Review
Pharmacology & Pharmacy
Tugce Boztepe, Guillermo R. Castro, Ignacio E. Leon
Summary: Platinum drugs like carboplatin, cisplatin, and oxaliplatin are widely used in cancer treatment but their toxicity limits their application. Recent research focuses on developing new formulations to expand therapeutic options. Advances in drug delivery carriers aim to increase drug stability and reduce toxic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Yi Zhu, Lina M. Marin, Yizhi Xiao, Elizabeth R. Gillies, Walter L. Siqueira
Summary: Salivary proteins like histatins play important roles in tooth health. Chitosan nanoparticles show promise in protecting these proteins from enzymatic degradation in the oral environment, especially in acidic conditions. The results demonstrate their potential as carriers for oral applications.
Article
Nanoscience & Nanotechnology
Ranhua Xiong, Dawei Hua, Jelter Van Hoeck, Dominika Berdecka, Laurens Leger, Stijn De Munter, Juan C. Fraire, Laurens Raes, Aranit Harizaj, Felix Sauvage, Glenn Goetgeluk, Melissa Pille, Jeffrey Aalders, Joke Belza, Thibaut Van Acker, Eduardo Bolea-Fernandez, Ting Si, Frank Vanhaecke, Winnok H. De Vos, Bart Vandekerckhove, Jolanda van Hengel, Koen Raemdonck, Chaobo Huang, Stefaan C. De Smedt, Kevin Braeckmans
Summary: Photothermal nanofibres embedded with iron oxide nanoparticles can deliver effector macromolecules to different types of cells without causing cellular toxicity or diminishing therapeutic potency, showing promise for safe and efficient production of engineered cells for therapeutic applications.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Farzin Firozian, Zahra Arabkhani, Mohammad Mehdi Mahboobian, Mojdeh Mohammadi, Gholamabbas Chehardoli
Summary: The study developed a cationic dextran stearate-glycidyl trimethylammonium chloride (Dex-St-GTMAC) copolymer as a drug carrier to deliver indomethacin to cornea tissues. The prepared polymeric micelles showed sustained drug release and improved penetration of indomethacin into cornea tissues.
Article
Pharmacology & Pharmacy
Tais C. Ribeiro, Rafael M. Sabio, Gabriela C. Carvalho, Bruno Fonseca-Santos, Marlus Chorilli
Summary: Neurodegenerative diseases are a public health problem causing cognitive and behavioral impairments. Current drugs can only control symptoms but cannot prevent neural loss. Nanotechnology-based drug delivery systems have been developed to optimize treatment, especially for Alzheimer's and Parkinson diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Polymer Science
Nguyen Hoc Thang, Truong Bach Chien, Dang Xuan Cuong
Summary: Polymer-based hydrogels are widely used for drug delivery applications due to their ability to absorb water, control drug release, and be tailored to specific triggers. Current trends in hydrogel drug delivery include targeted drug release, injectable formulations, nano hydrogels, and improved mechanical properties. The field is also gaining attention in personalized medicine for tailored drug release, combination therapies, and cost reduction.
Review
Pharmacology & Pharmacy
Huiqun Huang, Ronghui Liu, Jie Yang, Jing Dai, Shuhao Fan, Jiang Pi, Yubo Wei, Xinrong Guo
Summary: Cancer immunotherapy is a novel approach to enhance the immune system's ability to detect and eliminate cancer cells. Gold nanoparticles (AuNPs) have been explored as drug carriers in immunotherapy due to their stability, surface versatility, and optical properties. This review summarizes the synthesis routes and utilization of AuNPs as drug carriers, focusing on drug loading, targeting strategies, and drug release mechanisms in AuNP-based immunotherapy. The application and therapeutic efficacy of AuNPs in combination with cancer immunotherapy are also briefly discussed.
Article
Materials Science, Biomaterials
Quan-Bing Chen, Mei-Hua Shen, Xiao-He Ren, Shuai Zhu, Jin-Ting Shang, Wei Liu, Zhao-Wei Zhang, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang, Qiong Yuan, Tao Zou
Summary: This study utilizes tumor-triggered targeting ammonium bicarbonate liposomes for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic multimodal therapy, which effectively treats tumors without significant side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity for enhancing the effectiveness of active pharmaceutical ingredients and targeting alternative routes of drug administration. By understanding the binding behavior of polymers on nanoparticle surfaces, it is possible to optimize nanoparticle formulations and guide mucoadhesion.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity as they improve the effectiveness of pharmaceutical ingredients and enhance absorption through mucosal drug delivery. However, the binding behavior of polymer-coated nanoparticles to mucin proteins can differ from that of polymer in solution, and the nanoparticle core influences the binding fate of polymer materials.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Pharmacology & Pharmacy
Mahima Jadav, Deep Pooja, David J. Adams, Hitesh Kulhari
Summary: In the past three decades, polymers have greatly contributed to the advancement of drug delivery technologies by providing controlled and sustained release of therapeutic agents, versatility in designing different delivery systems, and the ability to encapsulate both hydrophobic and hydrophilic molecules. Natural and synthetic polymers have been explored for delivering various therapeutic agents. However, due to the drawbacks of synthetic polymers, there is a shift towards using naturally occurring biopolymers. Xanthan gum (XG), a high molecular weight microbial heteropolysaccharide, has shown promising applications in drug delivery due to its favorable properties such as hydrophilicity, biodegradability, biocompatibility, and easy chemical modification. It has been used as a thickener and emulsion stabilizer and has been explored for various applications in the food, pharmaceutical, and cosmetic industries.
Article
Polymer Science
Khaled M. Hosny, Hala M. Alkhalidi, Waleed S. Alharbi, Shadab Md, Amal M. Sindi, Sarah A. Ali, Rana B. Bakhaidar, Alshaimaa M. Almehmady, Eman Alfayez, Mallesh Kurakula
Summary: Natural polymers, such as cellulose and its derivatives, have gained significant importance in the design of pharmaceutical dosage forms as excipients and have revolutionized formulation development and drug delivery. These polymers are highly biocompatible, biodegradable, non-toxic, and stable. The review focuses on the origin, extraction, and preparation of cellulose derivatives, as well as their various applications in pharmaceutical excipients, drug delivery, dentistry, protein and peptide delivery, colorectal cancer treatment, and 3D printable dosage forms.
Article
Chemistry, Multidisciplinary
Kristen N. Sikora, Laura J. Castellanos-Garcia, Joseph M. Hardie, Yuanchang Liu, Michelle E. Farkas, Vincent M. Rotello, Richard W. Vachet
Summary: A dual-mode mass spectrometry imaging method was used to evaluate the distributions and biochemical effects of anti-TNF-alpha nanoparticle stabilized capsules in mice, revealing that most anticipated biochemical changes occur in sub-organ regions separate from where the nanomaterials accumulate. The study demonstrates the power of matrix-assisted laser desorption/ionization mass spectrometry imaging in evaluating both expected and unexpected outcomes associated with complex therapeutic delivery systems.
Review
Chemistry, Physical
Radhakrishnan Sreena, Arputharaj Joseph Nathanael
Summary: Biopolymers, obtained from renewable or non-renewable sources, are ideal for creating tailor-made nanoparticles due to their biocompatibility, biodegradability, low toxicity, and low immunogenicity. Biopolymeric nanoparticles can be classified as natural (based on polysaccharides and proteins) or synthetic. They have gained significant interest for biomedical applications such as tissue engineering, drug delivery, imaging, and cancer therapy. Various fabrication strategies can be used to synthesize biopolymeric nanoparticles, including emulsification, ionic gelation, nanoprecipitation, and electrospray drying. This review aims to explore the use of biodegradable biopolymeric nanoparticles in biomedical applications, which has been overlooked in previous reviews. It highlights the use of protein-based (albumin, gelatin, collagen, silk fibroin), polysaccharide-based (chitosan, starch, alginate, dextran), and synthetic (poly lactic acid, poly vinyl alcohol, poly caprolactone) biopolymeric nanoparticles, as well as the fabrication strategies employed. Future perspectives and challenges in utilizing biopolymeric nanoparticles are also discussed.
Review
Chemistry, Inorganic & Nuclear
Chunyan Jia, Glen B. Deacon, Yingjie Zhang, Chuanzhu Gao
Summary: This article summarizes the main problems of platinum-based anticancer drugs, introduces Pt-IV drugs and their characteristics, and focuses on the combination therapy with nanocarriers, looking forward to the application prospects of Pt-IV drugs and nanotechnology in the field of cancer chemotherapy.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Graciela Dolores Avila-Quezada, Patrycja Golinska, Mahendra Rai
Summary: Engineered nanomaterials have high potential for applications in agriculture, particularly in plant disease management. They offer eco-friendly and economically viable alternatives for diagnosis and delivery of fungicides to improve the efficacy of plant disease treatment.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Jaelson Santos Silva, Everton Leandro Franca Ferreira, Amanda Maciel Lima, Ruth Raquel Soares de Farias, Bruno Quirino Araujo, Jose Carlos Quilles Junior, Rodolfo Ritchelle Lima Santos, Fernando Aecio de Amorim Carvalho, Mahendra Rai, Gerardo Magela Vieira Junior, Mariana Helena Chaves
Summary: The study identified various cycloartane-type triterpenoids for the first time from the leaves of Combretum mellifluum Eichler. The ethyl acetate and aqueous fractions showed high antioxidant activity, correlated with total flavonoid content. Additionally, the extract exhibited significant antileishmanial activity, suggesting the potential therapeutic applications of this plant as an antioxidant agent and in disease treatment.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Ecology
Abdul Arif Khan, Fozia Farooq, Sudhir K. Jain, Patrycja Golinska, Mahendra Rai
Summary: COVID-19 has caused a global catastrophe, with an increased occurrence of invasive pulmonary aspergillosis infection in patients, even in the absence of traditional risk factors. Further research is needed to explore the mechanism between SARS-CoV2 and aspergillosis in order to better address these diseases.
Article
Environmental Sciences
Pramod U. Ingle, Jayanta K. Biswas, Monojit Mondal, Mahendra K. Rai, P. Senthil Kumar, Aniket K. Gade
Summary: This study successfully synthesized silver, copper oxide, iron oxide, and alumina nanoparticles through the Moringa oleifera aqueous extract-mediated method. These nanoparticles exhibited antimicrobial activity and biofilm inhibition against various pathogens in vitro, with stronger inhibitory effects against Gram-negative bacteria. Therefore, these nanoparticles have potential for the development of alternative antimicrobials against diverse bacterial infections.
Review
Biochemistry & Molecular Biology
Paulo Wender P. Gomes, Luiza Martins, Emilli Gomes, Abraao Muribeca, Sonia Pamplona, Andrea Komesu, Carissa Bichara, Mahendra Rai, Consuelo Silva, Milton Silva
Summary: Diseases caused by viruses are a global threat and medicinal plants can be used as complementary treatments. This review explores the potential of antiviral plants from Marajo island, which show promise in combatting future viral diseases.
Editorial Material
Microbiology
Mehdi Razzaghi-Abyaneh, Zhi-Yuan Chen, Masoomeh Shams-Ghahfarokhi, Mahendra Rai
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Swapnil Gaikwad, Sonal Birla, Avinash P. Ingle, Aniket Gade, Pramod Ingle, Patrycja Golinska, Mahendra Rai
Summary: This study evaluated the wound-healing ability of mycofabricated silver nanoparticles and developed a novel nanogel that demonstrated excellent wound-healing activity and effectively suppressed bacterial growth on wound surfaces, providing an improved healing environment.
FRONTIERS IN MICROBIOLOGY
(2022)
Editorial Material
Pharmacology & Pharmacy
Fadia S. Youssef, Elisa Ovidi, Mahendra Rai
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Mahendra Rai, Beata Zimowska, Aniket Gade, Pramod Ingle
Summary: The increasing multidrug-resistance in pathogenic microbes and the emergence of new microbial pathogens have led to the search for new antimicrobials. This review focuses on the antimicrobial potential of secondary metabolites produced by different Phoma species and the biogenic synthesis of antimicrobial silver nanoparticles from Phoma.
Review
Microbiology
Mousa A. Alghuthaymi, Kamel A. Abd-Elsalam, Hussien M. AboDalam, Farah K. Ahmed, Mythili Ravichandran, Anu Kalia, Mahendra Rai
Summary: Traditional nanoparticle synthesis methods are expensive and hazardous, while microbial synthesis offers a green and rapid alternative for various applications. This review focuses on the synthesis of metal nanoparticles from Trichoderma species for agri-food applications and discusses their potential benefits and drawbacks.
Review
Plant Sciences
Graciela Dolores Avila-Quezada, Mahendra Rai
Summary: This article discusses the emerging role of nano-materials in the detection and treatment of Phytophthora species, including slow delivery of agrochemicals. The authors propose integrating these tools into an integrated management program to reduce pesticide use and provide more effective and sustainable control of Phytophthora pathogens.
TRENDS IN PLANT SCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Mahendra Rai, Beata Zimowska, Aniket Gade, Pramod Ingle
Summary: The genus Phoma is a major group that secretes a wide range of secondary metabolites with various bioactivities. These metabolites, including phomenon, phomin, phomodione, cytochalasins, cercosporamide, phomazines, and phomapyrone, exhibit antimicrobial, antiviral, antinematode, and anticancer activities. This review highlights the importance of Phoma fungi as a natural source of biologically active secondary metabolites and their potential as anticancer agents.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fernanda Wariss Figueiredo Bezerra, Jonilson de Melo e Silva, Gustavo Guadagnucci Fontanari, Johnatt Allan Rocha de Oliveira, Mahendra Rai, Renan Campos Chiste, Luiza Helena da Silva Martins
Summary: Nanopropolis, a natural nanomaterial with various applications, including food preservation and prevention of foodborne illness, has smaller size and higher antibacterial activity compared to common propolis.
Review
Chemistry, Physical
Szymon Graczyk, Robert Paslawski, Arkadiusz Grzeczka, Urszula Paslawska, Beata Swieczko-Zurek, Klaudia Malisz, Ketul Popat, Alina Sionkowska, Patrycja Golinska, Mahendra Rai
Summary: Microbial colonization in veterinary stents is a significant issue in veterinary medicine. Prolonged colonization can lead to infections, inflammation, and compromise the effectiveness of the stents, affecting the overall well-being of animal patients. Managing and mitigating the impact of these pathogens is a crucial challenge that veterinarians and researchers are actively addressing.
Review
Chemistry, Multidisciplinary
Graciela Dolores Avila-Quezada, Avinash P. Ingle, Patrycja Golinska, Mahendra Rai
Summary: Nano-fertilizers are emerging as a promising research field in agriculture, offering a novel way to optimize nutrient supply and increase global food production. The use of nanocarriers can reduce the amount of active chemicals deposited in plants and provide slow-release nutrients. This review addresses the potential benefits, synthesis, mode of entry, mechanisms of action, and fate of nanomaterials in soil for NFs in agriculture.
NANOTECHNOLOGY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
