Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD

Druggability of the enzymes of the non-mevalonate-pathway

(2013) Tiziana Masini et al.   DRUG DISCOVERY TODAY

Drug-resistant tuberculosis: time for visionary political leadership

(2013) Ibrahim Abubakar et al.   LANCET INFECTIOUS DISEASES

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

In search of new herbicidal inhibitors of the non-mevalonate pathway

(2013) Matthias Witschel et al.   PEST MANAGEMENT SCIENCE

Screening of Antifungal Azole Drugs and Agrochemicals with an Adapted alamarBlue-Based Assay Demonstrates Antibacterial Activity of Croconazole against Mycobacterium ulcerans

(2012) Nicole Scherr et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Halogen bonding in solution: thermodynamics and applications

(2012) Thomas M. Beale et al.   CHEMICAL SOCIETY REVIEWS

Identification and validation of a novel lead compound targeting 4-diphosphocytidyl-2-C-methylerythritol synthetase (IspD) of mycobacteria

(2012) Peng Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Global malaria mortality between 1980 and 2010: a systematic analysis

(2012) Christopher JL Murray et al.   LANCET

The use of phosphate bioisosteres in medicinal chemistry and chemical biology

(2012) Thomas S. Elliott et al.   MedChemComm

Agrochemicals against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease

(2012) Matthias Witschel et al.   PLoS Neglected Tropical Diseases

Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding

(2011) Matthias C. Witschel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Second Target of the Antimalarial and Antibacterial Agent Fosmidomycin Revealed by Cellular Metabolic Profiling

(2011) Baichen Zhang et al.   BIOCHEMISTRY

Identification of 1,3-Diiminoisoindoline Carbohydrazides as Potential Antimalarial Candidates

(2011) Paolo Mombelli et al.   ChemMedChem

Experimental and Computational Active Site Mapping as a Starting Point to Fragment-Based Lead Discovery

(2011) Jürgen Behnen et al.   ChemMedChem

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

(2011) Leo A. Hardegger et al.   ChemMedChem

Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure–Activity Study

(2011) Matthias Preller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

(2011) Ellen Yeh et al.   PLOS BIOLOGY

Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions

(2010) Leo A. Hardegger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae

(2010) Yukiko Matsue et al.   JOURNAL OF ANTIBIOTICS

Halogenated Compounds from Marine Algae

(2010) Maria Teresa Cabrita et al.   Marine Drugs

Nonbonding interactions of organic halogens in biological systems: implications for drug discovery and biomolecular design

(2010) Yunxiang Lu et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Total Synthesis of Pentabromo- and Pentachloropseudilin, and Synthetic Analogues-Allosteric Inhibitors of Myosin ATPase

(2009) René Martin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Halogen BondingA Novel Interaction for Rational Drug Design?

(2009) Yunxiang Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Halogen Bonding in Supramolecular Chemistry

(2008) Pierangelo Metrangolo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expansion of the σ-hole concept

(2008) Jane S. Murray et al.   JOURNAL OF MOLECULAR MODELING