Review
Pharmacology & Pharmacy
Celine Deraison, Chrystelle Bonnart, Philippe Langella, Karine Roget, Nathalie Vergnolle
Summary: Elafin and its precursor trappin-2 play an important role in protecting the intestinal mucosal barrier from microbial invasion, especially in gut inflammation. They have shown protective effects in gut intestinal disorders associated with acute or chronic inflammation, as well as gluten sensitization disorders, through various mechanisms. The potential therapeutic application of delivering trappin-2/elafin to the intestinal mucosa surface and its role in intestinal tissue repair are also discussed.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Oncology
Zijun Zhang, Fenghuang Zhan
Summary: Type 2 cystatins are a group of small secreted protease inhibitors that play important roles in regulating cellular processes related to immune response and tumor progression. This review provides an overview of the biological similarities and differences of type 2 cystatins, their regulatory effect on human immune responses, and their roles in tumor progression, immune evasion, and metastasis.
Review
Immunology
Yanling Ai, Hengyi Wang, Qiao Zheng, Songtao Li, Jingwen Liu, Ju Huang, Jianyuan Tang, Xiangrui Meng
Summary: The global pandemic of COVID-19 has had an unprecedented and persistent impact on oncological practice, particularly for lung cancer patients who are more vulnerable to the virus. The two diseases may interact with each other, with inflammation playing a crucial role. The chronic inflammation in lung cancer patients may increase the risk of COVID-19 infection and worsen secondary damage, while the acute inflammation caused by COVID-19 may induce tumor progression or immune activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Guanglei Zhuang, Gang Chen, Li Tan, Lingli Tan, Hengyue Shan, Chao Han, Zhenfeng Zhang, Jiali Shen, Xiao Zhang, Huaijiang Xiang, Kuankuan Lu, Chunting Qi, Ying Li
Summary: This study describes the lead identification and optimization of a dual inhibitor, 61, targeting OTUB1 and USP8. It demonstrates highly potent and selective inhibition of both targets, resulting in antiproliferative effects in non-small-cell lung cancer cell lines and tumor growth mitigation in vivo. These findings highlight the potential of dual DUB inhibition as a therapeutic strategy for treating NSCLC.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Respiratory System
Ama-Tawiah Essilfie, Neralee Houston, Pramila Maniam, Gunter Hartel, Satomi Okano, David W. W. Reid
Summary: Imbalance of proteases and anti-proteases in the lung can lead to tissue damage, especially in patients with cystic fibrosis. Deficiency of SLPI in the airway is associated with reduced lung function. Treatment with antibiotics after infection can improve anti-protease defenses and enhance lung function.
Review
Immunology
Richard A. Strugnell
Summary: IgA deficiency is a common immunodeficiency disease that affects a significant number of individuals. Recent studies have shown that the removal of secretory IgA can have subtle inflammatory consequences, suggesting a potential role for the excretory immune system in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Megan Osbourn, Aoife M. Rodgers, Alice V. Dubois, Donna M. Small, Fiachra Humphries, Nezira Delagic, Paul N. Moynagh, Sinead Weldon, Clifford C. Taggart, Rebecca J. Ingram
Summary: The study reveals the important role of secretory leucoprotease inhibitor (SLPI) in controlling Pseudomonas aeruginosa infection and suppressing inflammatory responses. Mice lacking SLPI showed enhanced susceptibility to P. aeruginosa infection, while administration of human recombinant SLPI attenuated inflammation. These findings suggest that SLPI could be a promising therapeutic strategy for inflammatory diseases.
Article
Gastroenterology & Hepatology
Ying Xie, Lindsey Fontenot, Andrea Chupina Estrada, Becca Nelson, Jiani Wang, David Q. Shih, Wendy Ho, S. Anjani Mattai, Florian Rieder, Dane D. Jensen, Nigel W. Bunnett, Hon Wai Koon
Summary: The study demonstrates that Elafin can suppress collagen synthesis in intestinal fibroblasts by inhibiting protease-activated receptor 2, which is dependent on cathelin S, leading to a reduction in intestinal fibrosis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tatiana F. R. Costa, Amy Goundry, Alexandre Morrot, Dennis J. Grab, Jeremy C. Mottram, Ana Paula C. A. Lima
Summary: This study reveals the mechanism of Trypanosoma brucei rhodesiense penetration through the blood-brain barrier and causing sleeping sickness. The Cathepsin L-like cysteine peptidase and its endogenous inhibitor ICP play important roles in the infection process and regulate inflammatory responses. The results suggest that ICP helps to downregulate inflammatory responses and control the infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Brice Korkmaz, Anne-Sophie Lamort, Roxane Domain, Celine Beauvillain, Artur Gieldon, Ali Oender Yildirim, Georgios T. Stathopoulos, Moez Rhimi, Dieter E. Jenne, Ralph Kettritz
Summary: Cathepsin C plays a crucial role in cancer development and metastasis, and is considered as a potential therapeutic target for various types of cancer. Recent studies have highlighted the important interaction between tumor-associated CatC, NSPs, and NETs in cancer progression, providing new insights for cancer treatment strategies.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Immunology
Indiwari Gopallawa, Ruchika Dehinwal, Vaibhav Bhatia, Vikramsingh Gujar, Narendra Chirmule
Summary: Lungs are vital organs involved in gas exchange and are directly affected by allergens, inflammatory mediators, and pathogens. The immune system in the lungs plays a crucial role in maintaining immune homeostasis. Imbalances and dysregulations in the immune responses can lead to inflammatory and autoimmune diseases. This review focuses on the immunology of the lungs, advancements in therapies, and the impact of inhalation devices in managing lung diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alba Ramos-Llorca, Camilla Scarpellini, Koen Augustyns
Summary: This review examines the implications of proteases in the development and severity of dry eye disease and discusses the progress in utilizing protease inhibitors as potential therapeutic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jie Sun, Jinfan Li, Zhen Wu, Yuwan Liang, Rong Duan, Mengsha Zheng, Jing Wang, Derun Kong
Summary: The expression of SLPI is significantly down-regulated in HCC tissues and cell lines. Low level of SLPI predicts worse survival in HCC. Silencing of SLPI promotes HCC cell proliferation, migration and invasion, while overexpression of SLPI suppresses these abilities. SLPI plays a protective role in HCC progression by activating ER stress-mediated apoptosis of hepatoma cells through MAPK signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Zhaoming Dong, Lingna An, Mengyao Lu, Muya Tang, Haiqin Chen, Xuan Huang, Yong Hou, Guanwang Shen, Xiaolu Zhang, Yan Zhang, Qingyou Xia, Ping Zhao
Summary: SPINK7 plays a significant role in regulating immune defense in silkworms by recognizing fungal PAMP and promoting encapsulation, melanization, and other defense responses by hemocytes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Leon Hosang, Roger Cugota Canals, Felicia Joy van der Flier, Jacqueline Hollensteiner, Rolf Daniel, Alexander Flugel, Francesca Odoardi
Summary: The lung microbiota plays an important role in regulating the immune reactivity of the central nervous system and influencing the susceptibility to autoimmune disease development.
Article
Chemistry, Multidisciplinary
Berengere Villeret, Alexandra Dieu, Marjolene Straube, Brigitte Solhonne, Pika Miklavc, Sena Hamadi, Remi Le Borgne, Arnaud Mailleux, Xavier Norel, Joel Aerts, Devy Diallo, Francois Rouzet, Paul Dietl, Jean-Michel Sallenave, Ignacio Garcia-Verdugo
Article
Biochemistry & Molecular Biology
Awen Menou, Pauline Flajolet, JanWillem Duitman, Aurelien Justet, Sophie Moog, Madeleine Jaillet, Laure Tabeze, Brigitte Solhonne, Marc Garnier, Herve Mal, Pierre Mordant, Yves Castier, Aurelie Cazes, Jean-Michel Sallenave, Arnaud A. Mailleux, Bruno Crestani
Article
Immunology
Fabien Bastaert, Saade Kheir, Vinciane Saint-Criq, Berengere Villeret, Pham My-Chan Dang, Jamel El-Benna, Jean-Claude Sirard, Rome Voulhoux, Jean-Michel Sallenave
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Juliette Simonin, Emmanuelle Bille, Gilles Crambert, Sabrina Noel, Elise Dreano, Aurelie Edwards, Aurelie Hatton, Iwona Pranke, Berengere Villeret, Charles-Henry Cattart, Jean-Patrick Vrel, Valerie Urbach, Nesrine Baatallah, Alexandre Hinzpeter, Anita Golec, Lhousseine Touqui, Xavier Nassif, Luis J. Galietta, Gabrielle Planelles, Jean-Michel Sallenave, Aleksander Edelman, Isabelle Sermet-Gaudelus
SCIENTIFIC REPORTS
(2019)
Article
Engineering, Biomedical
Daniel Sanchez-Guzman, Pierre Le Guen, Berengere Villeret, Nuria Sola, Remi Le Borgne, Alice Guyard, Alix Kemmel, Bruno Crestani, Jean-Michel Sallenave, Ignacio Garcia-Verdugo
Article
Multidisciplinary Sciences
Juliette Simonin, Emmanuelle Bille, Gilles Crambert, Sabrina Noel, Elise Dreano, Aurelie Edwards, Aurelie Hatton, Iwona Pranke, Berengere Villeret, Charles-Henry Cottart, Jean-Patrick Vrel, Valerie Urbach, Nesrine Baatallah, Alexandre Hinzpeter, Anita Golec, Lhousseine Touqui, Xavier Nassif, Luis J. V. Galietta, Gabrielle Planelles, Jean-Michel Sallenave, Aleksander Edelman, Isabelle Sermet-Gaudelus
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Berengere Villeret, Brigitte Solhonne, Marjolene Straube, Flora Lemaire, Aurelie Cazes, Ignacio Garcia-Verdugo, Jean-Michel Sallenave
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
Jean-Michel Sallenave, Loic Guillot
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Saade Kheir, Berengere Villeret, Ignacio Garcia-Verdugo, Jean-Michel Sallenave
Summary: This study evaluated the effectiveness of direct pulmonary transplantation of gene-modified macrophages in a mouse model of P.a infection. The genetically modified macrophages provided protection against P.a infection and enhanced epithelial cell proliferation and tissue repair in the lungs.
Article
Biochemistry & Molecular Biology
Berengere Villeret, Reem Ghinnagow, Saade Kheir, Maelys Born-Bony, Jay K. Kolls, Ignacio Garcia-Verdugo, Jean-Michel Sallenave
Summary: This study reveals the importance of lymphocytes in fighting against Pseudomonas aeruginosa infection. The bacterium down-regulates IL-23 and IL-22 protein accumulation in the lungs, but up-regulates their RNA production. Adenovirus-mediated over-expression of IL-1, IL-23, and IL-7 can rescue mice from Pseudomonas aeruginosa-induced lethality, suggesting its potential value in locally immunosuppressed individuals like cystic fibrosis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lisa Prince, Lydie Martin-Faivre, Berengere Villeret, Daniel Sanchez-Guzman, Pierre Le Guen, Jean-Michel Sallenave, Ignacio Garcia-Verdugo
Summary: Eosinophils play a crucial role in inducing a complete vaccine response, promoting antibody secretion in the early stage of the immune response. They migrate to the lungs and secrete cytokines to activate B cells, promoting antibody production. However, the absence of eosinophils does not impair late immune responses due to a compensating mechanism involving the Th17 pathway. This study reveals a novel role for eosinophils in lung mucosal vaccination, accelerating early immune responses while regulating IgA production in the late stages.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Meeting Abstract
Respiratory System
Saade Kheir, Berengere Villeret, Nicolas Serafini, Rome Voulhoux, Ignacio Garcia Verdugo, James Di Santo, Jean-Michel Sallenave
EUROPEAN RESPIRATORY JOURNAL
(2018)
Meeting Abstract
Respiratory System
Reem Ghinnagow, Saade Kheir, Berengere Villeret, Nicolas Serafini, Ignacio Garcia-Verdugo, Jean Michel Sallenave
EUROPEAN RESPIRATORY JOURNAL
(2018)
Meeting Abstract
Respiratory System
Awen Menou, Sophie Moog, Pauline Flajolet, Jan Willem Duitman, Aurelien Justet, Brigitte Solhonne, Yves Castier, Pierre Mordant, Herve Mal, Aurelie Cazes, Jean-Michel Sallenave, Arnaud Mailleux, Bruno Crestani
EUROPEAN RESPIRATORY JOURNAL
(2017)
Article
Physiology
Aurelien Justet, Audrey Joannes, Valerie Besnard, Joelle Marchal-Somme, Madeleine Jaillet, Philipe Bonniaud, Jean Michel Sallenave, Brigitte Solhonne, Yves Castier, Pierre Mordant, Herve Mal, Aurelie Cazes, Raphael Borie, Arnaud A. Mailleux, Bruno Crestani
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2017)