Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis

Stimulatory Role of Lysophosphatidic Acid in Cyclooxygenase-2 Induction by Synovial Fluid of Patients with Rheumatoid Arthritis in Fibroblast-Like Synovial Cells

(2014) H. Nochi et al.   JOURNAL OF IMMUNOLOGY

Lysophosphatidic acid receptor 1 suppression sensitizes rheumatoid fibroblast-like synoviocytes to tumor necrosis factor-induced apoptosis

(2012) Beatriz Orosa et al.   ARTHRITIS AND RHEUMATISM

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Pathways for Bone Loss in Inflammatory Disease

(2012) Tobias Braun et al.   Current Osteoporosis Reports

Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort

(2011) Siri Lillegraven et al.   ANNALS OF THE RHEUMATIC DISEASES

In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trial

(2011) Hamed Rezaei et al.   ANNALS OF THE RHEUMATIC DISEASES

The association of treatment response and joint damage with ACPA-status in recent-onset RA: a subanalysis of the 8-year follow-up of the BeSt study

(2011) M van den Broek et al.   ANNALS OF THE RHEUMATIC DISEASES

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

(2011) Flavia V. Castelino et al.   ARTHRITIS AND RHEUMATISM

Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass

(2011) Isabelle Gennero et al.   BONE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model

(2011) Samuel García et al.   ARTHRITIS RESEARCH & THERAPY

Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis

(2010) Daniel Cejka et al.   ARTHRITIS AND RHEUMATISM

Lysophosphatidic Acid Signals through Multiple Receptors in Osteoclasts to Elevate Cytosolic Calcium Concentration, Evoke Retraction, and Promote Cell Survival

(2010) Danielle M. Lapierre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts

(2010) Marion David et al.   PLoS One

Bone remodeling in rheumatic disease: a question of balance

(2009) Nicole C. Walsh et al.   IMMUNOLOGICAL REVIEWS

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Osteoblast Function Is Compromised at Sites of Focal Bone Erosion in Inflammatory Arthritis

(2009) Nicole C Walsh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist

(2009) Lin Ma et al.   JOURNAL OF NEUROCHEMISTRY

Rheumatoid arthritis

(2009) Lars Klareskog et al.   LANCET

When patients with rheumatoid arthritis fail tumour necrosis factor inhibitors: what is the next step?

(2008) J. S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum–transfer arthritis

(2008) Mei Chen et al.   ARTHRITIS AND RHEUMATISM

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY