Article
Biochemistry & Molecular Biology
Maciej Trzaskowski, Marcin Drozd, Tomasz Ciach
Summary: This study investigated the attachment process of saccharide particles to cell receptors responsible for glucose transport across the cell membrane. The interactions between simple saccharides, such as glucose and sucrose, and dextran nanoparticles with two species of GLUT proteins were measured. The results showed that polysaccharide nanoparticles interacted with GLUT proteins, and the strengths of interactions varied between proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Petteri Parkkila, Kai Harkonen, Petra Ilvonen, Saara Laitinen, Tapani Viitala
Summary: This study presents a protocol for the analysis of nanoparticles using a Protein A/G-functionalized biosensor. Antibodies and specific surface functionalization enable efficient capture and analysis of nanoparticles and their subpopulations.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Chemistry, Multidisciplinary
Ben Tadgell, Luis M. Liz-Marzan
Summary: Chiral plasmonic nanoparticles interact with biomolecules in distinct ways and can be probed using circular dichroism spectroscopy, offering potential advantages in biosensing and biomedical applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Devi Taufiq Nurrohman, Nan-Fu Chiu
Summary: The surface plasmon resonance (SPR) biosensor is a powerful analytical tool for investigating biomolecular interactions, and graphene has been widely studied as a material to increase the sensor's sensitivity through various excitation methods. Current development of graphene-based SPR biosensor includes discussion on graphene properties, its application in biosensors, simulation, and experimental results of different excitation methods. Additionally, a review on graphene-based Surface-Enhanced Raman Scattering (SERS) biosensor expands the discussion on SPR biosensors, providing an overview of future material development in biosensors.
Article
Chemistry, Analytical
Prerit Mathur, Anna Fomitcheva Khartchenko, Stavros Stavrakis, Govind V. Kaigala, Andrew J. deMello
Summary: We developed a method for monitoring localized antigen-antibody binding on cell and tissue sections using fluorescence lifetime imaging. By measuring the difference in fluorescence decay times of tagged antibodies in free solution and in the bound state, we can track the binding fraction over time and determine the binding kinetics. This method allows us to measure binding constants and observe biomarker expression effects on kinetics.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Aline dos Santos Almeida, Dario A. Bahamon, Nuno M. R. Peres, Christiano J. S. de Matos
Summary: The use of graphene in surface plasmon resonance sensors has advantages such as protecting the film and increasing sensitivity. However, the role of single and few layers of graphene in sensitivity enhancement was critically examined, and it was found that only the isotropic layer model provides significant sensitivity increases.
Article
Chemistry, Analytical
Nurzad Zakirov, Shaodi Zhu, Aurelien Bruyant, Gilles Lerondel, Renaud Bachelot, Shuwen Zeng
Summary: In this study, structures based on copper nanosubstrate with graphene and two-dimensional transition metal dichalcogenides (TMDC) were designed to achieve an ultrasensitive surface plasmon resonance biosensor. Theoretical calculations showed an enhanced sensitivity with a detection limit of 10^(-9) refractive index unit (RIU) by optimizing the parameters of the SPR sensing substrate.
Article
Chemistry, Multidisciplinary
Nikhil Bhalla, Preetam Kumar Sharma, Supriya Chakrabarti
Summary: This study addresses the low sensitivity issue of spherical Au nanostructures in harsh chemical environments for LSPR sensing applications by developing a stable and high refractive index-sensitive Au-graphene-layered hybrid (Au G). The relationship between stability and sensitivity of the developed system is analyzed using principal component analysis, revealing that the shelf life of the material is proportional to its sensitivity, while the stability of the sensor during liquid measurement decreases with increased sensitivity. This work serves as a benchmark in understanding and establishing new correlations between sensing parameters.
Review
Chemistry, Multidisciplinary
Jiangming Wang, Weina Fang, Huajie Liu
Summary: This review extensively studies gold triangular nanoprisms (AuTNPs) as a novel type of nanomaterials with well-defined structures and excellent plasmonic properties. It covers the synthetic methodologies, morphological evolution, and applications of AuTNPs.
Review
Nanoscience & Nanotechnology
Anamika Kumari, Vibha Vyas, Santosh Kumar
Summary: This article is a review of the synthesis, characterization methods and applications of gold nanoparticles (Au-NPs) in fiber optic sensors. It analyzes the reported research work to understand the trends and gaps in developing plasmonic optical fiber sensors.
Article
Chemistry, Analytical
Nour Beydoun, Yann Niberon, Laurent Arnaud, Julien Proust, Komla Nomenyo, Shuwen Zeng, Gilles Lerondel, Aurelien Bruyant
Summary: This research demonstrates that applying a thin layer of aluminum oxide to copper films can effectively slow down the oxidation rate. This simple method could provide a new approach for producing alternative and more sustainable biochips.
Review
Chemistry, Analytical
Hasan Kurt, Parsa Pishva, Zeki Semih Pehlivan, Elif Gul Arsoy, Qandeel Saleem, Mustafa Kemal Bayaz, Meral Yuce
Summary: Nanoplasmonic biosensing holds great promise in meeting the demands of the global health industry, offering advantages such as low cost, high sensitivity, real-time detection, and miniaturization. By discussing nanostructure design, material selection, and nanofabrication methods, this review highlights the wide range of clinically relevant applications of nanoplasmonic biosensors, along with the challenges and proposed strategies for clinical translation.
ANALYTICA CHIMICA ACTA
(2021)
Article
Materials Science, Multidisciplinary
Chongzhen Li, Zhiquan Li, Shiliang Guo, Xin Li, Qiufan Cheng, Shuhan Meng
Summary: This study investigates the application of BiFeO3 film in enhancing the sensitivity of SPR biosensors, achieving the highest sensitivity through structural adjustments. The results demonstrate that BiFeO3 film as a supporting material can effectively enhance the SPR effect, showing promising potential applications in the field of biosensors.
Article
Biophysics
Lixuan Liu, Kun Ye, Zhiyan Jia, Tianyu Xue, Anmin Nie, JianYong Xiang, CongPu Mu, Bochong Wang, Fusheng Wen, Kun Zhai, Zhisheng Zhao, Yongji Gong, Zhongyuan Liu, Yongjun Tian
Summary: This study demonstrates the selective functionalization of high-density grain boundaries in polycrystalline 1L WS2 films with complementary DNA receptors using gold nanoparticle linkers. The biosensor showed highly sensitive and selective detection of RNA sequences from the novel coronavirus, highlighting the immense potential of AuNP-decorated GB-rich 2DLMs in designing ultra-sensitive biosensing platforms.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Analytical
Franziska Beck, Michael Loessl, Antje J. J. Baeumner
Summary: Silver nanoparticles (AgNPs) have unique physical, (electro)chemical, and optical properties that make them suitable for sensor and point-of-care (POC) applications. Recent advances have demonstrated that controlling the inherent higher instability toward oxidation of AgNPs can improve sensor performance and enable specific detection of analytes at low concentrations. However, further research is needed to simplify assay procedures and facilitate the successful application of AgNPs in POC settings.
