Steering Target Selectivity and Potency by Fragment-Based De Novo Drug Design

De novo design and optimization of Aurora A kinase inhibitors

(2013) Tiago Rodrigues et al.   Chemical Science

Drugs by Numbers: Reaction-Driven De Novo Design of Potent and Selective Anticancer Leads

(2012) Birgit Spänkuch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The mechanisms that regulate the localization and overexpression of VEGF receptor-2 are promising therapeutic targets in cancer biology

(2012) Kim R. Kampen   ANTI-CANCER DRUGS

Multi-Objective Evolutionary Design of Adenosine Receptor Ligands

(2012) Eelke van der Horst et al.   Journal of Chemical Information and Modeling

International, Randomized, Placebo-Controlled, Double-Blind Phase III Study of Motesanib Plus Carboplatin/Paclitaxel in Patients With Advanced Nonsquamous Non–Small-Cell Lung Cancer: MONET1

(2012) Giorgio V. Scagliotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs

(2012) E.-M. E. Hedlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DOGS: Reaction-Driven de novo Design of Bioactive Compounds

(2012) Markus Hartenfeller et al.   PLoS Computational Biology

A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis

(2011) J Kankanala et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

(2010) Sara Van de Veire et al.   CELL

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

(2009) Wenjun Zhou et al.   NATURE

Measurement of Phosphorylated Extracellular Signal-Regulated Kinase 1 and 2 in an Undergraduate Teaching Laboratory with ALPHAscreen Technology

(2009) D. L. Hay   Science Signaling