Creative use of analytical techniques and high-throughput technology to facilitate safety assessment of engineered nanomaterials

Surface Oxidation of Graphene Oxide Determines Membrane Damage, Lipid Peroxidation, and Cytotoxicity in Macrophages in a Pulmonary Toxicity Model

(2018) Ruibin Li et al.   ACS Nano

Uptake and Intracellular Fate of Engineered Nanoparticles in Mammalian Cells: Capabilities and Limitations of Transmission Electron Microscopy-Polymer-Based Nanoparticles

(2018) Martin Reifarth et al.   ADVANCED MATERIALS

Modulation of the effective density and refractive index of carbon nanotube forests via nanoimprint lithography

(2018) Sei Jin Park et al.   CARBON

Environmental risk assessment of engineered nano-SiO2 , nano iron oxides, nano-CeO2 , nano-Al2 O3 , and quantum dots

(2018) Yan Wang et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Nanomaterials for solid oxide fuel cells: A review

(2018) Abdalla M. Abdalla et al.   RENEWABLE & SUSTAINABLE ENERGY REVIEWS

Toxicological Profiling of Highly Purified Single-Walled Carbon Nanotubes with Different Lengths in the Rodent Lung and Escherichia Coli

(2018) Xiang Wang et al.   Small

Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials

(2017) Glen M DeLoid et al.   Nature Protocols

The Genetic Heterogeneity among Different Mouse Strains Impacts the Lung Injury Potential of Multiwalled Carbon Nanotubes

(2017) Xiang Wang et al.   Small

PEGylated graphene oxide elicits strong immunological responses despite surface passivation

(2017) Nana Luo et al.   Nature Communications

Bio-Plex immunoassay measuring the quantity of lysosomal N -acetylgalactosamine-6-sulfatase protein in dried blood spots for the screening of mucopolysaccharidosis IVA in newborn: a pilot study

(2017) Chih-Kuang Chuang et al.   BMJ Open

Repetitive Dosing of Fumed Silica Leads to Profibrogenic Effects through Unique Structure–Activity Relationships and Biopersistence in the Lung

(2016) Bingbing Sun et al.   ACS Nano

Toxicological Profiling of Highly Purified Metallic and Semiconducting Single-Walled Carbon Nanotubes in the Rodent Lung and E. coli

(2016) Xiang Wang et al.   ACS Nano

Identification and Optimization of Carbon Radicals on Hydrated Graphene Oxide for Ubiquitous Antibacterial Coatings

(2016) Ruibin Li et al.   ACS Nano

Interactions of graphene with mammalian cells: Molecular mechanisms and biomedical insights

(2016) Bo Zhang et al.   ADVANCED DRUG DELIVERY REVIEWS

Development, Characterisation and Application of Monoclonal Antibodies for the Detection and Quantification of Infectious Salmon Anaemia Virus in Plasma Samples Using Luminex Bead Array Technology

(2016) R. Hoare et al.   PLoS One

Polyelemental nanoparticle libraries

(2016) P.-C. Chen et al.   SCIENCE

Use of compositional and combinatorial nanomaterial libraries for biological studies

(2016) Zhaoxia Ji   Science Bulletin

Immunomodulatory Effects of Coated Gold Nanoparticles in LPS-Stimulated In Vitro and In Vivo Murine Model Systems

(2016) Daniel F. Moyano et al.   Chem

Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the Lung by Adjusting Silanol Display through Calcination and Metal Doping

(2015) Bingbing Sun et al.   ACS Nano

Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials

(2015) Xiang Wang et al.   ACS Nano

Enhancing the Imaging and Biosafety of Upconversion Nanoparticles through Phosphonate Coating

(2015) Ruibin Li et al.   ACS Nano

Hydrogels: Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport (Adv. Mater. 28/2015)

(2015) Minkyu Kim et al.   ADVANCED MATERIALS

Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In V.itro

(2015) Angela Ivask et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Defining human dendritic cell progenitors by multiparametric flow cytometry

(2015) Gaëlle Breton et al.   Nature Protocols

Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice

(2015) Jennifer D. Sisler et al.   Particle and Fibre Toxicology

Advanced computational modeling for in vitro nanomaterial dosimetry

(2015) Glen M. DeLoid et al.   Particle and Fibre Toxicology

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Mechanistic Investigation of the Biological Effects of SiO2, TiO2, and ZnO Nanoparticles on Intestinal Cells

(2015) Magdiel I. Setyawati et al.   Small

Linking Exposures of Particles Released From Nano-Enabled Products to Toxicology: An Integrated Methodology for Particle Sampling, Extraction, Dispersion, and Dosing

(2015) Anoop K. Pal et al.   TOXICOLOGICAL SCIENCES

Sorting of small infectious virus particles by flow virometry reveals distinct infectivity profiles

(2015) Raphaël Gaudin et al.   Nature Communications

Inhibition of Inflammatory Arthritis Using Fullerene Nanomaterials

(2015) Anthony L. Dellinger et al.   PLoS One

Interference in Autophagosome Fusion by Rare Earth Nanoparticles Disrupts Autophagic Flux and Regulation of an Interleukin-1β Producing Inflammasome

(2014) Ruibin Li et al.   ACS Nano

Aspect Ratio Plays a Role in the Hazard Potential of CeO2 Nanoparticles in Mouse Lung and Zebrafish Gastrointestinal Tract

(2014) Sijie Lin et al.   ACS Nano

Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design

(2014) Ruibin Li et al.   ACS Nano

Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation

(2014) Christian Schmidt-Lauber et al.   ANNALS OF THE RHEUMATIC DISEASES

Effects of physicochemical properties of nanomaterials on their toxicity

(2014) Xiaoming Li et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Single-cell technologies for monitoring immune systems

(2014) Pratip K Chattopadhyay et al.   NATURE IMMUNOLOGY

Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model

(2014) Ali Kermanizadeh et al.   Particle and Fibre Toxicology

An integrated approach for the in vitro dosimetry of engineered nanomaterials

(2014) Joel M Cohen et al.   Particle and Fibre Toxicology

Estimating the effective density of engineered nanomaterials for in vitro dosimetry

(2014) Glen DeLoid et al.   Nature Communications

High-throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry

(2014) Filippos Porichis et al.   Nature Communications

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Cytokine assays: An assessment of the preparation and treatment of blood and tissue samples

(2013) Genoveva C.E. Keustermans et al.   METHODS

Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential

(2013) Xiang Wang et al.   Small

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

(2012) Andre Nel et al.   ACCOUNTS OF CHEMICAL RESEARCH

Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation

(2012) Haiyuan Zhang et al.   ACS Nano

Designed Synthesis of CeO2 Nanorods and Nanowires for Studying Toxicological Effects of High Aspect Ratio Nanomaterials

(2012) Zhaoxia Ji et al.   ACS Nano

The role of the lateral dimension of graphene oxide in the regulation of cellular responses

(2012) Hua Yue et al.   BIOMATERIALS

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter

(2012) Jeremy A. Hirota et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic

(2012) Haiyuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury

(2012) Xiang Wang et al.   NANO LETTERS

Gaining confidence in high-throughput screening

(2012) J. Bibette   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological Applications of Rare-Earth Based Nanoparticles

(2011) Cedric Bouzigues et al.   ACS Nano

Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells

(2011) Haiyuan Zhang et al.   ACS Nano

Aspect Ratio Determines the Quantity of Mesoporous Silica Nanoparticle Uptake by a Small GTPase-Dependent Macropinocytosis Mechanism

(2011) Huan Meng et al.   ACS Nano

Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos

(2011) Tian Xia et al.   ACS Nano

Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung

(2011) Xiang Wang et al.   ACS Nano

Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity

(2011) Tian Yu et al.   ACS Nano

Polyamidoamine-Grafted Multiwalled Carbon Nanotubes for Gene Delivery: Synthesis, Transfection and Intracellular Trafficking

(2011) Min Liu et al.   BIOCONJUGATE CHEMISTRY

Novel functionalized carbon nanotubes for improving the surface properties and performance of polyethersulfone (PES) membrane

(2011) Ahmad Rahimpour et al.   DESALINATION

SiRNA delivery with functionalized carbon nanotubes

(2011) Amir Khashayar Varkouhi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Silica nanoconstruct cellular toleration threshold in vitro

(2011) Heather L. Herd et al.   JOURNAL OF CONTROLLED RELEASE

Role of Fe Doping in Tuning the Band Gap of TiO2for the Photo-Oxidation-Induced Cytotoxicity Paradigm

(2011) Saji George et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polyethylenimine–carbon nanotube nanohybrids for siRNA-mediated gene silencing at cellular level

(2011) Stéphanie Foillard et al.   Nanoscale

Phytotoxicity and biotransformation of La2O3nanoparticles in a terrestrial plant cucumber (Cucumis sativus)

(2011) Yuhui Ma et al.   Nanotoxicology

High-resolution dose-response screening using droplet-based microfluidics

(2011) O. J. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping

(2010) Saji George et al.   ACS Nano

Quantitative Techniques for Assessing and Controlling the Dispersion and Biological Effects of Multiwalled Carbon Nanotubes in Mammalian Tissue Culture Cells

(2010) Xiang Wang et al.   ACS Nano

Functional Assessment of Metal Oxide Nanoparticle Toxicity in Immune Cells

(2010) Melissa A. Maurer-Jones et al.   ACS Nano

Does Vitreous Silica Contradict the Toxicity of the Crystalline Silica Paradigm?

(2010) Mara Ghiazza et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metal Oxide Nanoparticles Induce Unique Inflammatory Footprints in the Lung: Important Implications for Nanoparticle Testing

(2010) Wan-Seob Cho et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity

(2010) Yu-Shen Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics

(2010) Erik K. Rushton et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Synthesis and Characterization of PEGylated Gd2O3Nanoparticles for MRI Contrast Enhancement

(2010) Maria Ahrén et al.   LANGMUIR

Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging

(2010) Sung You Hong et al.   NATURE MATERIALS

Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity

(2010) Raymond F Hamilton et al.   Particle and Fibre Toxicology

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

Comparative pulmonary toxicity assessment of pristine and functionalized multi-walled carbon nanotubes intratracheally instilled in rats

(2010) E. Roda et al.   TOXICOLOGY LETTERS

Internalisation of hybrid titanium dioxide/para-amino benzoic acid nanoparticles in human dendritic cells did not induce toxicity and changes in their functions

(2010) Camille Migdal et al.   TOXICOLOGY LETTERS

A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials

(2009) Huan Meng et al.   ACS Nano

Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications

(2009) Bengt Fadeel et al.   ADVANCED DRUG DELIVERY REVIEWS

Potential Health Impact of Nanoparticles

(2009) Tian Xia et al.   Annual Review of Public Health

Chemistry of carbon nanotubes in biomedical applications

(2009) Hai-Chen Wu et al.   JOURNAL OF MATERIALS CHEMISTRY

Synthesis and Characterization of Stable Monodisperse Silica Nanoparticle Sols forin VitroCytotoxicity Testing

(2009) Leen C. J. Thomassen et al.   LANGMUIR

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Rare Earth Oxide Nanocrystals Induce Autophagy in HeLa Cells

(2009) Le Yu et al.   Small

Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano- and Microparticles

(2009) Qianjun He et al.   Small

Noble Metals on the Nanoscale: Optical and Photothermal Properties and Some Applications in Imaging, Sensing, Biology, and Medicine

(2008) Prashant K. Jain et al.   ACCOUNTS OF CHEMICAL RESEARCH

Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties

(2008) Tian Xia et al.   ACS Nano

Efficacy of Simple Short-Term in Vitro Assays for Predicting the Potential of Metal Oxide Nanoparticles to Cause Pulmonary Inflammation

(2008) Senlin Lu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

(2008) Ning Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells

(2008) Igor I. Slowing et al.   Small