Discovery, Biosynthesis, and Engineering of Lantipeptides

Biosynthesis of Aminovinyl-Cysteine-Containing Peptides and Its Application in the Production of Potential Drug Candidates

(2011) Clarissa S. Sit et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and Activity of Thioether-Containing Analogues of the Complement Inhibitor Compstatin

(2011) Patrick J. Knerr et al.   ACS Chemical Biology

Efficacy of the New Lantibiotic NAI-107 in Experimental Infections Induced by Multidrug-Resistant Gram-Positive Pathogens

(2011) Daniela Jabés et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lichenicidin Biosynthesis in Escherichia coli:licFGEHIImmunity Genes Are Not Essential for Lantibiotic Production or Self-Protection

(2011) Tânia Caetano et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Mechanistic Studies of Ser/Thr Dehydration Catalyzed by a Member of the LanL Lanthionine Synthetase Family

(2011) Yuki Goto et al.   BIOCHEMISTRY

Leader Peptide-Directed Processing of Labyrinthopeptin A2 Precursor Peptide by the Modifying Enzyme LabKC

(2011) Wolfgang M. Müller et al.   BIOCHEMISTRY

Identification of the amino acid labionin and its desulfurised derivative in the type-III lantibiotic LabA2 by means of GC/MS

(2011) Alexander Pesic et al.   CHEMICAL COMMUNICATIONS

Artificial lantipeptides from in vitro translations

(2011) Florian P. Seebeck et al.   CHEMICAL COMMUNICATIONS

Heterologous Expression, Biosynthesis, and Mutagenesis of Type II Lantibiotics from Bacillus licheniformis in Escherichia coli

(2011) Tânia Caetano et al.   CHEMISTRY & BIOLOGY

Biosynthesis of the Antimicrobial Peptide Epilancin 15X and Its N-Terminal Lactate

(2011) Juan E. Velásquez et al.   CHEMISTRY & BIOLOGY

Methodologies and Strategies for the Bioengineering of Lantibiotics

(2011) Jun-ichi Nagao et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

CysteineS-glycosylation, a new post-translational modification found in glycopeptide bacteriocins

(2011) Judith Stepper et al.   FEBS LETTERS

Feed-Forward Regulation of Microbisporicin Biosynthesis in Microbispora corallina

(2011) L. Foulston et al.   JOURNAL OF BACTERIOLOGY

Biosynthesis and Regulation of Grisemycin, a New Member of the Linaridin Family of Ribosomally Synthesized Peptides Produced by Streptomyces griseus IFO 13350

(2011) J. Claesen et al.   JOURNAL OF BACTERIOLOGY

Biological Systems Discovery In Silico: Radical S-Adenosylmethionine Protein Families and Their Target Peptides for Posttranslational Modification

(2011) D. H. Haft et al.   JOURNAL OF BACTERIOLOGY

Lantibiotic Transporter Requires Cooperative Functioning of the Peptidase Domain and the ATP Binding Domain

(2011) Mami Nishie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Recognition and Specificity of the NisB Protein, the Lantibiotic Dehydratase Involved in Nisin Biosynthesis

(2011) Antonino Mavaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107

(2011) Francesca Vasile et al.   JOURNAL OF PEPTIDE SCIENCE

Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry

(2011) Trent J. Oman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147

(2011) Wei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nine Post-translational Modifications during the Biosynthesis of Cinnamycin

(2011) Ayşe Ökesli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Salivaricin 9, a new lantibiotic produced by Streptococcus salivarius

(2011) P. A. Wescombe et al.   MICROBIOLOGY-SGM

Determining sites of interaction between prenisin and its modification enzymes NisB and NisC

(2011) Rustem Khusainov et al.   MOLECULAR MICROBIOLOGY

Sublancin is not a lantibiotic but an S-linked glycopeptide

(2011) Trent J Oman et al.   Nature Chemical Biology

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

(2011) Alethea B. Tabor   ORGANIC & BIOMOLECULAR CHEMISTRY

Expression of the Lantibiotic Mersacidin in Bacillus amyloliquefaciens FZB42

(2011) Anna Maria Herzner et al.   PLoS One

Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics

(2010) Kathrin Meindl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vitro Biosynthesis of the Prepeptide of Type-III Lantibiotic Labyrinthopeptin A2 Including Formation of a CC Bond as a Post-Translational Modification

(2010) Wolfgang M. Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides

(2010) Gert N. Moll et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage

(2010) Annechien Plat et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Isolation, Structure Elucidation, and Synergistic Antibacterial Activity of a Novel Two-Component Lantibiotic Lichenicidin fromBacillus licheniformisVK21

(2010) Zakhar O. Shenkarev et al.   BIOCHEMISTRY

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

(2010) Daniel H Haft et al.   BMC BIOLOGY

In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria

(2010) Alan J Marsh et al.   BMC GENOMICS

BACTIBASE second release: a database and tool platform for bacteriocin characterization

(2010) Riadh Hammami et al.   BMC MICROBIOLOGY

Photochemical cleavage of leader peptides

(2010) Noah Bindman et al.   CHEMICAL COMMUNICATIONS

Morphogenetic Signaling Molecules of the Streptomycetes

(2010) Joanne M. Willey et al.   CHEMICAL REVIEWS

Effect of Bioengineering Lacticin 3147 Lanthionine Bridges on Specific Activity and Resistance to Heat and Proteases

(2010) Srinivas Suda et al.   CHEMISTRY & BIOLOGY

Genome mining for ribosomally synthesized natural products

(2010) Juan E Velásquez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Organization of the biosynthetic genes encoding deoxyactagardine B (DAB), a new lantibiotic produced by Actinoplanes liguriae NCIMB41362

(2010) Steven Boakes et al.   JOURNAL OF ANTIBIOTICS

Antibiotic discovery in the twenty-first century: current trends and future perspectives

(2010) Stefano Donadio et al.   JOURNAL OF ANTIBIOTICS

Fundamental functionality: recent developments in understanding the structure–activity relationships of lantibiotic peptides

(2010) Avena C Ross et al.   JOURNAL OF ANTIBIOTICS

Crystal Structure of the Peptidase Domain ofStreptococcusComA, a Bifunctional ATP-binding Cassette Transporter Involved in the Quorum-sensing Pathway

(2010) Seiji Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Production of Lantipeptides inEscherichia coli

(2010) Yanxiang Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissection of the bridging pattern of bovicin HJ50, a lantibiotic containing a characteristic disulfide bridge

(2010) Yuheng Lin et al.   MICROBIOLOGICAL RESEARCH

The dawning of a ‘Golden era’ in lantibiotic bioengineering

(2010) Des Field et al.   MOLECULAR MICROBIOLOGY

BAGEL2: mining for bacteriocins in genomic data

(2010) Anne de Jong et al.   NUCLEIC ACIDS RESEARCH

Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides

(2010) J. Claesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

(2010) L. C. Foulston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

To protect peptide pharmaceuticals against peptidases

(2010) R. Rink et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

(2010) Yuki Goto et al.   PLOS BIOLOGY

Lacticin 481 Synthetase as a General Serine/Threonine Kinase

(2009) Young Ok You et al.   ACS Chemical Biology

Insights into the Mode of Action of the Two-Peptide Lantibiotic Haloduracin

(2009) Trent J. Oman et al.   ACS Chemical Biology

Nukacin ISK-1, a Bacteriostatic Lantibiotic

(2009) S. M. Asaduzzaman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Influence of Ca2+ Ions on the Activity of Lantibiotics Containing a Mersacidin-Like Lipid II Binding Motif

(2009) T. Bottiger et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of a Novel Two-Peptide Lantibiotic, Lichenicidin, following Rational Genome Mining for LanM Proteins

(2009) M. Begley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of modification enzyme NukM and engineering of a novel thioether bridge in lantibiotic nukacin ISK-1

(2009) Kouki Shioya et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Investigation of the Substrate Specificity of Lacticin 481 Synthetase by Using Nonproteinogenic Amino Acids

(2009) Matthew R. Levengood et al.   CHEMBIOCHEM

Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides

(2009) Yuki Goto et al.   CHEMICAL COMMUNICATIONS

Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin

(2009) Antony N. Appleyard et al.   CHEMISTRY & BIOLOGY

Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications

(2009) Rijing Liao et al.   CHEMISTRY & BIOLOGY

Lantibiotics: Mode of Action, Biosynthesis and Bioengineering

(2009) G. Bierbaum et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A unique lantibiotic, thermophilin 1277, containing a disulfide bridge and two thioether bridges

(2009) T. Kabuki et al.   JOURNAL OF APPLIED MICROBIOLOGY

Directionality and Coordination of Dehydration and Ring Formation during Biosynthesis of the Lantibiotic Nisin

(2009) Jacek Lubelski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-dependent leader peptide cleavage by NukT, a bifunctional ABC transporter, during lantibiotic biosynthesis

(2009) Mami Nishie et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Lantibiotics: Diverse activities and unique modes of action

(2009) Sikder M. Asaduzzaman et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Structure Revision of the Lantibiotic 97518

(2009) Sonia I. Maffioli et al.   JOURNAL OF NATURAL PRODUCTS

Pharmacokinetic and pharmacodynamic evaluation of the lantibiotic MU1140

(2009) Oliver Ghobrial et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Distributive and Directional Behavior of Lantibiotic Synthetases Revealed by High-Resolution Tandem Mass Spectrometry

(2009) M. Violet Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids

(2009) Matthew R. Levengood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiostrepton Biosynthesis: Prototype for a New Family of Bacteriocins

(2009) Wendy L. Kelly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu

(2009) Rowan P. Morris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase

(2009) Avena C. Ross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characteristics of the bovicin HJ50 gene cluster in Streptococcus bovis HJ50

(2009) G. Liu et al.   MICROBIOLOGY-SGM

Evaluation of essential and variable residues of nukacin ISK-1 by NNK scanning

(2009) Mohammad R. Islam et al.   MOLECULAR MICROBIOLOGY

Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

(2009) Steven Boakes et al.   MOLECULAR MICROBIOLOGY

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

(2009) John A. McIntosh et al.   NATURAL PRODUCT REPORTS

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Synthesis and Biological Activity of Oxa-Lacticin A2, a Lantibiotic Analogue with Sulfur Replaced by Oxygen

(2009) Hongqiang Liu et al.   ORGANIC LETTERS

Mapping and identification of the region and secondary structure required for the maturation of the nukacin ISK-1 prepeptide

(2009) Jun-ichi Nagao et al.   PEPTIDES

Production of the Novel Two-Peptide Lantibiotic Lichenicidin by Bacillus licheniformis DSM 13

(2009) Jasmin Dischinger et al.   PLoS One

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

(2009) Laura C. Wieland Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulation of charged residues within the two-peptide lantibiotic lacticin 3147

(2009) Lucy H. Deegan et al.   Microbial Biotechnology

Solid-Supported Synthesis and Biological Evaluation of the Lantibiotic Peptide Bis(desmethyl) Lacticin 3147 A2

(2008) Vijaya R. Pattabiraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanistic Dissection of the Enzyme Complexes Involved in Biosynthesis of Lacticin 3147 and Nisin

(2008) A. Kuipers et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Distinct Contributions of the Nisin Biosynthesis Enzymes NisB and NisC and Transporter NisT to Prenisin Production by Lactococcus lactis

(2008) H. B. van den Berg van Saparoea et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Influence of Shifting Positions of Ser, Thr, and Cys Residues in Prenisin on the Efficiency of Modification Reactions and on the Antimicrobial Activities of the Modified Prepeptides

(2008) J. Lubelski et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Substrate Recognition Mechanism of the Peptidase Domain of the Quorum-Sensing-Signal−Producing ABC Transporter ComA fromStreptococcus†

(2008) Yatsugu Kotake et al.   BIOCHEMISTRY

In VitroReconstitution and Substrate Specificity of a Lantibiotic Protease†

(2008) L. A. Furgerson Ihnken et al.   BIOCHEMISTRY

The Importance of the Leader Sequence for Directing Lanthionine Formation in Lacticin 481†

(2008) Gregory C. Patton et al.   BIOCHEMISTRY

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides

(2008) Matthew R. Levengood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

How Nature Morphs Peptide Scaffolds into Antibiotics

(2008) Elizabeth M. Nolan et al.   CHEMBIOCHEM

Structure-Activity Relationship Studies of the Two-Component Lantibiotic Haloduracin

(2008) Lisa E. Cooper et al.   CHEMISTRY & BIOLOGY

Determining the Structure and Mode of Action of Microbisporicin, a Potent Lantibiotic Active Against Multiresistant Pathogens

(2008) Franca Castiglione et al.   CHEMISTRY & BIOLOGY

Therapeutic potential of type A (I) lantibiotics, a group of cationic peptide antibiotics

(2008) Leif Smith et al.   CURRENT OPINION IN MICROBIOLOGY

Lantibiotic Immunity

(2008) Colin Hill et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

N-terminal acetylation in paenibacillin, a novel lantibiotic

(2008) Zengguo He et al.   FEBS LETTERS

99mTc-Labeled Duramycin as a Novel Phosphatidylethanolamine-Binding Molecular Probe

(2008) M. Zhao et al.   JOURNAL OF NUCLEAR MEDICINE

Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog

(2008) L. D. Kluskens et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The generation of nisin variants with enhanced activity against specific Gram-positive pathogens

(2008) Des Field et al.   MOLECULAR MICROBIOLOGY