Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

Ring Expansion of 3-Oxetanone-Derived Spirocycles: Facile Synthesis of Saturated Nitrogen Heterocycles

(2013) Stefan A. Ruider et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Construction of α-Quaternary Cyclobutanones by Catalytic Asymmetric Allylic Alkylation

(2013) Corey M. Reeves et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoselectivity Control in the Reactions of 1,2-Cyclic Sulfamidates with Amines

(2013) Lara Mata et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Cytotoxicity of the Proposed Structure of Piperazirum, Its Stereoisomers and Analogues

(2013) Gangarajula Sudhakar et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain

(2013) Sujit Suwal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of a Practical Synthesis of a TORC1/2 Inhibitor: A Scalable Application of Memory of Chirality

(2013) Frederick Hicks et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Structure-based optimization of aminopyridines as PKCθ inhibitors

(2012) Juan-Miguel Jimenez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Asymmetric Synthesis of 3-Substituted Morpholinones and Piperazinones by L-Malate-mediated Dynamic Kinetic Resolution of α-Bromo Esters

(2012) Jin-Ho Baek et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors

(2012) James J. Crawford et al.   JOURNAL OF MEDICINAL CHEMISTRY

Short Synthesis of Enantiopure trans-3-Arylpiperazine-2-carboxylic Acid Derivatives via Diaza-Cope Rearrangement

(2012) Soon Ho Kwon et al.   ORGANIC LETTERS

3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation

(2011) Jian Jeffrey Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope, and Mechanistic Studies

(2011) Douglas C. Behenna et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in the Therapeutic Perspectives of Nutlin-3

(2011) Paola Secchiero et al.   CURRENT PHARMACEUTICAL DESIGN

Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams

(2011) Douglas C. Behenna et al.   Nature Chemistry

Asymmetric synthesis of 4-formyl-1-(?-haloalkyl)-?-lactams and their transformation to functionalized piperazines and 1,4-diazepanes

(2011) Stijn Dekeukeleire et al.   TETRAHEDRON

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects

(2010) Prabodh Chander Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A palladium-catalysed enolate alkylation cascade for the formation of adjacent quaternary and tertiary stereocentres

(2010) Jan Streuff et al.   Nature Chemistry

Piperazine Scaffolds via Isocyanide-Based Multicomponent Reactions

(2010) Alexander Dömling et al.   SYNTHESIS-STUTTGART

Dynamic thermodynamic resolution of lithiated N-Boc-N′-alkylpiperazines

(2010) Steven P. Robinson et al.   TETRAHEDRON LETTERS

Mastering chiral substituted 2-oxopiperazines

(2010) Carmela De Risi et al.   TETRAHEDRON-ASYMMETRY

Unusual Allylpalladium Carboxylate Complexes: Identification of the Resting State of Catalytic Enantioselective Decarboxylative Allylic Alkylation Reactions of Ketones

(2009) Nathaniel H. Sherden et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Piperazinyl pyrimidine derivatives as potent γ-secretase modulators

(2009) Alexey Rivkin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expedite Protocol for Construction of Chiral Regioselectively N-Protected Monosubstituted Piperazine, 1,4-Diazepane, and 1,4-Diazocane Building Blocks

(2009) François Crestey et al.   JOURNAL OF ORGANIC CHEMISTRY

Facile synthesis of structurally diverse 5-oxopiperazine-2-carboxylates as dipeptide mimics and templates

(2009) Michael Limbach et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic Enantioselective Alkylation of Substituted Dioxanone Enol Ethers: Ready Access to C(α)-Tetrasubstituted Hydroxyketones, Acids, and Esters

(2008) Masaki Seto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines, and Piperazines from β-Heteroatom Amino Compounds and Vinyl Sulfonium Salts

(2008) Muhammad Yar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pleuromutilin derivatives having a purine ring. Part 3: Synthesis and antibacterial activity of novel compounds possessing a piperazine ring spacer

(2008) Yoshimi Hirokawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

First Example of s-BuLi/(-)-Sparteine-Mediated Chiral Deprotonation of a Piperazine and Proof of the Sense of Induction

(2008) Benjamin McDermott et al.   SYNLETT

Synthesis and Application of Novel Proline-Derived Chiral Piperazinones and Sulfamide-Amine Alcohols

(2008) Y.-Q. Fu et al.   SYNTHETIC COMMUNICATIONS

New efficient enantioselective synthesis of 2-oxopiperazines: a practical access to chiral 3-substituted 2-oxopiperazines

(2008) Claiton Leoneti Lencina et al.   TETRAHEDRON-ASYMMETRY

Synthesis of 2,6-Disubstituted Piperazines by a Diastereoselective Palladium-Catalyzed Hydroamination Reaction

(2007) Brian M. Cochran et al.   ORGANIC LETTERS