Review
Neurosciences
Giulia Costa, Krystyna Golembiowska
Summary: Studies suggest that MDMA, commonly known as 'ecstasy', not only has abuse potential, but may also cause acute and persistent central level abnormalities with demonstrated neurotoxic effects in experimental animals. This could pose serious health risks since MDMA is frequently used recreationally by young and adult individuals.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
David H. Allendorf, Guy C. Brown
Summary: Activated microglia can release active Neu1, which enhances microglial phagocytosis and sensitizes neurons to glutamate, potentially leading to neuronal death.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Wolfgang Loescher, Pavel Klein
Summary: The prevailing standard in drug discovery has shifted from designing highly selective compounds to multi-target and combinatorial drug therapies. Although drug combination therapy is effective for symptomatic treatment, identifying clinically effective disease-modifying treatments for complex brain diseases remains challenging.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Medicine, Research & Experimental
Prabhat Shrestha, Nikita Katila, Sooyeun Lee, Ji Hae Seo, Jee-Heon Jeong, Simmyung Yook
Summary: Methamphetamine (MA) is an extremely addictive drug that can cause neurotoxic effects and increase the risk of developing neurodegenerative diseases. There is currently no FDA-approved therapy for MA-induced neurotoxicity, but there are ongoing studies to develop effective treatments.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
B. Martins, J. P. Novo, E. Fonseca, R. Raposo, V. A. Sardao, F. Pereira, R. B. Oria, C. Fontes-Ribeiro, J. Malva
Summary: Methylmercury is a dangerous environmental contaminant that accumulates in the food chain and has neurotoxic properties. This study found that high concentrations of methylmercury can impair cell production, decrease the release of inflammatory mediators, and increase cell death.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Aman B. Upaganlawar, Nitu L. Wankhede, Mayur B. Kale, Mohit D. Umare, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Agnieszka Najda, Renata Nurzynska-Wierdak, Simona Bungau, Tapan Behl
Summary: Epilepsy, affecting nearly 50 million people worldwide, can be caused by genetic predisposition or acquired acute insult leading to alteration of cellular and molecular mechanisms. The imbalanced state of enhanced excitatory glutamatergic and reduced inhibitory GABAergic signaling is considered to be accountable for seizures associated damage. Neurodegeneration contributing to epileptogenesis has become increasingly appreciated, with potential intervention through vitamin E therapy in managing epilepsy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Neurosciences
Richard Fairless, Hilmar Bading, Ricarda Diem
Summary: Glutamate signalling plays a crucial role in neuroinflammatory diseases, influencing neurodegeneration as well as regulating blood vessels, immune cells, and glial cells. Efforts are being made to utilize the growing understanding of these processes in the development of neuroprotective strategies.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Natalia Lopez-Gonzalez del Rey, Tiziano Balzano, Lucia Martin-Rodriguez, Constanza Salinas-Rebolledo, Ines Trigo-Damas, Alejandro Rojas-Fernandez, Lydia Alvarez-Erviti, Javier Blesa
Summary: Proteinaceous inclusions known as LBs are used as a pathological hallmark for PD, with early deposits in the OB and amygdala containing insoluble alpha-synuclein and other ubiquitinated proteins. Injecting lactacystin into the OB and amygdala of mice did not result in significant differences in neuronal numbers, alpha-synuclein expression, or dopaminergic integrity, indicating that long-term injections in extra nigrostriatal regions may not mimic the spreading aspects of PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Neurosciences
Monika Jankowska-Kieltyka, Adam Roman, Irena Nalepa
Summary: Air pollution, particularly particulate matter, is closely associated with cardiopulmonary disorders and neurodegenerative diseases. Studies have shown a noticeable link between exposure to PM and neurotoxicity, with potential mechanisms including oxidative stress, inflammation, and neuronal death in both the peripheral and central nervous systems. Further research is needed to fully understand the impact of air pollutants on neurodegeneration.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ioannis Gkekas, Anna Gioran, Marina Kleopatra Boziki, Nikolaos Grigoriadis, Niki Chondrogianni, Spyros Petrakis
Summary: Neurodegenerative polyglutamine (polyQ) disorders are caused by trinucleotide repeat expansions within disease-causing genes, leading to protein inclusions and oxidative stress. The interplay between oxidative stress, neurodegeneration, and neuroinflammation in polyQ diseases is discussed, with potential pharmaceutical interventions to delay disease progression.
Review
Behavioral Sciences
Alexandra M. Stafford, Bryan K. Yamamoto, Tamara J. Phillips
Summary: Through animal studies, it has been found that comorbid exposure to alcohol and methamphetamine can have additive or synergistic effects on behavior and physiology. This exposure impacts the dopaminergic, serotonergic, and glutamatergic systems, potentially leading to neurotoxic consequences.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemical Research Methods
Tanthai Polvat, Tanya Prasertporn, Piyada Na Nakorn, Supitcha Pannengpetch, Wilasinee Suwanjang, Jiraporn Panmanee, Sukhonthar Ngampramuan, Jennifer L. Cornish, Banthit Chetsawang
Summary: This study aimed to investigate the cognitive impairment caused by chronic methamphetamine addiction in mice and explore the potential mechanisms. It was found that methamphetamine administration led to poor cognitive performance in mice, which partially recovered after withdrawal. Treatment with melatonin during withdrawal enhanced the recovery by restoring neuronal impairments.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Brian M. Polster, Karla A. Mark, Rafael Arze, Derek Hudson
Summary: Glutamate excitotoxicity contributes to neurodegenerative diseases by causing calcium deregulation and mitochondrial depolarization. The experiment shows that glutamate increases protease activity in neurons before calcium deregulation, and this increase can be suppressed by glutamate receptor antagonists but not by calpain.
Review
Biochemistry & Molecular Biology
Juan Prieto-Villalobos, Tanhia F. Alvear, Andres Liberona, Claudia M. Lucero, Claudio J. Martinez-Araya, Javiera Balmazabal, Carla A. Inostroza, Gigliola Ramirez, Gonzalo I. Gomez, Juan A. Orellana
Summary: Maternal inflammation can lead to later-in-life brain abnormalities in offspring, affecting the survival and support of neurons, and increasing the risk of neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lorena Cuenca-Bermejo, Elisa Pizzichini, Valeria C. Goncalves, Maria Guillen-Diaz, Elena Aguilar-Monino, Consuelo Sanchez-Rodrigo, Ana-Maria Gonzalez-Cuello, Emiliano Fernandez-Villalba, Maria Trinidad Herrero
Summary: The study demonstrates that Octodon degus are sensitive to MPTP intoxication and can be used as a model for studying Parkinson's disease. MPTP-intoxicated animals showed significant behavioral and cognitive changes, a decrease in dopaminergic neurons, and an increase in neuroinflammatory responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Anna Moszczynska, Kyle J. Burghardt, Dongyue Yu
Article
Neurosciences
Bin Liu, Roberta Traini, Bryan Killinger, Bernard Schneider, Anna Moszczynska
EXPERIMENTAL NEUROLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Shiona K. Glass, Anna Moszczynska, Teresa J. Crease
Article
Biochemistry & Molecular Biology
Heli Chauhan, Bryan A. Killinger, Cheryl V. Miller, Anna Moszczynska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2014)
Article
Biochemistry & Molecular Biology
Bryan Killinger, Mrudang Shah, Anna Moszczynska
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Anna Moszczynska, Sean A. Locke, J. Daniel McLaughlin, David J. Marcogliese, Teresa J. Crease
MOLECULAR ECOLOGY RESOURCES
(2009)
Article
Genetics & Heredity
Anna Moszczynska
Article
Biochemistry & Molecular Biology
Viktoriia Bazylianska, Akhil Sharma, Heli Chauhan, Bernard Schneider, Anna Moszczynska
Summary: Methamphetamine is a highly abused stimulant that is neurotoxic and increases the risk of Parkinson's disease. The study found that Methamphetamine itself contributes to mitochondrial dysfunction in the striatum, while dopamine only decreases the levels of certain subunits. The study also suggests that parkin does not regulate the turnover of NDUFS3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Frank J. S. Lee, Lin Pei, Anna Moszczynska, Brian Vukusic, Paul J. Fletcher, Fang Liu
Article
Biochemistry & Molecular Biology
A Mirecki, P Fitzmaurice, L Ang, KS Kalasinsky, FJ Peretti, SS Aiken, DJ Wickham, A Sherwin, JN Nobrega, HJ Forman, SJ Kish
JOURNAL OF NEUROCHEMISTRY
(2004)
Article
Neurosciences
L Pei, FJS Lee, A Moszczynska, B Vukusic, F Liu
JOURNAL OF NEUROSCIENCE
(2004)
Article
Clinical Neurology
A Moszczynska, P Fitzmaurice, L Ang, KS Kalasinsky, GA Schmunk, FJ Peretti, SS Aiken, DJ Wickham, SJ Kish
Article
Substance Abuse
BM Ross, A Moszczynska, FJ Peretti, V Adams, GA Schmunk, KS Kalasinsky, L Ang, N Mamalias, SD Turenne, SJ Kish
DRUG AND ALCOHOL DEPENDENCE
(2002)
Article
Biochemistry & Molecular Biology
Anna Moszczynska, Jurnana Saleh, Hongyu Zhang, Brian Vukusic, Frank J. S. Lee, Fang Liu
JOURNAL OF MOLECULAR NEUROSCIENCE
(2007)