Article
Chemistry, Applied
Mohammad Taghi Nazeri, Siamak Javanbakht, Mohadese Nabi, Ahmad Shaabani
Summary: In this study, pectin was used as a green support to construct an efficient heterogeneous catalytic system based on metal phthalocyanines. The catalytic activity of the copper phthalocyanine-conjugated pectin in the CO2 fixation reaction was investigated. Pectin successfully improved the catalytic properties of the Cu-PcTA.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Dong Li, Zhishuang Wang, Hualin Zhang, Ningyi Lu, Lei Cui, Ningmin Wu, Chunju Li, Jian Li
Summary: We present a multicomponent reaction based on isocyanide that allows the assembly of various tricyclic chromenopyrrole derivatives with diastereoselectivity. By utilizing phenol as an electron-rich species, this protocol achieves diverse structures through a bicyclization process.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Physical
Hassan Farhid, Hanieh Mohammadi Araghi, Ahmad Shaabani, Behrouz Notash
Summary: An efficient synthetic strategy based on higher-order multicomponent reactions (MCRs) is established for the synthesis of quinoxaline-furan bis-heterocyclic structures. The method involves a one-pot, pseudo-five-component reaction using readily available precursors. The notable features of this method include high atom economy, operational simplicity, high yields, and applicability on a gram scale. Indolo[2,3-b]quinoxaline-furan tris-heterocycles were also successfully synthesized using isatin derivatives via consecutive reactions.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Mohammad Bagher Teimouri, Zahra Bozorgpour Savadjani, Morteza Shiri, Rahman Bikas, Soheila Naderi
Summary: A new class of quinone dyes, xanthoquinones, have been synthesized through a cycloaddition reaction, resulting in a specific structure of xanthone and quinone subunits.
Article
Chemistry, Multidisciplinary
Jasper L. Tyler, Adam Noble, Varinder K. Aggarwal
Summary: This study reports a multicomponent reaction method for the synthesis of diverse compound libraries based on azetidine rings. The method allows for rapid reactions and high variability, and has been demonstrated in the synthesis of the EP2 receptor antagonist PF-04418948.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ru-Yu Hua, Si-Fan Yu, Xiao-Ting Jie, Huang Qiu, Wen-Hao Hu
Summary: Chiral oxindoles are important chemical structures found in many natural products. While there are well-developed methods for constructing C3 quaternary oxindoles with high selectivity, the efficient synthesis of chiral 3-substituted tertiary oxindoles is rarely reported. In this study, a multicomponent assembly method for complex oxindoles through enantioselective cooperative catalysis is presented.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Bidong Zhang, Katarzyna Kurpiewska, Alexander Domling
Summary: This paper describes a simple and short synthesis method for the privileged scaffold dihydropyrrolo[1,2-a]pyrazine-dione, a compound with potential bioactivity, using readily accessible starting materials and a multicomponent reaction-based protocol.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Barbara Klausfelder, Patricia Blach, Niels de Jonge, Rhett Kempe
Summary: This study reports a method for the synthesis of 3,4-dihydro-2H-pyrroles via the hydrogenation and cyclization of nitro ketones. The use of inexpensive and readily available starting materials allows for the flexible introduction of various substitution patterns. The reaction shows a broad scope and 23 out of the 33 synthesized compounds are previously unreported.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Pau Nadal Rodriguez, Ouldouz Ghashghaei, Andrea Bagan, Carmen Escolano, Rodolfo Lavilla
Summary: This article introduces a synthetic approach for dealing with the structural complexity of molecules, which offers advantages in terms of synthetic economy and the preparation of larger amounts of drugs. The article summarizes the scientific methodology and main results of the research, provides a general appraisal of the current situation, and offers perspectives on future research directions.
Article
Chemistry, Applied
Tahereh Nasiriani, Mohammad Taghi Nazeri, Ahmad Shaabani
Summary: Due to its porosity, high hydrothermal and mechanical stability, SBA-15 has attracted significant attention from researchers for catalytic systems design. In this work, SBA-15 was used as an eco-friendly support for the synthesis of an effective heterogeneous catalytic nanocomposite based on metallophthalocyanines. The modified SBA-15 showed improved catalytic properties in the CO2 fixation reaction.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Shima Nasri, Mohammad Bayat, Faezeh Mirzaei
Summary: Spiroindole and spirooxindole scaffolds are important in drug design for their bioactivity against various diseases, with novel synthetic procedures being actively researched. This review focuses on their pharmacological significance and recent synthesis strategies, highlighting the potential for discovering new therapeutic agents.
TOPICS IN CURRENT CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ariel Leyton, Walter A. Rabanal-Leon, Juliana Andrea Murillo-Lopez, Julio Belmar, Odette Concepcion, Alexander F. de la Torre, Francisco M. Muniz, Reynier Baez, Claudio A. Jimenez
Summary: This work presents a one-pot procedure to assemble novel 2-pyrazolin-5-one derivative functionalized through an isocyanide based formal [4+1] cycloaddition. A surprising multicomponent reaction resulted in nine novel molecules with an embedded alkyl carboxamide group in moderate yield. The isolation and characterization of an unforeseen orthoamide intermediate provides evidence for the plausible mechanism of the formal [4+1] cycloaddition. Such an approach represents a significant advance in preparing pyrazolone derivatives functionalized with amides.
Article
Chemistry, Physical
Zhenhao Zhang, Nazarii Sabat, Gilles Frison, Angela Marinetti, Xavier Guinchard
Summary: This study presents a new gold(I) catalyst for highly enantioselective multicomponent reactions between aldehydes, hydroxylamines, and cyclic yne-enones. The method shows broad applicability and achieves high yields, total diastereoselectivity, and high enantiomeric excess.
Article
Chemistry, Organic
Mohammad Bagher Teimouri, Elham Batebi, Shabnam Mohammadnia, Hamid Reza Khavasi
Summary: An efficient protocol has been developed for the selective synthesis of different compounds via a multicomponent cascade reaction, obtaining one type of product in dry CH2Cl2 and another in wet CH2Cl2. The reaction proceeds through the formation of a highly reactive O-acylatedoxonium intermediate, leading to the desired products with excellent diastereoselectivity and yields.
Review
Chemistry, Multidisciplinary
Monu Agarwal, Kanchan Verma, Gargi Pathak, Sakshi Pathak, Jaya Mathur, Mahendra Kumar
Summary: This review discusses recent advances in the synthesis of structurally and functionally diversified quinoxalines-drug-like small molecules. It also focuses on the research work on isocyanide-based multicomponent reactions. These synthetic methods provide access to a wide range of natural product mimetic scaffolds using isocyanide-based combinatorial synthesis, which is significant for the synthesis of complex bioactive natural products and potential synthetic pharmaceuticals.
Article
Biochemistry & Molecular Biology
David R. Koes, Alexander Domling, Carlos J. Camacho
Review
Chemistry, Multidisciplinary
Markella Konstantinidou, Tryfon Zarganes-Tzitzikas, Katarzyna Magiera-Mularz, Tad A. Holak, Alexander Domling
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Review
Oncology
Angel J. Ruiz-Moreno, Patricia Torres-Barrera, Mireya Velazquez-Paniagua, Alexander Domling, Marco A. Velasco-Velazquez
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Sergey Lunev, Soraya S. Bosch, Fernando A. Batista, Chao Wang, Jingyao Li, Marleen Linzke, Paul Kruithof, George Chamoun, Alexander S. S. Domling, Carsten Wrenger, Matthew R. Groves
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Tjie Kok, Hannah Wapenaar, Kan Wang, Constantinos G. Neochoritis, Tryfon Zarganes-Tzitzikas, Giordano Proietti, Nikolaos Eleftheriadis, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Robbert H. Cool, Gerrit J. Poelarends, Alexander Domling, Frank J. Dekker
BIOORGANIC & MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Organic
Rudrakshula Madhavachary, Naganaboina Naveen, Yuanze Wang, Qian Wang, Markella Konstantinidou, Alexander Doemling
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Applied
Rudrakshula Madhavachary, Tryfon Zarganes-Tzitzikas, Pravin Patil, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Alexander Domling
ACS COMBINATORIAL SCIENCE
(2018)
Article
Chemistry, Applied
Pravin Patil, Bhupendra Mishra, Gitanjali Sheombarsing, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Alexander Domling
ACS COMBINATORIAL SCIENCE
(2018)
Article
Chemistry, Medicinal
Shabnam Shaabani, Harmen P. S. Huizinga, Roberto Butera, Ariana Kouchi, Katarzyna Guzik, Katarzyna Magiera-Mularz, Tad A. Holak, Alexander Domling
EXPERT OPINION ON THERAPEUTIC PATENTS
(2018)
Article
Biochemistry & Molecular Biology
Shabnam Shaabani, Louis Gadina, Ewa Surmiak, Zefeng Wang, Bidong Zhang, Roberto Butera, Tryfon Zarganes-Tzitzikas, Ismael Rodriguez, Justyna Kocik-Krol, Katarzyna Magiera-Mularz, Lukasz Skalniak, Alexander Domling, Tad A. Holak
Summary: Novel biphenyl-based chimeric compounds containing pomalidomide were found to exhibit strong inhibitory activity against PD-1/PD-L1, with compound 3 showing the best performance. Compounds 4 and 5 were able to significantly restore suppressed immunity in an ex vivo PD-1/PD-L1 blockade cell line bioassay.
Article
Biochemistry & Molecular Biology
Domna Iordanidou, Michael G. Kallitsakis, Marina A. Tzani, Dimitris I. Ioannou, Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Alexander Domling, Michael A. Terzidis, Ioannis N. Lykakis
Summary: This study reported the synthesis of 3,4-dihydroquinoxalin-2-ones through the selective reduction reaction catalyzed by supported gold nanoparticles. The reaction proceeded through heterogeneous transfer hydrogenation and intramolecular C-N transamidation, resulting in good functional-group tolerance and high yields.
Article
Environmental Sciences
Shamma AlMuraikhy, Najeha Anwardeen, Aisha Naeem, Maha Sellami, Alexander Domling, Abdelali Agouni, Mohamed A. Elrayess
Summary: This study aimed to analyze the metabolic profiles of young non-obese individuals and compare the effects of physical activity on insulin-sensitive and insulin-resistant groups. The results showed that physical activity had a positive impact on the health status of insulin-resistant individuals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Analytical
Saeed Alshahrani, Abdullah Mohammed Al-Majid, M. Ali, Abdullah Saleh Alamary, Marwa M. M. Abu-Serie, Alexander Doemling, Muhammad Shafiq, Zaheer Ul-Haq, Assem Barakat
Summary: A new spiroxindoles with a benzimidazole scaffold was designed and synthesized as a new murine double minute two (MDM2) inhibitor. The desired spiroxindoles were obtained through a [3+2] cycloaddition reaction with excellent regioselectivity and diastereoselectivity. Biochemical assays showed that compound 7d exhibited the most active anticancer reactivity with an IC50 value of 3.797 +/- 0.205 μM. Compound 7a showed promising results as an MDM2 inhibitor with a KD value of 2.38 μM, as confirmed by molecular docking studies.
Article
Biochemistry & Molecular Biology
Shamma Almuraikhy, Najeha Anwardeen, Asmma Doudin, Maha Sellami, Alexander Domling, Abdelali Agouni, Asmaa A. Althani, Mohamed A. Elrayess
Summary: This study investigated the metabolic pathways involved in the protective effects of moderate physical activity in non-obese and healthy individuals. The results showed increased activation of antioxidative stress pathways in active participants, as well as significant associations between glutathione metabolites and certain clinical traits.
Article
Biochemistry & Molecular Biology
Shamma Almuraikhy, Najeha Anwardeen, Asmma Doudin, Maha Sellami, Alexander Domling, Abdelali Agouni, Asmaa A. Al Thani, Mohamed A. Elrayess
Summary: Healthy non-obese insulin resistant individuals have a higher risk of metabolic syndrome. Physical activity can lower insulin resistance, but the metabolic pathways involved are still unknown. This study analyzed data from 305 non-obese participants and found that active insulin resistant individuals showed differences in fatty acid metabolism, while sedentary insulin resistant individuals showed changes in glucose metabolism. These findings have important implications for the prevention and treatment of metabolic syndrome. Rating: 8 out of 10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
