Article
Multidisciplinary Sciences
Gusty R. T. Ryanto, Koji Ikeda, Kazuya Miyagawa, Ly Tu, Christophe Guignabert, Marc Humbert, Tomoyuki Fujiyama, Masashi Yanagisawa, Ken-ichi Hirata, Noriaki Emoto
Summary: The dysregulation of the activin A-bone morphogenetic protein receptor type 2 link in endothelium plays a critical role in the progression of pulmonary arterial hypertension. Inhibin-beta -A/activin-A in endothelial cells could be a potential pharmacotherapeutic target for the treatment of pulmonary arterial hypertension.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Pei Long, Yong Li, Qing Wen, Maohua Huang, Songtao Li, Yuning Lin, Xiaojun Huang, Minfeng Chen, Jie Ouyang, Yunlin Ao, Qi Qi, Haipeng Zhang, Wencai Ye, Guohua Cheng, Xiaoqi Zhang, Dongmei Zhang
Summary: The study shows that OTNA relaxes pulmonary arteries by antagonizing AhR, providing a potential therapeutic mechanism for PAH.
Article
Cell Biology
Mo-Li Zhu, Zhi-Tao Gao, Jun-Xiu Lu, Yang Wang, Ge Wang, Tian-Tian Zhu, Peng Li, Chao Liu, Shuang-Xi Wang, Lin Yang
Summary: The study shows that A-SeQDs can prevent pulmonary arterial hypertension by increasing endogenous tetrahydrobiopterin levels, and exert a protective effect by recoupling endothelial nitric oxide synthase.
Article
Biochemistry & Molecular Biology
Ting He, Junzhi Zhang, Ting Qiao, Zhongjun Zhang, Hui Han, Chao Yang, Yong Chen, Yiwen Ruan, Liukun Meng
Summary: This study found that the compensatory decrease of PRDC in patients with pulmonary arterial hypertension (PAH) may slow down the natural course of the disease and have therapeutic potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaofei Zhou, Yuanqing Jiang, Yuewen Wang, Linge Fan, Yunhui Zhu, Yefeng Chen, Yiran Wang, Yingyi Zhu, Hongkun Wang, Zihang Pan, Zhoubin Li, Xiaolong Zhu, Ruizhe Ren, Zhen Ge, Dongwu Lai, En Yin Lai, Ting Chen, Kai Wang, Ping Liang, Lingfeng Qin, Cuiqing Liu, Cong Qiu, Michael Simons, Luyang Yu
Summary: This study found that the FIS1 protein in endothelial mitochondria undergoes a transition between SUMOylation and deSUMOylation in hypoxia-induced pulmonary hypertension (PH). Short-term hypoxia promotes the translocation of SENP1 to endothelial mitochondria and deSUMOylation of FIS1, maintaining mitochondrial integrity and calcium communication. Prolonged hypoxia inhibits this process, leading to mitochondrial dysfunction and metabolic reprogramming.
CIRCULATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Qing-Fan Lin, Jing-Hong Rao, Shi-Mu Luo, Qing-Mu Wang, Li-Feng Deng, Xuan Chen, Chang-Di Chen, You-Fang Chen
Summary: This study found that gene polymorphisms of eNOS were associated with the development of PAH in newborns with CHD in South Fujian. Specifically, the GT/TT genotype of eNOS rs1799983 was associated with a higher risk of PAH, and this may be due to decreased nitric oxide production.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Pharmacology & Pharmacy
Ning Huang, Tian-Tian Zhu, Ting Liu, Xiao-Yue Ge, Di Wang, Hong Liu, Guang-Xuan Zhu, Zheng Zhang, Chang-Ping Hu
Summary: Pulmonary vascular remodeling is the pathological basis of pulmonary hypertension, with Endothelial-to-mesenchymal transition playing a key role in its pathogenesis. Aspirin, through inhibiting the HIF-1 alpha/TGF-beta 1/Smads/Snail signaling pathway, shows promise in ameliorating PVR in hypoxia-induced PH, suggesting it as a potential therapeutic option for patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Qianqian Wang, Jingjing Tian, Xuan Li, Xiaolin Liu, Tengfei Zheng, Yachao Zhao, Xiao Li, Hongyu Zhong, Dongdong Liu, Wencheng Zhang, Meng Zhang, Mengmeng Li, Mei Zhang
Summary: This study found that DKK1 was upregulated in patients with PH, hypoxia-induced PH mice, and human pulmonary artery endothelial cells. DKK1 regulated SHMT2 transcription, impacting cellular metabolism and mitochondrial function, leading to a proproliferative and antiapoptotic phenotype in endothelial cells. Treatment with a neutralizing anti-DKK1 antibody showed potential in attenuating PH.
Article
Multidisciplinary Sciences
Hua Mao, Luge Li, Qiying Fan, Aude Angelini, Pradip K. Saha, Huaizhu Wu, Christie M. Ballantyne, Sean M. Hartig, Liang Xie, Xinchun Pi
Summary: The role of endothelial BMPER function in glucose homeostasis is crucial, and overexpression of BMPER has been shown to alleviate insulin resistance and hyperglycemia in diabetic mice.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Wytrwal, Malgorzata Sekula-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubialka
Summary: This study investigated the covalent binding of recombinant human bone morphogenetic protein-2 and -7 in stem cells and its effects on cell adhesion, migration, and osteogenesis. The presence of both proteins enhanced cell adhesion but limited cell motility, while the presence of single proteins promoted cell migration activity. Additionally, the coexistence of the proteins significantly increased early osteogenic marker expression.
Article
Biochemistry & Molecular Biology
Annapoorna Mohandas, Jayakumar Rangasamy
Summary: This study developed an injectable nanocurcumin and arginine incorporated chitosan hydrogel to prevent hypoxia induced endothelial damage. The hydrogel showed significant antioxidant activity and biodegradation in vitro, with better release of curcumin and arginine at acidic pH. The hydrogel effectively reduced the effect of hypoxia induced endothelial dysfunction in cultured endothelial cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Ushashi C. Dadwal, Fazal Ur Rehman Bhatti, Olatundun D. Awosanya, Rohit U. Nagaraj, Anthony J. Perugini, Seungyup Sun, Conner R. Valuch, Caio de Andrade Staut, Stephen K. Mendenhall, Nikhil P. Tewari, Sarah L. Mostardo, Murad K. Nazzal, Hanisha L. Battina, Donghui Zhou, Deepa Kanagasabapathy, Rachel J. Blosser, Patrick L. Mulcrone, Jiliang Li, Melissa A. Kacena
Summary: Aging is associated with decreased vascular function and impaired fracture healing, with TPO potentially being a better alternative to BMP-2 for fracture treatment in elderly patients due to its improved angiogenic effects and lack of associated side effects.
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Yin Wu, Ye Ding, Tharmarajan Ramprasath, Ming-Hui Zou
Summary: This review highlights the importance of nitric oxide in maintaining vascular homeostasis and its role in hypertension. Recent studies suggest that BH4 treatment could be a promising therapeutic for hypertension, but abnormalities in BH4 availability can trigger pathological events that affect blood pressure regulation. Continued research in this area is crucial to improve potential therapies for treating hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Cell & Tissue Engineering
Shoichiro Kokabu, Jonathan W. Lowery, Eijiro Jimi
STEM CELLS INTERNATIONAL
(2016)
Article
Biochemistry & Molecular Biology
Shoichiro Kokabu, Chihiro Nakatomi, Takuma Matsubara, Yusuke Ono, William N. Addison, Jonathan W. Lowery, Mariko Urata, Aaron M. Hudnall, Suzuro Hitomi, Mitsushiro Nakatomi, Tsuyoshi Sato, Kenji Osawa, Tetsuya Yoda, Vicki Rosen, Eijiro Jimi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Michael S. Eaton, Nicholas Weinstein, Jordan B. Newby, Maggie M. Plattes, Hanna E. Foster, Jon W. Arthur, Taylor D. Ward, Stephen R. Shively, Ryann Shor, Justin Nathan, Hannah M. Davis, Lilian I. Plotkin, Eric M. Wauson, Brian J. Dewar, Aaron Broege, Jonathan W. Lowery
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Review
Biochemistry & Molecular Biology
Shoichiro Kokabu, Jonathan W. Lowery, Takashi Toyono, Tsuyoshi Sato, Tetsuya Yoda
Article
Cell Biology
Jonathan W. Lowery, Vicki Rosen
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2018)
Review
Physiology
Jonathan W. Lowery, Vicki Rosen
PHYSIOLOGICAL REVIEWS
(2018)
Review
Cell & Tissue Engineering
Diane R. Wagner, Sonali Karnik, Zachary J. Gunderson, Jeffery J. Nielsen, Alanna Fennimore, Hunter J. Promer, Jonathan W. Lowery, M. Terry Loghmani, Philip S. Low, Todd O. McKinley, Melissa A. Kacena, Matthias Clauss, Jiliang Li
WORLD JOURNAL OF STEM CELLS
(2019)
Review
Biology
Jon Vincze, Brian W. Skinner, Katherine A. Tucker, Kory A. Conaway, Jonathan W. Lowery, Julia M. Hum
Summary: X-linked hypophosphatemia (XLH) is a renal phosphate wasting disorder caused by loss of function mutations in the PHEX gene, characterized by elevated FGF23 levels leading to hypophosphatemia. Typical symptoms include skeletal deformities, short stature, and joint pain. Burosumab, an FDA-approved medication for XLH, effectively increases serum phosphate levels and converts inactive vitamin D to active form.
Article
Biology
Yu-Tin Hsiao, Kelli J. Manikowski, Samantha Snyder, Nicole Griffin, Ashley L. Orr, Elizabeth Q. Hulsey, Gabriella Born-Evers, Tara Zukosky, Maria E. Squire, Julia M. Hum, Corinne E. Metzger, Matthew R. Allen, Jonathan W. Lowery
Summary: NMU is a peptide with various physiological effects, including regulating bone remodeling. While NMU can enhance the activity of osteoblasts in vitro, the downstream pathway utilized by NMU in vivo remains unclear and requires further studies.
Review
Cell Biology
Kevin J. Gries, Victoria S. Zysik, Tyler K. Jobe, Nicole Griffin, Benjamin P. Leeds, Jonathan W. Lowery
Summary: The endocrine-like function of skeletal muscle in regulating bone remodeling has attracted significant attention. Multiple factors, such as exercise, aging, and inactivity, can affect both bone and muscle systems. Recent evidence suggests that soluble factors released by skeletal muscle, known as myokines, play a crucial role in the communication between muscle and bone. Understanding this interaction may lead to therapeutic opportunities for improving muscle and bone health in aging individuals.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Gabriella Born-Evers, Ashley L. Orr, Elizabeth Q. Hulsey, Maria E. Squire, Julia M. Hum, Lilian Plotkin, Catherine Sampson, Jonathan Hommel, Jonathan W. Lowery
Summary: Knocking down Nmu expression in the hypothalamus of male rats did not result in significant changes in bone mass, suggesting that hypothalamus-derived NMU does not directly regulate bone remodeling in the postnatal skeleton. Further studies are needed to determine the direct versus indirect effects of NMU on bone remodeling.
Article
Education & Educational Research
Krista L. Jackson, Oladipupo Ogunbekun, Benjamin Nick, Nicole Griffin, Tyler Hamby, Jake Herber, Julia M. Hum, Sarah Zahl, Michael Baumann, Jonathan W. Lowery
Summary: Osteopathic medical students in the United States are interested in research and perceive research experience as valuable for future career development. The primary barrier to involvement in research is the potential negative impact on coursework performance.
EDUCATION SCIENCES
(2022)
Article
Medicine, General & Internal
Tyler Hamby, Don P. Wilson, Priya Bui, Jonathan Lowery, Riyaz Basha
Summary: Our surveys provide a summary of the research opportunities currently offered by COMs in the United States. Our data demonstrates significant variability in research opportunities among COMs.
JOURNAL OF OSTEOPATHIC MEDICINE
(2022)
Article
Biology
Ruthann E. Gorrell, Madeline H. Totten, Laura J. Schoerning, Jordan B. Newby, Logan J. Geyman, Warren G. Lawless, Julia M. Hum, Jonathan W. Lowery
BMC RESEARCH NOTES
(2019)
Article
Endocrinology & Metabolism
Mehdi Shadmand, Krista Jackson, Cecelia Bender, Stephen Donnelly, Henry Guan, Kirby Tobin, Sydni Yates, Julia Hum, Jonathan W. Lowery
CLINICAL REVIEWS IN BONE AND MINERAL METABOLISM
(2018)