Review
Immunology
George Fromm, Suresh de Silva, Taylor H. Schreiber
Summary: The extracellular domain of tumor necrosis factor receptors (TNFR) needs to assemble into a homotrimeric quaternary structure in order to initiate signaling. Synthetic agonists targeting TNF receptors have potential clinical benefits in amplifying immune responses, but their translation into human clinical studies has been limited and raised questions about the biology of TNF receptors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nina M. van Sorge, Daniel A. Bonsor, Liwen Deng, Erik Lindahl, Verena Schmitt, Mykola Lyndin, Alexej Schmidt, Olof R. Nilsson, Jaime Brizuela, Elena Boero, Eric J. Sundberg, Jos A. G. van Strijp, Kelly S. Doran, Bernhard B. Singer, Gunnar Lindahl, Alex J. McCarthy
Summary: Streptococcus agalactiae, also known as group B Streptococcus (GBS), is a major cause of neonatal sepsis in humans. In a recent study, it was found that the surface-expressed beta protein of GBS binds to human CEACAM1 and CEACAM5 receptors, with the crystal structure revealing a novel IgI3 fold. This discovery suggests a potentially widely applicable mechanism for bacteria to target CEACAMs.
Review
Cell Biology
Kirstin Kucka, Harald Wajant
Summary: Most TNFRSF receptors are signaling competent and require secondary clustering in cell-cell contacts for full activation after binding to ligands. Two groups of TNFRs were identified based on their response to soluble ligand trimers, with one group being robustly activated and the other failing to be properly activated despite high affinity binding.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Eva S. Vanamee, Denise L. Faustman
Summary: This review paper synthesizes key findings from recent studies on the tumor necrosis factor (TNF) receptor superfamily signaling, emphasizing the importance of clustering. The underlying molecular mechanisms of signaling, functional consequences of receptor clustering, and potential therapeutic implications of targeting surface structures of receptor complexes are discussed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hina Qaiser, Maria Saeed, Dmitry Nerukh, Zaheer Ul-Haq
Summary: In this study, three potential small molecule inhibitors targeting TNF-α were identified using in silico approaches, and their stability and mechanism of action were confirmed through molecular dynamics studies. ADME analysis indicated good pharmacokinetic properties of these compounds with low toxicity risks, except for one compound.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Immunology
Lichchavi D. Rajasinghe, Melissa A. Bates, Abby D. Benninghoff, Kathryn A. Wierenga, Jack R. Harkema, James J. Pestka
Summary: Repeated intranasal instillation of lupus-prone mice with crystalline silica induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, which can be suppressed by dietary supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA). The inflammatory proteins induced by crystalline silica in bronchoalveolar alveolar lavage fluid (BALF) were time-dependently increased, but were attenuated by DHA supplementation. Analysis revealed that the inflammatory proteome in BALF correlated positively with gene expression, ectopic lymphoid tissue neogenesis, and autoantibody induction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kemelly Karolliny Moreira Resende, Margot Charlotte Riou, Paulo Marcio Yamaguti, Benjamin Fournier, Sophie Rondeau, Laurence Pacot, Ariane Berdal, Rufino Felizardo, Juliana Forte Mazzeu, Valerie Cormier-Daire, Celine Gaucher, Ana Carolina Acevedo, Muriel de la Dure-molla
Summary: Amelogenesis imperfecta (AI) is a rare genetic condition characterized by enamel alterations in the teeth. Recent research has identified five disease-causing variants in the RELT gene, which is expressed during tooth development but its function is still unknown. This study reports new variants in the RELT gene and expands our understanding of the dental phenotypes associated with ARAI.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Oncology
Claire Battin, Annika De Sousa Linhares, Judith Leitner, Anna Grossmann, Daniela Lupinek, Shiva Izadi, Alexandra Castilho, Petra Waidhofer-Soellner, Katharina Grabmeier-Pfistershammer, Jochen Stritzker, Peter Steinberger
Summary: Targeting co-stimulatory receptors enhances the functions of anti-tumor lymphocytes. The use of a secreted 4-1BBL ectodomain with a trimerization domain derived from human collagen as a payload in therapeutic viral vectors has been shown to be effective in reducing tumor burden in a CD34(+) humanized mouse model.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Feng Wang, Bryant Chau, Sean M. West, Christopher R. Kimberlin, Fei Cao, Flavio Schwarz, Barbara Aguilar, Minhua Han, Winse Morishige, Christine Bee, Gavin Dollinger, Arvind Rajpal, Pavel Strop
Summary: Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and GITR ligand (GITRL) are members of the tumor necrosis superfamily that regulate immune cell activities, including anti-tumor immune responses. The structures and visualization of human and mouse GITR-GITRL complexes provide insights into the architecture of higher-order membrane assemblies and their signaling mechanisms.
NATURE COMMUNICATIONS
(2021)
Review
Biology
Yaoguo Li, Tiaoyi Xiao, Jun Zou
Summary: This review summarizes recent advances in the study of fish TNF biology and focuses on the molecular properties and immunological functions of the TNF and TNFR superfamily. The research found that fish have a diversified TNF family, partly due to whole genome duplication events.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Immunology
Cornelia Schuster, Badr Kiaf, Teri Hatzihristidis, Anna Ruckdeschel, Janice Nieves-Bonilla, Yuki Ishikawa, Bin Zhao, Peilin Zheng, Paul E. Love, Stephan Kissler
Summary: CD5 is a negative regulator of lymphocyte function and plays a crucial role in modulating gut immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lisanne Storm, Jesse Bruijnesteijn, Natasja G. de Groot, Ronald E. Bontrop
Summary: The genes of the leukocyte immunoglobulin-like receptor (LILR) family, located on chromosome 19 in the leukocyte receptor complex (LRC), play a significant role in immune responses. While the organization of the LILR region remained largely conserved during primate evolution, the common marmoset species exhibits a substantial contraction in the number of LILR genes. This genomic analysis also reveals differences in the number of killer-cell immunoglobulin-like receptor gene copies between human and non-human primate species.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Hope Steele, Jason Cheng, Ashley Willicut, Garrison Dell, Joey Breckenridge, Erica Culberson, Andrew Ghastine, Virginie Tardif, Rana Herro
Summary: Fibrosis, resulting from extracellular matrix protein deposition, is a leading cause of death in the USA. Therapeutic options targeting the tumor necrosis super family (TNFSF) members show promise in degrading or reversing fibrosis in various organs. This review provides insights into the involvement of TNFSF in fibrosis and emphasizes the importance of targeting this superfamily to improve current therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Isabel Vogel, Valerie Acolty, Tibor Keler, Stanislas Goriely, Oberdan Leo, Muriel Moser
Summary: CD27/CD70 costimulation enhances T-cell function and suppresses IL-17 production, suggesting its potential as a therapeutic target for diseases characterized by excessive IL-17 production.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuki Kawana, Hiraku Suga, Hiroaki Kamijo, Tomomitsu Miyagaki, Makoto Sugaya, Shinichi Sato
Summary: MF and SS are the most common types of cutaneous T-cell lymphoma, with poor prognosis in advanced-stage patients. The expression of OX40 and OX40L is correlated with disease severity, and targeting the disruption of OX40-OX40L interactions may offer a new therapeutic strategy for MF/SS treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)