Article
Oncology
M. Gerwing, E. Hoffmann, C. Geyer, A. Helfen, B. Maus, R. Schinner, L. Wachsmuth, W. Heindel, M. Eisenblaetter, C. Faber, M. Wildgruber
Summary: This study used non-invasive magnetic resonance imaging (MRI) to evaluate changes in tumor composition after targeted therapy in murine models of breast cancer. The results showed that different targeted treatments led to different intratumoral changes, and mp MRI can serve as a biomarker for treatment response assessment.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Immunology
Zachary J. J. Bernstein, Anjali Shenoy, Amy Chen, Nicola M. M. Heller, Jamie B. B. Spangler
Summary: IL-4 and IL-13 cytokines play important roles in immune activity, especially in T helper 2 cell-mediated inflammation, immune regulation, antibody production, and fibrosis. Manipulating the IL-4/IL-13 axis through cytokine engineering, fusion protein formulation, antagonist development, cell engineering, and biosensor design can lead to the discovery of new immunotherapies targeting allergy, autoimmune diseases, and cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Medical Laboratory Technology
Afaf Elsaid, Rasha M. S. Shoaib, Sara S. Badr, Yahya Wahba, Seif-Eldin N. Ayyad
Summary: The study found that IL4 VNTR and IL4R (A1902G) gene polymorphisms are associated with the risk of bronchial asthma among Egyptian children, with certain genotypes of IL4 VNTR and IL4R (A1902G) showing significantly higher frequencies in asthmatic patients.
CLINICAL BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Vasile Valeriu Lupu, Elena Jechel, Silvia Fotea, Ionela Daniela Morariu, Iuliana Magdalena Starcea, Alice Azoicai, Adriana Mocanu, Elena Cristina Mitrofan, Ancuta Lupu, Dragos Munteanu, Minerva Codruta Badescu, Magdalena Cuciureanu, Ileana Ioniuc
Summary: This article discusses the challenges of managing asthma during adolescence, including individualized therapy, compliance control, social integration, and the importance of communication in monitoring the condition. Currently, there is an increasing morbidity and mortality among children with asthma, highlighting the need for better symptom control and maintenance of quality of life.
Article
Medicine, Research & Experimental
Daphne N. Dorst, Esther M. M. Smeets, Christian Klein, Cathelijne Frielink, Daan Geijs, Marija Trajkovic-Arsic, Phyllis F. Y. Cheung, Martijn W. J. Stommel, Martin Gotthardt, Jens T. Siveke, Erik H. J. G. Aarntzen, Sanne A. M. van Lith
Summary: Patients with pancreatic ductal adenocarcinoma (PDAC) have a low 5-year survival rate of 9%. The dense tumor-supporting stroma, which is composed of cancer-associated fibroblasts, is a major factor limiting the efficacy of chemotherapy and immunotherapy. In this study, the feasibility of fibroblast activation protein (FAP)-targeted photodynamic therapy (tPDT) for treating PDAC was demonstrated in murine models.
MOLECULAR PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Sabrina Solorzano, Jisoo Kim, Jichun Chen, Xingmin Feng, Neal S. Young
Summary: The study reveals that IL-6, TLR2, and TLR4 have limited roles in immune-mediated BMF in mice, while adaptive immunity appears to be the major contributor to the disease.
Article
Medicine, Research & Experimental
Youji Hong, Yvette Robbins, Xinping Yang, Wojciech K. Mydlarz, Anastasia Sowers, James B. Mitchell, James L. Gulley, Jeffrey Schlom, Sofia R. Gameiro, Cem Sievers, Clint T. Allen
Summary: This study demonstrates that local administration of a tumor-targeted IL-12 antibody fusion protein can achieve potent immune control of established tumors with low doses to avoid systemic toxicity. The treatment leads to reinvigoration and proliferation of exhausted T lymphocytes, induction of Th1 immunity, and a decrease in regulatory T cells and suppressive myeloid cells. Single-cell analysis also reveals similar IL-12 receptor expression patterns in human head and neck carcinomas.
Article
Physiology
Amanda L. Tatler, Christopher J. Philp, Michael R. Hill, Sam Cox, Andrew M. Bullock, Anthony Habgood, Alison John, Robert Middlewick, Katherine E. Stephenson, Amanda T. Goodwin, Charlotte K. Billington, Reuben D. O. ' Dea, Simon R. Johnson, Bindi S. Brook
Summary: Airway remodeling in chronic asthma involves increased ASM and ECM. A new method reveals that ASM and ECM changes are more pronounced in small and large airways compared to intermediate airways. Changes in ASM resolve over 7 days, while ECM and epithelial changes persist. The method highlights important spatial differences in remodeling and could set new analysis standards for murine asthma models.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Review
Medicine, General & Internal
Shin Ariga
Summary: Human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase that is overexpressed in 20% of gastric or gastroesophageal junction cancers. While effective in breast cancer, the use of anti-HER2 agents in gastric cancer has not shown survival benefits compared to standard therapies due to inherent differences in tumor biology. However, the development of a novel anti-HER2 agent, trastuzumab deruxtecan, offers promising future prospects for HER2-targeted therapy in gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Siqi Guo, Ronald B. Smeltz, Anthony Nanajian, Richard Heller
Summary: The study demonstrates that IL-15/IL-15R alpha complex enhances CD8 T cell expansion and has potential efficacy in inhibiting breast cancer growth and improving cytotoxicity. Further research is needed to optimize the effectiveness of IL-15cx as an immunotherapy for breast cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Allison Boboltz, Sahana Kumar, Gregg A. Duncan
Summary: Asthma is a chronic lung disease with diverse pathobiological subtypes, leading to variable responses to anti-inflammatory therapies. Patient-specific treatments and effective inhalation formulations are needed. The review discusses disease progression, genetic modifiers, limitations of current treatments, and new approaches such as monoclonal antibody delivery, mucolytic therapy, and gene therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Materials Science, Biomaterials
Matthias Ruopp, Sha Zhu, Rafael Worschech, Dorothee Haas, Simone Maschauer, Olaf Prante, Lorenz Meinel, Tessa Luhmann
Summary: This study reports the successful conjugation of murine interleukin-4 with a fibroblast activation protein inhibitor, resulting in a bioconjugate with rapid targeting to inflammatory disease sites and bioactivity.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Hye-Hyun Ahn, Christine Carrington, Yizong Hu, Heng-Wen Liu, Christy Ng, Hwanhee Nam, Andrew Park, Catherine Stace, Will West, Hai-Quan Mao, Martin G. Pomper, Christopher G. Ullman, Il Minn
Summary: Effective treatment of lung tumors in mice was achieved through nanoparticle-mediated tumor-specific gene expression, improving survival without systemic toxicity, raising hope for translation to human therapy.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Emily Hoffmann, Mirjam Gerwing, Tobias Kraehling, Uwe Hansen, Katharina Kronenberg, Max Masthoff, Christiane Geyer, Carsten Hoeltke, Lydia Wachsmuth, Regina Schinner, Verena Hoerr, Walter Heindel, Uwe Karst, Michel Eisenblaetter, Bastian Maus, Anne Helfen, Cornelius Faber, Moritz Wildgruber
Summary: This study aimed to noninvasively assess changes in tumor perfusion and vessel permeability after targeted therapy using DCE-MRI, and found that the response patterns differed between low malignant tumors and highly malignant tumors.
BREAST CANCER RESEARCH
(2023)
Article
Hematology
Marc V. A. van Moorsel, Steven de Maat, Kristof Vercruysse, Esther M. van Leeuwen, Charlene Jacqmarcq, Thomas Bonnard, Denis Vivien, H. Bart van der Worp, Rick M. Dijkhuizen, Coen Maas
Summary: Recombinant human tissue plasminogen activator (rh-tPA) and Microlyse are both important thrombolytic agents for the treatment of acute ischemic stroke, but they have different mechanisms. rh-tPA activates plasminogen by binding to fibrin, while Microlyse activates plasminogen by binding to von Willebrand factor (VWF). The study results show that both thrombolytic agents can increase cortical reperfusion and reduce cerebral lesion volume in different types of thrombus models. However, only Microlyse can reduce cerebral lesion volume in the platelet-rich model.
Article
Critical Care Medicine
Grace E. Cooper, Jemma Mayall, Chantal Donovan, Tatt J. Haw, Kurtis F. Budden, Nicole G. Hansbro, Evy E. Blomme, Tania Maes, Chia Wei Kong, Jay C. Horvat, Salim Khakoo, Tom M. A. Wilkinson, Philip M. Hansbro, Karl J. Staples
Summary: This study investigates the phenotype and antiviral responses of tissue-resident natural killer (trNK) cells in murine chronic obstructive pulmonary disease (COPD) and human COPD lung tissue. The results show that CD49a(+) NK cells in the lung have a distinct phenotype compared to circulating NK cells and their proportions increase with worsening disease. The study suggests that trNK cell function is altered in cigarette smoke-induced disease and may contribute to excessive inflammation during viral exacerbations of COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Geriatrics & Gerontology
Sara R. A. Wijnant, Elizabeth Benz, Annemarie Luik, Fernando Rivadeneira, Trudy Voortman, Guy G. Brusselle, Lies Lahousse
Summary: Frailty transitions are more common in participants with PRISm or COPD, and physical frailty assessment improves risk stratification for predicting increased life years in patients with impaired spirometry.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Respiratory System
Hannelore P. Van Eeckhoutte, Chantal Donovan, Richard Y. Kim, Thomas M. Conlon, Meshal Ansari, Haroon Khan, Ranjith Jayaraman, Nicole G. Hansbro, Yves Dondelinger, Tom Delanghe, Allison M. Beal, Brad Geddes, John Bertin, Tom Vanden Berghe, Joyceline De Volder, Tania Maes, Peter Vandenabeele, Bart M. Vanaudenaerde, Dieter Deforce, Sonja Skevin, Filip Van Nieuwerburgh, Fien M. Verhamme, Guy F. Joos, Sobia Idrees, Herbert B. Schiller, Ali Oender Yildirim, Alen Faiz, Mathieu J. M. Bertrand', Guy G. Brusselle, Philip M. Hansbro, Ken R. Bracke
Summary: RIPK1 plays a key role in COPD pathogenesis by mediating cell death and inflammation. Inhibition of RIPK1 kinase activity can alleviate airway inflammation and cell death caused by COPD, making it a potential therapeutic approach.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Critical Care Medicine
Guy Brusselle, Sebastian Riemann
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Guy Brusselle, Sebastian Riemann
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Nilakash Das, Sofie Happaerts, Iwein Gyselinck, Michael Staes, Eric Derom, Guy Brusselle, Felip Burgos, Marco Contoli, Anh Tuan Dinh-Xuan, Frits M. E. Franssen, Sherif Gonem, Neil Greening, Christel Haenebalcke, William D-C. Man, Jorge Moises, Rudi Peche, Vitalii Poberezhets, Jennifer K. Quint, Michael C. Steiner, Eef Vanderhelst, Mustafa Abdo, Marko Topalovic, Wim Janssens
Summary: Collaboration between pulmonologists and explainable AI (XAI) is superior in diagnosing pulmonary function tests (PFTs) compared to individual pulmonologists or XAI alone. XAI's suggestions improve accuracy, confidence, and inter-rater agreement of pulmonologists. Therefore, the collaboration between pulmonologists and XAI is crucial for interpreting PFTs.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Respiratory System
Guy Brusselle, Sebastian Riemann, Tania Maes
Letter
Respiratory System
Johnmary T. Arinze, Tjeerd van der Veer, Daniel Bos, Bruno Stricker, Katia M. C. Verhamme, Guy Brusselle
Letter
Respiratory System
Dave Singh, Alberto Papi, Guy Brusselle, J. Christian Virchow, Giorgio Walter Canonica, Eva Topole, Andrea Vele, George Georges
Article
Environmental Sciences
Joyceline De Volder, Annelies Bontinck, Katrien De Grove, Iris Dirven, Valerie Haelterman, Guy Joos, Guy Brusselle, Tania Maes
Summary: Experimental studies suggest that neutrophils could contribute to allergic asthma pathogenesis, that is mainly driven by type 2 immunity. Inhalation of diesel exhaust particles (DEP) is implicated in both exacerbation and development of asthma. Since exposure to DEP is associated with a neutrophilic component, we aimed to investigate how exposure to the combination of allergens and DEP modulates neutrophilic responses.
ENVIRONMENTAL POLLUTION
(2023)
Article
Respiratory System
Alberto Papi, Diogenes S. Ferreira, Ioana Agache, Eugenio Baraldi, Richard Beasley, Guy Brusselle, Courtney Coleman, Mina Gaga, Carolina Maria Gotera Rivera, Erik Melen, Ian D. Pavord, Deborah Penate Gomez, Daniel Schuermans, Antonio Spanevello, Thomy Tonia, Florence Schleich
Summary: Recent clinical trials have shown that using as-needed ICS/formoterol could be a potential treatment option for mild asthma. The European Respiratory Society's Task Force has provided evidence-based recommendations, suggesting that adults with mild asthma should use as-needed ICS/formoterol instead of regular ICS maintenance treatment plus as-needed SABA, while adolescents can choose either as-needed ICS/formoterol or ICS maintenance treatment plus as-needed SABA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
G. Brusselle, U. Himpe, P. Fievez, M. Leys, S. Perez Bogerd, R. Peche, E. Vanderhelst, M. Lins, TRIVOLVE investigators
Summary: This study investigated whether the use of single inhaler extrafine triple therapy combined with inhalation technique training can improve inhalation technique and treatment adherence in COPD patients, and evaluated its impact on patient outcomes. The results showed that this treatment approach improved inhalation technique and treatment adherence, leading to increased patient satisfaction.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Elizabeth Benz, Lies Lahousse, Johnmary T. Arinze, Sara Wijnant, Maria de Ridder, Fernando Rivadeneira, Guy Brusselle, Bruno H. Stricker
Summary: This study aimed to investigate the association between the use of OCS and muscle strength and mass in older people, as well as its interaction with chronic airway diseases. The results showed that OCS use was associated with a decline in handgrip strength in people with COPD, and this association was dependent on the frequency and duration of OCS use.