Membrane-Anchored Serine Proteases in Vertebrate Cell and Developmental Biology

Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium

(2010) M. Steensgaard et al.   Acta Physiologica

A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA

(2010) Sandro Altamura et al.   BIOCHEMICAL JOURNAL

Mice Lacking Two Sperm Serine Proteases, ACR and PRSS21, Are Subfertile, but the Mutant Sperm Are Infertile In Vitro1

(2010) Natsuko Kawano et al.   BIOLOGY OF REPRODUCTION

Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6

(2010) A. Lenoir et al.   BLOOD

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

(2010) A.-S. Zhang et al.   BLOOD

Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals

(2010) Víctor Quesada et al.   BMC GENOMICS

Processing of Pro-B-Type Natriuretic Peptide: Furin and Corin as Candidate Convertases

(2010) A. G. Semenov et al.   CLINICAL CHEMISTRY

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

(2010) Eric Camerer et al.   DEVELOPMENTAL CELL

The mouse frizzy (fr) and rat ‘hairless’ (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8)

(2010) Damek V. Spacek et al.   EXPERIMENTAL DERMATOLOGY

Identification of the Matriptase Second CUB Domain as the Secondary Site for Interaction with Hepatocyte Growth Factor Activator Inhibitor Type-1

(2010) Kuniyo Inouye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transport via the Transcytotic Pathway Makes Prostasin Available as a Substrate for Matriptase

(2010) Stine Friis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

(2010) Katiuchia Uzzun Sales et al.   NATURE GENETICS

Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice

(2010) Syazana Hanifa et al.   NEUROREPORT

Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine

(2010) M. S. Buzza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in SPINT2 Cause a Syndromic Form of Congenital Sodium Diarrhea

(2009) Peter Heinz-Erian et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of Matriptase Suppression Underlies Spint1 Mutation-Associated Ichthyosis and Postnatal Lethality

(2009) Roman Szabo et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

(2009) Karin List et al.   AMERICAN JOURNAL OF PATHOLOGY

The Glycosylphosphatidylinositol-Anchored Serine Protease PRSS21 (Testisin) Imparts Murine Epididymal Sperm Cell Maturation and Fertilizing Ability1

(2009) Sarah Netzel-Arnett et al.   BIOLOGY OF REPRODUCTION

A genome-wide association analysis of serum iron concentrations

(2009) T. Tanaka et al.   BLOOD

Suppression of the hepcidin-encoding geneHamppermits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

(2009) Jaroslav Truksa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Autosomal recessive ichthyosis with hypotrichosis syndrome: further delineation of the phenotype

(2009) L Avrahami et al.   CLINICAL GENETICS

Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice

(2009) R. Szabo et al.   DEVELOPMENT

ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1

(2009) Carole Planès et al.   EMBO Molecular Medicine

Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms

(2009) Andrew J. Ramsay et al.   HUMAN MOLECULAR GENETICS

Neutral Cysteine Protease Bleomycin Hydrolase Is Essential for the Breakdown of Deiminated Filaggrin into Amino Acids

(2009) Yayoi Kamata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type II Transmembrane Serine Proteases

(2009) Thomas H. Bugge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

(2009) John C Chambers et al.   NATURE GENETICS

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

(2009) Santhi K Ganesh et al.   NATURE GENETICS

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

(2009) Beben Benyamin et al.   NATURE GENETICS

Defect of Hepatocyte Growth Factor Activator Inhibitor Type 1/Serine Protease Inhibitor, Kunitz Type 1 (Hai-1/Spint1) Leads to Ichthyosis-Like Condition and Abnormal Hair Development in Mice

(2008) Koki Nagaike et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of the Epithelial Sodium Channel (ENaC) by Serine Proteases

(2008) Bernard C. Rossier et al.   Annual Review of Physiology

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

(2008) A. R. Folgueras et al.   BLOOD

Forging a field: the golden age of iron biology

(2008) N. C. Andrews   BLOOD

RETRACTED: The Hepcidin-Binding Site on Ferroportin Is Evolutionarily Conserved

(2008) Ivana De Domenico et al.   Cell Metabolism

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Serine peptidases: Classification, structure and function

(2008) M. J. Page et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Corin Variant Associated With Hypertension and Cardiac Hypertrophy Exhibits Impaired Zymogen Activation and Natriuretic Peptide Processing Activity

(2008) Wei Wang et al.   CIRCULATION RESEARCH

Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment

(2008) Misuzu Yamashita et al.   GENES TO CELLS

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ENaC Proteolytic Regulation by Channel-activating Protease 2

(2008) Agustín García-Caballero et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ichthyosis, Follicular Atrophoderma, and Hypotrichosis Caused by Mutations in ST14 Is Associated with Impaired Profilaggrin Processing

(2008) Thomas Alef et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Corin: new insights into the natriuretic peptide system

(2008) Qingyu Wu et al.   KIDNEY INTERNATIONAL

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Corin is co-expressed with pro-ANP and localized on the cardiomyocyte surface in both zymogen and catalytically active forms

(2007) Inna P. Gladysheva et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY