Emerging Molecular Targets for the Treatment of Nonalcoholic Fatty Liver Disease

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

Prolonged saturated fat–induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver

(2009) Giovanni Musso et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Targeting the AMPK pathway for the treatment of Type 2 diabetes

(2009) Benoit Viollet   Frontiers in Bioscience-Landmark

MicroRNAs involved in tumor suppressor and oncogene pathways: Implications for hepatobiliary neoplasia

(2009) Justin L. Mott   HEPATOLOGY

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte

(2009) Amélie Moreau et al.   HEPATOLOGY

Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones

(2009) Seong Hwan Hwahng et al.   HEPATOLOGY

Activation of the Nuclear Receptor PXR Decreases Plasma LDL-Cholesterol Levels and Induces Hepatic Steatosis in LDL Receptor Knockout Mice

(2009) Menno Hoekstra et al.   MOLECULAR PHARMACEUTICS

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes

(2009) Niresh Hariparsad et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs: role in cardiovascular biology and disease

(2008) Chunxiang Zhang   CLINICAL SCIENCE

Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis

(2008) L. Valenti et al.   DIABETES

Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels

(2008) L. Li et al.   DIABETES OBESITY & METABOLISM

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

(2008) H. Boon et al.   DIABETOLOGIA

MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease

(2008) X. Jin et al.   DIGESTIVE AND LIVER DISEASE

Selective thyromimetics for atherosclerosis and dyslipidaemia: another old target making progress

(2008) Keith Suckling   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Thyroid hormone (T3) and TRβ agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats

(2008) Andrea Perra et al.   FASEB JOURNAL

Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH

(2008) Giovanni Musso et al.   HEPATOLOGY

Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist

(2008) Edward E. Cable et al.   HEPATOLOGY

Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

(2008) Onpan Cheung et al.   HEPATOLOGY

Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma

(2008) Shunsuke Ura et al.   HEPATOLOGY

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes

(2008) Manlio Vinciguerra et al.   HEPATOLOGY

Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways

(2008) Keun-Gyu Park et al.   HEPATOLOGY

MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations

(2008) Yannick Ladeiro et al.   HEPATOLOGY

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle

(2008) Eric B. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet

(2008) B. Kong et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of Thyroid Hormone Analogs on Lipid Metabolism and Thermogenesis

(2008) Miriam O. Ribeiro   THYROID

Regulating the regulators: mechanisms controlling the maturation of microRNAs

(2008) Xavier C. Ding et al.   TRENDS IN BIOTECHNOLOGY

The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and Consequences

(2007) Jean-Marc Pascussi et al.   Annual Review of Pharmacology and Toxicology

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY