Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Neurosciences
Asher A. Mendelson, Stephanie Milkovich, Timothy Hunter, Raashi Vijay, Yun-Hee Choi, Shaun Milkovich, Edward Ho, Daniel Goldman, Christopher G. Ellis
Summary: The capillary module, traditionally thought to be the building block of complex capillary networks, fails to explain how blood flow is regulated in skeletal muscle. The concept of a capillary fascicle, consisting of interconnected modules, plays a crucial role in determining blood flow distribution in skeletal muscle. The findings provide direct evidence for microvascular flow regulation at the level of the capillary module, updating the paradigm for characterizing blood flow and red blood cell distribution in capillary networks.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Cardiac & Cardiovascular Systems
Yoon Kyung Choi, Young-Myeong Kim
Summary: The interaction between CO and NO plays a crucial role in maintaining vascular homeostasis and regeneration by improving endothelial function and promoting cell-cell communication, thus sustaining the health of cardiovascular and neurovascular systems.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Amy C. Keller, Ji H. Chun, L. A. Knaub, M. M. Henckel, S. E. Hull, R. L. Scalzo, G. B. Pott, L. A. Walker, J. E. B. Reusch
Summary: This study found that housing rats in thermoneutral conditions leads to dysfunctional vasoreactivity, decreased lipid mitochondrial metabolism, and modified cellular signaling.
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Laurent Kiger, Julia Keith, Abdullah Freiwan, Alfonso G. Fernandez, Heather Tillman, Brant E. Isakson, Mitchell J. Weiss, Christophe Lechauve
Summary: This study examines the expression and cellular localization of eNOS, CyB5a, and CyB5R3 in mouse arterial endothelial cells, showing that alpha-globin can be reduced by two independent redox systems, CyB5R3/CyB5a and eNOS. These findings provide new insights into the regulation of blood vessel contractility.
Article
Engineering, Biomedical
Maheshika Somarathna, Patrick TJ. Hwang, Reid C. Millican, Grant C. Alexander, Tatyana Isayeva-Waldrop, Jennifer A. Sherwood, Brigitta C. Brott, Isabelle Falzon, Hannah Northrup, Yan-Ting Shiu, Chris J. Stubben, John Totenhagen, Ho-Wook Jun, Timmy Lee
Summary: The study found that nitric oxide plays an important regulatory role in AVF development, but there are currently no effective treatments to prevent AVF maturation failure. By using a self-assembled NO releasing nanomatrix gel, intimal hyperplasia formation can be inhibited, and vascular outward remodeling and hemodynamic adaptation can be improved, thereby enhancing AVF development. This research is crucial for providing long-term and durable vascular access for hemodialysis patients.
Article
Endocrinology & Metabolism
Y. Xu, C. Li, G. Liu, H. Zhang, S. Tian, H. Hao, Y. Hao
Summary: This study found that Ang 1-7 significantly increased NO synthesis in rat VSMCs cultured under high glucose conditions by regulating Cav-1 expression, Cav-1-eNOS interaction, oxidative stress, and intracellular Ca2+ levels.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Biochemistry & Molecular Biology
Payal Chakraborty, Ali Khamit, Edit Hermesz
Summary: This study explores the impact of twin/multiple pregnancy on fetal development and the significant role of nitric oxide (NO) in the circulation. The activation of RBC-NOS3 is significantly upregulated during weeks 33-35 of pregnancy, correlating with the birth weight of the fetuses.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Peripheral Vascular Disease
Bianca Nitzsche, Wen Wei Rong, Andrean Goede, Bjoern Hoffmann, Fabio Scarpa, Wolfgang M. Kuebler, Timothy W. Secomb, Axel R. Pries
Summary: The study introduces a new non-sprouting mode of angiogenesis, termed coalescent angiogenesis, which involves the gradual enlargement of preferential flow pathways by merging capillaries and eliminating internal tissue pillars. This process remodels the initial inefficient mesh-like capillary network into a hierarchical tree structure that ensures efficient convective transport and rapid expansion of the vasculature.
Article
Biochemistry & Molecular Biology
Jakob R. Kaeppler, Jianzhou Chen, Mario Buono, Jenny Vermeer, Pavitra Kannan, Wei-Chen Cheng, Dimitrios Voukantsis, James M. Thompson, Mark A. Hill, Danny Allen, Ana Gomes, Veerle Kersemans, Paul Kinchesh, Sean Smart, Francesca Buffa, Claus Nerlov, Ruth J. Muschel, Bostjan Markelc
Summary: This study used multiphoton microscopy to investigate the effect of radiation therapy on tumor vasculature. The results showed that there was minimal structural change in the perfused vasculature after radiation therapy, but non-perfused vessels and blind ends were significantly impaired, accompanied by apoptosis and reduced proliferation of endothelial cells.
Article
Biochemistry & Molecular Biology
Szabolcs Zahoran, Peter R. Szanto, Nikolett Bodi, Maria Bagyanszki, Jozsef Maleth, Peter Hegyi, Tamas Sari, Edit Hermesz
Summary: The study investigated the mechanisms of prenatal endothelial dysfunction induced by maternal smoking, revealing deactivation of endothelial nitric oxide synthase and up-regulation of compensatory pathways in UC vessels. Smoking-induced damage in vessels is proportional to exposure level, with increased formation of reactive oxygen species and up-regulation of highly efficient NO production pathway in primarily exposed veins.
Review
Biochemistry & Molecular Biology
J. C. DiNatale, K. M. Crowe-White
Summary: Resveratrol supplementation shows promise for improving NO-mediated vascular outcomes and blood pressure. Further research is needed to determine its effects in humans and to establish standardized tests for NO-mediated vascular outcomes.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Kazunori Igarashi, Horacio Cabral, Taehun Hong, Yasutaka Anraku, Fotios Mpekris, Triantafyllos Stylianopoulos, Thahomina Khan, Akira Matsumoto, Kazunori Kataoka, Yu Matsumoto, Tatsuya Yamasoba
Summary: Recent research has highlighted the potential of dynamic bursting in tumor vasculature as a novel route for drug delivery, allowing for the transportation of sub-100 nm nanoparticles into tumors and possibly affecting the access of other blood-borne particles. Mathematical modeling and experimental comparisons have revealed the characteristics and sizes of burst vents in tumor vasculature, as well as different types of therapeutic drugs and cells that can utilize this phenomenon for transportation.
Article
Physiology
L. Gliemann, R. Buess, M. Nyberg, H. Hoppeler, A. Odriozola, P. Thaning, Y. Hellsten, O. Baum, S. P. Mortensen
Article
Physiology
M. Bigler, D. Koutsantonis, A. Odriozola, S. Halm, S. A. Tschanz, A. Zakrzewicz, A. Weichert, O. Baum
Review
Cardiac & Cardiovascular Systems
Oliver Baum, Marius Bigler
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Review
Cardiac & Cardiovascular Systems
I. Mark Olfert, Oliver Baum, Ylva Hellsten, Stuart Egginton
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Article
Physiology
Oliver Baum, Eleonora Torchetti, Corinna Malik, Birgitte Hoier, Meegan Walker, Philip J. Walker, Adolfo Odriozola, Franziska Graber, Stefan A. Tschanz, Jens Bangsbo, Hans Hoppeler, Christopher D. Askew, Ylva Hellsten
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2016)
Article
Biology
Oliver Baum, Carole Sollberger, Andrea Raaflaub, Adolfo Odriozola, Gunnar Spohr, Sebastian Frese, Stefan A. Tschanz
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Oliver Baum, Dea Aaldijk, Anna Lena Engeli, Matthias Spree, Serge Summermatter, Christoph Handschin, Andreas Zakrzewicz
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2018)
Article
Sport Sciences
Stefan Peter Mortensen, Kamilla Munch Winding, Ulrik Winning Iepsen, Gregers Winding Munch, Niels Marcussen, Ylva Hellsten, Bente Klarlund Pedersen, Oliver Baum
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2019)
Article
Nutrition & Dietetics
Gianni Parise, Coral L. Murrant, Matthew Cocks, Tim Snijders, Oliver Baum, Michael J. Plyley
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2020)
Article
Physiology
Oliver Baum, Jonathan Bernd, Samuel Becker, Adolfo Odriozola, Benoit Zuber, Stefan A. Tschanz, Andreas Zakrzewicz, Stuart Egginton, Janine Berkholz
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Katharina Jandl, Leigh M. Marsh, Julia Hoffmann, Ayse Ceren Mutgan, Oliver Baum, Wilhelm Bloch, Helene Thekkekara-Puthenparampil, Dagmar Kolb, Katharina Sinn, Walter Klepetko, Akos Heinemann, Andrea Olschewski, Horst Olschewski, Grazyna Kwapiszewska
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Weronika Karle, Samuel Becker, Philipp Stenzel, Christoph Knosalla, Guenter Siegel, Oliver Baum, Andreas Zakrzewicz, Janine Berkholz
Summary: The study found that PML is strongly expressed in atherosclerotic coronary arteries and concentrated in smooth muscle cells in plaque areas. Transfection of cells with intact PML gene resulted in higher levels of SUMOylated proteins but lower differentiation markers, leading to increased proliferation and migration activities. PML was upregulated only after IFN-gamma stimulation, indicating its role in the molecular cascades associated with atherosclerosis pathogenesis.
Article
Biochemistry & Molecular Biology
Oliver Baum, Felicitas A. M. Huber-Abel, Martin Fluck
Summary: This study investigated the relationship between nNOS expression and capillarity in the TA muscle of mice undergoing treadmill training. The results showed that both mRNA and protein levels of nNOS were up-regulated after 28 days of treadmill training. Additionally, ZsGreen1-positive fibers in the nNOS-transfected TA muscle of trained mice exhibited higher immunofluorescence for nNOS and more capillary contacts around MHC-IIb fibers compared to ZsGreen1-negative fibers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Tom Aschman, Emanuel Wyler, Oliver Baum, Andreas Hentschel, Rebekka Rust, Franziska Legler, Corinna Preusse, Lil Meyer-Arndt, Ivana Buettnerova, Alexandra Foerster, Derya Cengiz, Luiz Gustavo Teixeira Alves, Julia Schneider, Claudia Kedor, Judith Bellmann-Strobl, Aminaa Sanchin, Hans-Hilmar Goebel, Markus Landthaler, Victor Corman, Andreas Roos, Frank L. Heppner, Helena Radbruch, Friedemann Paul, Carmen Scheibenbogen, Nora F. Dengler, Werner Stenzel
Summary: This study conducted an in-depth analysis of skeletal muscle biopsies from eleven patients who experienced enduring fatigue and post-exertional malaise after being infected with SARS-CoV-2. The results showed that these patients had fewer capillaries, thicker capillary basement membranes, and increased numbers of CD169+ macrophages in their muscle tissues. SARS-CoV-2 RNA was not detected in the muscle tissues. Additionally, complement system related proteins were found to be more abundant in the serum of patients with post-COVID exertion intolerance, which matched observations on the transcriptomic level in the muscle tissue. The researchers hypothesize that the initial viral infection may have caused immune-mediated structural changes in the microvasculature, potentially explaining the exercise-dependent fatigue and muscle pain.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Anatomy & Morphology
Oliver Baum, Lena Jentsch, Adolfo Odriozola, Stefan A. Tschanz, I. Mark Olfert
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2017)