Article
Chemistry, Multidisciplinary
Aline dos Santos Almeida, Dario A. Bahamon, Nuno M. R. Peres, Christiano J. S. de Matos
Summary: The use of graphene in surface plasmon resonance sensors has advantages such as protecting the film and increasing sensitivity. However, the role of single and few layers of graphene in sensitivity enhancement was critically examined, and it was found that only the isotropic layer model provides significant sensitivity increases.
Article
Materials Science, Multidisciplinary
Chongzhen Li, Zhiquan Li, Shiliang Guo, Xin Li, Qiufan Cheng, Shuhan Meng
Summary: This study investigates the application of BiFeO3 film in enhancing the sensitivity of SPR biosensors, achieving the highest sensitivity through structural adjustments. The results demonstrate that BiFeO3 film as a supporting material can effectively enhance the SPR effect, showing promising potential applications in the field of biosensors.
Article
Chemistry, Analytical
Prerit Mathur, Anna Fomitcheva Khartchenko, Stavros Stavrakis, Govind V. Kaigala, Andrew J. deMello
Summary: We developed a method for monitoring localized antigen-antibody binding on cell and tissue sections using fluorescence lifetime imaging. By measuring the difference in fluorescence decay times of tagged antibodies in free solution and in the bound state, we can track the binding fraction over time and determine the binding kinetics. This method allows us to measure binding constants and observe biomarker expression effects on kinetics.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Nurzad Zakirov, Shaodi Zhu, Aurelien Bruyant, Gilles Lerondel, Renaud Bachelot, Shuwen Zeng
Summary: In this study, structures based on copper nanosubstrate with graphene and two-dimensional transition metal dichalcogenides (TMDC) were designed to achieve an ultrasensitive surface plasmon resonance biosensor. Theoretical calculations showed an enhanced sensitivity with a detection limit of 10^(-9) refractive index unit (RIU) by optimizing the parameters of the SPR sensing substrate.
Article
Chemistry, Physical
M. Amin, O. Siddiqui, H. Abutarboush, M. Farhat, R. Ramzan
Summary: A novel method utilizing the chirality of highly sensitive graphene plasmonic metasurfaces is proposed to characterize the complex refractive indexes of viruses by detecting the polarization state of the reflected electric fields in the THz spectrum. The method exploits chiral surface currents to couple linearly polarized incident fields to circularly polarized reflected fields, resulting in unique polarization states in the far-field with ellipticity values that change rapidly with the analyte's refractive index. The method demonstrates potential for virus characterization with simpler instrumentation compared to traditional spectroscopic methods.
Article
Biochemistry & Molecular Biology
Maciej Trzaskowski, Marcin Drozd, Tomasz Ciach
Summary: This study investigated the attachment process of saccharide particles to cell receptors responsible for glucose transport across the cell membrane. The interactions between simple saccharides, such as glucose and sucrose, and dextran nanoparticles with two species of GLUT proteins were measured. The results showed that polysaccharide nanoparticles interacted with GLUT proteins, and the strengths of interactions varied between proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Nour Beydoun, Yann Niberon, Laurent Arnaud, Julien Proust, Komla Nomenyo, Shuwen Zeng, Gilles Lerondel, Aurelien Bruyant
Summary: This research demonstrates that applying a thin layer of aluminum oxide to copper films can effectively slow down the oxidation rate. This simple method could provide a new approach for producing alternative and more sustainable biochips.
Review
Chemistry, Analytical
Hasan Kurt, Parsa Pishva, Zeki Semih Pehlivan, Elif Gul Arsoy, Qandeel Saleem, Mustafa Kemal Bayaz, Meral Yuce
Summary: Nanoplasmonic biosensing holds great promise in meeting the demands of the global health industry, offering advantages such as low cost, high sensitivity, real-time detection, and miniaturization. By discussing nanostructure design, material selection, and nanofabrication methods, this review highlights the wide range of clinically relevant applications of nanoplasmonic biosensors, along with the challenges and proposed strategies for clinical translation.
ANALYTICA CHIMICA ACTA
(2021)
Article
Materials Science, Multidisciplinary
M. Muthu Meenakshi, Gowri Annasamy, Mugesh Sankaranarayanan
Summary: The study synthesized graphene oxide gold nanocomposites with enhanced optical properties and biocompatibility for sensing the critical ferritin biomarker for anemia and severe COVID conditions. The nanocomposites were synthesized using a simple chemical reaction with natural reducing agents, achieving label-free detection of ferritin under environmentally friendly conditions.
Article
Biochemical Research Methods
Youjun Zeng, Zhaogang Nie, Dongyun Kai, Jiajie Chen, Yonghong Shao, Weifu Kong, Zhengqiang Yuan, Ho-Pui Ho, Fangteng Zhang
Summary: This paper presents a novel WSPRi sensing system with a high anti-interference capability and low cost. By introducing devices such as an acousto-optic tunable filter and a halogen lamp, real-time recording of brine concentration and formation of the coffee ring effect were successfully achieved, and the performance of the biosensor was improved. The high anti-interference capability and accuracy of this system will greatly contribute to the exploration of biomolecule behaviors in biological and biochemistry studies.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Petteri Parkkila, Kai Harkonen, Petra Ilvonen, Saara Laitinen, Tapani Viitala
Summary: This study presents a protocol for the analysis of nanoparticles using a Protein A/G-functionalized biosensor. Antibodies and specific surface functionalization enable efficient capture and analysis of nanoparticles and their subpopulations.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Analytical
Ting Sun, Mengyao Li, Feng Zhao, Lin Liu
Summary: The research proposed a one-step, real-time method for the design of SPR biosensors by integrating magnetic preconcentration and separation, which is valuable for the detection of small molecules and ultra-low concentrations of analytes.
Article
Chemistry, Analytical
Manel Hedhly, Yuye Wang, Shuwen Zeng, Faouzi Ouerghi, Jun Zhou, Georges Humbert
Summary: The study presents a highly sensitive plasmonic biosensor based on a symmetric metal cladding plasmonic waveguide structure for the detection of low concentration small molecules. By precise design and tuning of the guiding layer, ultra-high order modes can be excited, leading to steep phase change and large position shift for the detection of biomolecules that are difficult to detect using traditional SPR techniques.
Article
Materials Science, Multidisciplinary
Mariana Rodrigues Villarim, Diomadson Rodrigues Belfort, Cleonilson Protasio de Souza
Summary: Biosensors are a popular type of sensor that offer advantages over traditional sensing methods. An optical biosensor based on SPR achieves high sensitivity and allows for selective analysis. In this study, a simulation tool was developed to facilitate the mathematical analysis of SPR biosensors. The tool offers an easy-to-use interface and various design options, making it a useful alternative for analyzing biosensor parameters.
Article
Multidisciplinary Sciences
Khaled Aliqab, Kavan Dave, Vishal Sorathiya, Meshari Alsharari, Ammar Armghan
Summary: In this study, a parametric analysis was conducted on a phase transition material Ge2Sb2Te5(GST)-based, graphene-based structure with a wide dynamic range in the infrared and visible electromagnetic spectrum. The reflectance behavior of multi-layered structures composed of GST, graphene, silicon, and silver materials was simulated using the finite element method. The impact of material heights on the structure's performance was investigated, and resonating tracing curves were presented to determine the sensing behavior across a specific wavelength range and refractive index values. The proposed structure was also examined for wide-angle stability at various inclined angles of incidence. Computational study of this structure can contribute to the development of biosensors for detecting a wide range of biomolecules.
SCIENTIFIC REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Shi-Yuan Fan, Nan-Fu Chiu, Chie-Pein Chen, Chia-Chen Chang, Chen-Yu Chen
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Correction
Nanoscience & Nanotechnology
S. Y. Fan, N. F. Chiu, C. P. Chen, C. C. Chang, C. Y. Chen
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Nan-Fu Chiu, Hao-Tang Yang
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Devi Taufiq Nurrohman, Ying-Hao Wang, Nan-Fu Chiu
FRONTIERS IN CHEMISTRY
(2020)
Article
Nanoscience & Nanotechnology
Nan-Fu Chiu, Ming-Jung Tai, Devi Taufiq Nurrohman, Ting-Li Lin, Ying-Hao Wang, Chen-Yu Chen
Summary: A highly sensitive SPR biosensor using carboxyl-MoS2 film was developed for evaluating PAPP-A2 levels in maternal serum samples for Down's syndrome screening. The technology showed acceptable accuracy and recovery rates, suggesting potential advantages over conventional ELISA.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Electrical & Electronic
Devi Taufiq Nurrohman, Nan-Fu Chiu
Summary: Gold nanoparticles (AuNPs) have unique properties and are widely used. This study investigates the signal characteristics of AuNPs-based localized surface plasmon resonance (LSPR) immunosensor through theoretical and experimental approaches. Simulation results show that the particle distance and the presence of dielectric material greatly affect the extinction and scattering spectra, while experimentally, the detection range of the sensor is limited by the enhanced electric field and the occurrence of the Hook effect at higher concentrations.
IEEE SENSORS JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Nan-Fu Chiu, Ying-Hao Wang, Chen-Yu Chen
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Materials Science, Multidisciplinary
Devi Taufiq Nurrohman, Nan-Fu Chiu
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2020)
Proceedings Paper
Engineering, Electrical & Electronic
Yu-Chieh Yen, Nan-Fu Chiu
OPTICAL SENSORS 2019
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Nan-Fu Chiu, Shi-Yuan Fan
OPTICAL SENSORS 2019
(2019)
