Article
Ophthalmology
Anat Galor, Pedram Hamrah, Sameena Haque, Nadine Attal, Marc Labetoulle
Summary: Chronic ocular surface pain (COSP) refers to ongoing pain originating from the ocular surface, which lasts for more than three months. It is a complex condition with various risk factors that significantly impact an individual's daily activities and overall quality of life. There is also a substantial burden on global healthcare costs due to COSP.
Article
Behavioral Sciences
Katherine M. Contreras, Martial Caillaud, Bradley Neddenriep, Deniz Bagdas, Jane L. Roberts, Esad Ulker, Alyssa B. White, Raneem Aboulhosn, Wisam Toma, Tala Khalefa, Ahd Adel, Jared A. Mann, M. Imad Damaj
Summary: Treatment with CFA reduced the distance traveled in C57BL/6J mice but not in DBA/2J mice; paclitaxel induced CIPN in mice, with only female C57BL/6J mice showing a decrease in distance traveled following treatment;amp; CCI surgery resulted in a gradual decrease in mechanical sensitivity and distance traveled in mice. Comparing these chronic pain models in different mouse strains may help to understand the genetic differences underlying pain perception and its impact on behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Immunology
George Sideris-Lampretsas, Marzia Malcangio
Summary: This review summarizes the existing preclinical evidence on how the CNS compartment and sex impact microglia functions in health, emphasizing recent advances in transcriptomics analyses for characterizing disease-associated microglial states. The specific scenario of peripheral nerve or tissue injury inducing expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord is discussed, along with the possibility of a unique microglia transcriptional profile associated with chronic pain conditions. The evidence also suggests microglial activation in pain-related areas of the brain can be observed in models of neuropathic pain, highlighting the potential for future studies to further explore neuroimmune interactions in chronic pain using novel approaches like scRNA-seq and CYTOF.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Dermatology
Mathilde HAYOUN-VIGOUROUX, Laurent MISERY
Summary: Pain is a common problem in dermatology, with various skin diseases and treatments potentially causing pain. Understanding the situations that cause pain can help provide suitable analgesic solutions.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Clinical Neurology
Ezgi Keskiner-Ozturk, Semra Akkaya-Turhan, Ebru Toker, Kayihan Uluc, Hande Alibas, Tulin Tanridag, Pinar Kahraman-Koytak
Summary: Despite primary myelin-related pathophysiology, small fiber neuropathy (SFN) and axonal degeneration are also considered to be involved and associated with disabling symptoms and impaired quality of life in chronic inflammatory demyelinating polyneuropathy (CIDP). In vivo corneal confocal microscopy (IVCCM) has evolved as a non-invasive, easily applied method for quantification of small fiber involvement in peripheral nerve disorders. This study aimed to investigate the potential role of IVCCM in CIDP.
NEUROLOGICAL SCIENCES
(2023)
Article
Immunology
Tahmineh Mokhtari, Min Lu, Ayman El-Meghawry El-Kenawy
Summary: This study aimed to investigate the effects of luteolin on chronic neuropathic pain-induced mood disorders by regulating oxidative stress, neurotrophic factors, and neuroinflammation. The results showed that luteolin treatment reversed the behavioral alterations and improved chronic pain-induced anxiety and depressive-like symptoms through its antioxidant, anti-inflammatory, and neuroprotective properties. This study highlights the potential of luteolin as a therapeutic agent for mood disorders associated with chronic pain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Masaru Tanaka, Nora Torok, Fanni Toth, Agnes Szabo, Laszlo Vecsei
Summary: Chronic pain is a persistent or recurrent, unpleasant sensory and emotional experience lasting more than three months. Recent classifications by the International Association for the Study of Pain will come into effect in 2022, emphasizing neurological pathology in chronic pain while downplaying psychological or social factors. This review delves into the pain pathway, mechanisms of pain, sensitization, chronic inflammation, and the role of metabolites, exploring how psychosocial and behavioral factors contribute to the development of chronic pain.
Article
Anesthesiology
Matthew Lyes, Kevin H. Yang, Joel Castellanos, Timothy Furnish
Summary: This article presents the experiences of three individuals using low-dose psilocybin to manage chronic neuropathic pain. They achieved significant pain relief and reduced reliance on traditional analgesics through self-administration of psilocybin. These commonalities highlight the therapeutic potential of psilocybin in the treatment of chronic pain.
Review
Plant Sciences
Geovanna N. Quinonez-Bastidas, Andres Navarrete
Summary: Most studies on Mexican medicinal plants have focused on inflammatory experimental models for testing their anti-pain properties, with results showing lack of adverse effects and safety for consumption. However, there is still no convincing evidence on the possible mechanisms of action involved in the anti-pain properties of Mexican plants, highlighting the need for further isolation and pharmacological characterization of their compounds for future preclinical studies.
Review
Chemistry, Medicinal
Marion Voute, Veronique Morel, Gisele Pickering
Summary: Topical lidocaine is a safe and effective option for pain management, with proven efficacy in various pain conditions. It can be used alone or in conjunction with systemic drugs and non-pharmacological approaches for optimized pain management and multimodal analgesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Anesthesiology
Jami L. Saloman, Darwin L. Conwell, Evan Fogel, Santhi Swaroop Vege, Liang Li, Shuang Li, Dana K. Andersen, William E. Fisher, Christopher E. Forsmark, Phil A. Hart, Stephen J. Pandol, Walter G. Park, Anna Evans Phillips, Mark Topazian, Stephen K. Van den Eeden, Jose Serrano, Dhiraj Yadav
Summary: Pain is common and significantly reduces quality of life in patients with chronic pancreatitis. This study aimed to classify the pain types in these patients, finding that patients with multiple pain types have worse health and quality of life scores. Further research is needed to identify biomarkers associated with specific pain types and predict responses to interventions.
Article
Immunology
Nayeon Lee, Gyu Tae Park, Jae Kyung Lim, Eun Bae Choi, Hye Ji Moon, Dae Kyoung Kim, Seong Min Choi, Young Cheol Song, Tae Kyun Kim, Jae Ho Kim
Summary: This study demonstrates that MSC spheroids formed by three-dimensional culture exhibit enhanced therapeutic effects and prolonged in vivo survival, as well as reduced host inflammatory response in alleviating chronic neuropathic pain. These findings provide new possibilities for the treatment of chronic pain.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alessandra Bennici, Carmen Mannucci, Fabrizio Calapai, Luigi Cardia, Ilaria Ammendolia, Sebastiano Gangemi, Gioacchino Calapai, Daniel Griscti Soler
Summary: Products derived from Cannabis sativa are commonly used for treating chronic neuropathic pain, with nabiximols being the only product approved by regulatory authorities for neuropathic pain and spasticity in European countries and Canada. Safety and risk-benefit profiles of other cannabis preparations widely used for medical purposes remain unclear, highlighting the need for further research on adverse reactions.
Review
Pharmacology & Pharmacy
Clayton Culp, Hee Kee Kim, Salahadin Abdi
Summary: Ketamine has shown promising effectiveness in treating chronic pain, especially cancer-related neuropathic pain. It has the potential to reduce opioid use and exhibits improved safety profiles at sub-anesthetic concentrations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Panagiotis Zis, Christiana Ioannou, Artemios Artemiadis, Katerina Christodoulou, Stefania Kalampokini, Georgios M. Hadjigeorgiou
Summary: This study found that chronic pain, especially neuropathic pain, is widely prevalent in COVID-19 survivors. The most common sites of pain are the low back and joints. Age and gender are predictors of chronic pain, while headache during COVID-19 is associated with neuropathic pain.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
George Goodwin, Sheridan McMurray, Edward B. Stevens, Franziska Denk, Stephen B. McMahon
Summary: Na(v)1.7 is a promising drug target for pain treatment, but there is a mismatch between the analgesia produced by Na(v)1.7 loss-of-function and the peripherally restricted Na(v)1.7 inhibitors. The function of Na(v)1.7 in axonal propagation in nociceptors is not clearly defined.
Article
Neurosciences
Ali Mazaheri, David A. Seminowicz, Andrew J. Furman
Summary: Valentini et al. found that participants' peak alpha frequency (PAF) became slower after exposure to painful and unpleasant stimuli. This challenges previous research suggesting that resting PAF can serve as a reliable biomarker for measuring pain sensitivity. However, there are concerns about Valentini et al.'s assumptions and methodology, as well as their misrepresentation of previous work.
Review
Behavioral Sciences
Maxwell B. Madden, Brent W. Stewart, Michael G. White, Samuel R. Krimmel, Houman Qadir, Frederick S. Barrett, David A. Seminowicz, Brian N. Mathur
Summary: Early hypotheses of claustrum function suggested its involvement in processes ranging from salience detection to multisensory integration for perceptual binding. However, these views have inherent incompatibilities that need to be reconciled. This review proposes a novel functional model, Network Instantiation in Cognitive Control (NICC), which suggests that the frontal cortices direct the claustrum to flexibly instantiate cortical networks to support cognitive control.
TRENDS IN COGNITIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Erika Salvi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: This study assessed the role of fifteen ion channel genes in neuropathic pain. Variants in ion channel genes were identified in SFN patients, with TRP genes being the most frequent. Patients with these variants reported more severe pain. This study provides promising gene candidates for future research on neuropathic pain etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Nahian S. Chowdhury, Patrick Skippen, Emily Si, Alan K. Chiang, Samantha K. Millard, Andrew J. Furman, Shuo Chen, Siobhan M. Schabrun, David A. Seminowicz
Summary: This study evaluated the reliability of pain biomarkers PAF and CME during sustained pain. The results showed that PAF had high reliability, even in the presence of pain. The study also found that 80% of individuals exhibited either facilitation or depression of CME, and these changes remained stable across multiple sessions.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Cell Biology
Houman Qadir, Brent W. Stewart, Jonathan W. VanRyzin, Qiong Wu, Shuo Chen, David A. Seminowicz, Brian N. Mathur
Summary: Spatially distant areas of the cerebral cortex coordinate their activity into networks, with a common structural motif of co-activation of frontal and posterior cortical regions. Using fMRI in mice, this study reveals significant functional connectivity between the frontal and posterior cortical regions and the subcortical nucleus called the claustrum. Moreover, synaptic connectivity from frontal cortices to contralateral sensory and sensory association cortices through the claustrum was observed, supporting the cortical network architecture.
Article
Rehabilitation
Sarah M. Margerison, Kelly P. Westlake, David A. Seminowicz
Summary: This article emphasizes the role of the dorsal horn in nociceptive processing and its impact on chronic pain conditions. It describes key processes occurring in the spinal cord, including cellular changes and local network responses to pain stimuli. Understanding the dynamic nature of the spinal cord can help clinicians better address the nervous system's response to prolonged pain.
MUSCULOSKELETAL SCIENCE AND PRACTICE
(2022)
Article
Psychology, Clinical
Madhav Goyal, Jennifer A. Haythornthwaite, Sharat Jain, Barbara Lee Peterlin, Megha Mehrotra, David Levine, Jason D. Rosenberg, Mary Minges, David A. Seminowicz, Daniel E. Ford
Summary: In this study, intensive Vipassana meditation training for 10 days was found to reduce the frequency and burden of migraine. Participants experienced a decrease in average migraine frequency and headache days. The training also had positive effects on migraine-specific quality of life, pain catastrophizing, and perceived stress.
Article
Biochemistry & Molecular Biology
Rowida Almomani, Maurice Sopacua, Margherita Marchi, Milena Sleczkowska, Patrick Lindsey, Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Erika Salvi, Ingemar S. J. Merkies, Maryam A. Ferdousi, Rayaz Malik, Dan Ziegler, Kasper W. J. Derks, Gidon Boenhof, Filippo Martinelli-Boneschi, Daniele Cazzato, Raffaella Lombardi, Sulayman G. Dib-Hajj, Stephen Waxman, Hubert J. M. M. Smeets, Monique G. Gerrits, Catharina Faber, Giuseppe Lauria
Summary: Rare SCG genetic variants may contribute to the development of painful neuropathy. Genetic profiling and SCG variant identification can provide better understanding of the genetic variability in patients with painful and painless neuropathy, leading to improved risk stratification and personalized pain treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Vani A. Mathur, Janell S. Payano Sosa, Michael L. Keaser, Timothy F. Meiller, David A. Seminowicz
Summary: This article investigates the experience of individuals living with burning mouth syndrome (BMS) within a social context, revealing the compounding effects of stigma related to pain, diagnosis, and intersectional identities. The findings indicate that internalized BMS stigma is related to greater clinical pain severity and interference, highlighting the importance of considering lived experience and social context in future BMS research.
Article
Psychology, Clinical
Carly A. Hunt, Janelle E. Letzen, Samuel R. Krimmel, Shana A. B. Burrowes, Jennifer A. Haythornthwaite, Michael Keaser, Matthew Reid, Patrick H. Finan, David A. Seminowicz
Summary: This study investigated biopsychosocial predictors and outcomes associated with formal, daily-life meditation practice in migraine patients. The findings suggest that mesocorticolimbic system functioning is related to meditation practice duration and change in headache frequency. Formal meditation practice benefits pain-related cognitions but not clinical pain.
Correction
Anesthesiology
S. A. B. Burrowes, O. Goloubeva, K. Stafford, P. F. McArdle, M. Goyal, B. L. Peterlin, J. A. Haythornthwaite, D. A. Seminowicz
Meeting Abstract
Clinical Neurology
Patrick Finan, Carly Hunt, Michael Keaser, Sheera Lerman, Katie Smith, Clifton Bingham, Frederick Barrett, Fadel Zeidan, Eric Garland, David Seminowicz
Meeting Abstract
Clinical Neurology
Luis Hernandez, Joyce T. Da Silva, Shelby Hanson, Alison Scott, Robert Ernst, Ohannes Melemedjian, David Seminowicz, Richard J. Traub
Meeting Abstract
Clinical Neurology
Carly Hunt, Sheera F. Lerman, Katie Smith, Michael L. Keaser, Clifton Bingham, Fadel Zeidan, Eric L. Garland, David Seminowicz, Patrick H. Finan
