Article
Clinical Neurology
Anan Shtaya, Leslie R. Bridges, Rebecca Williams, Sarah Trippier, Liqun Zhang, Anthony C. Pereira, James A. R. Nicoll, Delphine Boche, Atticus H. Hainsworth
Summary: The study identified an anti-inflammatory process occurring alongside neuroinflammation post-sICH in clinical patients, involving native microglia and blood monocytes. This novel pathway offers therapeutic targets and a treatment opportunity window for delivering therapeutics through invading monocytes during 3-5 days post-sICH.
Article
Cell Biology
Chuang Guo, Pengfei Cai, Liying Jin, Qing Sha, Qiaoni Yu, Wen Zhang, Chen Jiang, Qian Liu, Dandan Zong, Kun Li, Jingwen Fang, Fangting Lu, Yanshi Wang, Daojing Li, Jun Lin, Lu Li, Zhutian Zeng, Xianhong Tong, Haiming Wei, Kun Qu
Summary: The study revealed significant differences in the distribution of decidual immune cell subsets in patients with recurrent pregnancy loss, as well as a reduced proportion of NK cells supporting embryo growth. Furthermore, alterations in cellular interactions between immune cell subsets within the decidua and those with stromal cells and extravillous trophoblast were observed in the disease state.
Article
Medicine, Research & Experimental
P. Vishnyakova, A. Poltavets, E. Karpulevich, A. Maznina, V. Vtorushina, L. Mikhaleva, E. Kananykhina, A. Lokhonina, S. Kovalchuk, A. Makarov, A. Elchaninov, G. Sukhikh, T. Fatkhudinov
Summary: Macrophages play a crucial role in innate immunity and are activated by various factors. This study found that macrophages derived from CD14+ monocytes exhibit higher sensitivity to pro-inflammatory induction, showing increased levels of pro-inflammatory and anti-inflammatory cytokines compared to CD16+-derived macrophages. This data may be valuable for macrophage-based cell therapy applications, providing insights for manipulating donor monocytes for transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Buesra Geckin, Gizem Kilic, Priya A. Debisarun, Konstantin Fohse, Azahara Rodriguez-Luna, Pablo Fernandez-Gonzalez, Ana Lopez Sanchez, Jorge Dominguez-Andres
Summary: The proper functioning of the immune system relies on the balance between pro-inflammation and anti-inflammation. Disruption of this balance can lead to autoimmune or inflammatory diseases. A fungal compound called AM3 has been found to modulate immune responses by decreasing excessive cytokine production and maintaining the capacity of immune cells to respond to stimuli. AM3 may help reduce immune activation and keep immune responses within a normal range.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Toxicology
Adelaide Sousa, Ana T. Rufino, Rui Fernandes, Ana Malheiro, Felix Carvalho, Eduarda Fernandes, Marisa Freitas
Summary: Silver nanoparticles exert harmful effects on both monocytes and macrophages, through the establishment of a strong pro-inflammatory response that leads to cell death. Smaller polyvinylpyrrolidone-coated silver nanoparticles exhibit more pronounced cytotoxic effects. Human monocytes are more sensitive to silver nanoparticle exposure compared to human macrophages.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Immunology
Marco Orecchioni, Hiroaki Matsunami, Klaus Ley
Summary: Olfactory receptors in macrophages play a significant role in inflammation regulation and pathological processes. By triggering specific receptors and their ligand binding, the formation of inflammasomes and the release of inflammatory mediators can be induced.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Itay Moshkovits, Ayelet Kaminitz, Debby Reuveni, Metsada Pasmanik-Chor, Eli Brazowski, Alexander Mildner, Achim Leutz, Ehud Zigmond
Summary: This study found that immune-restricted deficiency of C/EBP beta affects the composition of hepatic mononuclear phagocytes and leads to mild spontaneous hepatitis. However, steatohepatitis-associated fibrosis is not dependent on the expression of C/EBP beta by immune cells.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Review
Cell Biology
Andreas Mamilos, Lina Winter, Volker H. Schmitt, Friedrich Barsch, David Grevenstein, Willi Wagner, Maximilian Babel, Karsten Keller, Christine Schmitt, Florian Guertler, Stephan Schreml, Tanja Niedermair, Markus Rupp, Volker Alt, Christoph Brochhausen
Summary: Macrophages have a significant impact on the biocompatibility and degradation of implanted biomaterials, making them important in biomaterial-based tissue engineering and regeneration. Understanding their functionality allows for guiding and modulating inflammation towards regeneration. This knowledge improves scaffold material biocompatibility, integration, maturation, preservation, and regeneration.
Article
Cell Biology
Zichao Luo, Erlinda The, Peijian Zhang, Yufeng Zhai, Qingzhou Yao, Lihua Ao, Qingchun Zeng, David A. Fullerton, Xianzhong Meng
Summary: This study found that monocytes enhance inflammatory responses in aortic valve interstitial cells (AVICs) to soluble extracellular matrix (ECM) protein. Monocyte beta(2)-integrin interacts with AVIC ICAM-1 to augment AVIC inflammatory responses by enhancing the activation of YAP and NF-kappa B signaling pathways.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Monica Alejandra Valtierra-Alvarado, Geanncarlo Lugo-Villarino, Fatima Duenas-Arteaga, Beatriz Elena Gonzalez-Contreras, Anahi Lugo-Sanchez, Julio Enrique Castaneda-Delgado, Roberto Gonzalez-Amaro, Omar Alberto Venegas Gurrola, Alejandra del Rocio Gonzalez Valadez, Jose Antonio Enciso-Moreno, Carmen Judith Serrano
Summary: Type 2 diabetes mellitus may not have a major impact on the bystander effect of monocyte differentiation to macrophages, despite affecting basal macrophage activation.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Cell Biology
Chengxin Zhou, Fengyang Lei, Mirja Mittermaier, Bruce Ksander, Reza Dana, Claes H. Dohlman, Demetrios G. Vavvas, James Chodosh, Eleftherios I. Paschalis
Summary: Limbal stem cell (LSC) deficiency is a common and severe complication after chemical injury to the eye. This study reveals that LSC damage is mediated by immune cell mediators, even without direct injury to LSCs. Elevated pH in the anterior chamber triggers uveal stress, release of inflammatory cytokines, and subsequent LSC damage and death.
Article
Medicine, Research & Experimental
Evangelos Triantafyllou, Cathrin L. C. Gudd, Marie-Anne Mawhin, Hannah C. Husbyn, Francesca M. Trovato, Matthew K. Siggins, Thomas O'Connor, Hiromi Kudo, Sujit K. Mukherjee, Julia A. Wendon, Christine Bernsmeier, Robert D. Goldin, Marina Botto, Wafa Khamri, Mark J. W. McPhail, Lucia A. Possamai, Kevin J. Woollard, Charalambos G. Antoniades, Mark R. Thursz
Summary: The PD-1/PD-L1 pathway regulates KC and monocyte antimicrobial responses after acute liver injury, suppressing immune response and increasing susceptibility to infections.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Zhiping Liu, Huidong Shi, Jiean Xu, Qiuhua Yang, Qian Ma, Xiaoxiao Mao, Zhimin Xu, Yaqi Zhou, Qingen Da, Yongfeng Cai, David J. R. Fulton, Zheng Dong, Akrit Sodhi, Ruth B. Caldwell, Yuqing Huo
Summary: Pathological angiogenesis leading to irreversible blindness is closely related to the abnormal retinal angiogenesis caused by microglia cells within neovascular areas. The study explores the heterogeneity of microglia associated with neovascularization and characterizes the transcriptional profiles and metabolic pathways of proangiogenic microglia in the mouse model of oxygen-induced proliferative retinopathy (PR). Several unique types of microglia associated with PR were identified and found to potentially promote retinal angiogenesis, which may have implications for the future treatment of PR and other pathological ocular angiogenesis-related diseases.
Article
Nutrition & Dietetics
Nuha A. Alkhattabi, Sowsan A. Hussein, Nesrin I. Tarbiah, Reem Y. Alzahri, Reham Khalifa
Summary: This study found that thymoquinone can enhance the immunological properties of macrophages by activating phagocytosis ability and increasing the expression of HLA-DR and the secretion of IFN-gamma. This may enhance the antigen-presentation capabilities of macrophages.
Article
Immunology
Nadeem Akhter, Shihab Kochumon, Amal Hasan, Ajit Wilson, Rasheeba Nizam, Ashraf Al Madhoun, Fatema Al-Rashed, Hossein Arefanian, Fawaz Alzaid, Sardar Sindhu, Fahd Al-Mulla, Rasheed Ahmad
Summary: The co-stimulation of IFN-gamma and LPS can enhance the expression of CCL2 through the acetylation of H3K27, leading to augmented inflammation in obesity. These findings contribute to a better understanding of the regulatory mechanisms of CCL2 in the pathogenesis of obesity.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Allergy
Ian D. Pavord, Peter J. Barnes, Catherine Lemiere, Peter G. Gibson
Summary: Optimizing asthma diagnosis is crucial for reducing the burden of asthma globally. A compound diagnostic approach and label are now required due to the complexity and heterogeneity of different forms of asthma. By recognizing typical symptoms and abnormal physiology, asthma can be identified, and further features such as eosinophilic or type 2 inflammation can be used to give a compound diagnostic label of eosinophilic asthma, which provides important information about future exacerbation risk and treatment responsiveness. Implementing treatable traits and using targeted assessment allows for a specific treatment plan based on a pragmatic and iterative process. (c) 2022 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:1-8)
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Respiratory System
Mona Bafadhel, Rosa Faner, Camille Taille, Richard E. K. Russell, Tobias Welte, Peter J. Barnes, Alvar Agusti
Summary: Inhaled corticosteroids (ICS) may have beneficial effects and potential protective mechanisms on outcomes in patients with COVID-19.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Critical Care Medicine
Mario Cazzola, Paola Rogliani, Peter J. Barnes, Francesco Blasi, Bartolome Celli, Nicola A. Hanania, Fernando J. Martinez, Bruce E. Miller, Marc Miravitlles, Clive P. Page, Ruth Tal-Singer, Maria Gabriella Matera
Summary: This paper reviews the advances in chronic obstructive pulmonary disease research and highlights the need to update the original report. New measurement tools and evaluation methods are proposed to facilitate the development of personalized treatment and precision medicine.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Alvar Agusti, Bartolome R. Celli, Gerard J. Criner, David Halpin, Antonio Anzueto, Peter Barnes, Jean Bourbeau, MeiLan K. Han, Fernando J. Martinez, Maria Montes de Oca, Kevin Mortimer, Alberto Papi, Ian Pavord, Nicolas Roche, Sundeep Salvi, Don D. Sin, Dave Singh, Robert Stockley, Victorina Lopez Varela, Jadwiga A. Wedzicha, Claus F. Vogelmeier
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Respiratory System
Don D. Sin, Dany Doiron, Alvar Agusti, Antonio Anzueto, Peter J. Barnes, Bartolome R. Celli, Gerard J. Criner, David Halpin, MeiLan K. Han, Fernando J. Martinez, Maria Montes de Oca, Alberto Papi, Ian Pavord, Nicolas Roche, Dave Singh, Robert Stockley, Victorina Lopez Varlera, Jadwiga Wedzicha, Claus Vogelmeier, Jean Bourbeau, GOLD Sci Comm
Summary: Exposure to air pollution is a major contributor to COPD worldwide. Strong public health policies should be implemented to reduce ambient air pollution, accompanied by public warning systems and advisories to alert patients when air pollution levels exceed acceptable thresholds. Patients should consider using air cleaners and filters when household particulate content exceeds acceptable levels.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Alvar Agusti, Bartolome R. Celli, Gerard J. Criner, David Halpin, Antonio Anzueto, Peter Barnes, Jean Bourbeau, MeiLan K. Han, Fernando J. Martinez, Maria Montes de Oca, Kevin Mortimer, Alberto Papi, Ian Pavord, Nicolas Roche, Sundeep Salvi, Don D. Sin, Dave Singh, Robert Stockley, M. Victorina Lopez Varela, Jadwiga A. Wedzicha, Claus F. Vogelmeier
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Suhana Ahmad, Norhayati Mohd Noor, E. A. R. Engku Nur Syafirah, Ahmad Adebayo Irekeola, Rafidah Hanim Shueb, Yean Yean Chan, Peter J. Barnes, Rohimah Mohamud
Summary: This study evaluated the efficacy and safety of anti-tumor necrosis factor (TNF) as a supplementary therapy for patients with severe asthma. The results showed that anti-TNF treatment improved asthma control, but there was limited evidence for improvement in lung function and reduction of asthma exacerbation. Therefore, prescribing anti-TNF in adults with severe asthma is unlikely.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2023)
Article
Biology
Vanessa Ho, Jonathan R. Baker, Keith R. Willison, Peter J. Barnes, Louise E. Donnelly, David R. Klug
Summary: An amplification-free sandwich hybridisation assay using a microfluidic platform is developed to detect single miRNA molecules in single cells. The absolute quantification of miRNAs at a single cell level is achieved and validated using real-time qPCR. The sensitivity of the assay is demonstrated by quantifying single miRNA molecules in nasal fluid, showing its potential utility in clinical studies.
COMMUNICATIONS BIOLOGY
(2023)
Article
Primary Health Care
Gillian Doe, Stephanie J. C. Taylor, Marko Topalovic, Richard Russell, Rachael A. Evans, Julie Maes, Karolien Van Orshovon, Anthony Sunjaya, David Scott, A. Toby Prevost, Ethaar El-Emir, Jennifer Harvey, Nicholas S. Hopkinson, Samantha S. Kon, Suhani Patel, Ian Jarrold, Nanette Spain, William D-C Man, Ann Hutchinson
Summary: This study aimed to explore perspectives on spirometry provision in primary care and the potential for artificial intelligence (AI) decision support software to improve quality and interpretation. The study found historical challenges and the impact of the pandemic on inequity in spirometry provision. It suggests delivering services closer to patients’ homes by appropriately trained staff and highlights the potential role of AI in supporting clinicians. However, sufficient validation of the software is crucial for clinician and healthcare commissioner trust in the process.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Review
Primary Health Care
Jennifer K. Quint, Amnon Ariel, Peter J. Barnes
Summary: Inhaled corticosteroids (ICS) are commonly used for asthma treatment, but their role in chronic obstructive pulmonary disease (COPD) is still a topic of debate. Recent trials have shown that ICS combined with dual bronchodilator therapy can significantly reduce exacerbations in COPD patients. However, the suggestion of a mortality benefit associated with ICS in these trials has been rejected. Observational evidence suggests that dual bronchodilation is associated with better outcomes than triple therapy in a broad population of COPD patients. It is recommended that ICS be reserved for patients with frequent or severe exacerbations and high blood eosinophils or those with concomitant asthma.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2023)
Letter
Biochemistry & Molecular Biology
Hugo C. J. Ombredane, Peter S. Fenwick, Peter J. Barnes, Mona Bafadhel, Kazuhiro Ito, Louise E. Donnelly, Jonathan R. Baker
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Meeting Abstract
Critical Care Medicine
P. Fenwick, J. R. Baker, C. K. Koss, F. Ramirez, P. J. Barnes, K. C. El Kasmi, L. E. Donnelly
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
J. R. Baker, P. S. Fenwick, C. K. Koss, H. B. Owles, K. C. El Kasmi, P. J. Barnes, L. E. Donnelly
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
R. Wysoczanski, J. R. Baker, P. Fenwick, Y. Alexandrov, C. Dunsby, P. French, P. J. Barnes, L. E. Donnelly
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)