Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biotechnology & Applied Microbiology
Kristin Bowers, Lisa Amelse, Austin Bow, Steven Newby, Amber MacDonald, Xiaocun Sun, David Anderson, Madhu Dhar
Summary: This study aimed to assess the therapeutic potential of mesenchymal stem cells (MSCs) for tendon injury treatment. Through in vitro and in vivo experiments, the study found that rat adipose-derived MSCs had tenogenic potential and could be induced towards a tenogenic lineage with tenogenic growth factors. However, in the in vivo experiments, no significant differences were observed between the MSC-treated tendons and control tendons, regardless of the MSC dose.
BIOENGINEERING-BASEL
(2022)
Review
Cell Biology
Yue-Yue Song, Dan Liang, De-Kun Liu, Lin Lin, Lei Zhang, Wen-Qing Yang
Summary: The main treatment strategy for ischemic diseases involves repairing vascular damage and encouraging angiogenesis by regulating the ERK signaling pathway. The mechanism by which ERK alleviates the ischemic state is not fully understood, but significant evidence suggests its critical role in the occurrence and development of ischemic diseases. The prospect of developing drugs that specifically act on the ERK pathway to promote angiogenesis in the treatment of ischemic diseases is promising.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Xiaoyan Yu, Qing Su, Jianan Geng, Hui Liu, Yumeng Liu, Jinm Eng Liu, Yan Shi, Yinggang Zou
Summary: The present study demonstrates that GBE prevents ECM accumulation in DN by suppressing tTG expression, primarily mediated by TGF-beta.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Psychology, Developmental
Craig A. Erickson, Charles R. Tessier, Christina Gross, Ernest Pedapati, Logan K. Wink, Kelli C. Dominick, Rebecca C. Shaffer, Hilary Rosselot, Michael P. Hong, Andrew P. Bantel, Elizabeth Berry-Kravis, Paul S. Horn, Ryan Adams, John A. Sweeney
Summary: This study investigated the activity of ERK1/2 in autism spectrum disorder (ASD). The results showed that lymphocytic ERK1/2 activation was faster in individuals with ASD, and this was correlated with greater social impairment. The differences in ERK1/2 activation were more pronounced in younger individuals.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Nozomi Tokunaga, Tomoyo Takimoto, Yoki Nakamura, Kazue Hisaoka-Nakashima, Norimitsu Morioka
Summary: This study investigates the relationship between Connexin 43 (Cx43) expression and induction of brain-derived neurotrophic factor(BDNF) production by antidepressants. The results show that downregulated Cx43 expression in depression patients might contribute to the therapeutic efficacy of antidepressants rather than the pathogenesis of depression. Furthermore, the study reveals that amitriptyline treatment potentiates BDNF expression in Cx43-knockdown astrocytes through LPA receptor(1/3) stimulation and subsequent activation of Src-ERK signaling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jieun Jeon, Tamanna Jahan Mony, Eunbi Cho, Huiyoung Kwon, Wan-Seob Cho, Ji Woong Choi, Byeong C. Kim, Jong Hoon Ryu, Se Jin Jeon, Kyoung Ja Kwon, Chan Young Shin, Se Jin Park, Dong Hyun Kim
Summary: In this study, it was found that rubrofusarin enhances learning and memory in mice and promotes neurite outgrowth. These effects may be achieved through activation of the ERK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hidenori Kanno, Sei Naito, Yutaro Obara, Hiromi Ito, Osamu Ichiyanagi, Takafumi Narisawa, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya
Summary: ERK5 has been found to be highly expressed in clear cell renal cell carcinoma (ccRCC) and is associated with high grade, high recurrence rate, and high cancer-specific survival. The expression of ERK5 is regulated by miR-143. Inhibition of ERK5 holds promise as a potential target for ccRCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Batoul Maatouk, Miran A. Jaffa, Mia Karam, Duaa Fahs, Wared Nour-Eldine, Anwarul Hasan, Ayad A. Jaffa, Rami Mhanna
Summary: DFUs lack CTGF and IGF-I, leading to poor tissue repair. AlgSulf/PCL NPs with high affinity and sustained release of CTGF and IGF-I could promote diabetic wound healing, with no cytotoxic effects observed in HaCaT cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Rheumatology
Jiaqi Ren, Lin Sun, Xing Sun, Zhenzhen Ma, Xinyu Wang, Zhuo An, Jinxia Zhao
Summary: The prevalence of serum CTGF was significantly higher in RA patients compared to other rheumatic diseases and healthy controls, indicating its potential value as a diagnostic biomarker for RA. CTGF-positive patients had higher levels of anti-CCP antibody, RF, IgG, and IgM, while the presence of ILD in RA patients was associated with a higher positivity rate of serum CTGF. Further studies are needed to fully understand the diagnostic performance of CTGF in RA.
CLINICAL RHEUMATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jiafeng Zhu, Qian Li, Yan Sun, Shiyu Zhang, Ruiyan Pan, Yanguang Xie, Jinyan Chen, Lihong Shi, Yanbo Chen, Zhipeng Sun, Lane Zhang
Summary: This study investigates the molecular mechanism of IGF1R in Ang II-induced cardiac fibrosis and demonstrates that IGF1R deficiency alleviates cardiac fibrosis. The results suggest that IGF1R may be a promising therapeutic target for cardiac fibrosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Nanoscience & Nanotechnology
Rong Liu, Min Zhu, Jiaojiao Chen, Junwei Gai, Jing Huang, Yingqun Zhou, Yakun Wan, Chuantao Tu
Summary: In this study, a novel nanobody (Nb) against human connective tissue growth factor (CTGF) was identified, which showed antifibrotic effects in vitro by regulating the biological functions of human stellate cells. This study is of great importance for the development of antifibrotic therapies for liver fibrosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Toxicology
Yujia Xie, Jixuan Ma, Meng Yang, Lieyang Fan, Weihong Chen
Summary: Silicosis is a scarring lung disease caused by inhaling fine particles of crystalline silica in the workplace. The underlying molecular mechanisms of silicosis are not fully understood, but recent studies have highlighted the role of the activated ERK signaling pathway in regulating oxidative stress, inflammatory response, fibroblast activation, and other processes involved in the formation and development of silicosis.
TOXICOLOGY RESEARCH
(2021)
Article
Cell Biology
You -Tien Tsai, Hsiang -Yuan Yeh, Chia -Ter Chao, Jenq-Wen Huang, Chih-Kang Chiang
Summary: This study found that the transforming growth factor-beta (TGF-beta) plays a crucial role in vascular calcification (VC). The mechanism of TGF-beta's involvement in VC was investigated using experimental models and clinical specimens. The results revealed that TGF-beta 1 can regulate the occurrence and progression of VC by modulating the miR-378a-3p/CTGF signaling pathway at specific time points.
Article
Cell Biology
Xiao Lin, Ting Zhu, Feng Xu, Jia-Yu Zhong, Fuxingzi Li, Su-Kang Shan, Feng Wu, Bei Guo, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Xiao-Bo Liao, Hong-Yu Lu, Xu-Biao Xie, Ling-Qing Yuan
Summary: This study found that plasma exosomes from ESRD patients significantly promoted vascular smooth muscle cells calcification, while renal transplantation partially attenuated this procalcification effect. Fetuin-A and MGP were decreased, but Annexin-A2 was increased in ESRD-Ex, and renal transplantation could increase the level of Fetuin-A rather than MGP. The levels of Fetuin-A and MGP in plasma exosomes were negatively while the levels of Annexin-A2 in plasma exosomes were positively correlated to coronary artery calcification scores (CACS).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Li-Min Lei, Xiao Lin, Feng Xu, Su-Kang Shan, Bei Guo, Fu-Xing-Zi Li, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Ling-Qing Yuan
Summary: Exosomes are extracellular vesicles that play a crucial role in delivering signal molecules from donor cells to recipient cells, with a cargo that includes proteins, DNA, and RNA targeting recipient tissues and organs, influencing disease development. Research indicates that exosomes are significant in the development of insulin resistance caused by obesity, showing promise for diagnosis and therapy of insulin resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Orthopedics
Hong-Li Li, Yi Shen, Li-Hua Tan, Song-Bo Fu, Ru-Chun Dai, Ling-Qing Yuan, Zhi-Feng Sheng, Zhong-Jian Xie, Xian-Ping Wu, Er-Yuan Liao, Xu-Lei Tang, Xi-Yu Wu
Summary: This study investigated the relationship between BMD and risk of fragility fracture in native Chinese population. The findings showed that decreasing BMD measurement parameters and anthropometric indicators increased the risk of clinical fragility fracture, with variations in fracture HR based on gender and site.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cell Biology
Feng Xu, Jia-Yu Zhong, Bei Guo, Xiao Lin, Feng Wu, Fu-Xing-Zi Li, Su-Kang Shan, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Li-Min Lei, Chang-Ming Tan, Xiao-Bo Liao, Ling-Qing Yuan
Summary: The study found that H19 plays a promoting role in arterial medial calcification, functioning as a competing endogenous RNA for miR-140-5p and activating the ERK1/2 and p38MAPK signaling pathways induced by Satb2.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Xiao Lin, Muhammad Hasnain Ehsan Ullah, Xiong Wu, Feng Xu, Su-Kang Shan, Li-Min Lei, Ling-Qing Yuan, Jun Liu
Summary: This review summarizes the cerebro-cardiovascular risk in primary aldosteronism (PA) and emphasizes the harmful effects of excess aldosterone on target organs. Both surgical and medical treatments show long-term benefits in improving cerebro-cardiovascular outcomes and reducing mortality. Understanding these risks is essential for early diagnosis and treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zhen-Xing Wang, Zhong-Wei Luo, Fu-Xing-Zi Li, Jia Cao, Shan-Shan Rao, Yi-Wei Liu, Yi-Yi Wang, Guo-Qiang Zhu, Jiang-Shan Gong, Jing-Tao Zou, Qiang Wang, Yi-Juan Tan, Yan Zhang, Yin Hu, You-You Li, Hao Yin, Xiao-Kai Wang, Ze-Hui He, Lu Ren, Zheng-Zhao Liu, Xiong-Ke Hu, Ling-Qing Yuan, Ran Xu, Chun-Yuan Chen, Hui Xie
Summary: This study uncovers the role of extracellular vesicles from bone matrix as a messenger in the development of osteoporosis and vascular calcification (calcification paradox) during skeletal aging and menopause by transferring miR-483-5p and miR-2861.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Endocrinology & Metabolism
Bei Guo, Ling-Qing Yuan
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Yun-Yun Wu, Su-Kang Shan, Xiao Lin, Feng Xu, Jia-Yu Zhong, Feng Wu, Jia-Yue Duan, Bei Guo, Fu-Xing-Zi Li, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Li-Min Lei, Wen-Lu Ou-Yang, Ke-Xin Tang, Chang-Chun Li, Muhammad Hasnain Ehsan Ullah, Ling-Qing Yuan
Summary: This review introduces the prevalence of vascular calcification in various diseases and the impact of the bidirectional interactions between vascular cells and their microenvironment on the calcification process. Additionally, the review highlights the significant role of exosomes in cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Xiao Lin, Su-Kang Shan, Feng Xu, Jia-Yu Zhong, Feng Wu, Jia-Yue Duan, Bei Guo, Fu-Xing-Zi Li, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Li-Min Lei, Wen-Lu Ou-Yang, Yun-Yun Wu, Ke-Xin Tang, Muhammad Hasnain Ehsan Ullah, Xiao-Bo Liao, Ling-Qing Yuan
Summary: Exosomal miR-670-3p derived from ECs can promote arterial calcification by targeting IGF-1, which may serve as a potential therapeutic target for arterial calcification in ESRD patients.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Bei Guo, Su-Kang Shan, Feng Xu, Xiao Lin, Fu-Xing-zi Li, Yi Wang, Qiu-Shuang Xu, Ming-Hui Zheng, Li-Min Lei, Chang-Chun Li, Zhi-Ang Zhou, Muhammad Hasnain Ehsan Ullah, Feng Wu, Xiao-Bo Liao, Ling-Qing Yuan
Summary: The pathogenesis of vascular calcification in diabetic patients is still not clear. In this study, it was found that small extracellular vesicles (sEVs) secreted by human umbilical vein endothelial cells (HUVECs) stimulated with advanced glycation end-products (AGEs) can target and regulate the calcification-related signaling pathway through miR-126-5p, inhibiting the osteogenic differentiation of vascular smooth muscle cells (VSMCs). Knockdown of miR-126-5p in HUVECs attenuated the anti-calcification effect of sEVs in a mouse model of type 2 diabetes.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Xi-Yu Wu, Hong-Li Li, Yi Shen, Li-Hua Tan, Ling-Qing Yuan, Ru-Chun Dai, Hong Zhang, Yi-Qun Peng, Zhong-Jian Xie, Zhi-Feng Sheng
Summary: The study found a significant positive correlation between body surface area (BSA) and bone mineral density (BMD) in both male and female fracture patients. Decreased BSA may be a potential new risk factor for osteoporotic fractures in Chinese men.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Ye-Chi Cao, Su-Kang Shan, Bei Guo, Chang-Chun Li, Fu-Xing-Zi Li, Ming-Hui Zheng, Qiu-Shuang Xu, Yi Wang, Li-Min Lei, Ke-Xin Tang, Wen-Lu Ou-Yang, Jia-Yue Duan, Yun-Yun Wu, Muhammad Hasnain Ehsan Ullah, Zhi-Ang Zhou, Feng Xu, Xiao Lin, Feng Wu, Xiao-Bo Liao, Ling-Qing Yuan
Summary: Histone methylation modification may play a key role in the development of vascular calcification, which involves various complex pathophysiological processes. Comprehensive research on the role and mechanism of lysine methylation modification in VC is crucial for identifying new therapeutic targets and developing new drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Chang-Chun Li, Muhammad Hasnain Ehsan Ullah, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Yi Wang, Fuxingzi Li, Ling-Qing Yuan
Summary: The incidence of thyroid cancer has increased, particularly in women with papillary thyroid cancer. Although the mortality rate of thyroid cancer has remained stable or declined, the clinical prognosis of papillary thyroid cancer still poses challenges.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Su-Kang Shan, Tong Yan, Ling-Qing Yuan
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yan-Lin Wu, Zheng-Jun Lin, Chang-Chun Li, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Fuxingzi Li, Ling-Qing Yuan, Zhi-hong Li
Summary: Epigenetics, which regulates gene expression, plays a critical role in metabolic diseases. The term 'epigenetics' was proposed in 1942 and has since made significant progress with the development of technologies. There are four main epigenetic mechanisms, including DNA methylation, histone modification, chromatin remodelling, and noncoding RNA (ncRNA), which have different effects on metabolic diseases. Understanding epigenetics can be applied to diagnosing and treating metabolic diseases, including the use of epigenetic biomarkers, drugs, and editing.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)