Article
Nutrition & Dietetics
Jennifer K. K. Lee, Jung-Heun Ha, Do-Kyun Kim, JaeHee Kwon, Young-Eun Cho, In-Sook Kwun
Summary: This study investigated the effect of zinc deficiency on leptin secretion and osteoblastic apoptosis. The results showed that low zinc stimulated extracellular leptin secretion and increased the expression of leptin and its receptor in osteoblastic MC3T3-E1 cells. The JAK2/STAT3 signaling pathway was found to play a role in mediating leptin signaling and inducing osteoblastic apoptosis under zinc deficiency.
Article
Medicine, General & Internal
Changjun Luo, Xiao Ke, Si Xiong, Yun Sun, Qing Xu, Wei Zhang, Yiyan Lei, Yiqian Ding, Yulan Zhen, Jianqiang Feng, Fei Cheng, Jingfu Chen
Summary: This study provides new evidence that NRG may protect H9c2 cells against HG-induced injuries through modulation of the leptin-JAK2/STAT3 pathway. NRG significantly attenuated the increase in leptin and Ob-R expression induced by HG, thereby preventing injuries and inflammation.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jianping Pan, Xilin Ouyang, Qi Jin, Wei Wang, Jiali Xie, Baoming Yu, Zhijie Ling, Qizhen Wu, Baoping Zheng
Summary: This study found that ethanol extract from Chimonanthus nitens Oliv. leaf (COE) can improve liver function and lipid metabolism, and alleviate hyperlipidemia by activating the leptin/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ruolan Tan, Xiaoxuan Hu, Xinyi Wang, Meiqi Sun, Zhenlu Cai, Zixuan Zhang, Yali Fu, Xinlin Chen, Jing An, Haixia Lu
Summary: This study investigates the role of leptin in the biological properties of neural stem cells (NSCs). The findings suggest that leptin promotes the proliferation and neuronal differentiation of NSCs, potentially providing a promising approach for brain repair in neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Wan Zhou, Shan-Dong Ye, Wei Wang
Summary: This study suggests that RBP4 may be involved in the initiation or progression of diabetic atherosclerosis by regulating the JAK2/STAT3 signaling pathway, and serum RBP4 levels are positively correlated with several biochemical indicators.
WORLD JOURNAL OF DIABETES
(2021)
Article
Multidisciplinary Sciences
Mariah Mesquita de Figueiredo Cerqueira, Micaele Maria Lopes Castro, Amanda Almeida Vieira, Juliana Ayumi Azevedo Kurosawa, Fabio Leite do Amaral Junior, Fabiola de Carvalho Chaves de Siqueira Mendes, Marcia Consentino Kronka Sosthenes
Summary: Anxiety is increasingly being diagnosed in the elderly, and it is associated with cognitive decline, morbidity, and even mortality. The environment and age have an impact on anxiety-like behavior in mice, as assessed by the Elevated Plus Maze (EPM) and Open Field (OF) tests. The results from these tests suggest the need for a better evaluation of the parameters analyzed in each test.
Article
Behavioral Sciences
Parker Knight, Ranjithkumar Chellian, Ryann Wilson, Azin Behnood-Rod, Stefany Panunzio, Adriaan W. Bruijnzeel
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Raquel Cardoso Brito, Thairyne Olivato, Takae Tamy Kitabatake, Kelly Zhang, Elaine Caldeira de Oliveira Guirro, Joao Eduardo de Araujo
Summary: Studies have found that psychotropic drugs can alter rat behavior in the elevated plus-maze test. This study aimed to investigate whether static magnetic fields could impact alprazolam-induced rat behavior in the same test. The results showed that the south magnetic pole of the static magnetic field blocked the effect of alprazolam on the space-time variables of the open arms and ethological anxiolytic-like behavior in the elevated plus-maze test.
NEUROSCIENCE LETTERS
(2023)
Article
Pharmacology & Pharmacy
Vandna, Shruti Ahlawat, Krishna Kant Sharma, Hari Mohan
Summary: This study found that the co-administration of ketoprofen with Yersinia enterocolitica can cause significant damage to the rat gut, leading to altered expression of gut proteins and profound effects on the NF-kB signaling pathway, immune system, dysbiosis, and gut injury. Additionally, the biochemical and histopathological analysis of treated rats showed evidence of liver enzyme activity alteration and behavioral response changes, indicating the detrimental effects of the co-administration.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Lauren Gaspar, Sydney Bartman, Giuseppe Coppotelli, Jaime M. Ross
Summary: The incidence of anxiety-like disorders in humans decreases with aging, but it is unclear whether this is also true in mice. Mouse models can be used to understand the changes in neuronal networks that regulate anxiety-like behavior in aging. The elevated plus maze (EPM) test is commonly used to assess anxiety-like behavior, but it is unknown how the construction of the apparatus affects the behavior of younger and older mice. This study found that the distance traveled during the EPM test was most affected by the apparatus characteristics, and that old mice spent more time and had more entries in the open arms compared to young mice, suggesting a decrease in anxiety-like behavior with age.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Nicolas Cordeiro, Jose Augusto Pochapski, William Sanchez Luna, Gabriel Baltazar, Rainer K. Schwarting, Roberto Andreatini, Claudio Da Cunha
Summary: Ultrasonic vocalizations play a role in conveying emotional states in both young pups and adult rats, with differences observed between genders and developmental stages. Pup vocalizations can predict adult behaviors, while adult vocalizations are influenced by stimulants.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Gabriel Guillen-Ruiz, Jonathan Cueto-Escobedo, Fabiola Hernandez-Lopez, Lina E. Rivera-Aburto, Emma Herrera-Huerta, Juan Francisco Rodriguez-Landa
Summary: The study found that the effects of caffeine intake vary during different stages of the ovarian cycle in rats. In female rats during metestrus-diestrus, all doses of caffeine increased anxiety-like behavior, while during proestrus-estrus, only high doses had a slight increase in anxiety behavior. The observed effects may be associated with the naturally occurring low and high concentrations of steroid hormones during these phases.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychology, Biological
Patricia Gonzalez-Gaspar, Monserrat Macias-Carballo, Teresa Cadena-Mejia, Miguel A. Landa-Jimenez, Fernando M. Montes-Gonzalez, Maria Leonor Lopez-Meraz, Luis Beltran-Parrazal, Consuelo Morgado-Valle
Summary: Analixity is a video processing software designed for the elevated plus maze test (EPM) that automatically quantifies behavioral parameters, reducing analysis time and variability issues. Comparison with manual analysis and a commercial software showed that Analixity is as reliable and effective as the latter.
BEHAVIOURAL PROCESSES
(2021)
Article
Endocrinology & Metabolism
Wanxin Han, Lei Wang, Kento Ohbayashi, Masakazu Takeuchi, Libbey O'Farrell, Tamer Coskun, Yermek Rakhat, Daisuke Yabe, Yusaku Iwasaki, Yutaka Seino, Toshihiko Yada
Summary: The effects of glucose-dependent insulinotropic polypeptide (GIP) receptor agonists (GIPRAs) on feeding and body weight were investigated. The results showed that GIPRA can inhibit food intake and increase lipid utilization, leading to sustained weight loss in obese mice. This study highlights the therapeutic potential of GIPRAs for obesity and diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
M. Guo, C. Li, Y. Lei, S. Xu, D. Zhao, X-Y Lu
MOLECULAR PSYCHIATRY
(2017)
Article
Biochemistry & Molecular Biology
Fengjiao Sun, Yun Lei, Jingjing You, Chen Li, Linshan Sun, Jacob Garza, Di Zhang, Ming Guo, Phillip E. Scherer, Daniel Lodge, Xin-Yun Lu
MOLECULAR PSYCHIATRY
(2019)
Article
Clinical Neurology
Tao Yu, Ming Guo, Jacob Garza, Samantha Rendon, Xue-Li Sun, Wei Zhang, Xin-Yun Lu
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2011)
Article
Clinical Neurology
Ming Guo, Tung-Yi Huang, Jacob C. Garza, Streamson C. Chua, Xin-Yun Lu
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Jacob C. Garza, Ming Guo, Wei Zhang, Xin-Yun Lu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Article
Biochemistry & Molecular Biology
Di Zhang, Ming Guo, Wei Zhang, Xin-Yun Lu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
J. C. Garza, M. Guo, W. Zhang, X-Y Lu
MOLECULAR PSYCHIATRY
(2012)
Article
Multidisciplinary Sciences
Jing Liu, Ming Guo, Di Zhang, Shao-Ying Cheng, Meilian Liu, Jun Ding, Philipp E. Scherer, Feng Liu, Xin-Yun Lu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Psychiatry
M. Guo, Y. Lu, J. C. Garza, Y. Li, S. C. Chua, W. Zhang, B. Lu, X-Y Lu
TRANSLATIONAL PSYCHIATRY
(2012)
Article
Psychiatry
M. Guo, X-Y Lu
TRANSLATIONAL PSYCHIATRY
(2014)
Article
Biochemistry & Molecular Biology
Yun Lei, Jiangong Wang, Dan Wang, Chen Li, Bin Liu, Xing Fang, Jingjing You, Ming Guo, Xin-Yun Lu
MOLECULAR PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Chen Li, Fantao Meng, Jacob C. Garza, Jing Liu, Yun Lei, Sergei A. Kirov, Ming Guo, Xin-Yun Lu
Summary: The adipokine adiponectin is found to act on 5-HT neurons through AdipoR1 receptors to regulate depression-related behaviors in a sex-dependent manner, possibly by influencing 5-HT synthesis and reuptake.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Chen Li, Fantao Meng, Yun Lei, Jing Liu, Jingyan Zhang, Fang Liu, Cuilan Liu, Ming Guo, Xin-Yun Lu
Summary: Leptin induces exon-specific Bdnf expression via an AKT-p300 HAT epigenetic cascade, which is indispensable for the leptin-induced antidepressant-like effects.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yun Lei, Dan Wang, Yu Bai, Jayvon Nougaisse, Neal L. Weintraub, Ming Guo, Xin-Yun Lu
Summary: This study investigates the effect of stress on social interaction reward in adolescent mice and the role of leptin in attenuating social anhedonia. The results show that chronic stress impairs the reward effect of social interaction, while leptin treatment reverses this impairment by increasing oxytocin synthesis and oxytocin receptor activation.
MOLECULAR PSYCHIATRY
(2022)