Article
Cell Biology
Dasiel O. Borroto-Escuela, Mariana Pita-Rodriguez, Ramon Fores-Pons, Miguel A. Barbancho, Kjell Fuxe, Manuel Narvaez
Summary: The study demonstrates that coactivation of GALR2 and NPYY1R in the ventral hippocampus induces sustained antidepressant effects and promotes cell proliferation. This coactivation may enhance the formation of GALR2/NPYY1R heteroreceptor complexes in the ventral hippocampus, leading to a transformation of cell proliferation towards a neuronal lineage through the activation of the ERK pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Martino Caramia, Roman A. Romanov, Spyridon Syderomenos, Zsofia Hevesi, Ming Zhao, Marharyta Krasniakova, Zhi- Qing David Xu, Tibor Harkany, Tomas G. M. Hoekfelt
Summary: The locus coeruleus (LC), a small nucleus in the pons, plays a crucial role in the functioning of the central nervous system, particularly in wakefulness. This study used single-cell RNA sequencing to identify different subtypes of neurons in the LC and characterized their neuropeptide and receptor profiles. The results showed that NE neurons expressed various neuropeptide transcripts, with galanin being a notable one. Surprisingly, Galr1, a galanin receptor, was highly expressed in GABA neurons surrounding the NE ensemble. Functional experiments revealed that GalR1 agonist can inhibit a significant proportion of NE neurons. These findings provide insights into the role of the galanin system in NE function and have implications for understanding the actions of other peptides and their receptors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Dermatology
M. S. Al Abadie, D. J. Gawkrodger
Summary: This review highlights the relevance of neuronal theory to the convergence theory for the mechanism causing vitiligo, particularly the segmental type. Neuropeptides and neurotransmitters like neuropeptide Y and dopamine are central to the pathological mechanisms of melanocyte destruction, linking into a bidirectional network involving cutaneous nerves, the neuroendocrine axis, and the immune system. Through their local influence on cutaneous inflammation, they impact antigen-specific regulatory T cells and the chemokine ligand type 9/chemokine receptor type 1 axis, believed to be the final pathway for melanocyte destruction.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Neurosciences
Savanna-Rae H. Fahoum, Dawn M. Blitz
Summary: This study demonstrates that modulation of intrinsic properties can lead to switching a neuron into dual-frequency oscillations, rather than relying solely on synaptic modulation. This switching process enables a neuron to become an active contributor to rhythm generation in the second network.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Nouf K. Alaqeel, Mona H. AlSheikh, Mohammed T. Al-Hariri
Summary: The present study evaluates the role of quercetin nanoemulsion (QCNE) in attenuating neuronal dysfunction in aluminum chloride-induced Alzheimer's disease (AD). The results show that QCNE can reduce oxidative stress and inflammation, increase neurotransmitter levels, and potentially protect against aluminum-induced neurotoxicity.
Article
Neurosciences
Denise L. Gaskins, Andrew R. Burke, Tammy J. Sajdyk, William A. Truitt, Amy D. Dietrich, Anantha Shekhar
Summary: Repeated exposure to stress can induce chronic anxiety states, likely through the activation of CRFR receptors in the amygdala. Selective reduction of the Sstr2 gene expression in the BLA is associated with the persistent anxiety-like phenotype observed with Ucn1-priming, and Sstr2 agonist in the BLA can block acute anxiety-inducing effects.
Article
Chemistry, Multidisciplinary
Yan Zhang, Chun-Yuan Chen, Yi-Wei Liu, Shan-Shan Rao, Yi-Juan Tan, Yu-Xuan Qian, Kun Xia, Jie Huang, Xi-Xi Liu, Chun-Gu Hong, Hao Yin, Jia Cao, Shi-Kai Feng, Ze-Hui He, You-You Li, Zhong-Wei Luo, Ben Wu, Zi-Qi Yan, Tuan-Hui Chen, Meng-Lu Chen, Yi-Yi Wang, Zhen-Xing Wang, Zheng-Zhao Liu, Ming-Jie Luo, Xiong-Ke Hu, Ling Jin, Teng-Fei Wan, Tao Yue, Si-Yuan Tang, Hui Xie
Summary: This study reveals that osteocytes regulate the differentiation of BMSCs into osteoblasts or adipocytes by secreting neuropeptide Y (NPY), with increased NPY expression associated with aging and osteoporosis. Deletion of NPY in osteocytes leads to high bone mass phenotype and attenuated bone-fat imbalance. The study suggests a new mode of neuronal control of bone metabolism through ANS-induced regulation of osteocyte NPY.
Article
Developmental Biology
Behzad Yaghmaeian Salmani, Brad Balderson, Susanne Bauer, Helen Ekman, Annika Starkenberg, Thomas Perlmann, Michael Piper, Mikael Boden, Stefan Thor
Summary: This study reveals the impact of the loss of H3K27me3 on the development of specific neuronal subtypes in the hypothalamus, highlighting the unique sensitivity of certain subtypes to disruptions in the epigenomic landscape.
Article
Cell Biology
Renjie Liao, Manas Mondal, Christopher D. Nazaroff, Diego Mastroeni, Paul D. Coleman, Joshua Labaer, Jia Guo
Summary: The method presented achieves highly sensitive and multiplexed protein analysis using cleavable fluorescent tyramide and off-the-shelf antibodies, enhancing detection sensitivity and reducing imaging time. By studying genetically identical cell populations and profiling neurons in human brain tissue, it reveals protein expression heterogeneity and the presence of distinct neuron clusters within different sub-regions of the hippocampus.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Jonathan J. Chow, Rebecca S. Hofford, Joshua S. Beckmann
Summary: This study showed that neuronal activity measured as cFos expression in the brain regions OFC and NAc was not directly reflective of cocaine preference when cocaine intake was controlled for, but was related to overall cocaine intake in the OFC when cocaine intake varied. The results suggest that controlling for cocaine frequency and intake is important in isolating the neurobehavioral mechanisms underlying drug preference.
Article
Endocrinology & Metabolism
Amanda N. Rainey, Stephanie M. Fukui, Katie Mark, Hailey M. King, Dawn M. Blitz
Summary: Neuropeptides are a large class of neural signaling molecules with conserved functions. Crustacean TRPs in the TGM of Jonah crabs have potential sources that may regulate behaviors such as food intake, locomotion, respiration, and reproduction.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Review
Neurosciences
Bradey A. R. Stuart, Ariel L. Franitza, Lezi Lezi
Summary: Antimicrobial peptides (AMPs) not only have antimicrobial activity but also play a role in regulating neuronal function. Aging affects the expression pattern of AMPs and may be related to neurodegenerative diseases. This review discusses the interaction between AMPs and the nervous system.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Phillip Wibisono, Shawndra Wibisono, Jan Watteyne, Chia-Hui Chen, Durai Sellegounder, Isabel Beets, Yiyong Liu, Jingru Sun
Summary: This study demonstrates that NMUR-1 regulates the expression of immune genes in C. elegans by modulating the activity of transcription factors involved in binding to RNA polymerase II regulatory regions. This finding provides a molecular basis for the specificity of C. elegans innate immunity and could potentially shed light on the specificity of innate immunity in other animals, including mammals.
Article
Biophysics
Xueying Yu, Fang Cheng, Wei He
Summary: A new non-vinylic cationic microgel was successfully prepared, showing responsiveness to temperature and pH, as well as oxidative stability. The heterogeneous morphology formed on glass substrate by the microgel could strike a balance in promoting adhesion and differentiation of neuron-like cells while not stimulating proliferation of non-neuronal cells. This unconventional surface morphology created by the microgel could be a potential alternative strategy for neural interface engineering in the future.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Yan Huo, Xiangyi Huang, Yanan Wang, Cong Zhao, Ting Zheng, Weihong Du
Summary: The misfolding and conformational transformation of prion protein (PrP) play a crucial role in the progression of prion diseases. Screening for natural inhibitors against PrP proteins can contribute to the development of new anti-prion drugs. In this study, two sesquiterpene lactones were found to effectively prevent amyloid fibril formation and remodel preformed fibrils of PrP106-126. These compounds exhibited neuroprotective effects by reducing peptide oligomerization.
Article
Biochemistry & Molecular Biology
Fumiko Takenoya, Lihua Wang, Haruaki Kageyama, Satoshi Hirako, Nobuhiro Wada, Hirofumi Hashimoto, Yoichi Ueta, Junichi Sakagami, Naoko Nonaka, Seiji Shioda
JOURNAL OF MOLECULAR NEUROSCIENCE
(2015)
Review
Anatomy & Morphology
Seiji Shioda, Fumiko Takenoya, Nobuhiro Wada, Takahiro Hirabayashi, Tamotsu Seki, Tomoya Nakamachi
ANATOMICAL SCIENCE INTERNATIONAL
(2016)
Article
Endocrinology & Metabolism
Satoshi Hirako, Yoshihiro Wakayama, Hyounju Kim, Yuzuru Iizuka, Akiyo Matsumoto, Nobuhiro Wada, Ai Kimura, Mai Okabe, Junichi Sakagami, Mamiko Suzuki, Fumiko Takenoya, Seiji Shioda
OBESITY RESEARCH & CLINICAL PRACTICE
(2016)
Article
Multidisciplinary Sciences
Satoshi Hirako, Nobuhiro Wada, Haruaki Kageyama, Fumiko Takenoya, Yoshihiko Izumida, Hyounju Kim, Yuzuru Iizuka, Akiyo Matsumoto, Mai Okabe, Ai Kimura, Mamiko Suzuki, Satoru Yamanaka, Seiji Shioda
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Seiji Shioda, Fumiko Takenoya, Takahiro Hirabayashi, Nobuhiro Wada, Tamotsu Seki, Naoko Nonaka, Tomoya Nakamachi
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Article
Medicine, Research & Experimental
Takahiro Hirabayashi, Michio Yamashita, Nobuhiro Wada, Fumiko Takenoya, Hiroko Ikeda, Junzo Kamei, Tomoo Ryushi, Noriyuki Yamamoto, Seiji Shioda
BIOMEDICAL RESEARCH-TOKYO
(2018)
Article
Multidisciplinary Sciences
Haruaki Kageyama, Kanako Shiba, Satoshi Hirako, Nobuhiro Wada, Satoru Yamanaka, Yukinori Nogi, Fumiko Takenoya, Naoko Nonaka, Tsutomu Hirano, Shuji Inoue, Seiji Shioda
SCIENTIFIC REPORTS
(2016)
Review
Pharmacology & Pharmacy
Fumiko Takenoya, Satoshi Hirako, Nobuhiro Wada, Naoko Nonaka, Takahiro Hirabayashi, Haruaki Kageyama, Seiji Shioda
CURRENT PHARMACEUTICAL DESIGN
(2018)
Article
Biochemistry & Molecular Biology
Yuki Murayama, Naoya Yahagi, Yoshinori Takeuchi, Yuichi Aita, Zahra Mehrazad Saber, Nobuhiro Wada, EnXu Li, Xianying Piao, Yoshikazu Sawada, Akito Shikama, Yukari Masuda, Makiko Nishi-Tatsumi, Midori Kubota, Yoshihiko Izumida, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Yoko Sugano, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Hiroaki Suzuki, Hiroaki Yagyu, Yasushi Kawakami, Hitoshi Shimano
Article
Endocrinology & Metabolism
Takanori Hayashi, Tetsuya Kubota, Inoue Mariko, Iseki Takamoto, Masakazu Aihara, Yoshitaka Sakurai, Nobuhiro Wada, Takashi Miki, Toshimasa Yamauchi, Naoto Kubota, Takashi Kadowaki
Summary: The study revealed that brain Irs1 plays crucial roles in regulating neurite outgrowth of GHRH neurons, somatic growth, and glucose homeostasis.
Article
Biochemistry & Molecular Biology
Yoshikazu Sawada, Yoshihiko Izumida, Yoshinori Takeuchi, Yuichi Aita, Nobuhiro Wada, EnXu Li, Yuki Murayama, Xianying Piao, Akito Shikama, Yukari Masuda, Makiko Nishi-Tatsumi, Midori Kubota, Motohiro Sekiya, Takashi Matsuzaka, Yoshimi Nakagawa, Yoko Sugano, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Hiroaki Suzuki, Hiroaki Yagyu, Yasushi Kawakami, Takashi Kadowaki, Hitoshi Shimano, Naoya Yahagi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Pharmacology & Pharmacy
Satoshi Hirako, Nobuhiro Wada, Haruaki Kageyama, Fumiko Takenoya, Hyounju Kim, Yuzuru Iizuka, Akiyo Matsumoto, Mai Okabe, Seiji Shioda
CURRENT PHARMACEUTICAL DESIGN
(2017)
Article
Endocrinology & Metabolism
Eulalia A. Coutinho, Shiki Okamoto, Ayako Wendy Ishikawa, Shigefumi Yokota, Nobuhiro Wada, Takahiro Hirabayashi, Kumiko Saito, Tatsuya Sato, Kazuyo Takagi, Chen-Chi Wang, Kenta Kobayashi, Yoshihiro Ogawa, Seiji Shioda, Yumiko Yoshimura, Yasuhiko Minokoshi
Article
Genetics & Heredity
Nobuhiro Wada, Satoru Yamanaka, Junko Shibato, Randeep Rakwal, Satoshi Hirako, Yuzuru Iizuka, Hyounju Kim, Akiyo Matsumoto, Ai Kimura, Fumiko Takenoya, Genta Yasunaga, Seiji Shioda
Article
Multidisciplinary Sciences
Yuri Kintaka, Nobuhiro Wada, Seiji Shioda, Sadako Nakamura, Yuko Yamazaki, Kazuki Mochizuki
Article
Endocrinology & Metabolism
Andreia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R. de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Hinio Araijo de Castro, Anamelia Lorenzetti Bocca, Marcia Renata Mortari
Summary: This study synthesized three bioinspired peptides based on fraternine and tested their effects in a Parkinson's disease model. The peptides fra-10 and fra-14 improved motor coordination, but most of the peptides were toxic at the applied doses. All three peptides reduced the intensity of lesion-induced rotations. The peptide fra-24 increased the number of TH+ neurons in the substantia nigra and reduced the concentration of the cytokine TNF-alpha, suggesting it has neuroprotective effects in Parkinson's disease.