Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ramtin Hadighi, Aliehsan Heidari, Parviz Fallah, Hossein Keshavarz, Ziba Tavakoli, Sholeh Mansouri, Mehrdokht Sadrkhanloo
Summary: This study evaluated changes in plasma miRNA markers of Plasmodium vivax in patients with malaria in Chabahar, Iran. The results showed that the expression of miR-223, miR-145, and miR-155 was significantly increased in patients with P. vivax compared to healthy individuals, suggesting that these miRNAs may serve as biomarkers for P. vivax malaria assessment.
Review
Gastroenterology & Hepatology
Richie Manikat, Mindie H. Nguyen
Summary: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by excess fat accumulation in the liver. It is associated with metabolic syndrome and often presents with comorbidities such as obesity, type 2 diabetes mellitus, and dyslipidemia. NAFLD is also linked to non-liver comorbidities including cardiovascular disease, chronic kidney disease, and sleep apnea. Managing these comorbidities is crucial for improving liver-related and overall health outcomes in patients with NAFLD.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Review
Immunology
Wenhui Zhang, Ren Lang
Summary: NAFLD and NASH are significant contributors to liver disease worldwide. Macrophages play a crucial role in the pathogenesis of NAFLD and NASH, and their metabolic characteristics influence their activation state and functionality. Targeting macrophage metabolism could be a promising therapeutic approach for the management of NAFLD/NASH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hanyun Liu, Qinghui Niu, Ting Wang, Hongjing Dong, Cheng Bian
Summary: The study revealed that EVs-loaded miR-9-5p derived from lipotoxic hepatocytes can promote M1 polarization of macrophages in NAFLD by targeting TGM2 to inhibit its expression, thereby driving the progression of NAFLD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
D. Sharma, A. Koul, S. Bhushan, S. Gupta, S. Kaul, M. K. Dhar
Summary: MicroRNAs play a crucial role in regulating metabolic pathways in plants and animals. This study focuses on exploring the role of microRNAs in the biosynthesis of carotenoids in tomatoes. The findings suggest that microRNAs regulate carotenoid synthesis at different stages of tomato fruit development, and the identified microRNAs can be utilized to enhance the production of different carotenoids in plants.
Article
Gastroenterology & Hepatology
Dong Hyun Sinn, Danbee Kang, Sung Chul Choi, Yun Soo Hong, Di Zhao, Eliseo Guallar, Yewan Park, Juhee Cho, Geum-Youn Gwak
Summary: The clinical implications of nonalcoholic fatty liver disease (NAFLD) in subjects who fulfill the diagnostic criteria of metabolic (dysfunction)-associated fatty liver disease (MAFLD) are unknown.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Genetics & Heredity
Yang Xie, Yi Cao, Can-Jie Guo, Xing-Ya Guo, Ya-Fang He, Qing-Yang Xu, Feng Shen, Qin Pan
Summary: This study reveals that the downregulation of LNCPINT-derived circRNAs is associated with AMPK signaling pathway inactivation and hepatic steatosis in NAFLD induced by a high-fat, high-cholesterol diet. These findings contribute to our understanding of the pathogenesis of NAFLD and provide potential therapeutic targets.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Ningning You, Jiali Xu, Liyan Wang, Lili Zhuo, Jingxin Zhou, Yu Song, Aliaweis Ali, Yan Luo, Jin Yang, Wenjun Yang, Minghua Zheng, Jing Xu, Li Shao, Junping Shi
Summary: The study found that there are significant differences in the gut fungal structure of NAFLD patients, and some fungi may be associated with NAFLD development, liver injury, and lipid metabolism. Therefore, research on gut fungi may have important value for diagnosing and monitoring NAFLD.
Review
Food Science & Technology
Jing-Wen Yang, Hong-Fang Ji
Summary: Phytosterols are bioactive food components found in plant cell membranes, especially in nuts and oilseeds. Many studies have shown their therapeutic potential for nonalcoholic fatty liver disease (NAFLD). They lower total cholesterol and triglyceride levels through various mechanisms and improve NAFLD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Julia A. Golubeva, Anna F. Sheptulina, Anastasia Yu. Elkina, Ekaterina O. Liusina, Anton R. Kiselev, Oxana M. Drapkina
Summary: Non-alcoholic fatty liver disease (NAFLD) and arterial hypertension (AH) are common non-communicable diseases worldwide. They often coexist and are associated with each other regardless of the presence of other metabolic factors.
Article
Engineering, Biomedical
Mengjie Kong, Yan Peng, Liyan Qiu
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide, but there is no FDA-approved drug for its treatment. This study designed oligochitosan-derivated nanovesicles to deliver an FXR agonist and miR-34a antagomir for NAFLD treatment. The nanovesicles effectively reduced lipid deposition in cells and showed promising results in NAFLD mice models. The study also demonstrated the activation of SIRT1 through the FXR/miR-34a/SIRT1 regulatory loop.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Ilaria Umbro, Francesco Baratta, Francesco Angelico, Maria Del Ben
Summary: NAFLD is associated with extrahepatic manifestations like cardiovascular disease and sleep apnea, as well as an increased risk of incident CKD. Inflammation and oxidative stress play key roles in linking NAFLD to CKD. Studies show that CKD develops more frequently in NAFLD patients, persisting even after adjusting for risk factors and severity of NAFLD, emphasizing the need for multidisciplinary surveillance and early treatment for these patients.
Letter
Gastroenterology & Hepatology
Yan Li, Wen-Cheng Liu, Bing Chang
Summary: The interaction between gut microflora and liver diseases has attracted much attention. The composition of the intestinal microflora includes bacteria, archaea, fungi, and viruses. There is limited research on the intestinal virome, and its causal relationship with bacterial changes in the gut is still unclear. However, the importance of the intestinal virome in the development, diagnosis, and treatment of liver diseases cannot be denied.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Anna Di Sessa, Simona Riccio, Emilia Pirozzi, Martina Verde, Antonio Paride Passaro, Giuseppina Rosaria Umano, Stefano Guarino, Emanuele Miraglia del Giudice, Pierluigi Marzuillo
Summary: NAFLD, closely related to obesity, has become a global health issue. Lipotoxicity and the role of different lipid classes in NAFLD have gained attention. Lipidomic studies offer insights for innovative therapeutic approaches in NAFLD treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Jinzhou Zhu, Zhengqi Tan, Kelseanna Hollis-Hansen, Yong Zhang, Chaohui Yu, Youming Li
DIGESTIVE DISEASES AND SCIENCES
(2017)
Review
Gastroenterology & Hepatology
Li Cen, Jiaqi Pan, Boyan Zhou, Chaohui Yu, Youming Li, Weixing Chen, Zhe Shen
Article
Gastroenterology & Hepatology
Lan Li, Yini Ke, Chaohui Yu, Guogang Li, Ningmin Yang, Jianzhong Zhang, Youming Li
Article
Biochemistry & Molecular Biology
Yi Chen, Haixiu Huang, Chengfu Xu, Chaohui Yu, Youming Li
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Gastroenterology & Hepatology
Jinghua Wang, Wanlin Zhu, Shujun Huang, Lei Xu, Min Miao, Chenjiao Wu, Chaohui Yu, Youming Li, Chengfu Xu
LIVER INTERNATIONAL
(2017)
Article
Multidisciplinary Sciences
Tianlian Yan, Yini Ke, Yi Chen, Chengfu Xu, Chaohui Yu, Youming Li
Article
Infectious Diseases
D. -S. Liu, Y. -H. Wang, Z. -R. Zeng, Z. -Y. Zhang, H. Lu, J. -M. Xu, Y. -Q. Du, Y. Li, J. -B. Wang, S. -P. Xu, Y. Chen, C. -H. Lan, H. Cheng, M. -D. Jiang, L. -X. Zhang, L. -J. Huo, S. -Y. Chen, G. -X. Zhang, K. -C. Wu, X. Zhu, Y. -X. Chen, Y. Zhu, X. Shu, Y. Xie, N. -H. Lu
CLINICAL MICROBIOLOGY AND INFECTION
(2018)
Article
Gastroenterology & Hepatology
Jinghua Wang, Liang Ma, Shenghui Chen, Lei Xu, Min Miao, Chaohui Yu, Youming Li, Chengfu Xu
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Multidisciplinary Sciences
Yun Hong, Sirui Li, Jifeng Wang, Youming Li
SCIENTIFIC REPORTS
(2018)
Editorial Material
Surgery
Z. Y. Fang, H. X. Huang, C. Lu, X. X. Zhou, F. Ji, C. H. Yu, Y. M. Li
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2018)
Article
Multidisciplinary Sciences
Meng Li, Dahua Chen, Haixiu Huang, Jiewei Wang, Xingyong Wan, Chengfu Xu, Chunxiao Li, Han Ma, Chaohui Yu, Youming Li
Review
Medicine, General & Internal
Jiahui Hu, Dongdong Huang, Chengfu Xu, Yi Chen, Han Ma, Zhe Shen
Summary: We report a case of Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ iFDCS) presenting as a colon polyp in a 52-year-old woman with a special family history. The excised polypoid mass showed histopathological features consistent with EBV+ iFDCS, including infiltration of IgG4+ cells and positive expression of CD21, CD23, CD35, and EBER. The patient remained disease-free during the 1-year follow-up. This case highlights the importance of identifying the pathogenesis sites and sharing diagnostic experiences of EBV+ iFDCS, as well as summarizing its clinicopathological features presenting as a colon polyp.
MEDICINA-LITHUANIA
(2023)
Article
Pharmacology & Pharmacy
C-J Lei, B. Wang, Z-X Long, H. Ren, Q-Y Pan, Y. Li
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2018)
Article
Endocrinology & Metabolism
Jinzhou Zhu, Xingyong Wan, Yuming Wang, Kefu Zhu, Chunxiao Li, Chaohui Yu, Youming Li
Article
Medicine, Research & Experimental
Chao Lu, Jiande Gong, Zhe Shen, Chaohui Yu, Youming Li
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2017)