Article
Cell Biology
Minoru Fujino, Jun Fukuda, Hirohisa Isogai, Tetsuro Ogaki, Shiro Mawatari, Atsushi Takaki, Chikako Wakana, Takehiko Fujino
Summary: The study demonstrated that orally administered plasmalogens can alleviate negative mood states and sleep problems, as well as enhance mental concentration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Won-Young Bae, Hyunggyu Min, So Lim Shin, Tae-Rahk Kim, Hakbae Lee, Minn Sohn, Kyoung Sik Park
Summary: This study demonstrates that ingestion of heat-treated Lactobacillus plantarum LM1004 can significantly increase natural killer cell activity and enhance serum levels of interleukin-12 without any side effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Allergy
Bruce Zuraw, William R. Lumry, Douglas T. Johnston, Emel Aygoren-Pursun, Aleena Banerji, Jonathan A. Bernstein, Sandra C. Christiansen, Joshua S. Jacobs, Karl V. Sitz, Richard G. Gower, Remi Gagnon, H. James Wedner, Tamar Kinaciyan, Roman Hakl, Jana Hanzlikova, John T. Anderson, Donald L. McNeil, Stephen B. Fritz, William H. Yang, Raffi Tachdjian, Paula J. Busse, Timothy J. Craig, H. Henry Li, Henriette Farkas, Jessica M. Best, Desiree Clemons, Melanie Cornpropst, Sylvia M. Dobo, Heather A. Iocca, Deborah Kargl, Eniko Nagy, Sharon C. Murray, Phil Collis, William P. Sheridan, Marcus Maurer, Marc A. Riedl
Summary: In the APeX-2 trial, both 110-mg and 150-mg doses of Berotralstat significantly reduced HAE attack rates compared with placebo, with good safety and tolerability profiles.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Clinical Neurology
Christos M. Polymeropoulos, Vasilios M. Polymeropoulos, Emily L. Czeisler, Michaela A. Fisher, Sandra P. Smieszek, Changfu Xiao, Gunther Birznieks, Mihael H. Polymeropoulos
Summary: This study assessed the physiological mechanism of jet lag induced by transmeridian travel and found that tasimelteon can be an effective therapeutic tool for treating jet lag disorder, improving sleep and daytime alertness.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Seema Sahay, Sampada Bangar, Nomita Chandhiok
Summary: This study aims to evaluate the feasibility and effectiveness of providing daily oral PrEP to MSM and TGW in Pune and Jalandhar, India. Through screening 600 eligible participants and providing PrEP medication for 12 months, the study will assess PrEP acceptability, adherence, retention rate, and associated side effects and behavioral changes. The findings will provide crucial evidence for policymakers on implementing PrEP among MSM and TGW in India and identifying the target population and delivery strategies to enhance its effectiveness.
Article
Gastroenterology & Hepatology
Li Hua Peng, Jing Yuan Fang, Ning Dai, Xi Zhong Shen, You Lin Yang, Jing Sun, Yun Sheng Yang
Summary: Linaclotide (290 μg/d) was effective and well-tolerated in Chinese IBS-C patients, with a rapid onset of action.
JOURNAL OF DIGESTIVE DISEASES
(2022)
Article
Medicine, General & Internal
Linda C. Giudice, Sawsan As-Sanie, Juan C. Arjona Ferreira, Christian M. Becker, Mauricio S. Abrao, Bruce A. Lessey, Eric Brown, Krzysztof Dynowski, Krzysztof Wilk, Yulan Li, Vandana Mathur, Qurratul Ann Warsi, Rachel B. Wagman, Neil P. Johnson
Summary: The effectiveness and safety of relugolix combination therapy for treating endometriosis-associated pain were evaluated in this study. The results showed that the combination therapy significantly improved symptoms and was well tolerated.
Article
Gastroenterology & Hepatology
Mazen Noureddin, Shaharyar Khan, Francisco Portell, Diane Jorkasky, Jameel Dennis, Omer Khan, Lars Johansson, Edvin Johansson, Arun J. Sanyal
Summary: This study aimed to evaluate the safety and efficacy of HU6 in individuals with non-alcoholic fatty liver disease (NAFLD) and high BMI. The results showed that HU6 treatment resulted in a greater relative change in liver fat content compared to the placebo group, suggesting that HU6 could be a promising pharmacological agent for treating obesity and NAFLD and its metabolic complications.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Fabiana Cristina Rosa Mitelmao, Cristiane de Cassia Bergamaschi, Marli Gerenutti, Karin Hachel, Marcus Tolentino Silva, Victor M. Balcao, Marta Maria Duarte Carvalho Vila
Summary: This study aims to evaluate the efficacy and safety of a combination of different strains of Lactobacillus sp. and Bifidobacterium sp. in functional constipation. The outcomes of interest include changes in frequency of weekly bowel movements, stool quality, volunteer withdrawal, adverse events, and serious adverse effects.
Article
Pharmacology & Pharmacy
Teng Ma, Ni Yang, Yong Xie, Yingmeng Li, Qiuping Xiao, Qiong Li, Hao Jin, Longjin Zheng, Zhihong Sun, Kexuan Zuo, Lai-Yu Kwok, Heping Zhang, Nonghua Lu, Wenjun Liu
Summary: Chronic constipation (CC) is a common gastrointestinal condition that impairs patients' quality of life. A large-scale trial was conducted to investigate the effect of probiotics (Lactiplantibacillus plantarum P9 [P9]) on CC. Ingesting P9 significantly improved bowel movements and reduced worries and concerns. The P9 group had an enriched population of beneficial bacteria and changes in the fecal metagenome and metabolome. These findings support the use of probiotics in managing CC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Veterinary Sciences
Ashley Spencer, Jessica M. Quimby, Josh M. Price, Sally MacLane, Shanna Hillsman, Patty Secoura, Jorg M. Steiner, M. Katherine Tolbert
Summary: The study found that once-daily omeprazole did not significantly increase appetite in cats with chronic kidney disease, and should not be used as a first-line treatment method.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Xiaomei Zhang, Shanbin Chen, Ming Zhang, Fazheng Ren, Yimei Ren, Yixuan Li, Ning Liu, Yan Zhang, Qi Zhang, Ran Wang
Summary: This study investigated the effect of Lacticaseibacillus paracasei strain Shirota on constipation and depression symptoms in patients with specific etiology and gut microbiota. The results showed that LcS could alleviate certain symptoms of constipation and depression, regulate intestinal microbiota related to mental illness, and significantly decrease IL-6 levels.
Article
Biochemistry & Molecular Biology
Kaige Zhang, Hui Liu, Peng Liu, Qi Feng, Lihong Gan, Ling Yao, Gen Huang, Ziling Fang, Tingtao Chen, Nian Fang
Summary: This study shows that the administration of Lactiplantibacillus plantarum MH-301 can improve postoperative symptoms in patients with internal hemorrhoids. High-throughput sequencing analysis reveals that the group treated with L. plantarum MH-301 has a higher diversity of intestinal microbiota and a higher relative abundance of beneficial bacteria such as Bifidobacterium, Megamonas, and Lactobacillus. Therefore, L. plantarum MH-301 can enhance the efficacy of endoscopic sclerotherapy and improve bowel movements.
Article
Respiratory System
Jesse Nussbaum, Azher Hussain, Anthony Ford, Peter Butera, Michael Kitt, Steve Smith, Aubrey Stoch, Marian Iwamoto
Summary: This study aimed to assess the safety, tolerability, and pharmacokinetics (PK) of gefapixant in males and females of different ages. The results showed that the safety profile of gefapixant was consistent with previous studies. Further research is warranted to examine the PK of gefapixant in relation to age and sex.
Article
Immunology
Michelle K. Haas, Kaylynn Aiona, Kristine M. Erlandson, Robert W. Belknap
Summary: A retrospective cohort study in a US-based TB clinic comparing treatment completion and adverse events between patients initiating latent tuberculosis (LTBI) treatment with self-administered once-weekly isoniazid-rifapentine (3HP-SAT) and daily rifampin for 4 months (4R) found that 3HP-SAT was associated with higher treatment completion rates and lower rates of adverse events, particularly in individuals aged 50 and older. The study suggests that expanding the use of 3HP-SAT may enhance tuberculosis prevention strategies in the US.
CLINICAL INFECTIOUS DISEASES
(2021)
