Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors

Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice

(2016) Di Zhang et al.   ENDOCRINOLOGY

Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat

(2016) Daniel B. McKim et al.   JOURNAL OF NEUROSCIENCE

Is increased antidepressant exposure a contributory factor to the obesity pandemic?

(2016) S H Lee et al.   Translational Psychiatry

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Peripheral and central effects of repeated social defeat stress: Monocyte trafficking, microglial activation, and anxiety

(2015) B.F. Reader et al.   NEUROSCIENCE

Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPAR -driven enhancers

(2014) S. E. Step et al.   GENES & DEVELOPMENT

Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin

(2014) X Wang et al.   MOLECULAR PSYCHIATRY

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

(2014) S. Y. Yau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates

(2014) M Guo et al.   Translational Psychiatry

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity

(2012) Jing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression

(2012) M Guo et al.   Translational Psychiatry

Antidepressant-like effect of pioglitazone in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway

(2011) Mohammad Salehi Sadaghiani et al.   BEHAVIOURAL BRAIN RESEARCH

Adiponectin Is Required for PPARγ-Mediated Improvement of Endothelial Function in Diabetic Mice

(2011) Wing Tak Wong et al.   Cell Metabolism

Adiponectin Stimulates Proliferation of Adult Hippocampal Neural Stem/Progenitor Cells through Activation of p38 Mitogen-activated Protein Kinase (p38MAPK)/Glycogen Synthase Kinase 3β (GSK-3β)/β-Catenin Signaling Cascade

(2011) Di Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala

(2011) J Liu et al.   MOLECULAR PSYCHIATRY

Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling

(2011) J C Garza et al.   MOLECULAR PSYCHIATRY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22

(2011) Zheng Wang et al.   PLoS One

Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin

(2010) Sarah J. Hemauer et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Adipokines as novel biomarkers and regulators of the metabolic syndrome

(2010) Yingfeng Deng et al.   Annals of the New York Academy of Sciences

Validation of endogenous reference genes for qRT-PCR analysis of human visceral adipose samples

(2010) Rohini Mehta et al.   BMC MOLECULAR BIOLOGY

Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of depression with cognitive dysfunction

(2010) Tao Yu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice

(2010) Sabrina Le Bouter et al.   PPAR Research

Antidepressant-like effects of rosiglitazone, a PPARγ agonist, in the rat forced swim and mouse tail suspension tests

(2009) Amany Ali Eissa Ahmed et al.   BEHAVIOURAL PHARMACOLOGY

Adipocyte-specific Expression of Murine Resistin Is Mediated by Synergism between Peroxisome Proliferator-activated Receptor γ and CCAAT/Enhancer-binding Proteins

(2009) Takuya Tomaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine

(2009) Jing Liu et al.   PSYCHOPHARMACOLOGY

Impact of Increased PPARγ Activity in Adipocytes in vivo on Adiposity, Insulin Sensitivity and the Effects of Rosiglitazone Treatment

(2008) Katsuko TAKASAWA et al.   ENDOCRINE JOURNAL

Peroxisome Proliferator-Activated Receptor-γ-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status

(2008) William T. Festuccia et al.   ENDOCRINOLOGY

Examining a Bidirectional Association Between Depressive Symptoms and Diabetes

(2008) Sherita Hill Golden   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Leptin Increases Adult Hippocampal Neurogenesisin Vivoandin Vitro

(2008) Jacob C. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARγ agonists as therapeutics for the treatment of Alzheimer’s disease

(2008) Gary Landreth et al.   Neurotherapeutics

Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice

(2008) Angelo O. Rosa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY