Article
Computer Science, Information Systems
Danyang Li, Jingao Xu, Zheng Yang, Chenshu Wu, Jianbo Li, Nicholas D. Lane
Summary: This article presents ViViPlus, an indoor localization system based solely on WiFi fingerprints. By utilizing a novel RSS Spatial Gradient (RSG) matrix to enhance the spatial awareness of WiFi fingerprints, ViViPlus successfully overcomes the issues of spatial ambiguity and temporal instability without compromising ubiquity.
ACM TRANSACTIONS ON SENSOR NETWORKS
(2022)
Article
Computer Science, Information Systems
Jun Yang, Yaoru Sun, Maoyu Mao, Lizhi Bai, Siyu Zhang, Fang Wang
Summary: This paper presents a method for exposing Deepfake by analyzing temporal and spatial faint synthetic signals hidden in portrait videos. By extracting PPG features and AR features, the method can effectively detect fake content. Experimental results show that this method achieves state-of-the-art performance on multiple datasets and demonstrates better generalization.
IEEE TRANSACTIONS ON BIG DATA
(2023)
Article
Biochemistry & Molecular Biology
Julian Lommen, Julika Detken, Katharina Harr, Charlotte von Gall, Amira A. H. Ali
Summary: This study provides a detailed systematic analysis on the spatial and temporal distribution of P2 in the mouse hippocampus, revealing distinct spatial and temporal distribution patterns of P2 receptors in different hippocampal layers. The temporal distribution of P2 receptors can be segregated into two large time domains, the early to mid-day and the mid to late night.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Computer Science, Information Systems
Qianqian Ren, Yan Wang, Saining Liu, Xingfeng Lv
Summary: Due to the absence of GPS signal and the popularity of WLANs, WiFi fingerprinting has attracted attention in indoor positioning. However, accurate indoor positioning is challenging due to fingerprint ambiguity and instability. This paper proposes a deep learning framework called FSTNet to learn the spatial-temporal correlations from fingerprints and improve indoor positioning accuracy. Experimental results show that FSTNet effectively captures the temporal and spatial correlations in RSS measurements, achieving a 44% improvement in mean positioning error and 99.2% of positioning errors within 2 m.
Article
Cell & Tissue Engineering
Xin Zhou, Yufeng Lu, Fangqi Zhao, Ji Dong, Wenji Ma, Suijuan Zhong, Mengdi Wang, Bosong Wang, Yuqing Zhao, Yingchao Shi, Qiang Ma, Tian Lu, Jun Zhang, Xiaoqun Wang, Qian Wu
Summary: This study reveals the cell-type and spatiotemporal characteristics of human hypothalamus development and finds that different cell fates are produced sequentially with spatial developmental asynchrony. Human hypothalamic gliogenesis occurs at an earlier stage compared to mice and shows different transcription profiles. Early oligodendrocyte cells in humans interact with neuronal cells through Wnt, Hippo, and integrin signals to regulate neuronal maturation.
Article
Multidisciplinary Sciences
Ryann M. Fame, Peter N. Kalugin, Boryana Petrova, Huixin Xu, Paul A. Soden, Frederick B. Shipley, Neil Dani, Bradford Grant, Aja Pragana, Joshua P. Head, Suhasini Gupta, Morgan L. Shannon, Fortunate F. Chifamba, Hannah Hawks-Mayer, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Mark L. Andermann, Naama Kanarek, Jonathan O. Lipton, Maria K. Lehtinen
Summary: In this study, a platform was developed to analyze diurnal variations in the choroid plexus and cerebrospinal fluid of male mice. The ribosome profiling of epithelial cells in the choroid plexus revealed diurnal differences in the translatome related to metabolism, secretion, and barrier components. The study also identified diurnal variations in secretion of transthyretin, which correlated with cerebrospinal fluid thyroid hormone levels.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Hoi Yan Gladys Lau, Alex Fornito, Ben D. Fulcher
Summary: The study of spatial embedding of transcription patterns in mouse brain development reveals that transcriptional similarity decreases exponentially with separation distance, following a power-law relationship with brain size. This indicates a balance between local molecular similarity and longer-range diversity in the developing mouse brain. Extrapolating this relationship to the human cortex yields a prediction consistent with actual data.
Review
Chemistry, Multidisciplinary
Chihyeong Won, Chaebeen Kwon, Kijun Park, Jungmok Seo, Taeyoon Lee
Summary: Recent advances in diagnostics and medicines emphasize the importance of spatial and temporal aspects in monitoring and treating diseases. Electronic drugs (e-drugs), as an innovative approach, have been developed to overcome the limitations of conventional therapies and deliver specific treatments to targeted tissues or organs in a more precise spatiotemporal manner.
ADVANCED MATERIALS
(2021)
Article
Psychiatry
Sameer Jauhar, Robert A. McCutcheon, Mattia Veronese, Faith Borgan, Matthew Nour, Maria Rogdaki, Fiona Pepper, James M. Stone, Alice Egerton, George Vamvakas, Federico Turkheimer, Philip K. McGuire, Oliver D. Howes
Summary: The study aimed to measure the effect of antipsychotics on dopamine synthesis and glutamate concentrations in individuals with psychosis. The results showed that antipsychotic treatment did not significantly affect glutamate concentrations or dopamine synthesis capacity, but did alter the relationship between glutamate and dopamine.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Emilia Bergoglio, Ikuo K. Suzuki, Kazuya Togashi, Masato Tsuji, Shunsuke Takeuchi, Hiroyuki Koizumi, Kazuo Emoto
Summary: DCLK1 is an enzyme involved in brain development, with its different isoforms showing partially segregated localization in the developing mouse brain and suggesting distinct roles in brain development and function.
NEUROSCIENCE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yingchao Shi, Mengdi Wang, Da Mi, Tian Lu, Bosong Wang, Hao Dong, Suijuan Zhong, Youqiao Chen, Le Sun, Xin Zhou, Qiang Ma, Zeyuan Liu, Wei Wang, Junjing Zhang, Qian Wu, Oscar Marin, Xiaoqun Wang
Summary: Genetic variation contributes to susceptibility to neurodevelopmental disorders by impacting the development of specific cell types, such as cortical and striatal GABAergic neurons. Using single-cell RNA sequencing, this study characterized the diversity of cell emergence in the human ganglionic eminences, where these neurons are generated. The findings demonstrate a regulatory logic controlling the specification, migration, and differentiation of GABAergic neurons in the human telencephalon that is evolutionarily conserved.
Article
Psychiatry
Jiaxin Zeng, Wenjing Zhang, Guorong Wu, Xiaowan Wang, Chandan Shah, Siyi Li, Yuan Xiao, Li Yao, Hengyi Cao, Zhenlin Li, John A. Sweeney, Su Lui, Qiyong Gong
Summary: The study demonstrates that initiation of antipsychotic treatment alters brain features in ways that further distinguish individual schizophrenia patients from healthy individuals, with illness duration having a modest effect on this differentiation.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Medicine, Research & Experimental
Xuejiao Bian, Qin Xie, Yuxiao Zhou, Haibo Wu, Junqi Cui, Liling Jia, Lun Suo
Summary: The study investigated transcriptome variances and pathway enrichment during mouse folliculogenesis using RNA-seq, identifying eight master transcription factors driving folliculogenesis. The research provides novel insights into controlled ovarian stimulation in future infertility treatment.
Article
Multidisciplinary Sciences
Franziska Hildebrandt, Alma Andersson, Sami Saarenpaa, Ludvig Larsson, Noemi Van Hul, Sachie Kanatani, Jan Masek, Ewa Ellis, Antonio Barragan, Annelie Mollbrink, Emma R. Andersson, Joakim Lundeberg, Johan Ankarklev
Summary: Global transcriptional differences across lobular units in the liver remain unknown. Here the authors perform spatial transcriptomics of liver tissue to delineate transcriptional differences in physical space, confirm lobular zonation along transcriptional gradients and suggest the presence of previously uncharacterized structures within liver tissue.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Marsha Maredia, John Hamilton, Panayotis K. Thanos
Summary: This study found that a high-fat diet may increase microglial activation in certain brain regions in rats, while the antipsychotic drugs haloperidol and olanzapine had no effect on this activation. Additionally, the two different antipsychotic medications had differing effects on brain regions.
NEUROSCIENCE LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Tsukasa Sugo, Michiko Terada, Tatsuo Oikawa, Kenichi Miyata, Satoshi Nishimura, Eriya Kenjo, Mari Ogasawara-Shimizu, Yukimasa Makita, Sachiko Imaichi, Shumpei Murata, Kentaro Otake, Kuniko Kikuchi, Mika Teratani, Yasushi Masuda, Takayuki Kamei, Shuichi Takagahara, Shota Ikeda, Tetsuya Ohtaki, Hirokazu Matsumoto
JOURNAL OF CONTROLLED RELEASE
(2016)
Article
Endocrinology & Metabolism
Yasunori Nio, Natsu Hotta, Minoru Maruyama, Kenichi Hamagami, Toshimi Nagi, Masaaki Funata, Junichi Sakamoto, Masanori Nakakariya, Nobuyuki Amano, Tomohiro Okawa, Yasuyoshi Arikawa, Shinobu Sasaki, Shoki Okuda, Shizuo Kasai, Yugo Habata, Yasutaka Nagisa
Article
Pharmacology & Pharmacy
Keiji Nishiyama, Hirobumi Suzuki, Toshiya Harasawa, Noriko Suzuki, Emi Kurimoto, Takayuki Kawai, Minoru Maruyama, Hidetoshi Komatsu, Kensuke Sakuma, Yuji Shimizu, Masato Shimojo
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2017)
Article
Behavioral Sciences
Minoru Maruyama, Natsu Hotta, Yasunori Nio, Kenichi Hamagami, Toshimi Nagi, Masaaki Funata, Junichi Sakamoto, Masanori Nakakariya, Nobuyuki Amano, Mayumi Nishida, Tomohiro Okawa, Yasuyoshi Arikawa, Shinobu Sasaki, Shizuo Kasai, Yasutaka Nagisa, Yugo Habata, Masaaki Mori
BRAIN AND BEHAVIOR
(2018)
Article
Medicine, General & Internal
Hiroaki Nagai, Tomoko Satomi, Akiko Abiru, Kazumasa Miyamoto, Koji Nagasawa, Minoru Maruyama, Satoshi Yamamoto, Kuniko Kikuchi, Hiromitsu Fuse, Masakuni Noda, Yoshiyuki Tsujihata
Review
Biochemistry & Molecular Biology
Hidetoshi Komatsu, Mamoru Fukuchi, Yugo Habata
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Medicinal
Hidetoshi Komatsu
Summary: The discovery of a highly potent and specific GPR52 antagonist through high-throughput screening and structure-activity relationship study offers promising potential as a novel therapeutic approach for Huntington's disease. This strategy not only reduces mHTT protein levels, but also ameliorates HD-like phenotypes in animal disease models, providing a new direction in HD therapy compared to traditional nucleic acid medicine approaches.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Hidetoshi Komatsu, Emi Watanabe, Mamoru Fukuchi
Summary: Learning and environmental adaptation are crucial for survival and quality of life, with decision-making involving coordination among multiple neural network systems. Neurological and psychiatric disorders often impact these processes, but machine learning approaches have the potential to redefine mental illnesses and improve therapeutic outcomes. Early disease detection and personalized treatment regimes may be possible through measurable endophenotypes and the application of artificial intelligence in psychiatric practice.
Article
Multidisciplinary Sciences
Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C. Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida
Summary: The study reveals that an estrogen-related receptor gamma (ERR gamma) agonist and an S-phase kinase-associated protein 2 inhibitor enhance the maturation of cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by promoting larger cell size, longer sarcomere length, the presence of transverse tubules, and improved metabolic, contractile, and electrical properties.
NATURE COMMUNICATIONS
(2021)
Review
Neurosciences
Hidetoshi Komatsu
Summary: Huntington's disease is a fatal neurodegenerative disorder with no effective cure currently available. Lowering mutant huntingtin is a promising therapeutic strategy, mainly focusing on nucleic acid approaches. Inhibiting GPR52 may offer a novel treatment approach, with research showing potential effectiveness.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Akram Abbasi, Sachiko Imaichi, Vincent Ling, Anita Shukla
Summary: In this study, two-dimensional soft hydrogels with microscale aligned grooves were developed as culture substrates for human mesenchymal stem cells (HMSCs). The topographical features of the hydrogel surface led to reduced cellular spreading and senescence, while maintaining the multipotency and differentiation potential of the cells. HMSCs cultured on these hydrogels also exhibited an increased capacity to produce anti-inflammatory cytokines. Overall, the soft hydrogels showed great promise for maximizing the therapeutic potential of HMSCs in vitro.
ACS APPLIED BIO MATERIALS
(2022)
Article
Neurosciences
Keiji Nishiyama, Hirobumi Suzuki, Minoru Maruyama, Tomoki Yoshihara, Hiroyuki Ohta
Article
Pharmacology & Pharmacy
Kensuke Sakuma, Chiori Yabuki, Minoru Maruyama, Akiko Abiru, Hidetoshi Komatsu, Nobuyuki Negoro, Yoshiyuki Tsujihata, Koji Takeuchi, Yugo Habata, Masaaki Mori
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2016)