oral mucositis in cancer patients can be effectively reduced by using methylene blue oral rinse, which is a safe and affordable treatment. This study found that methylene blue oral rinse significantly decreased oral mucositis pain and improved oral function burden.
Article
Oncology
Tzu-Rong Peng, Hung-Hong Lin, Li-Jou Yang, Ta-Wei Wu
Summary: This meta-analysis showed that compared with placebo, glutamine significantly reduced the incidence of grade 3 and 4 oral mucositis induced by chemotherapy or radiation therapy. Oral administration of glutamine and the use of medium or low doses can decrease the risk. Glutamine also had a significant effect in reducing the risk of grade 3 and 4 oral mucositis induced by radiotherapy, especially in prevention.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Oncology
Shiyu Liu, Qin Zhao, Zhuangzhuang Zheng, Zijing Liu, Lingbin Meng, Lihua Dong, Xin Jiang
Summary: Radiation-induced oral mucositis is a common complication in head and neck cancer patients undergoing radiotherapy, leading to severe discomfort and treatment interruptions. Its pathogenesis is complex, involving the release of inflammatory transmitters. Understanding and implementing preventive measures and treatments are crucial for managing this condition effectively.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Clifton P. Thornton, Mengchi Li, Chakra Budhathoki, Chao Hsing Yeh, Kathy Ruble
Summary: Anti-inflammatory mouthwashes are a potentially effective means to prevent or reduce mucositis associated with cancer therapy, reducing the incidence of symptomatic mucositis and dose-limiting mucositis. Limited adverse effects and high adherence indicate the safety and feasibility of using these mouthwashes. They should be considered for supportive care in individuals at risk for mucositis and further evaluated for efficacy across various chemotherapy agents, adverse effects, and impacts on symptoms, pain, and quality of life.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Wakako Yatsuoka, Takao Ueno, Kanako Miyano, Ayame Enomoto, Sana Ota, Masahiro Sugimoto, Yasuhito Uezono
Summary: This study analyzed the time-course of salivary metabolomic profiles in patients with head and neck cancer undergoing radiation therapy. Specific metabolites such as histidine and tyrosine were found to be associated with the severity of oral mucositis before the start of radiation therapy. Further research is needed to validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Daniela Jicman (Stan), Mihaela Ionela Sarbu, Silvia Fotea, Alexandru Nechifor, Gabriela Balan, Mihaela Anghele, Claudiu Ionut Vasile, Elena Niculet, Nicolae Sarbu, Laura-Florentina Rebegea, Alin Laurent Tatu
Summary: Honey is a simple and effective product for the treatment of oral mucositis, with analgesic, anti-inflammatory, anti-cancerous, and antibacterial effects. It can improve the patient's quality of life and nutritional status by promoting tissue epithelialization and healing. Honey is a cheap and easily accessible treatment option.
MEDICINA-LITHUANIA
(2022)
Review
Oncology
Lauren F. Judge, Mark K. Farrugia, Anurag K. Singh
Summary: Oral mucositis is a significant issue for patients undergoing radiation or chemoradiation for head and neck cancer, with clinical interventions focused on reducing pain associated with mucositis. Various strategies including oral rinses, home humidification, and pharmacological treatments are used to address symptoms during radiotherapy.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Stephen Palasi, Ning Zhang, Mikaela Bankston, Joy Godby, Hannah Burrows, Jennifer Lagunas, William Perkison, Brandon Gunn, Mark S. Chambers, David Rosenthal, William Morrison, Adam Garden, Clifton David Fuller, Sharon Giordano, Eugene J. Koay
Summary: The purpose of this study was to identify clinical and epidemiological factors associated with the utilization of a complex oral treatment device for head and neck cancer patients undergoing radiation therapy. Retrospective analysis of data from the SEER-Medicare databases revealed that age, gender, and geographical disparities were linked to the utilization of the device. Further research and development are needed to improve availability and increase utilization among specific patient populations.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2021)