Article
Biology
Jingbo Ma, Yang Gu, Peng Xu
Summary: This study reports a systematic approach to improve the biosynthesis of the cannabinoid precursor olivetolic acid in yeast, leading to a significant increase in the production of the acid. The findings provide a baseline for engineering cannabinoids biosynthesis in oleaginous yeast species.
COMMUNICATIONS BIOLOGY
(2022)
Article
Agronomy
Tengfei Zhan, Xin Guo, Lu Ma, Shengyong Mao, Dengpan Bu
Summary: This study evaluated the effect of biotin and leucine on the synthesis of odd- and branched-chain fatty acids (OBCFA) in ruminants. The results showed that biotin promoted dry matter degradation, while leucine increased the concentration of branched-chain volatile fatty acids and valerate. In conclusion, biotin and leucine can be effective nutrition strategies to promote OBCFA synthesis.
Article
Agriculture, Dairy & Animal Science
Abdulkareem M. Matar, Abdulrahman S. Alharthi, Moez Ayadi, Maged A. Al-Garadi, Riyadh S. Aljummah
Summary: Recently, there has been a growing interest in sheep milk products, particularly their high content of saturated fatty acids (SFA), and their potential impact on human health. This study aimed to identify specific SNPs in the ACACa gene and explore their association with milk composition in Najdi sheep. The results showed that certain SNPs were significantly associated with the levels of fatty acids, milk protein, and milk fat in Najdi sheep. These findings have important implications for genetic selection and milk quality control in high-quality dairy sheep breeds.
Article
Thermodynamics
Ece Polat, Mahmut Altinbas
Summary: Mutagenesis using EMS and tralkoxydim treatment resulted in mutant microalgae strains with enhanced biofuel properties, including higher lipid content and improved biodiesel fuel properties compared to the wild type strain.
INTERNATIONAL JOURNAL OF GREEN ENERGY
(2023)
Article
Biochemistry & Molecular Biology
Qiaoyun Chu, Ping Liu, Yihan Song, Ronghui Yang, Jing An, Xuewei Zhai, Jing Niu, Chuanzhen Yang, Binghui Li
Summary: Reprogramming of lipid metabolism is a hallmark of cancer, but the involvement of specific fatty acids and enzymes in tumorigenesis is not well understood. This study shows that depletion of the enzyme acetyl-CoA carboxylase inhibits the synthesis and elongation of very long-chain fatty acids in human cancer cells. Deficiency of very long-chain fatty acids impairs mitochondrial morphology and makes cancer cells susceptible to oxidative stress and cell death.
Article
Pharmacology & Pharmacy
Brian J. Kirby, Justin D. Lutz, Mun Sang Yue, Kimberly L. Garrison, Ann Ran-Ran Qin, Lorraine Ampaw, Carine Beysen, Robert P. Myers, Brian P. Kearney, Anita Mathias
Summary: The study investigated the impact of Firsocostat on hepatic de novo lipogenesis and found that the drug maintained the same hepatic efficacy even when affected by an OATP inhibitor. These findings provide practical guidance for drug administration in settings of reduced OATP function.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Nutrition & Dietetics
Claudia Tonini, Marco Segatto, Simona Bertoli, Alessandro Leone, Arianna Mazzoli, Luisa Cigliano, Laura Barberio, Maurizio Mandala, Valentina Pallottini
Summary: This study found that maternal exposure to BPA affects hepatic lipid metabolism in female offspring, and it also reveals the potential impact of BPA on human health at doses currently considered safe.
Review
Pharmacology & Pharmacy
Yong Yu, Qingzhu Nie, Ziyi Wang, Yu Di, Xiaolong Chen, Kaiming Ren
Summary: Metabolic adaptation in tumors is heavily influenced by fatty acid synthesis, with acetyl-CoA carboxylase 1 playing a crucial role. This enzyme is involved in the production of fatty acids and has potential therapeutic implications for metabolic diseases and anti-tumor therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Lu Liu, Mohan Bai, Sai Zhang, Jiantao Li, Xianhua Liu, Biswarup Sen, Guangyi Wang
Summary: In this study, a mutant library of Schizochytrium was obtained through ARTP mutagenesis and ACCase inhibitor-based screening, resulting in the mutant A78 with improved growth and DHA content. Further optimization of medium components and supplementation led to increased DHA production. Interestingly, supplementation of biotin, citric acid, or sodium citrate enhanced the ACCase activity of mutant A78.
Article
Multidisciplinary Sciences
Ananaya Charaya, Neena Chawla, Ajmer Singh Dhatt, Madhu Sharma, Sanjula Sharma, Inderpal Kaur
Summary: Pumpkin seeds are functional foods with a wide range of uses as both edible seeds and oilseeds. However, their utilization is limited by the presence of a thick seed coat, which requires decortication and increases costs. This study characterized the biochemical composition of hulled and hull-less pumpkin seeds to assess nutritional differences and applications. The hulled seeds had higher content of proteins, amino acids, moisture, fiber, antioxidants, polyamines, sterols, and enzymatic activity, while the hull-less seeds had higher amounts of minerals, tocopherols, and oil. These two genotypes of seeds complement each other in their biochemical and nutritional composition rather than competing with each other.
Article
Oncology
Yiping Shen, Xin Wang, Zhiyu Ni, Shiyu Xu, Shi Qiu, Wenjie Zheng, Jie Zhang
Summary: This study found that Acetyl-CoA carboxylase alpha (ACACA) has prognostic value and carcinogenic roles in hepatocellular carcinoma (HCC). High expression of ACACA is associated with poor prognosis in HCC patients, and it promotes malignant phenotypes of HCC through activation of the Wnt/β-catenin signaling pathway.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Battsetseg Batchuluun, Stephen L. Pinkosky, Gregory R. Steinberg
Summary: Fatty acids play essential roles in cellular survival and function as bioenergetic substrates, structural components, and signaling molecules. Cells have evolved de novo lipogenesis (DNL) to generate fatty acids from alternative carbon sources. However, abnormal upregulation of DNL is associated with various pathologies. Inhibiting core enzymes of DNL represents a potential therapeutic strategy, and several synthetic DNL inhibitors are currently in development. Aberrant upregulation of DNL is implicated in conditions such as cardiovascular disease, metabolic disorders, and cancers.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Microbiology
John E. Cronan
Summary: This review provides an update on the research of Escherichia coli acetyl-CoA carboxylase (ACC), focusing on the structures, stoichiometry, regulation of ACC activity and expression.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Matthew K. Craft, Grover L. Waldrop
Summary: The rise of antibacterial-resistant bacteria is a major problem globally, requiring novel antibacterial agents to combat. Acetyl-CoA carboxylase (ACC) is a validated target, and SABA1 represents a potentially new class of antibiotics that can be used to combat the antibacterial resistance crisis.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Orthopedics
Huanhuan Liu, Luke Witzigreuter, Roshini Sathiaseelan, Martin-Paul Agbaga, Richard S. Brush, Michael B. Stout, Shouan Zhu
Summary: Obesity promotes the development of osteoarthritis by increasing lipid deposition in cartilage. This study provides evidence that inhibiting de novo lipogenesis may be a potential treatment for obesity-associated osteoarthritis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Emma Sole, Rayner Gonzalez-Prendes, Yelyzaveta Oliinychenko, Marc Tor, Roger Ros-Freixedes, Joan Estany, Ramona N. Pena
Summary: Restricting dietary vitamin A during the fattening period did not improve intramuscular fat content, but there was an interaction between vitamin A and SCD genotype on the desaturation of fatty acids in muscle.
Article
Genetics & Heredity
Houssemeddine Srihi, Jose Luis Noguera, Victoria Topayan, Melani Martin de Hijas, Noelia Ibanez-Escriche, Joaquim Casellas, Marta Vazquez-Gomez, Maria Martinez-Castillero, Juan Pablo Rosas, Luis Varona
Summary: This study analyzed the hybrid pig breed CASTUA by estimating the additive and dominance variances, as well as the genetic correlations between purebred and crossbred populations. It identified four genomic regions associated with additive genetic variance in chromosomes 6, 8, and 12.
Article
Multidisciplinary Sciences
Christos Dadousis, Maria Munoz, Cristina Ovilo, Maria Chiara Fabbri, Jose Pedro Araujo, Samuele Bovo, Marjeta Candek Potokar, Rui Charneca, Alessandro Crovetti, Maurizio Gallo, Juan Maria Garcia-Casco, Danijel Karolyi, Goran Kusec, Jose Manuel Martins, Marie-Jose Mercat, Carolina Pugliese, Raquel Quintanilla, Cedomir Radovic, Violeta Razmaite, Anisa Ribani, Juliet Riquet, Radomir Savic, Giuseppina Schiavo, Martin Skrlep, Silvia Tinarelli, Graziano Usai, Christoph Zimmer, Luca Fontanesi, Riccardo Bozzi
Summary: This study revealed the ancestral information and evolutionary relationships of several local pig breeds in Europe through genetic analysis and discriminant analysis on principal components. It also validated the reliability of SNP data in traceability of breed-specific pig products.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
Emilio Marmol-Sanchez, Susanna Cirera, Laura M. Zingaretti, Mette Juul Jacobsen, Yuliaxis Ramayo-Caldas, Claus B. Jorgensen, Merete Fredholm, Taina Figueiredo Cardoso, Raquel Quintanilla, Marcel Amills
Summary: This study investigated the role of miRNAs in mRNA post-transcriptional regulation in porcine tissues. The results suggest that miRNAs play a more prominent role in the regulation of gene expression in the skeletal muscle system. Several genes related to energy homeostasis were also identified.
Article
Agriculture, Dairy & Animal Science
Laura Sarri, Joaquim Balcells, Ahmad Reza Seradj, Ramona N. Pena, Gustavo A. Ramirez, Marc Tor, Gabriel de la Fuente
Summary: Fat metabolism is an important process in meat production companies, which affects the quality of meat. The source and incorporation rate of fat differ in different growth phases. The liver plays a critical role in fat metabolism during the fattening phase. Leaner pigs rely more on dietary fatty acids for fat deposition compared to fatter pigs. The activity of stearoyl-CoA desaturase is higher in the fattening phase.
Article
Agriculture, Dairy & Animal Science
Eduard Molinero, Ramona N. Pena, Joan Estany, Roger Ros-Freixedes
Summary: In this study, a missense polymorphism in the AGPAT5 gene was found to be significantly associated with fat content and composition traits in pigs. The variant showed positive effects on intramuscular fat content and fatty acid composition. The impact of the variant on fat content was more pronounced in fatter pigs and it interacts with other genes that affect overall fatness.
Article
Agriculture, Dairy & Animal Science
Martina Macri, Maria Gracia Luigi-Sierra, Dailu Guan, Juan Vicente Delgado, Javier Fernandez Alvarez, Marcel Amills, Amparo Martinez Martinez
Summary: Hematological traits are important indicators of health status. In humans, the genomic architecture of blood traits has been extensively studied, but the association between marker genotypes and hematological traits in goats has not been investigated yet.
Article
Agriculture, Dairy & Animal Science
Davinia I. Perdomo-Gonzalez, Luis Varona, Antonio Molina, Nora Laseca, Mercedes Valera
Summary: It has been found that gene expression can be blocked by methylation during gametogenesis, resulting in unequal genetic contribution from parents to offspring. The study on a population of Purebred Spanish (PRE) horses revealed that both maternal and paternal gametic effects influence reproductive and morphological traits. The maternal gametic effect generally has a stronger influence on most traits.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2023)
Article
Agriculture, Dairy & Animal Science
Rafael Suarez-Mesa, Roger Ros-Freixedes, Houda Laghouaouta, Ramona N. Pena, Byron Hernandez-Ortiz, Iang Rondon-Barragan, Joan Estany
Summary: Dissecting genetic variation is important for conservation success. This study investigated the genomic variation of Colombian Creole pigs and identified breed-specific variants in genes related to adaptive and economic traits. The findings suggest that Colombian Creole pigs are not exempt from selective introgression of other breeds and provide insights for effective breeding and conservation.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Agriculture, Dairy & Animal Science
Houssemeddine Srihi, David Lopez-Carbonell, Noelia Ibanez-Escriche, Joaquim Casellas, Pilar Hernandez, Sara Negro, Luis Varona
Summary: INGA FOOD, S.A. conducted a crossbreeding program to produce hybrid pigs, and studies revealed differences in litter size between reciprocal crosses, suggesting the presence of genomic imprinting effects. A multivariate gametic model was introduced to estimate the gametic correlations between paternal and maternal effects from different genetic backgrounds. The results showed distinct differences in the posterior distribution of gametic correlations between the two populations, which may explain the performance outcomes in the reciprocal crosses.
Article
Agriculture, Dairy & Animal Science
Houssemeddine Srihi, David Lopez-Carbonell, Noelia Ibanez-Escriche, Joaquim Casellas, Pilar Hernandez, Sara Negro, Luis Varona
Summary: This study investigates the effects of reciprocal crosses between different pig breeds on reproductive traits and proposes a multivariate gametic model to address this issue. The results show that all the gametic correlations are positive, and the variance estimates of maternal gametic effects consistently surpass those for paternal effects.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2023)
Article
Genetics & Heredity
Carlos Hervas-Rivero, Houssemeddine Srihi, David Lopez-Carbonell, Joaquim Casellas, Noelia Ibanez-Escriche, Sara Negro, Luis Varona
Summary: This study conducted a genomic scan and identified eight genomic regions associated with inbreeding depression for litter size in two varieties of Iberian pigs. These regions contain relevant genes and suggest that the genetic determinism of inbreeding depression may be heterogeneous across the genome.
Article
Biochemistry & Molecular Biology
Haonan Zeng, Wenjing Zhang, Qing Lin, Yahui Gao, Jinyan Teng, Zhiting Xu, Xiaodian Cai, Zhanming Zhong, Jun Wu, Yuqiang Liu, Shuqi Diao, Chen Wei, Wentao Gong, Xiangchun Pan, Zedong Li, Xiaoyu Huang, Xifan Chen, Jinshi Du, Fuping PigGTEx Consortium, Fuping Zhao, Yunxiang Zhao, Maria Ballester, Daniel Crespo-Piazuelo, Marcel Amills, Alex Clop, Peter Karlskov-Mortensen, Merete Fredholm, Pinghua Li, Ruihua Huang, Guoqing Tang, Mingzhou Li, Xiaohong Liu, Yaosheng Chen, Qin Zhang, Jiaqi Li, Xiaolong Yuan, Xiangdong Ding, Lingzhao Fang, Zhe Zhang
Summary: To unlock the potential of pigs in agriculture and biomedical research, the PigBiobank was created to investigate the molecular and cellular mechanisms underlying complex traits in pigs and translate the findings to other species.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Houda Laghouaouta, Lorenzo Fraile, Rafael Suarez-Mesa, Roger Ros-Freixedes, Joan Estany, Ramona Natacha Pena
Summary: This study provides new insights into the genetic make-up of resilience in growing pigs by identifying genomic regions and candidate genes associated with resilience indicators. The findings suggest that there are novel genomic regions associated with two resilience indicators (increment BW and increment HP) in pigs, which harbour potential candidate genes involved in immune response and growth pathways, highlighting the strong relationship between resilience and immune response.
GENETICS SELECTION EVOLUTION
(2022)