Role of Cigarette Smoke–Induced Aggresome Formation in Chronic Obstructive Pulmonary Disease–Emphysema Pathogenesis

Parkin-mediated K63-linked polyubiquitination: A signal for targeting misfolded proteins to the aggresome-autophagy pathway

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Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration

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Autophagy: a potential therapeutic target in lung diseases

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Create and preserve: Proteostasis in development and aging is governed by Cdc48/p97/VCP

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The Hallmarks of Aging

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The activation sequence of cellular protein handling systems after proteasomal inhibition in dopaminergic cells

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Oxidative Stress in COPD

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Second hand smoke and COPD: lessons from animal studies

(2013) Monica P. Goldklang et al.   Frontiers in Physiology

Tobacco smoke induced COPD/emphysema in the animal model—are we all on the same page?

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Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy

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Acute cigarette smoke exposure impairs proteasome function in the lung

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Salubrinal Protects Against Cigarette Smoke Extract-induced HBEpC Apoptosis Likely Via Regulating the Activity of PERK-eIF2α Signaling Pathway

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Therapeutic Strategies to Correct Proteostasis-Imbalance in Chronic Obstructive Lung Diseases

(2012) M. Bodas et al.   CURRENT MOLECULAR MEDICINE

Cigarette smoke induces endoplasmic reticulum stress response and proteasomal dysfunction in human alveolar epithelial cells

(2012) Anita Somborac-Bačura et al.   EXPERIMENTAL PHYSIOLOGY

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

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Age-Related Oxidative Stress Compromises Endosomal Proteostasis

(2012) Elvira S. Cannizzo et al.   Cell Reports

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

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Critical role of CFTR-dependent lipid rafts in cigarette smoke-induced lung epithelial injury

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Autophagy in Pulmonary Diseases

(2011) Stefan W. Ryter et al.   Annual Review of Physiology

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

(2011) Bryan J. Bartlett et al.   Autophagy

Deadly triplex: Smoke, autophagy and apoptosis

(2011) Stefan W. Ryter et al.   Autophagy

The Effect of Secondhand Smoke Exposure on Markers of Elastin Degradation

(2011) Natalie Slowik et al.   CHEST

Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

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Critical Role of VCP/p97 in the Pathogenesis and Progression of Non-Small Cell Lung Carcinoma

(2011) Christopher W. Valle et al.   PLoS One

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

(2011) T.-F. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes

(2010) Sven B. Jänen et al.   GLIA

Critical Modifier Role of Membrane-Cystic Fibrosis Transmembrane Conductance Regulator-Dependent Ceramide Signaling in Lung Injury and Emphysema

(2010) M. Bodas et al.   JOURNAL OF IMMUNOLOGY

Identification of an Autophagy Defect in Smokers' Alveolar Macrophages

(2010) M. M. Monick et al.   JOURNAL OF IMMUNOLOGY

Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries

(2010) Mattias Öberg et al.   LANCET

Early-Age-Related Changes in Proteostasis Augment Immunopathogenesis of Sepsis and Acute Lung Injury

(2010) Manish Bodas et al.   PLoS One

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

(2010) Z.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Heightened Endoplasmic Reticulum Stress in the Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2009) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

COPD as a Disease of Accelerated Lung Aging

(2009) Kazuhiro Ito et al.   CHEST

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Protein Aggregate Handling and Clearance Underlie the Pathogenesis of p97/VCP-associated Disease

(2008) Jeong-Sun Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential

(2008) Neeraj Vij   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Second-hand smoke and human lung cancer

(2008) Ahmad Besaratinia et al.   LANCET ONCOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation

(2008) Changcheng Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY