期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 30, 页码 7856-7859出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402632
关键词
anaerobes; antibiotics; Clostridium beijerinckii; polyketides; polyphenols
资金
- Pakt fur Forschung und Innovation
- Alexander von Humboldt Postdoctoral Fellowship
Genome mining of the strictly anaerobic bacterium Clostridium beijerinckii, an industrial producer of solvents, revealed the presence of several cryptic gene clusters for secondary metabolite biosynthesis. To unearth its metabolic potential, a C. beijerinckii strain was cultured under various conditions, which led to the discovery of a deep purple pigment. This novel metabolite, named clostrubin (1), was isolated and its structure was fully elucidated. The pentacyclic polyphenol features a benzo[a]tetraphene ring topology that is unprecedented for natural products. Stable-isotope labeling experiments showed that 1 is an aromatic polyketide that folds in a noncanonical manner to form the unusual perifused ring system. In addition to being the first reported polyketide from an anaerobic bacterium, 1 is a potent antibiotic with pronounced activity against various pathogenic bacteria, such as MRSA, VRE, and mycobacteria, with minimum inhibitory concentrations (MIC) of 0.12-0.97 mu m.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据