Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells

(2020) Christos Karathanasis et al.   Science Signaling

O‐glycans on death receptors in cells modulate their sensitivity to TRAIL‐induced apoptosis through affecting on their stability and oligomerization

(2020) Yuliang Jiang et al.   FASEB JOURNAL

A systems-biology model of the tumor necrosis factor (TNF) interactions with TNF receptor 1 and 2

(2020) Juan Pablo Prada et al.   BIOINFORMATICS

TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity

(2019) Juliane Medler et al.   Cell Death & Disease

Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling

(2019) Liqiang Pan et al.   CELL

Decoding the sweet regulation of apoptosis: the role of glycosylation and galectins in apoptotic signaling pathways

(2019) Kamil Seyrek et al.   CELL DEATH AND DIFFERENTIATION

Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity

(2019) Pamela Zhang et al.   Cell Reports

HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality

(2019) David M. Richards et al.   Journal for ImmunoTherapy of Cancer

Molecular Mode of Action of TRAIL Receptor Agonists—Common Principles and Their Translational Exploitation

(2019) Wajant   Cancers

Palmitoylation is required for TNF-R1 signaling

(2019) Philipp Zingler et al.   Cell Communication and Signaling

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

(2018) Xiaojie Yu et al.   CANCER CELL

Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier

(2018) Aruna Bitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia

(2018) Holm Schneider et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer

(2018) Gururaj Shivange et al.   CANCER CELL

Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain

(2018) Hyun Ho Park   CELL DEATH AND DIFFERENTIATION

Chimeric mice with humanized livers demonstrate human-specific hepatotoxicity caused by a therapeutic antibody against TRAIL-receptor 2/death receptor 5

(2018) Kaito Nihira et al.   TOXICOLOGICAL SCIENCES

Structure of TRAF Family: Current Understanding of Receptor Recognition

(2018) Hyun H. Park   Frontiers in Immunology

Death receptor 5 is activated by fucosylation in colon cancer cells

(2018) Baojie Zhang et al.   FEBS Journal

Regulatory T Cell–Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9

(2017) Shravan Madireddi et al.   JOURNAL OF IMMUNOLOGY

Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney disease

(2017) Aitor G. Granja et al.   PLoS One

Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling

(2017) Cristian R Smulski et al.   Cell Death & Disease

Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement

(2016) Rony Dahan et al.   CANCER CELL

Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2

(2016) Daniela Siegmund et al.   FEBS Journal

CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice

(2016) Amanda Poissonnier et al.   IMMUNITY

Melanoma-Directed Activation of Apoptosis Using a Bispecific Antibody Directed at MCSP and TRAIL Receptor-2/Death Receptor-5

(2016) Yuan He et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis

(2016) P. Bru nker et al.   MOLECULAR CANCER THERAPEUTICS

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

(2016) Tian-Min Fu et al.   MOLECULAR CELL

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor

(2016) Qingshan Fu et al.   MOLECULAR CELL

Antitherapeutic antibody-mediated hepatotoxicity of recombinant human Apo2L/TRAIL in the cynomolgus monkey

(2016) Christina L Zuch de Zafra et al.   Cell Death & Disease

Crystal structure of the death effector domains of caspase-8

(2015) Chen Shen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

(2015) Ann L. White et al.   CANCER CELL

Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor

(2015) Kyriakos P. Papadopoulos et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Principles of antibody-mediated TNF receptor activation

(2015) H Wajant   CELL DEATH AND DIFFERENTIATION

Soluble TL1A is sufficient for activation of death receptor 3

(2015) Sebastian Bittner et al.   FEBS Journal

Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties

(2015) Sonia Schuepbach-Mallepell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding Studies of TNF Receptor Superfamily (TNFRSF) Receptors on Intact Cells

(2015) Isabell Lang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

(2015) C. Gajate et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability

(2014) A Rossin et al.   CELL DEATH AND DIFFERENTIATION

Dominant Negative Effects of Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL) Receptor 4 on TRAIL Receptor 1 Signaling by Formation of Heteromeric Complexes

(2014) Simon Neumann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies

(2014) Shravan Madireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fcγ Receptor Dependency of Agonistic CD40 Antibody in Lymphoma Therapy Can Be Overcome through Antibody Multimerization

(2014) Ann L. White et al.   JOURNAL OF IMMUNOLOGY

Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death

(2014) Kim L Brunekreeft et al.   Molecular Cancer

CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants

(2014) J Trebing et al.   Cell Death & Disease

Fibroblast Growth Factor Inducible (Fn14)-specific Antibodies Concomitantly Display Signaling Pathway-specific Agonistic and Antagonistic Activity

(2013) Steffen Salzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine-rich Domain 1 of CD40 Mediates Receptor Self-assembly

(2013) Cristian R. Smulski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo

(2013) Johannes Trebing et al.   mAbs

TWEAK-Independent Fn14 Self-Association and NF-κB Activation Is Mediated by the C-Terminal Region of the Fn14 Cytoplasmic Domain

(2013) Sharron A. N. Brown et al.   PLoS One

Antitumor activities of agonistic anti-TNFR antibodies require differential Fc RIIB coengagement in vivo

(2013) F. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Active CD95 Receptor Molecules Trigger Co-translocation of Inactive CD95 Molecules into Lipid Rafts

(2012) Isabell Lang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation

(2012) HyeMee Joo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Tumor Necrosis Factor Receptor Stalk Regions Define Responsiveness to Soluble versus Membrane-Bound Ligand

(2012) C. Richter et al.   MOLECULAR AND CELLULAR BIOLOGY

Galectin-9 Controls CD40 Signaling through a Tim-3 Independent Mechanism and Redirects the Cytokine Profile of Pathogenic T Cells in Autoimmunity

(2012) Gisela M. Vaitaitis et al.   PLoS One

The Transmembrane Domains of TNF-Related Apoptosis-Inducing Ligand (TRAIL) Receptors 1 and 2 Co-Regulate Apoptotic Signaling Capacity

(2012) Simon Neumann et al.   PLoS One

Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fc  receptor engagement

(2012) F. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors

(2012) E. Varfolomeev et al.   Science Signaling

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

(2011) B. B. Aggarwal et al.   BLOOD

An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells

(2011) Nicholas S. Wilson et al.   CANCER CELL

Engineering death receptor ligands for cancer therapy

(2011) Harald Wajant et al.   CANCER LETTERS

Antibody-based fusion proteins to target death receptors in cancer

(2011) Marco de Bruyn et al.   CANCER LETTERS

Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells

(2011) N Mazurek et al.   CELL DEATH AND DIFFERENTIATION

Targeting pre-ligand assembly domain of TNFR1 ameliorates autoimmune diseases – An unrevealed role in downregulation of Th17 cells

(2011) Yen-Ling Wang et al.   JOURNAL OF AUTOIMMUNITY

Studies of Binding of Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) to Fibroblast Growth Factor Inducible 14 (Fn14)

(2011) Andrea Fick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization

(2011) Rebecca Feltham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region

(2011) Raquel Herrero et al.   JOURNAL OF CLINICAL INVESTIGATION

Virally-Induced Upregulation of Heparan Sulfate on B Cells via the Action of Type I IFN

(2011) N. Jarousse et al.   JOURNAL OF IMMUNOLOGY

Interaction with Fc RIIB Is Critical for the Agonistic Activity of Anti-CD40 Monoclonal Antibody

(2011) A. L. White et al.   JOURNAL OF IMMUNOLOGY

Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation

(2011) Olga M. Shatnyeva et al.   PLoS One

Expression and Purification of a Natural N-Terminal Pre-ligand Assembly Domain of Tumor Necrosis Factor Receptor 1 (TNFR1 PLAD) and Preliminary Activity Determination

(2011) Jin Cao et al.   PROTEIN JOURNAL

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Inhibitory Fc  Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

(2011) F. Li et al.   SCIENCE

The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway

(2011) Sébastien Tauzin et al.   PLOS BIOLOGY

Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice

(2010) Guo-Min Deng et al.   ARTHRITIS AND RHEUMATISM

Soluble and Transmembrane TNF-Like Weak Inducer of Apoptosis Differentially Activate the Classical and Noncanonical NF- B Pathway

(2010) C. Roos et al.   JOURNAL OF IMMUNOLOGY

Asymmetric Recruitment of cIAPs by TRAF2

(2010) Peter D. Mace et al.   JOURNAL OF MOLECULAR BIOLOGY

SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity

(2010) E Charlier et al.   LEUKEMIA

Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

(2010) Chao Zheng et al.   MOLECULAR CELL

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

(2010) Liwei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional analysis of the posttranslational modifications of the death receptor 6

(2009) Martin Klíma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The proteoglycan (heparan sulfate proteoglycan) binding domain of APRIL serves as a platform for ligand multimerization and cross-linking

(2009) Fiona C. Kimberley et al.   FASEB JOURNAL

Biological Activity of Ectodysplasin A Is Conditioned by Its Collagen and Heparan Sulfate Proteoglycan-binding Domains

(2009) Lee Kim Swee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

(2009) A. Wyzgol et al.   JOURNAL OF IMMUNOLOGY

The Fas–FADD death domain complex structure unravels signalling by receptor clustering

(2009) Fiona L. Scott et al.   NATURE

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers

(2009) Marçal Vilar et al.   NEURON

Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

(2008) Aurélie Rossin et al.   BIOCHEMICAL JOURNAL

Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization

(2008) Nicole Müller et al.   FEBS Journal