标题
Engineering the IL‐4/IL‐13 axis for targeted immune modulation
作者
关键词
-
出版物
IMMUNOLOGICAL REVIEWS
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2023-06-08
DOI
10.1111/imr.13230
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Targeting the IL4 Receptor with MDNA55 in Patients with Recurrent Glioblastoma: Results of a Phase 2b Trial
- (2023) John H Sampson et al. NEURO-ONCOLOGY
- Efficacy and Safety of Lebrikizumab in Combination With Topical Corticosteroids in Adolescents and Adults With Moderate-to-Severe Atopic Dermatitis
- (2023) Eric L. Simpson et al. JAMA Dermatology
- Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds
- (2023) Huilin Yang et al. Nature Chemical Biology
- Frequency and Clinical Significance of Elevated IgG4 in Rheumatoid Arthritis: A Systematic Review
- (2022) Rajalingham Sakthiswary et al. Biomedicines
- Engineered IL13 variants direct specificity of IL13Rα2-targeted CAR T cell therapy
- (2022) Lawrence A. Stern et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells
- (2022) Sisi Chen et al. Cell Discovery
- Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial
- (2022) Amy S Paller et al. LANCET
- Emerging principles of cytokine pharmacology and therapeutics
- (2022) Robert A. Saxton et al. NATURE REVIEWS DRUG DISCOVERY
- Comprehensive analysis of human IL‐4 receptor subunits shows compartmentalization in steady state and dupilumab treatment
- (2022) Lukas E. M. Heeb et al. ALLERGY
- Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma
- (2022) Gabriele Matschiner et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis
- (2022) Evan S. Dellon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Integration of transcriptional and metabolic control in macrophage activation
- (2021) Gioacchino Natoli et al. EMBO REPORTS
- The Enigma of Eosinophil Degranulation
- (2021) Timothée Fettrelet et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metabolism of tissue macrophages in homeostasis and pathology
- (2021) Stefanie K. Wculek et al. Cellular & Molecular Immunology
- A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL‐13Rα2‐mediated JNK‐AP‐1 signals
- (2021) Yong Sun Lee et al. Molecular Oncology
- Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
- (2021) Milena Iwaszko et al. Cells
- IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints
- (2020) Sudeepta Kumar Panda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Efficacy and Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis
- (2020) Emma Guttman-Yassky et al. JAMA Dermatology
- MEK5/ERK5 signaling mediates IL‐4‐induced M2 macrophage differentiation through regulation of c‐Myc expression
- (2020) João Paulo M. Luiz et al. JOURNAL OF LEUKOCYTE BIOLOGY
- A Small-Molecule Inhibitor to the Cytokine Interleukin-4
- (2020) Sean P. Quinnell et al. ACS Chemical Biology
- Tralokinumab for moderate‐to‐severe atopic dermatitis: results from two 52‐week, randomized, double‐blind, multicentre, placebo‐controlled phase III trials (ECZTRA 1 and ECZTRA 2)
- (2020) A. Wollenberg et al. BRITISH JOURNAL OF DERMATOLOGY
- IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis
- (2020) Heather J. Faust et al. JOURNAL OF CLINICAL INVESTIGATION
- Prolonged residence of an albumin–IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis
- (2020) Ako Ishihara et al. Nature Biomedical Engineering
- High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma
- (2020) Gloria B. Kim et al. Bioactive Materials
- De novo design of potent and selective mimics of IL-2 and IL-15
- (2019) Daniel-Adriano Silva et al. NATURE
- A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy
- (2019) Matthew T. Wolf et al. Science Translational Medicine
- IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation
- (2019) Daniela Impellizzieri et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Helper T cell differentiation
- (2019) Jordy Saravia et al. Cellular & Molecular Immunology
- Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
- (2019) Daniel J. Puleston et al. Cell Metabolism
- Th2 cell‐derived IL‐4/IL‐13 promote ILC2 accumulation in the lung by ILC2‐intrinsic STAT6 signaling in mice
- (2019) Cornelia Symowski et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Combination immunotherapy with IL-4 Pseudomonas exotoxin and IFN-α and IFN-γ mediate antitumor effects in vitro and in a mouse model of human ovarian cancer
- (2019) Daniel S Green et al. Immunotherapy
- Cell-Based Biosensors For Immunology, Inflammation, and Allergy
- (2019) Maria Eugenia Inda et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Engineering of anti-human interleukin-4 receptor alpha antibodies with potent antagonistic activity
- (2019) Jung-Eun Kim et al. Scientific Reports
- An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment
- (2019) Yi Wang et al. Frontiers in Immunology
- Mechanisms of Dupilumab
- (2019) Hani Harb et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials
- (2019) Claus Bachert et al. LANCET
- The Regulatory Effects of Interleukin-4 Receptor Signaling on Neutrophils in Type 2 Immune Responses
- (2019) Cecilie Egholm et al. Frontiers in Immunology
- Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma
- (2019) Abdolreza Esmaeilzadeh et al. BIOMEDICINE & PHARMACOTHERAPY
- A Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis
- (2018) Joseph M. Parker et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Potential Risks Related to Modulating Interleukin-13 and Interleukin-4 Signalling: A Systematic Review
- (2018) Martin Braddock et al. DRUG SAFETY
- Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma
- (2018) Klaus F. Rabe et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
- (2018) Mario Castro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes
- (2018) Ilkka S. Junttila Frontiers in Immunology
- IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View
- (2018) Achsah D. Keegan et al. Frontiers in Immunology
- IL4-10 fusion protein: a novel immunoregulatory drug combining activities of interleukin 4 and interleukin 10
- (2018) C. Steen-Louws et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- SAR156597 in idiopathic pulmonary fibrosis: a phase 2 placebo-controlled study (DRI11772)
- (2018) Ganesh Raghu et al. EUROPEAN RESPIRATORY JOURNAL
- Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2
- (2018) David E. Sanin et al. IMMUNITY
- Autocrine VEGF signalling on M2 macrophages regulates PD ‐L1 expression for immunomodulation of T cells
- (2018) Yin‐Siew Lai et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice
- (2018) Theresa M. Raimondo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-4 impairs wound healing potential in the skin by repressing fibronectin expression
- (2017) Ana P.M. Serezani et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Macrophages as Key Drivers of Cancer Progression and Metastasis
- (2017) Sebastian R. Nielsen et al. MEDIATORS OF INFLAMMATION
- Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
- (2017) David Richter et al. Nature Communications
- Sensing and responding to allergic response cytokines through a genetically encoded circuit
- (2017) Hélène Chassin et al. Nature Communications
- IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice
- (2017) Yusuke Shintani et al. Scientific Reports
- Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers
- (2017) Ignacio Moraga et al. eLife
- Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation
- (2016) Janine Woytschak et al. IMMUNITY
- Macrophages in Tissue Repair, Regeneration, and Fibrosis
- (2016) Thomas A. Wynn et al. IMMUNITY
- The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2
- (2016) Kristi J. Warren et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
- (2016) Meenakshi Hegde et al. JOURNAL OF CLINICAL INVESTIGATION
- IL-12 drives functional plasticity of human group 2 innate lymphoid cells
- (2016) Ai Ing Lim et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Shp2 Deficiency Impairs the Inflammatory Response AgainstHaemophilus influenzaeby Regulating Macrophage Polarization
- (2016) Lifang Zhao et al. JOURNAL OF INFECTIOUS DISEASES
- IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain
- (2016) N. Eijkelkamp et al. JOURNAL OF NEUROSCIENCE
- The coming of age of de novo protein design
- (2016) Po-Ssu Huang et al. NATURE
- IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity
- (2016) Yoichiro Ohne et al. NATURE IMMUNOLOGY
- IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
- (2016) Suzanne M Bal et al. NATURE IMMUNOLOGY
- An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells
- (2016) Amir Hossein Massoud et al. NATURE MEDICINE
- Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
- (2016) Eric L. Simpson et al. NEW ENGLAND JOURNAL OF MEDICINE
- OUP accepted manuscript
- (2016) PROTEIN ENGINEERING DESIGN & SELECTION
- The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation
- (2016) Preeta Dasgupta et al. Science Signaling
- IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells
- (2016) Hui Cao et al. Oncotarget
- Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
- (2016) Anthony J Covarrubias et al. eLife
- The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation
- (2016) Preeta Dasgupta et al. Science Signaling
- Insights into Cytokine–Receptor Interactions from Cytokine Engineering
- (2015) Jamie B. Spangler et al. Annual Review of Immunology
- A pharmacokinetic comparison of anrukinzumab, an anti- IL-13 monoclonal antibody, among healthy volunteers, asthma and ulcerative colitis patients
- (2015) Fei Hua et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- History of interleukin-4
- (2015) William E. Paul CYTOKINE
- Commentary: IL-4 and IL-13 receptors and signaling
- (2015) Sarah M. McCormick et al. CYTOKINE
- IL-4 and IL-13 signaling in allergic airway disease
- (2015) Naina Gour et al. CYTOKINE
- Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps
- (2015) Suman Mitra et al. IMMUNITY
- Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit
- (2015) Jakob von Moltke et al. NATURE
- Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin
- (2015) Galina Obmolova et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency
- (2015) Ignacio Moraga et al. Science Signaling
- Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis
- (2015) Lina Schukur et al. Science Translational Medicine
- Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies
- (2015) Nicola A Hanania et al. THORAX
- Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency
- (2015) Ignacio Moraga et al. Science Signaling
- Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial
- (2015) Christopher E Brightling et al. Lancet Respiratory Medicine
- Sublingual immunotherapy alters expression of IL-4 and its soluble and membrane-bound receptors
- (2014) C. E. Nestor et al. ALLERGY
- T cells redirected to interleukin-13Rα2 with interleukin-13 mutein–chimeric antigen receptors have anti-glioma activity but also recognize interleukin-13Rα1
- (2014) Simone Krebs et al. CYTOTHERAPY
- Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis
- (2014) Bo Tao et al. JOURNAL OF IMMUNOLOGY
- Catalytic Mechanism of Histone Acetyltransferase p300: From the Proton Transfer to Acetylation Reaction
- (2014) Xinlei Zhang et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor
- (2014) Ann M Leen et al. MOLECULAR THERAPY
- A designer cell-based histamine-specific human allergy profiler
- (2014) David Ausländer et al. Nature Communications
- Eosinophil Secretion of Granule-Derived Cytokines
- (2014) Lisa A. Spencer et al. Frontiers in Immunology
- Mast Cell Mediators: Their Differential Release and the Secretory Pathways Involved
- (2014) Tae Chul Moon et al. Frontiers in Immunology
- In Vitro Assessment of IL-4- or IL-13-Mediated Changes in the Structural Components of Keratinocytes in Mice and Humans
- (2013) Miyuki Omori-Miyake et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab
- (2013) Mark Ultsch et al. JOURNAL OF MOLECULAR BIOLOGY
- The TSC-mTOR pathway regulates macrophage polarization
- (2013) Vanessa Byles et al. Nature Communications
- Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2
- (2013) Chuan Hua He et al. Cell Reports
- Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation
- (2012) Andrew Q Ford et al. BMC IMMUNOLOGY
- STAT6-dependent and -independent mechanisms in Th2 polarization
- (2012) Elisabeth Maier et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti–IL-4 receptor α antagonist
- (2012) Rebecca E. Slager et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Regulation of inflammation by interleukin-4: a review of “alternatives”
- (2012) Irina G. Luzina et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines
- (2012) Ilkka S Junttila et al. Nature Chemical Biology
- IL-4 Engagement of the Type I IL-4 Receptor Complex Enhances Mouse Eosinophil Migration to Eotaxin-1 In Vitro
- (2012) Nicola M. Heller et al. PLoS One
- Cytokine release from innate immune cells: association with diverse membrane trafficking pathways
- (2011) P. Lacy et al. BLOOD
- Preclinical development of CAT-354, an IL-13 neutralizing antibody, for the treatment of severe uncontrolled asthma
- (2011) RD May et al. BRITISH JOURNAL OF PHARMACOLOGY
- Alternative activation of macrophages by IL-4 requires SHIP degradation
- (2011) Shelley B. Weisser et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- An Anti-Inflammatory Role for Carbon Monoxide and Heme Oxygenase-1 in Chronic Th2-Mediated Murine Colitis
- (2011) S. Z. Sheikh et al. JOURNAL OF IMMUNOLOGY
- Silencing IL-13R 2 Promotes Glioblastoma Cell Death via Endogenous Signaling
- (2011) L. C. Hsi et al. MOLECULAR CANCER THERAPEUTICS
- Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway
- (2011) Robert M. Anthony et al. NATURE
- Lebrikizumab Treatment in Adults with Asthma
- (2011) Jonathan Corren et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interleukin-13 Signaling and Its Role in Asthma
- (2011) Efren L. Rael et al. World Allergy Organization Journal
- Expression of IL-4/IL-13 receptors in differentiating human airway epithelial cells
- (2010) Steven R. White et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Paradoxical Roles of IL-4 in Tumor Immunity
- (2010) Zhiguang Li et al. Cellular & Molecular Immunology
- DARPins against a functional IgE epitope
- (2010) Michael J. Baumann et al. IMMUNOLOGY LETTERS
- IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist
- (2010) Rebecca E. Slager et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- IgE, mast cells, basophils, and eosinophils
- (2010) Kelly D. Stone et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- More alternative activation of macrophages in lungs of asthmatic patients
- (2010) Barbro N. Melgert et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Selective Expansion of Chimeric Antigen Receptor-targeted T-cells with Potent Effector Function using Interleukin-4
- (2010) Scott Wilkie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma
- (2010) S. Kunwar et al. NEURO-ONCOLOGY
- Molecular Basis for Shared Cytokine Recognition Revealed in the Structure of an Unusually High Affinity Complex between IL-13 and IL-13Rα2
- (2010) Patrick J. Lupardus et al. STRUCTURE
- Inhaled vs subcutaneous effects of a dual IL-4/IL-13 antagonist in a monkey model of asthma
- (2009) A. Tomkinson et al. ALLERGY
- Epigenetic regulation of the alternatively activated macrophage phenotype
- (2009) M. Ishii et al. BLOOD
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- IL-13 receptor-α2: a novel target for cancer therapy
- (2009) Bharat H Joshi et al. Immunotherapy
- IL-4R , a New Member that Associates with Syk Kinase: Implication in IL-4-Induced Human Neutrophil Functions
- (2009) J. Ennaciri et al. JOURNAL OF IMMUNOLOGY
- Epitope Mapping of Anti-Interleukin-13 Neutralizing Antibody CNTO607
- (2009) Alexey Teplyakov et al. JOURNAL OF MOLECULAR BIOLOGY
- Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
- (2009) Kazuyo Moro et al. NATURE
- Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System
- (2008) Sherry L. LaPorte et al. CELL
- Reoxygenation of Hypoxic Glioblastoma Multiforme Cells Potentiates the Killing Effect of an Interleukin-13-Based Cytotoxin
- (2008) T. F. Liu et al. CLINICAL CANCER RESEARCH
- Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system
- (2008) Y. Kondo et al. INTERNATIONAL IMMUNOLOGY
- Interleukin-13 Neutralization by Two Distinct Receptor Blocking Mechanisms Reduces Immunoglobulin E Responses and Lung Inflammation in Cynomolgus Monkeys
- (2008) M. T. Kasaian et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages
- (2008) N. M. Heller et al. Science Signaling
- Cellular and molecular mechanisms of fibrosis
- (2007) TA Wynn JOURNAL OF PATHOLOGY
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