Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jian Chen, Xian Lin, Kangdi Liu, Juan He, Xin Li, Chuchu Zhang, Yongxing Deng, Lianxiang Luo, Cheng Tao, Qingwen Wang
Summary: This study demonstrated that a novel compound CT2-3 inhibits the abnormal functions of RA-fibroblastlike synoviocytes (RA-FLSs) by inducing cell cycle arrest and apoptosis through modulating the PI3K/AKT pathway, offering a potential lead compound for the development of novel anti-RA drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mei Meng, Zhenggang Yue, Lu Chang, Yanru Liu, Jinhang Hu, Zhongxing Song, Zhishu Tang, Rui Zhou, Changli Wang
Summary: PS VII inhibits the proliferation and induces apoptosis of RA-FLS and MH7A cells by regulating the mitochondrial apoptotic pathway and the JNK and p38 MAPK pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
M. Vomero, M. Caliste, C. Barbati, M. Speziali, A. I. Celia, F. Ucci, C. Ciancarella, E. Putro, T. Colasanti, G. Buoncuore, E. Corsiero, M. Bombardieri, F. R. Spinelli, F. Ceccarelli, F. Conti, C. Alessandri
Summary: The study demonstrates that tofacitinib has the ability to modulate autophagy in fibroblast-like synoviocytes, contributing to its effectiveness in treating patients with rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Jia-Ying Wu, Ying-Jie Chen, Xiu-Qiong Fu, Jun-Kui Li, Ji-Yao Chou, Cheng-Le Yin, Jing-Xuan Bai, Ying Wu, Xiao-Qi Wang, Amy Sze-man Li, Lut Yi Wong, Zhi-Ling Yu
Summary: The study demonstrates that chrysoeriol suppresses the hyperproliferation of RA-FLS and induces apoptosis. This is achieved by inhibiting the JAK2/STAT3 signaling pathway and downregulating the expression of Bcl-2 and Mcl-1.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Immunology
Yanhua Zuo, Huaheng Xu, Yanxia Li, Zongfang Zhang, Ran Tao, Manxiang Wang
Summary: Synovial samples from RA patients and normal controls were used to isolate FLSs. Increased expression of circ_0007707 was observed in synovial samples from RA patients and FLS-RA cells. Circ_0007707 silencing inhibited cell proliferation, induced cell apoptosis, and decreased cell inflammatory response in FLS-RA cells. Mechanistically, circ_0007707 mediated cell apoptosis and inflammatory response in FLS-RA cells through the miR-27b-3p/PDE3B axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Weihong Xu, Lu Ye, Huaxiang Wu
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.
Review
Immunology
Zihan Wang, Jinping Wang, Tianyi Lan, Liubo Zhang, Zeran Yan, Nan Zhang, Yuan Xu, Qingwen Tao
Summary: Fibroblast-activated protein-a (FAP) is overexpressed by activated fibroblasts during fibrosis or inflammation. It plays important roles in regulating the cellular responses in the synovial region of rheumatoid arthritis (RA), and its overexpression is regulated by the initial inflammatory microenvironment and epigenetic signaling. Targeted therapies for FAP are currently being developed. This review discusses the features of FAP in FLSs and its role in RA pathophysiology, as well as advances in targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Jian Chen, Xian Lin, Juan He, Dandan Liu, Lianhua He, Miaomiao Zhang, Huijie Luan, Yiping Hu, Cheng Tao, Qingwen Wang
Summary: The study found that ATT has potential therapeutic effects on RA by suppressing proliferation, migration, and invasion of RA-FLSs, as well as inducing apoptosis. ATT achieves therapeutic potential for RA by modulating the METTL3/ICAM2/PI3K/AKT/p300 feedback loop.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Yu Tai, Bei Huang, Pai-pai Guo, Zhen Wang, Zheng-wei Zhou, Man-man Wang, Han-fei Sun, Yong Hu, Sheng-lin Xu, Ling-ling Zhang, Qing-tong Wang, Wei Wei
Summary: Our study demonstrates the impact of TNF-alpha on cAMP homeostasis and the interaction between TNF-alpha and EP4 signaling, revealing the potential role of TRAF2 and GRK2 in the treatment of inflammatory diseases. The findings provide valuable insights into a novel form of cross-talk between cytokine receptors and G protein-coupled receptors, suggesting TRAF2-GRK2 interaction as a potential new drug target.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Immunology
Yirixiati Aihaiti, Xiadiye Tuerhong, Haishi Zheng, YongSong Cai, Mingyi Yang, Peng Xu
Summary: PRDX4 is up-regulated in synovial tissue of RA patients and regulates the tumor cell-like characteristics of RA-FLS through activation of the PI3K/Akt signaling pathway.
CLINICAL IMMUNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Wang Xiao-He, Dai Ce, Wang Jun, Liu Rui, Li Lei, Yin Zong-Sheng
Summary: Neohesperidin (Neo) has shown potential as a therapeutic drug for rheumatoid arthritis by inhibiting abnormal activation of RA fibroblast-like synoviocytes, reducing inflammation and oxidative stress, inducing apoptosis, and blocking migration of the cells. The compound may offer promise in managing RA progression.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Cell Biology
Parisa Zafari, Mahdi Taghadosi, Fatemeh Faramarzi, Misagh Rajabinejad, Alireza Rafiei
Summary: This study demonstrates that DMF treatment can suppress the proliferation and promote apoptosis of RA synovial cells, and reduce the release of inflammatory factors. These findings suggest that DMF may be considered as a therapeutic approach in the treatment of RA.
Letter
Rheumatology
Cristina Regueiro, Antonio Gonzalez
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Rheumatology
Cristina Regueiro, Antonio Gonzalez
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Alejandro Ibanez-Costa, Carlos Perez-Sanchez, Alejandra Maria Patino-Trives, Maria Luque-Tevar, Pilar Font, Ivan Arias de la Rosa, Cristobal Roman-Rodriguez, Ma Carmen Abalos-Aguilera, Carmen Conde, Antonio Gonzalez, Sergio Pedraza-Arevalo, Mercedes del Rio-Moreno, Ricardo Blazquez-Encinas, Pedro Segui, Jerusalem Calvo, Rafaela Ortega Castro, Alejandro Escudero-Contreras, Nuria Barbarroja, Ma Angeles Aguirre, Justo P. Castano-Fuentes, Raul M. Luque, Eduardo Collantes-Estevez, Chary Lopez-Pedrera
Summary: This study identified altered expression of several splicing machinery elements in leucocytes of rheumatoid arthritis patients, with 8 elements equally affected in all leucocyte subtypes. These alterations could discriminate patients from healthy donors, classify high disease activity, recognize radiological involvement, and identify patients with atheroma plaques. The signature was also found in RA synovial fluid and ankle joints of arthritic mice, and could be reversed by anti-TNF therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Geriatrics & Gerontology
Alicia Usategui, Cristina Municio, Elena G. Arias-Salgado, Maria Martin, Beatriz Fernandez-Varas, Manuel J. Del Rey, Patricia Carreira, Antonio Gonzalez, Gabriel Criado, Rosario Perona, Jose L. Pablos
Summary: Cell senescence is associated with telomere shortening in systemic sclerosis (SSc), especially in patients with lung disease or anti-topoisomerase I antibodies. Targeting DNA damage with the GSE4 peptide attenuates experimental skin fibrosis and reduces profibrotic factor expression in fibroblasts, suggesting a role for oxidative DNA damage in scleroderma.
Article
Rheumatology
Ana Igea, Tiago Carvalheiro, Beatriz Malvar-Fernandez, Sara Martinez-Ramos, Carlos Rafael-Vidal, Ellis Niemantsverdriet, Jezabel Varade, Andrea Fernandez-Carrera, Norman Jimenez, Trudy McGarry, Angela Rodriguez-Trillo, Douglas Veale, Ursula Fearon, Carmen Conde, Jose M. Pego-Reigosa, Africa Gonzalez-Fernandez, Kris A. Reedquist, Timothy R. D. J. Radstake, Annette van der Helm-Van Mil, Samuel Garcia
Summary: The study reveals that Sema3B plays a protective role in a mouse model of arthritis and its expression levels in RA patients are associated with the disease stage.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Lorena Rodriguez-Martinez, Cristina Regueiro, Samer Amhaz-Escanlar, Carmen Pena, Paloma Herbello-Hermelo, Antonio Moreda-Pineiro, Javier Rodriguez-Garcia, Antonio Mera-Varela, Eva Perez-Pampin, Antonio Gonzalez
Summary: This study analyzed the autoantibody response of rheumatoid arthritis (RA) patients to four specific protein modifications. However, except for glycated collagen II, the other three modifications did not induce significant autoantibody response. Therefore, the repertoire of specific modified autoantigens in RA patients is limited.
Article
Biochemistry & Molecular Biology
Djedjiga Ait Eldjoudi, Alfonso Cordero Barreal, Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Yousof Farrag, Mariam Farrag, Francisca Lago, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera Varela, Jesus Pino, Oreste Gualillo
Summary: White adipose tissue is a specialized tissue involved in lipid synthesis and storage. It serves as an active organ that secretes hormones and cytokines called adipokines, with leptin being a key molecule. Leptin not only regulates energy balance and food intake, but also plays roles in reproduction, glucose metabolism, hematopoiesis, and immune system interactions. It is involved in innate and adaptive immunity and contributes to the pathogenesis of chronic inflammation and immune-related diseases like osteoarthritis and rheumatoid arthritis. This review summarizes recent findings on the involvement of leptin in immunity and inflammatory responses in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Angela Rodriguez-Trillo, Carmen Pena, Samuel Garcia, Eva Perez-Pampin, Marina Rodriguez-Lopez, Antonio Mera-Varela, Antonio Gonzalez, Carmen Conde
Summary: This article investigates the role of ROCK in rheumatoid arthritis and finds that ROCK inhibition can significantly improve arthritis inflammation and bone erosion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Cristina Ruiz-Romero, Patricia Fernandez-Puente, Lucia Gonzalez, Anna Illiano, Lucia Lourido, Rocio Paz, Patricia Quaranta, Eva Perez-Pampin, Antonio Gonzalez, Francisco J. Blanco, Valentina Calamia
Summary: This study utilizes a proteomic biomarker pipeline to analyze the molecular changes associated with the RF and ACPA status of rheumatoid arthritis patients. The results identify specific proteins that show altered abundance in relation to RF and ACPA status, and two putative biomarkers, A1AG1 and HPT, are validated as increased in the double seropositive group. These findings provide valuable information for the stratification and personalized medicine of rheumatoid arthritis patients.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Sara Martinez-Ramos, Carlos Rafael-Vidal, Beatriz Malvar-Fernandez, Angela Rodriguez-Trillo, Douglas Veale, Ursula Fearon, Carmen Conde, J. Conde-Aranda, Timothy R. D. J. Radstake, Jose Maria Pego-Reigosa, Kris A. Reedquist, Samuel Garcia
Summary: The expression of class 3 semaphorins is reduced in RA synovial tissue, and TCF-3, EBF-1, and HOXA5 are identified as transcription factors involved in their expression. Silencing TCF-3, EBF-1, and HOXA5 significantly reduces the expression of class 3 semaphorins in RA fibroblast-like synoviocytes and human umbilical vein endothelial cells. HOXA5 expression is decreased in RA synovium and is negatively correlated with clinical disease parameters, and TNF-alpha down-regulates HOXA5 expression. Silencing HOXA5 enhances the migratory and invasive capacities of fibroblast-like synoviocytes and the viability of human umbilical vein endothelial cells.
Review
Chemistry, Medicinal
Maria Gonzalez-Rodriguez, Djedjiga Ait Edjoudi, Alfonso Cordero Barreal, Clara Ruiz-Fernandez, Mariam Farrag, Beatriz Gonzalez-Rodriguez, Francisca Lago, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera Varela, Jesus Pino, Yousof Farrag, Oreste Gualillo
Summary: Progranulin (PGRN) is a glycoprotein that plays an important role in immunity, inflammatory response, and tissue recovery. It has become an important target for research in musculoskeletal inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and intervertebral disc degeneration. This review systematically summarizes recent findings on the role of PGRN in the development and resolution of inflammatory diseases.
Article
Plant Sciences
Shanshuo Zhu, Lixia Pan, Lam Dai Vu, Xiangyu Xu, Beatriz Orosa-Puente, Tingting Zhu, Pia Neyt, Brigitte van de Cotte, Thomas B. Jacobs, Joshua M. Gendron, Steven H. Spoel, Kris Gevaert, Ive De Smet
Summary: SLOMO is a negative regulator of hypocotyl growth, and its activity is regulated by warm temperature, which affects the abundance of proteins involved in hypocotyl growth through ubiquitin-mediated degradation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria Florinda Otero, Pablo Garcia Tahoces, Antonio Mera, Jorge Mira
Summary: This study aims to improve the imaging quality of cone beam computed tomography (CBCT) for the diagnosis of juvenile idiopathic arthritis (JIA) in the temporomandibular joint (TMJ). Researchers applied a filter to CBCT images to enhance the visual quality and compared the results with MRI images, showing the effectiveness of the filter in improving image quality.
ACTA RADIOLOGICA OPEN
(2022)