Article
Plant Sciences
Chen Sheng, Shengnan Song, Rong Zhou, Donghua Li, Yuan Gao, Xianghua Cui, Xuehui Tang, Yanxin Zhang, Jinxing Tu, Xiurong Zhang, Linhai Wang
Summary: In this study, QTL-seq approach and SSR marker mapping were used to identify candidate genomic regions controlling leaf size traits in sesame. A major pleiotropic locus, qLS15-1, for leaf length and width was identified on LG15, with three candidate genes associated with leaf growth and development in sesame. These findings provide insights into genetic characteristics of sesame leaf and set up foundation for improvement of sesame plant architecture.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Ruiyuan Li, Zhengfeng Chen, Ran Zheng, Qingfu Chen, Jiao Deng, Hongyou Li, Juan Huang, Chenggang Liang, Taoxiong Shi
Summary: In this study, QTLs/genes for grain weight/size were identified in Tartary buckwheat through genetic research and breeding programs. A total of 32 QTLs were detected in four different environments, including QTLs for grain yield, 1000-grain weight, grain length, grain width, and grain length-width ratio. Two QTL clusters containing stable major QTLs were found to have significant effects on grain weight/size. Six potential key candidate genes were identified within these QTL clusters, which may play important roles in controlling grain weight/size in Tatary buckwheat.
Article
Plant Sciences
Qing Meng, Zhiyuan Liu, Chunda Feng, Helong Zhang, Zhaosheng Xu, Xiaowu Wang, Jian Wu, Hongbing She, Wei Qian
Summary: In this study, a major quantitative trait locus (QTL) related to early bolting in spinach was identified, and two candidate genes associated with flowering regulatory pathways were proposed. This research provides a basis for understanding the molecular mechanisms of bolting in spinach.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Horticulture
Huiling Wang, Ailing Yan, Xiaoyue Wang, Guojun Zhang, Zhenhua Liu, Haiying Xu, Lei Sun
Summary: In this study, significant QTLs and candidate genes related to berry size were identified through evaluating the grapes from F1 progenies. The results provide new insights into the variation of berry size in grapevine.
SCIENTIA HORTICULTURAE
(2022)
Article
Biotechnology & Applied Microbiology
Ke Wang, Xinfeng Liu, Tang Qi, Yiqing Hui, Hailong Yan, Lei Qu, Xianyong Lan, Chuanying Pan
Summary: By managing goats and analyzing genes, candidate genes related to prolificacy were identified. The study revealed that some genes are significantly associated with fecundity, providing reference and assistance for artificial breeding of goats.
Article
Plant Sciences
Anne Brown, David Grant, Rex T. Nelson
Summary: QTL play a key role in studying seed quality traits and breeding, but identifying the specific genes behind each QTL would greatly enhance our understanding of the genetic mechanisms.
Article
Plant Sciences
Qun Lian, Qiushi Fu, Yongyang Xu, Zhicheng Hu, Jing Zheng, Aiai Zhang, Yuhua He, Changsheng Wang, Chuanqiang Xu, Benxue Chen, Jordi Garcia-Mas, Guangwei Zhao, Huaisong Wang
Summary: Two high-density genetic maps were constructed using whole-genome resequencing with two F-2 segregating populations and two loci for fruit size were identified on chromosome 11 in WAP and chromosome 5 in MAP. An auxin response factor and a YABBY transcription factor were inferred to be the candidate genes for both loci.
Article
Biochemistry & Molecular Biology
Yudi Wu, Shifan Zhang, Hui Zhang, Fei Li, Guoliang Li, Chuchuan Fan, Rifei Sun, Shujiang Zhang
Summary: This study identified two major quantitative trait loci (QTLs) for swollen root formation in turnip, FR1.1 and FR7.1, and narrowed down a major QTL region to 220 kb containing 47 putative genes. Candidate gene Bra003652, a homolog of AT1G78240 in Arabidopsis thaliana, was suggested to play a crucial role in swollen root formation. These findings may provide new insights into the molecular mechanism of swollen root formation in root crops.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Giacomo Mangini, Antonio Blanco, Domenica Nigro, Massimo Antonio Signorile, Rosanna Simeone
Summary: The study identified QTL clusters for yield components in a durum wheat RIL population, with candidate genes affecting grain yield identified within these clusters.
Article
Agriculture, Dairy & Animal Science
Fengyan Wang, Mingxing Chu, Linxiang Pan, Xiangyu Wang, Xiaoyun He, Rensen Zhang, Lin Tao, Yongfu La, Lin Ma, Ran Di
Summary: GDF9 and BMPR1B are important reproduction genes. This study sequenced the entire coding region of GDF9 and identified mutations in Luzhong mutton sheep, with two SNPs being associated with litter size. The missense mutation g.41768485 G > A in GDF9 is predicted to affect the protein's tertiary structure. These mutations could potentially serve as genetic markers for improving litter size in sheep.
Article
Horticulture
Chunqing Liu, Xueqin Yao, Guangqing Li, Lei Huang, Xinyan Wu, Zhujie Xie
Summary: This study identified two QTLs closely associated with anthocyanin biosynthesis in broccoli, narrowing down the major QTL region through high-throughput SNP technology and identifying candidate genes. The study revealed multiple biomarkers related to anthocyanin biosynthesis, providing genetic insights for broccoli breeding and the development of new varieties with enhanced health-promoting properties and improved appearance.
Article
Agronomy
Zhi Zheng, Haiyan Hu, Shang Gao, Hong Zhou, Wei Luo, Udaykumar Kage, Chunji Liu, Jizeng Jia
Summary: In this study, the first genetic assessment of leaf thickness in cereals was conducted. Major and stable QTL were detected in barley, and candidate genes were identified. The findings broaden our understanding of the genetic basis of leaf thickness and its relationship with other traits in cereal crops, and provide a foundation for gene cloning and functional analysis.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Agriculture, Dairy & Animal Science
Chang Yue, Wen L. Bai, Yuan Y. Zheng, Tai Y. Hui, Jia M. Sun, Dan Guo, Su L. Guo, Ze Y. Wang
Summary: This study identified a relationship between the polymorphisms of several genes in Liaoning cashmere goats and litter size and cashmere performance. Particularly, specific genotypes at the FecB C94T and ESR C463T loci were associated with higher litter numbers in goats. These findings suggest a significant correlation between FecB and ESR genes and the high fecundity of Liaoning cashmere goats.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Plant Sciences
Yu Xu, Bingbing Zhang, Ning Ma, Xia Liu, Mengfan Qin, Yan Zhang, Kai Wang, Na Guo, Kaifeng Zuo, Xiang Liu, Miao Zhang, Zhen Huang, Aixia Xu
Summary: By utilizing SSR and SLAF-seq technologies, this study successfully mapped QTLs for flowering time in rapeseed and identified three target intervals. A total of 186 genes with genetic variations, including 14 related to flowering time pathways, were found in these intervals. Development of six InDel markers linked to flowering time indicates the credibility of the results for further genetic studies in Brassica napus L.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Yanli Cui, Qun Ge, Pei Zhao, Wei Chen, Xiaohui Sang, Yunlei Zhao, Quanjia Chen, Hongmei Wang
Summary: This study identified two QTLs related to Verticillium wilt resistance in cotton through BSA-seq analysis, and screened a series of candidate genes in the qvw-D05-2 region by SnpEff analysis. Further investigation showed that GhDRP is involved in resistance to V. dahliae infection, as silencing this gene resulted in higher susceptibility of plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Microbiology
Daniel Sepulveda-Crespo, Ana Trevino-Nakoura, Jose M. Bellon, Maria A. Jimenez-Sousa, Pablo Ryan, Isidoro Martinez, Amanda Fernandez-Rodriguez, Salvador Resino
Summary: The standard algorithm for diagnosing hepatitis C virus (HCV) infection involves an HCV antibody test for screening and a nucleic acid amplification test (NAAT) for confirmation. The accuracy of the Abbott ARCHITECT HCV Ag assay was evaluated in people living with HIV/AIDS (PLWHA), showing good performance in high-prevalence settings but poor in low-prevalence settings. It was excellent in excluding active HCV infection.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Virology
Ana Virseda-Berdices, Leyre Concostrina-Martinez, Oscar Martinez-Gonzalez, Rafael Blancas, Salvador Resino, Pablo Ryan, Maria Martin-Vicente, Oscar Brochado-Kith, Natalia Blanca-Lopez, Maria J. Mallol Poyato, Blanca Lopez Matamala, Carmen Martin Parra, Maria A. Jimenez-Sousa, Amanda Fernandez-Rodriguez
Summary: Increasing age is associated with severity and higher mortality of COVID-19. Telomere shortening is associated with higher risk of infections and may be used to identify those patients who are more likely to die. This study evaluated the association between relative telomere length (RTL) and COVID-19 mortality. Lower RTL was associated with a higher risk of death in women at 30 and 90 days.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
J. Castilla, M. Garcia Cenoz, R. Abad, L. Sanchez-Cambronero, N. Lorusso, C. Izquierdo, S. Canellas Llabres, J. Roig, A. Malvar, F. Gonzalez Carril, A. L. D. Boone, J. Perez Martin, M. J. Rodriguez Recio, A. Galmes, A. Caballero, A. Garcia Rojas, F. Juanas, M. Nieto, L. J. Viloria Raymundo, E. Martinez Ochoa, A. Rivas, D. Castrillejo, D. Moreno Perez, A. Martinez, E. Borras, A. Sanchez Gomez, E. Pastor, V Nartallo, J. M. Arteagoitia, B. Alvarez-Fernandez, R. Garcia Pina, S. Fernandez Arribas, J. Vanrell, S. Garcia Hernandez, R. M. Mendoza, M. Mendez, M. M. Lopez-Tercero, A. Fernandez-Rodriguez, A. Blanco, F. J. Carrillo de Albornoz, J. Ruiz Olivares, R. Ruiz-Montero, A. Limia, J. A. Navarro-Alonso, J. A. Vazquez, A. Barricarte
Summary: This study assessed the effectiveness of a protein-based meningococcal vaccine in preventing invasive meningococcal disease in Spanish children. The results showed that complete vaccination with the vaccine was 76% effective against invasive meningococcal disease caused by any serogroup, and partial vaccination was 54% effective.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Sergio Salguero, Oscar Brochado-Kith, Ana Virseda Verdices, Juan Berenguer, Juan Gonzalez-Garcia, Isidoro Martinez, Cristina Diez, Victor Hontanon, Leire Perez-Latorre, Amanda Fernandez-Rodriguez, Maria Angeles Jimenez-Sousa, Salvador Resino
Summary: We identified a gene expression signature associated with advanced cirrhosis with high risk for clinically significant portal hypertension (CSPH) in HIV/HCV coinfected patients through analyzing the gene expression profile of peripheral blood mononuclear cells (PBMCs). A cross-sectional study on 68 patients was conducted, and liver stiffness measurement (LSM) was used for stratification. We found 60 differentially expressed transcripts between patients with LSM < 12.5 kPa and >= 25 kPa, and two of them were validated in a different cohort.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Violeta Lara-Aguilar, Daniel Valle-Millares, Celia Crespo-Bermejo, Sergio Grande-Garcia, Manuel Llamas-Adan, Maria Engracia Cortijo-Alfonso, Luz Martin-Carbonero, Lourdes Dominguez, Pablo Ryan, Ignacio de los Santos, Sofia Bartolome-Sanchez, Erick Joan Vidal-Alcantara, Maria Angeles Jimenez-Sousa, Amanda Fernandez-Rodriguez, Veronica Briz
Summary: This study examined the senescence profiles in people living with HIV who have acute or chronic Hepatitis C. The results showed that the profiles improved after HCV elimination, either spontaneously or with direct-acting antivirals.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Dairy & Animal Science
Davinia I. Perdomo-Gonzalez, Luis Varona, Antonio Molina, Nora Laseca, Mercedes Valera
Summary: It has been found that gene expression can be blocked by methylation during gametogenesis, resulting in unequal genetic contribution from parents to offspring. The study on a population of Purebred Spanish (PRE) horses revealed that both maternal and paternal gametic effects influence reproductive and morphological traits. The maternal gametic effect generally has a stronger influence on most traits.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2023)
Article
Multidisciplinary Sciences
Erola Pairo-Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu, Isar Nassiri, Glenn A. McConkey, Marie Zechner, Lucija Klaric, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Anne Richmond, Jonathan Millar, Clark D. Russell, Tomas Malinauskas, Ryan Thwaites, Kirstie Morrice, Sean Keating, David Maslove, Alistair Nichol, Malcolm G. Semple, Julian Knight, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter J. M. Openshaw, Colin Begg, Timothy Walsh, Albert Tenesa, Carlos Flores, Jose A. Riancho, Augusto Rojas-Martinez, Pablo Lapunzina, Jian Yang, Chris P. Ponting, James F. Wilson, Veronique Vitart, Malak Abedalthagafi, Andre D. Luchessi, Esteban J. Parra, Raquel Cruz, Angel Carracedo, Angie Fawkes, Lee Murphy, Kathy Rowan, Alexandre C. Pereira, Andy Law, Benjamin Fairfax, Sara Clohisey Hendry, J. Kenneth Baillie
Summary: This study analyzed genetic data from 24,202 severe COVID-19 cases and identified potentially druggable targets, including inflammatory signaling, monocyte-macrophage activation and endothelial permeability, immunometabolism, and host factors required for viral entry and replication.
Review
Virology
Daniel Sepulveda-Crespo, Ana Trevino-Nakoura, Jose M. Bellon, Amanda Fernandez-Rodriguez, Pablo Ryan, Isidoro Martinez, Maria A. Jimenez-Sousa, Salvador Resino
Summary: This meta-analysis evaluated the diagnostic performance of the Abbott ARCHITECT HCV Ag assay for diagnosing active hepatitis C. The assay showed excellent sensitivity, specificity, and accuracy. However, its diagnostic utility may be limited in low prevalence settings, and further confirmation is recommended.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Psychiatry
M. Alemany-Navarro, S. Diz-de Almeida, R. Cruz, J. A. Riancho, A. Rojas-Martinez, P. Lapunzina, C. Flores, A. Carracedo
Summary: Despite individual variation in the clinical presentation of COVID-19, schizophrenia patients show a higher risk and severity of the disease compared to control counterparts. The genetic risk for schizophrenia, but not for bipolar disorder or depression, is associated with a higher risk of SARS-CoV-2 infection and COVID-19 severity, especially among women. However, the predictive accuracy is limited.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Agriculture, Dairy & Animal Science
Houssemeddine Srihi, David Lopez-Carbonell, Noelia Ibanez-Escriche, Joaquim Casellas, Pilar Hernandez, Sara Negro, Luis Varona
Summary: INGA FOOD, S.A. conducted a crossbreeding program to produce hybrid pigs, and studies revealed differences in litter size between reciprocal crosses, suggesting the presence of genomic imprinting effects. A multivariate gametic model was introduced to estimate the gametic correlations between paternal and maternal effects from different genetic backgrounds. The results showed distinct differences in the posterior distribution of gametic correlations between the two populations, which may explain the performance outcomes in the reciprocal crosses.
Correction
Medicine, Research & Experimental
Sergio Salguero, Oscar Brochado-Kith, Ana Virseda Verdices, Juan Berenguer, Juan Gonzalez-Garcia, Isidoro Martinez, Cristina Diez, Victor Hontanon, Leire Perez-Latorre, Amanda Fernandez-Rodriguez, Maria Angeles Jimenez-Sousa, Salvador Resino
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Ruben Martin-Escolano, Ana Virseda-Berdices, Juan Berenguer, Juan Gonzalez-Garcia, Oscar Brochado-Kith, Amanda Fernandez-Rodriguez, Cristina Diez, Victor Hontanon, Salvador Resino, Maria Angeles Jimenez-Sousa
Summary: This study aimed to evaluate the association between plasma immune checkpoint proteins at baseline with hepatic steatosis index increase at the end of follow-up in HIV/HCV-coinfected patients. The results showed that higher levels of immune checkpoint proteins BTLA, CD137, CD80, GITR, LAG-3, and PD-L1 before HCV therapy were associated with a long-term increase in hepatic steatosis index after successful HCV therapy, suggesting a potential predictive role for early detection of progression towards steatosis in HIV/HCV-coinfected patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Dairy & Animal Science
Houssemeddine Srihi, David Lopez-Carbonell, Noelia Ibanez-Escriche, Joaquim Casellas, Pilar Hernandez, Sara Negro, Luis Varona
Summary: This study investigates the effects of reciprocal crosses between different pig breeds on reproductive traits and proposes a multivariate gametic model to address this issue. The results show that all the gametic correlations are positive, and the variance estimates of maternal gametic effects consistently surpass those for paternal effects.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2023)
Article
Genetics & Heredity
Carlos Hervas-Rivero, Houssemeddine Srihi, David Lopez-Carbonell, Joaquim Casellas, Noelia Ibanez-Escriche, Sara Negro, Luis Varona
Summary: This study conducted a genomic scan and identified eight genomic regions associated with inbreeding depression for litter size in two varieties of Iberian pigs. These regions contain relevant genes and suggest that the genetic determinism of inbreeding depression may be heterogeneous across the genome.
Article
Cell Biology
Patricia Castro-Santos, Augusto Rojas-Martinez, Jose A. Riancho, Pablo Lapunzina, Carlos Flores, Angel Carracedo, Roberto Diaz-Pena, Scourge Cohort Group
Summary: We investigated the relationship between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from 9373 COVID-19-positive cases and 5943 population controls were analyzed. The study found associations between HLA-B*14:02 and HLA-C*08:02 alleles with a lower risk of COVID-19 infection, and HLA-A*11:01 and HLA-C*04:01 alleles with disease severity.