The Genetic Theory of Infectious Diseases: A Brief History and Selected Illustrations

IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction

(2013) Stéphanie Bibert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

VLR-Based Adaptive Immunity

(2012) Thomas Boehm et al.   Annual Review of Immunology

The triumph of good over evil: protection by the sickle gene against malaria

(2012) H. F. Bunn   BLOOD

Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance

(2012) Gregory LaMonte et al.   Cell Host & Microbe

Intrinsic Cellular Defenses against Human Immunodeficiency Viruses

(2012) Daniel Blanco-Melo et al.   IMMUNITY

HeterozygousTBK1mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

(2012) Melina Herman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K

(2012) Mary Ellen Conley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis

(2012) Steve M Taylor et al.   LANCET INFECTIOUS DISEASES

Genome-wide association study indicates two novel resistance loci for severe malaria

(2012) Christian Timmann et al.   NATURE

Genetics of IL28B and HCV—response to infection and treatment

(2012) C. Nelson Hayes et al.   Nature Reviews Gastroenterology & Hepatology

Human genetic susceptibility to infectious disease

(2012) Stephen J. Chapman et al.   NATURE REVIEWS GENETICS

Evolution, revolution and heresy in the genetics of infectious disease susceptibility

(2012) A. V. S. Hill   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Analysis of IL28B Variants in an Egyptian Population Defines the 20 Kilobases Minimal Region Involved in Spontaneous Clearance of Hepatitis C Virus

(2012) Vincent Pedergnana et al.   PLoS One

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

Interferon lambdas: the next cytokine storm

(2011) C. Kelly et al.   GUT

NEMO is a key component of NF-κB– and IRF-3–dependent TLR3-mediated immunity to herpes simplex virus

(2011) Magali Audry et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

(2011) Vanessa Sancho-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

(2011) Yiqi Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Host genomics and HCV treatment response

(2011) Paul J Clark et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Genetic Polymorphism in IL28B Is Associated With Spontaneous Clearance of Hepatitis C Virus Genotype 4 Infection in an Egyptian Cohort

(2011) Fuat Kurbanov et al.   JOURNAL OF INFECTIOUS DISEASES

How Do Hemoglobins S and C Result in Malaria Protection?

(2011) T. N. Williams   JOURNAL OF INFECTIOUS DISEASES

Hemoglobin S and C Heterozygosity Enhances Neither the Magnitude nor Breadth of Antibody Responses to a Diverse Array of Plasmodium falciparum Antigens

(2011) Xiaolin Tan et al.   JOURNAL OF INFECTIOUS DISEASES

Nutrition in phenylketonuria

(2011) A. MacDonald et al.   MOLECULAR GENETICS AND METABOLISM

Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy

(2011) Furen Zhang et al.   NATURE GENETICS

Inborn errors of anti-viral interferon immunity in humans

(2011) Vanessa Sancho-Shimizu et al.   Current Opinion in Virology

Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?

(2010) Alexandre Alcaïs et al.   Annals of the New York Academy of Sciences

In the Absence of HCV Infection, Interferon Stimulated Gene Expression in Liver Is Not Associated With IL28B Genotype

(2010) Fatma M. Shebl et al.   GASTROENTEROLOGY

Hepatic ISG Expression Is Associated With Genetic Variation in Interleukin 28B and the Outcome of IFN Therapy for Chronic Hepatitis C

(2010) Masao Honda et al.   GASTROENTEROLOGY

Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

(2010) Andri Rauch et al.   GASTROENTEROLOGY

IL28B and the Control of Hepatitis C Virus Infection

(2010) Ashwin Balagopal et al.   GASTROENTEROLOGY

IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C

(2010) Thomas J. Urban et al.   HEPATOLOGY

Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

(2010) Rebeca Pérez de Diego et al.   IMMUNITY

Age-Dependent Mendelian Predisposition to Herpes Simplex Virus Type 1 Encephalitis in Childhood

(2010) Laurent Abel et al.   JOURNAL OF PEDIATRICS

How host defense is encoded in the mammalian genome

(2010) Bruce Beutler et al.   MAMMALIAN GENOME

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

(2010) Capucine Picard et al.   MEDICINE

Genetic control of resistance to human malaria

(2009) Anthony C Allison   CURRENT OPINION IN IMMUNOLOGY

Interferon-λ Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family

(2009) Hans Henrik Gad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human genetics of infectious diseases: between proof of principle and paradigm

(2009) Alexandre Alcaïs et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

Genome-wide and fine-resolution association analysis of malaria in West Africa

(2009) Muminatou Jallow et al.   NATURE GENETICS

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gross Deletions Involving IGHM, BTK, or Artemis: A Model for Genomic Lesions Mediated by Transposable Elements

(2008) Menno C. van Zelm et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Interleukin-29 Functions Cooperatively with Interferon to Induce Antiviral Gene Expression and Inhibit Hepatitis C Virus Replication

(2008) Nicole E. Pagliaccetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection

(2008) Keer Sun et al.   NATURE MEDICINE

Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin

(2008) R. Cholera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Forward Genetic Dissection of Immunity to Infection in the Mouse

(2007) S.M. Vidal et al.   Annual Review of Immunology