PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

Adult Cartilage-Specific Peroxisome Proliferator–Activated Receptor Gamma Knockout Mice Exhibit the Spontaneous Osteoarthritis Phenotype

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Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

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Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis

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Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion

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Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

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AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

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Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model

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Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection

(2011) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

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Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

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The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

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Loss of peroxisome proliferator-activated receptor γ in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis

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PPARγ activation induces autophagy in breast cancer cells

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Autophagy: A lysosomal degradation pathway with a central role in health and disease

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Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

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Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE