Article
Biochemistry & Molecular Biology
Karolina Maleckaite, Domantas Narkevicius, Rugile Zilenaite, Jelena Dodonova-Vaitkuniene, Stepas Toliautas, Sigitas Tumkevicius, Aurimas Vysniauskas
Summary: Mapping microviscosity, temperature, and polarity in biosystems is important for disease detection. This study investigates how different electron-withdrawing and electron-donating groups can alter the spectral and sensory properties of BODIPY compounds, providing insights for the development of fluorescent sensors. The research utilizes experimental results and quantum chemical calculations to understand the effects of non-radiative relaxation on the probe's sensitivity to temperature and viscosity.
Review
Biochemistry & Molecular Biology
Sachin B. Wagh, Vladimir A. Maslivetc, James J. La Clair, Alexander Kornienko
Summary: Fluorescent probes are widely used in various fields, and the development of new experimental designs has facilitated innovation in probe discovery methods.
Review
Materials Science, Multidisciplinary
Mariadel Mar Gonzalez del Campo, Andreu Vaquer, Roberto de la Rica
Summary: In recent years, paper has become a widely used material for developing various types of sensors, and a polymer-based toolbox has emerged to enhance the functionalities of these devices. This article compiles examples from recent literature on microfluidic systems and polymer-based transducers implemented in paper-based analytical platforms. The use of printing methods to pattern polymers allows for mass production of these advanced paper-based devices without requiring specialized facilities.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Multidisciplinary
Md Azahar Ali, Chunshan Hu, Eric A. Yttri, Rahul Panat
Summary: This paper reviews the unique and unusual properties of biomedical sensors enabled by 3D printing, exploring new possibilities for biomedical applications in various clinically important areas.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Yongkang Yue, Fangjun Huo, Caixia Yin
Summary: This review discusses the evolution of small organic molecular fluorescent probes for detecting thiols in the past 60 years, highlighting the design of thiol probes and their specific applications in semi-quantification of cellular thiols and real-time labeling. It also addresses current challenges that limit their further application.
Article
Materials Science, Biomaterials
Anna Luongo, Alexander Ritter von Stockert, Frank D. Scherag, Thomas Brandstetter, Markus Biesalski, Juergen Ruehe
Summary: Paper is a suitable material for developing disposable diagnostic devices due to its low cost, capillary action for liquid transport, and eco-friendliness. This study explores the use of fluorescence as a readout tool for paper-based diagnostics, which shows better optical readout compared to the current choice of colorimetric assays using nitrocellulose. Additionally, coating the paper fibers with a protein-repellent hydrogel enhances the sensitivity of paper-based analysis.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Analytical
Joao Flavio da Silveira Petruci, Diandra Nunes Barreto, Mariana A. Dias, Erika P. Felix, Arnaldo A. Cardoso
Summary: Ground-level ozone is increasing worldwide due to anthropogenic emissions and the use of ozone generators. This poses risks to public health, indoor air quality, and materials. Monitoring and control policies are essential, but determining ozone gas remains a challenge. Advances in measurement techniques have been made, but further exploration is needed for device construction and components active towards ozone.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Kawin Khachornsakkul, Jung-Jung Chang, Ping-Heng Lin, Yi-Han Lin, Wijitar Dungchai, Chih-Hsin Chen
Summary: The study introduces a highly sensitive distance-based liquid crystalline visualization for paper-based analytical devices, allowing for quantification of bilirubin concentration through naked eye measurement of color change on paper. This device offers a wide linear detection range, low detection limit, and high reproducibility, suitable for various biological samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Shaoheng Li, Shi Feng, Xuerong Song, Qingchuan Zheng, Guodong Feng, Zhiguang Song
Summary: Biological thiols, including cysteine, homocysteine, and glutathione, play important roles in physiological and pathological processes. Abnormal concentration of these thiols can lead to various diseases. In this study, a series of fluorescent molecules based on benzotriazole and coumarin were designed and synthesized. The molecule BTAC(e) showed high selectivity towards homocysteine and could react with it to enhance fluorescence. The probe also exhibited excellent selectivity towards homocysteine compared to cysteine and glutathione. The fluorescence intensity had a linear relationship with the concentration of homocysteine and the probe could be used for imaging homocysteine in living cells.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xue Tian, Lloyd C. Murfin, Luling Wu, Simon E. Lewis, Tony D. James
Summary: Small-molecule based fluorescent probes play an increasingly important role in detecting and imaging biological signaling molecules due to their simplicity, high selectivity, and real-time analysis capabilities. Various sensing mechanisms, including FRET, ICT, PeT, ESIPT, AIE, as well as dual/triple sensing mechanisms, are highlighted, but challenges remain. Future development should focus on improving small-molecule fluorescent probes for biosensing applications.
Article
Chemistry, Multidisciplinary
Lidia A. Perez-Marquez, Marcelle D. Perretti, Raul Garcia-Rodriguez, Fernando Lahoz, Romen Carrillo
Summary: 3-Nitrotyrosine (NT) is an important biomarker of renal damage, but lacks an appropriate sensing method for clinical diagnosis. This study presents a fluorescent supramolecular sensor that selectively detects NT in human blood serum, providing a sensitive detection limit within physiological concentrations observed in chronic kidney disease.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Lingfei Wang, Feng Jin, Xiqian Jiang, Jianwei Chen, Meng C. Wang, Jin Wang
Summary: This review focuses on the commonly used methods to detect and quantify thiols in living cells and the general approaches applied in mass spectrometry-based thiol quantification. Thiols play important roles in biological systems, and quantifying these species is crucial for understanding their functions. However, reliable quantification using fluorescent probes remains challenging.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Multidisciplinary Sciences
Hany Ibrahim, Ahmed Serag, Mohamed A. Farag
Summary: This article focuses on several analytical technologies used to determine H2S, including spectroscopic, chromatographic, and electrochemical methods. The advantages and limitations of each technique are highlighted, with special emphasis on their application for in vivo measurement of H2S (e.g., biofluids and tissues).
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Chemistry, Inorganic & Nuclear
Conor Geraghty, Conor Wynne, Robert B. P. Elmes
Summary: Fluorescent probes are essential tools in studying biological systems, and the 1,8-naphthalimide fluorophore is commonly used for detecting enzymatic conversions. With advancements in synthetic methods, the sensitivity and selectivity of these probes continue to improve.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Luanjing Li, Jiahe Wang, Shihan Xu, Chunxia Li, Biao Dong
Summary: This paper reviews the recent research progress and applications of metal ion fluorescent probes, and discusses the future development direction.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Liat Avram, Vaclav Havel, Ronit Shusterman-Krush, Mark A. Iron, Moritz Zaiss, Vladimir Sindelar, Amnon Bar-Shir
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Physical
Mark A. Iron, Trevor Janes
JOURNAL OF PHYSICAL CHEMISTRY A
(2019)
Correction
Chemistry, Physical
Mark A. Iron, Trevor Janes
JOURNAL OF PHYSICAL CHEMISTRY A
(2019)
Article
Chemistry, Multidisciplinary
Uttam Kumar Das, Amit Kumar, Yehoshoa Ben-David, Mark A. Iron, David Milstein
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Physical
Qian Zhang, Sidney R. Cohen, Irit Rosenhek-Goldian, Daniel Amgar, Omri Bar-Elli, Yael Tsarfati, Tatyana Bendikov, Linda J. W. Shimon, Yishay Feldman, Mark A. Iron, Haim Weissman, Igal Levine, Dan Oron, Boris Rybtchinski
JOURNAL OF PHYSICAL CHEMISTRY C
(2019)
Article
Biochemistry & Molecular Biology
Ruth Maron, Gad Armony, Michael Tsoory, Meir Wilchek, Dan Frenkel, Ruth Arnon
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Geochemistry & Geophysics
Jonathan Gropp, Mark A. Iron, Itay Halevy
Summary: Equilibrium isotope fractionation factors in anaerobic methane metabolisms were calculated and compared favorably with experimental constraints, providing a basis for further exploration of isotope effects in methane metabolism.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Olga Chovnik, Sidney R. Cohen, Iddo Pinkas, Lothar Houben, Tatiana E. Gorelik, Yishay Feldman, Linda J. W. Shimon, Mark A. Iron, Michal Lahav, Milko E. Van der Boom
Summary: The study demonstrates the solvent-free amorphous-to-cocrystalline transformations of nanoscale molecular films, showing that the process involves gradual strengthening of halogen-bonding interactions. In addition, mass transport during gas-solid diffusion and the rigidity of the amorphous films play important roles in the crystallization process.
Correction
Geochemistry & Geophysics
Jonathan Gropp, Mark A. Iron, Itay Halevy
GEOCHIMICA ET COSMOCHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Gad Armony, Albert J. R. Heck, Wei Wu
Summary: The study reveals that HLA molecules exhibit various modes of interactions on the plasma membrane, demonstrating their ability to be densely packed in this environment.
MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haim Feldman, Mark A. Iron, Dror Fixler, Sergei Moshkov, Naomi Zurgil, Elena Afrimzon, Mordechai Deutsch
Summary: This study challenges the common perception of glycerol providing an inert-like environment and investigates its effects on the spectroscopic properties of fluorescein. The presence of glycerol was found to significantly impact the fluorescence characteristics of fluorescein, altering quantum yield, fluorescence lifetime, absorption and emission spectra. Computational chemistry predictions corresponded to experimental results, suggesting that glycerol is not an innocent medium in aqueous solutions.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Physical
Satoshi Takebayashi, Mark A. Iron, Moran Feller, Orestes Rivada-Wheelaghan, Gregory Leitus, Yael Diskin-Posner, Linda J. W. Shimon, Liat Avram, Raanan Carmieli, Sharon G. Wolf, Ilit Cohen-Ofri, Rajashekharayya A. Sanguramath, Roy Shenhar, Moris Eisen, David Milstein
Summary: This study reports the discovery and mechanistic studies of three-coordinate iron(II) catalysts for ring-opening metathesis polymerization of olefins. The iron catalysts exhibited high reactivity and polymerization ability, suggesting their potential as economical and biocompatible catalysts for olefin metathesis reactions.
Article
Biochemistry & Molecular Biology
Gad Armony, Sven Brehmer, Tharan Srikumar, Lennard Pfennig, Fokje Zijlstra, Dennis Trede, Gary Kruppa, Dirk J. Lefeber, Alain J. van Gool, Hans J. C. T. Wessels
Summary: Real-time database searching simplifies and automates proteomics workflows and eliminates technical bottlenecks. It enables results-dependent acquisition (RDA), which is especially beneficial for glycoproteomics due to the wide range of optimal acquisition parameters. The GlycoPaSER prototype presented here provides the first proof-of-concept for real-time glycopeptide identification and unlocks the future development of RDA technology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Miriam Somekh, Mark A. Iron, Alexander M. Khenkin, Ronny Neumann
Article
Chemistry, Physical
Mark A. Iron, Jonathan Gropp
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
