Article
Biochemistry & Molecular Biology
Xianwen Yi, Youmei Xie, David A. Gerber
Summary: Transplantation of biliary tree stem/progenitor cells using a patch grafting approach can effectively improve T1D over a four-month observation period, demonstrating its potential for clinical applications.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Shuang Chen, Jing Luo, Lanlin Shen, Xuan Liu, Wenshuang Wang, Jia Xu, Yushuang Ren, Yixin Ye, Gang Shi, Fuyi Cheng, Lin Cheng, Xiaolan Su, Lei Dai, Maling Gou, Hongxin Deng
Summary: The study demonstrates that mini-capsule devices fabricated using digital light processing 3D printing can be used for the treatment of type 1 diabetes. These devices provide sufficient islet cell mass, prevent leakage, maintain long-term cell survival, and allow for easy retrieval.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Review
Immunology
Setareh Soltani, Kamran Mansouri, Mohammad Sajad Emami Aleagha, Narges Moasefi, Niloofar Yavari, Seyed Kazem Shakouri, Sara Notararigo, Ali Shojaeian, Flemming Pociot, Reza Yarani
Summary: This article summarizes the latest applications of extracellular vesicles (EVs), mainly from stem cells, in the treatment of type 1 diabetes (T1D), highlighting their regenerative, anti-inflammatory, and immunomodulatory effects, and identifying opportunities for further investigation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Marc Clos-Garcia, Tarunveer S. S. Ahluwalia, Signe A. A. Winther, Peter Henriksen, Mina Ali, Yong Fan, Evelina Stankevic, Liwei Lyu, Josef K. K. Vogt, Torben Hansen, Cristina Legido-Quigley, Peter Rossing, Oluf Pedersen
Summary: By studying the gut microbiome and blood metabolome of individuals with type 1 diabetes (T1D) and healthy controls, we identified distinct features in the microbiome and metabolome of individuals with T1D and progressive kidney disease stratified on levels of albuminuria.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sungwook Jung, Moufida Ben Nasr, Baharak Bahmani, Vera Usuelli, Jing Zhao, Gianmarco Sabiu, Andy Joe Seelam, Said Movahedi Naini, Hari Baskar Balasubramanian, Youngrong Park, Xiaofei Li, Salma Ayman Khalefa, Vivek Kasinath, MacKenzie D. Williams, Ousama Rachid, Yousef Haik, George C. Tsokos, Clive H. Wasserfall, Mark A. Atkinson, Jonathan S. Bromberg, Wei Tao, Paolo Fiorina, Reza Abdi
Summary: A novel and specific nanodelivery platform targeting high endothelial venules (HEVs) in pancreatic lymph nodes (PLNs) and pancreas is developed to address the limited efficacy, equipoise, or safety issues of immune therapeutics in treating type 1 diabetes (T1D). By encapsulating anti-CD3 mAb in poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles (NPs) conjugated with MECA79 mAb, the targeted delivery of these NPs improves the accumulation of anti-CD3 mAb in both PLNs and pancreas of nonobese diabetic (NOD) mice. Treatment with MECA79-anti-CD3-NPs significantly reverses T1D in hyperglycemic NOD mice by reducing T effector cell populations and pro-inflammatory cytokine production in PLNs.
ADVANCED MATERIALS
(2023)
Article
Endocrinology & Metabolism
Robert French, Dylan Kneale, Justin T. Warner, Holly Robinson, James Rafferty, Adrian Sayers, Peter Taylor, John W. Gregory, Colin M. Dayan
Summary: There is no strong evidence to suggest a significant association between type 1 diabetes and educational outcomes. However, the level of blood glucose control (HbA(1c)) is related to academic achievements.
Review
Immunology
Balasubramanian Krishnamurthy, Matthew Lacorcia, Thomas W. H. Kay, Helen E. Thomas, Stuart I. Mannering
Summary: Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells. Short-term treatment targeting T cells, B cells, and inflammatory cytokines has shown temporary disease activity pause. Lessons learned from these trials will be discussed, with the expectation that effective disease-modifying agents will be available for early-stage T1D. Advances in analyzing antigen-specific T cells and discovering biomarkers through high-dimensional profiling offer promising prospects for predicting disease onset, progression, and therapeutic efficacy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Mark A. Sperling, Lori M. Laffel
Summary: A 12.5-year-old pubertal girl is referred to a tertiary medical center for management of new-onset diabetes mellitus. The initial evaluation reveals glucosuria but no ketonuria. She has no family history of type 1 diabetes mellitus and her physical examination is normal except for Tanner stage 3 breast and pubic hair development.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Francesca Paris, Valeria Pizzuti, Pasquale Marrazzo, Andrea Pession, Francesco Alviano, Laura Bonsi
Summary: Human term placenta and other postpartum-derived biological tissues can provide perinatal cells with unique stem cell properties for the design of immunotherapy protocols, particularly for the treatment of chronic non-curable human diseases such as type 1 diabetes. This study outlines the advantages of cells derived from amniotic epithelial cells and umbilical cord matrix, and discusses their potential in supporting cell therapy development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xi Wang, Kristina G. Maxwell, Kai Wang, Daniel T. Bowers, James A. Flanders, Wanjun Liu, Long-Hai Wang, Qingsheng Liu, Chengyang Liu, Ali Naji, Yong Wang, Bo Wang, Jing Chen, Alexander U. Ernst, Juan M. Melero-Martin, Jeffrey R. Millman, Minglin Ma
Summary: The study introduces a novel device composed of nanofibers for transplanting stem cell-derived beta cells to treat T1D, demonstrating its safety, efficacy, and sustainability in animal experiments.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Multidisciplinary Sciences
Jeffrey A. Bluestone, Jane H. Buckner, Kevan C. Herold
Summary: Type 1 diabetes (T1D) is an autoimmune disease where T cells attack and destroy insulin-producing beta cells in the pancreas. While insulin therapy helps with symptoms, it does not cure the underlying disease or fully prevent complications. Current research is focused on developing immunological therapies to prevent and modify T1D.
Article
Medicine, General & Internal
Eleanor L. Ramos, Colin M. Dayan, Lucienne Chatenoud, Zdenek Sumnik, Kimber M. Simmons, Agnieszka Szypowska, Stephen E. Gitelman, Laura A. Knecht, Elisabeth Niemoeller, Wei Tian, Kevan C. Herold, PROTECT Study Investigators
Summary: Two 12-day courses of teplizumab in children and adolescents with newly diagnosed type 1 diabetes showed benefit with respect to the preservation of beta-cell function, but no significant differences between the groups were observed with respect to the secondary endpoints.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Review
Multidisciplinary Sciences
Colin M. Dayan, Rachel E. J. Besser, Richard A. Oram, William Hagopian, Manu Vatish, Owen Bendor-Samuel, Matthew D. Snape, John A. Todd
Summary: Recent studies have shown that monitoring pancreatic islet autoantibodies and genetic risk assessment can identify most children who will develop T1D, with immunotherapy and primary prevention methods showing success in delaying disease progression. By shifting focus towards early diagnosis and b cell preservation, a future without daily insulin injections for children with T1D is anticipated.
Editorial Material
Psychology, Clinical
Nia Kaleycheva, Alexis E. Cullen, Robyn Evans, Tirril Harris, Timothy Nicholson, Trudie Chalder
PSYCHOLOGICAL MEDICINE
(2023)
Letter
Rehabilitation
Trudie Chalder, Abigail Smakowski, James Adamson, Tracey Turner
DISABILITY AND REHABILITATION
(2023)
Article
Psychology, Clinical
Michael Rose, Christopher D. Graham, Nicola O'Connell, Chiara Vari, Victoria Edwards, Emma Taylor, Lance M. McCracken, Aleksander Radunovic, Wojtek Rakowicz, Sam Norton, Trudie Chalder
Summary: This study aimed to investigate whether Acceptance and Commitment Therapy (ACT) could improve the quality of life in patients with chronic muscle diseases. The results showed that ACT, as an adjunct to usual care, significantly improved the quality of life and other psychological and social outcomes in these patients.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Alessio Maria Monteleone, Giammarco Cascino, Laura Salerno, Ulrike Schmidt, Nadia Micali, Valentina Cardi, Janet Treasure
Summary: This study used network analysis to examine the relationship between eating disorder-related psychopathology and carers' responses to anorexia nervosa symptoms in adolescents. Results showed that depression in both carers and patients played a significant role in the maintenance of psychopathology. The findings suggest that depression could be a potential treatment target in family interventions.
EUROPEAN EATING DISORDERS REVIEW
(2023)
Letter
Gastroenterology & Hepatology
Calum D. Moulton, Emily Staite, Kirsty Winkley, Michael A. Heneghan, Khalida Ismail
JOURNAL OF HEPATOLOGY
(2023)
Article
Psychology, Clinical
Federica Picariello, Joseph Chilcot, Trudie Chalder, David Herdman, Rona Moss-Morris
Summary: This study evaluated the psychometric properties of the Cognitive and Behavioural Responses Questionnaire (CBRQ) and its shortened version in different long-term conditions. The results showed that the CBRQ and the shortened version were reliable and valid at assessing cognitive and behavioral responses to symptoms, highlighting the questionnaire's multi-symptom, transdiagnostic properties. Further research is needed to determine the test-retest reliability, sensitivity to change, and content validity of the items.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Endocrinology & Metabolism
Madeleine Benton, Jeni Baykoca, Khalida Ismail, Hermione Price
Summary: This study aims to explore the perspectives and experiences of healthcare professionals in identifying and supporting mental health problems in adults with type 1 diabetes in the UK. Through individual interviews with 15 healthcare professionals, barriers such as time constraints, lack of knowledge, service relationships, and stigma were identified, while facilitators included education, communication, and appropriate tools and services. The findings highlight the importance of educational tools to improve the skills and competency of healthcare professionals in identifying mental health problems in type 1 diabetes patients.
Article
Health Care Sciences & Services
Karianne Svendsen, Lise Solberg Nes, Anders Meland, Ine Marie Larsson, Ylva M. Gjelsvik, Elin Borosund, Christine M. Rygg, Tor Age Myklebust, Kristin Reinertsen, Cecilie E. Kiserud, Helle Skjerven, Michael H. Antoni, Trudie Chalder, Ingvil Mjaaland, Linda E. Carlson, Hege R. Eriksen, Giske Ursin
Summary: This study aims to investigate the effects of using two different eHealth interventions, StressProffen-CBI and StressProffen-MBI, compared to standard treatment in breast cancer survivors. The study is a randomized controlled trial with a goal of recruiting 430 participants, and currently 428 participants have been enrolled.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Respiratory System
Charles C. Reilly, Matthew Maddocks, Trudie Chalder, Katherine Bristowe, Irene J. Higginson
Summary: SELF-BREATHE is a digital breathlessness intervention that aims to improve the lives of people with chronic breathlessness. This study found that SELF-BREATHE was feasible to deliver and acceptable to patients, with users reporting improved breathlessness during daily life.
Article
Medicine, Research & Experimental
Kirsty Winkley, Taru Sorsa, Qingxiu Tian, Ilse Reece, Christina Fitzgerald, Mark Chamley, Khalida Ismail, Angus Forbes, Rebecca Upsher
Summary: The objective of this study was to determine the feasibility and acceptability of a diabetes insulin self-management education (DIME) group intervention for people with type 2 diabetes starting insulin. The study found that the DIME intervention was acceptable and feasible to deliver to participants with type 2 diabetes starting insulin in South London, UK.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Health Care Sciences & Services
Snehal M. Pinto Pereira, Roz Shafran, Manjula D. Nugawela, Laura Panagi, Dougal Hargreaves, Shamez N. Ladhani, Sophie D. Bennett, Trudie Chalder, Emma Dalrymple, Tamsin Ford, Isobel Heyman, Kelsey McOwat, Natalia K. Rojas, Kishan Sharma, Ruth Simmons, Simon R. White, Terence Stephenson
Summary: A follow-up study on children and young people (CYP) with acute COVID found that the prevalence of symptoms declined over a year. Some individuals reported adverse symptoms, such as fatigue, shortness of breath, poor quality of life, emotional difficulties, and fatigue, for the first time at six and 12 months post-infection, suggesting multiple factors contributing to these symptoms.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Gastroenterology & Hepatology
Calum D. Moulton, Cheryl Jordan, Bu'Hussain Hayee, Trudie Chalder
Summary: This study reveals that fatigue is common in patients with inflammatory bowel disease (IBD), yet the underlying reasons are not well-known. The study indicates that fluctuations between high activity and rest and negative thinking patterns contribute to worsening fatigue over time.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Respiratory System
Camilla Dawson, Gemma Clunie, Felicity Evison, Sallyanne Duncan, Julie Whitney, Linzy Houchen-Wolloff, Charlotte E. Bolton, Olivia C. Leavy, Matthew Richardson, Elneima Omer, Hamish McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Neil J. Greening, Claire Marie Nolan, Dan Gower Wootton, Enya Daynes, Gavin Donaldson, Jack Sargent, Janet Scott, John Pimm, Lettie Bishop, Melitta McNarry, Nicholas Hart, Rachael A. Evans, Sally Singh, Tom Yates, Trudie Chalder, William Man, Ewen Harrison, Annemarie Docherty, Nazir Lone, Jennifer K. Quint, James Chalmers, Ling-Pei Ho, Alex Robert Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Louise Wain, Chris Brightling, Neil PHOSP-COVID Collaborative Grp, Neil Sharma, Margaret Coffey, Amit Kulkarni, Sarah Wallace
Summary: This multicentre observational study in the UK examined the prevalence of self-reported swallowing, communication, voice, and cognitive problems in patients discharged from hospitals after COVID-19. The study found that compromised swallowing was reported by 20% of patients who had been admitted to the intensive care unit. Voice problems were reported by 34% of patients post-ICU admission. Communication compromise was reported by 23% of patients. Cognitive issues were reported by 70% of patients. These problems were associated with factors such as age, sex, social deprivation, and being a healthcare worker.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Psychology, Clinical
Maria Livanou, Anya Heneghan, Elli Bouliou, Grace Hill, Katharine Mills, Sophie Naylor Roll, Zara Smalley, Jun Teh, Janet Treasure
Summary: Eating disorders pose a chronic problem in child mental health services, and transitioning to adult care is a high-risk period for young people with EDs. This study aims to develop a youth-specific intervention called TEDYi for young people transitioning from adolescent to adult ED services. Lack of evidence on inclusive interventions addressing their complex needs during this transition period is a current challenge.
EUROPEAN EATING DISORDERS REVIEW
(2023)
Review
Psychology, Clinical
Anya Heneghan, Ifigeneia Manitsa, Maria Livanou, Janet Treasure
Summary: This study reviewed the literature on the experiences of siblings in the context of eating disorders (EDs). The findings revealed various impacts on siblings' lives, including family relationship fragmentation, parentification, and competition and jealousy. It is important to gain a better understanding of siblings' experiences and needs.
EUROPEAN EATING DISORDERS REVIEW
(2023)
