Article
Biochemistry & Molecular Biology
Yang Liu, Fei Wang, Zhe Li, Yanling Mu, Voon Wee Yong, Mengzhou Xue
Summary: This study found that chlorogenic acid (CGA) can provide neuroprotection in intracerebral hemorrhage (ICH) by inhibiting the expression of EMMPRIN and MMP-2/9, alleviating neuroinflammation, blood-brain barrier disruption, cell death, and brain injury.
Review
Immunology
Yang Liu, Yanling Mu, Zhe Li, Voon Wee Yong, Mengzhou Xue
Summary: This review explores the role of EMMPRIN in stroke and its pathological mechanisms. It discusses the regulation of matrix metalloproteinase expression, exacerbation of blood-brain barrier dysfunction and microvascular thrombosis, and promotion of neuroinflammation. Additionally, it summarizes various stroke treatments targeting the EMMPRIN signaling pathway, and suggests the potential of EMMPRIN as a biomarker of stroke injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Yang Liu, Zhe Li, Suliman Khan, Ruiyi Zhang, Ruixue Wei, Yan Zhang, Mengzhou Xue, V. Wee Yong
Summary: The study demonstrates that minocycline plays a protective role in ICH by reducing EMMPRIN and MMP-9 expression, alleviating BBB disruption, inhibiting neuroinflammation, and decreasing neuronal degeneration and death.
NEUROSCIENCE LETTERS
(2021)
Review
Clinical Neurology
Yang Liu, Lingxiao Qi, Zhe Li, V. Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a disease caused by cerebrovascular damage, leading to hematoma enlargement, brain edema, and physical injury in the brain parenchyma. Matrix metalloproteinases (MMPs) are a group of endopeptidases that can degrade components of the extracellular matrix and promote neuroinflammation. After ICH, several MMPs are upregulated and may have different functions at different stages. The glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) induces the production of MMPs. The interactions between MMPs and EMMPRIN/CD147 in ICH are complex.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Chemistry, Medicinal
Panagiotis Theofilis, Marios Sagris, Evangelos Oikonomou, Alexios S. Antonopoulos, George Lazaros, Anastasios Theofilis, Charalambos Papastamos, Spyridon Papaioannou, Gerasimos Siasos, Kostas Tsioufis, Dimitris Tousoulis
Summary: Atherosclerosis and coronary artery disease are significant causes of morbidity and mortality worldwide, requiring early detection and treatment. Extracellular matrix remodeling plays a crucial role in this process, and indicators of matrix degradation have been studied in relation to the existence, severity, and prognosis of coronary artery disease.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Lokender Kumar, Monish Bisen, Azhar Khan, Pradeep Kumar, Sanjay Kumar Singh Patel
Summary: This review discusses the role of MMPs in skeletal muscle function, muscle injury and repair, as well as the potential applications of MMPs in the treatment of musculoskeletal disorders.
Review
Biotechnology & Applied Microbiology
Victor Alfonso Solarte David, Viviana Raquel Guiza-Argueello, Martha L. Arango-Rodriguez, Claudia L. Sossa, Silvia M. Becerra-Bayona
Summary: The absence or damage of tissue is a major cause of diseases, and novel therapeutic alternatives aim to recover lost functions through tissue regeneration. Chronic cutaneous lesions are common wounds that require regenerative medicine and tissue engineering interventions to develop bioactive medical products for proper healing and prevention of complications. The coordination of cells, extracellular matrix (ECM), and biomolecules is crucial in tissue repair and regeneration, with ECM acting as a biological platform for their interactions. Tissue engineering utilizes synthetic polymers and decellularized tissues to mimic native ECM and provide necessary functionalities for cell differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Shuyan Li, Shiheng Lu, Lei Zhang, Shasha Liu, Lei Wang, Kai Lin, Jialun Du, Meixia Song
Summary: This study demonstrates that EMMPRIN and MMP-14 are upregulated in diabetic retinopathy (DR), with plasma levels positively correlated with other proteins (MMP-9 and VEGF). Experimental evidence shows that EMMPRIN promotes endothelial cell apoptosis and angiogenesis in DR through MMP-14, suggesting a potential role for plasma EMMPRIN and MMP-14 in predicting short-term prognosis of DR.
Article
Biology
Mehtap Yuksel Egrilmez, Semra Kocturk, Sebnem Aktan, Gulgun Oktay, Halil Resmi, Hatice Simsek Keskin, Gul Guner Akdogan, Sebnem Ozkan
Summary: Melatonin can protect against the adverse effects of UVB radiation by inhibiting MMP-1 and MMP-3 activity, and increasing TIMP-1 and PIP-C levels.
Article
Biochemistry & Molecular Biology
Hae Dong Jeong, Jin Hyung Kim, Go Eun Kwon, Seung-Taek Lee
Summary: Polyamine oxidase (PAOX) is an enzyme involved in the polyamine catabolism pathway and plays a crucial role in skin aging by generating hydrogen peroxide. Our study found that PAOX expression increased the secretion of MMP-1 and collagen degradation in fibroblast cultures, and this effect was mediated through the activation of specific signaling pathways and the increase in ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jiangli Lang, Chen Yang, Lixuan Liu, Li Li, Liangyan Wu, Yanyan Liu, Hengli Luo, Li Yan, Sifan Chen, Jie Ning, Chuan Yang
Summary: The increased expression of MMP9 in diabetic skin was found to be associated with the activation of ERK1/2 by high glucose, which stabilized AP1 and led to delayed wound healing.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Marina Marozzi, Arianna Parnigoni, Aide Negri, Manuela Viola, Davide Vigetti, Alberto Passi, Evgenia Karousou, Federica Rizzi
Summary: Cancer is a complex pathology characterized by uncontrolled cell proliferation and decreased apoptosis, often in an inflammatory environment. Changes in the extracellular matrix (ECM) and signaling pathways play crucial roles in tumor growth and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Preety Choudhary, Tapasi Roy, Abhishek Chatterjee, Vineet Kumar Mishra, Suyash Pant, Snehasikta Swarnakar
Summary: Forced swim stress induces gastric ulceration by promoting ROS overproduction, while melatonin provides gastroprotection by reducing inflammation burden, inhibiting MMP-3 activity, and other mechanisms.
Review
Chemistry, Medicinal
Usman Sabir, Hong-mei Gu, Da-Wei Zhang
Summary: MMPs have a complex role in liver fibrosis, with high expression in the early stage causing tissue damage and promoting fibrosis progression, and downregulation in the later stage facilitating ECM accumulation and disease progression. Phytochemicals can modulate MMP activity and ECM turnover, alleviating disease progression, but their effects depend on disease models, stages, and the dosage, timing, and duration of phytochemicals used.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Vinay Kumar Dubey, Souradeep R. Sarkar, Vairavan Lakshmanan, Rimple Dalmeida, Akash Gulyani, Dasaradhi Palakodeti
Summary: Extracellular matrix (ECM) plays a crucial role in stem cell function and tissue homeostasis. This study reveals the regulatory role of the transcription factor ETS-1 in the expression of ECM regulator mt-mmpA, which modulates basement membrane thickness and affects stem cell migration and epidermal progenitor distribution in planarians.
JOURNAL OF CELL SCIENCE
(2022)
Article
Oncology
Miriam Victoria Martin-Manzo, Carlos Lara, Cruz Vargas-de-Leon, Julio Carrero, Gloria Queipo, Miguel Fonseca-Sanchez, Nancy R. Mejia-Dominguez, David Kershenobich, Srinivas Mummidi, Alejandro Zentella-Dehesa, Joselin Hernandez
PATHOLOGY & ONCOLOGY RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Mihwa Kim, Liza D. Morales, Cheol Jung Lee, Serena A. Olivarez, Woo Jin Kim, Joselin Hernandez, Srinivas Mummidi, Christopher Jenkinson, Andrew T. Tsin, Ik-Soon Jang, Thomas J. Slaga, Dae Joon Kim
Article
Multidisciplinary Sciences
Juan C. Lopez-Alvarenga, Geetha Chittoor, Solomon F. D. Paul, Sobha Puppala, Vidya S. Farook, Sharon P. Fowler, Roy G. Resendez, Joselin Hernandez-Ruiz, Alvaro Diaz-Badillo, David Salazar, Doreen D. Garza, Donna M. Lehman, Srinivas Mummidi, Rector Arya, Christopher P. Jenkinson, Jane L. Lynch, Ralph A. DeFronzo, John Blangero, Daniel E. Hale, Ravindranath Duggirala
Article
Cell Biology
Sergiy Sukhanov, Yusuke Higashi, Tadashi Yoshida, Srinivas Mummidi, Annayya R. Aroor, Jacob Jeffrey Russell, Shawn B. Bender, Vincent G. DeMarco, Bysani Chandrasekar
Summary: Chronic inflammation and oxidative stress play crucial roles in the development of vascular proliferative diseases. This study found that proinflammatory cytokine IL-17A can induce oxidative stress and inflammatory signaling in human aortic smooth muscle cells, which can be prevented by the SGLT2 inhibitor EMPA. EMPA exerts beneficial effects in reducing oxidative stress, inflammation, proliferation, and migration of SMC, suggesting its therapeutic potential in vascular proliferative diseases.
CELLULAR SIGNALLING
(2021)
Article
Multidisciplinary Sciences
Liza D. Morales, Douglas T. Cromack, Devjit Tripathy, Marcel Fourcaudot, Satish Kumar, Joanne E. Curran, Melanie Carless, Harald H. H. Goring, Shirley L. Hu, Juan Carlos Lopez-Alvarenga, Kristina M. Garske, Paeivi Pajukanta, Kerrin S. Small, Craig A. Glastonbury, Swapan K. Das, Carl Langefeld, Robert L. Hanson, Wen-Chi Hsueh, Luke Norton, Rector Arya, Srinivas Mummidi, John Blangero, Ralph A. DeFronzo, Ravindranath Duggirala, Christopher P. Jenkinson
Summary: The expression of ADH1B is inversely correlated with BMI in Mexican Americans, African Americans, Europeans, and Pima Indians, with BMI increasing as ADH1B expression decreases. ADH1B plays a crucial role in the development and metabolic activity of adipose tissues, which is suppressed by obesity.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Srinivas Mummidi, Vidya S. Farook, Lavanya Reddivari, Joselin Hernandez-Ruiz, Alvaro Diaz-Badillo, Sharon P. Fowler, Roy G. Resendez, Feroz Akhtar, Donna M. Lehman, Christopher P. Jenkinson, Rector Arya, Jane L. Lynch, Jose A. Canas, Ralph A. DeFronzo, Daniel E. Hale, John Blangero, Juan Carlos Lopez-Alvarenga, Ravindranath Duggirala, Jairam K. P. Vanamala
Summary: High concentrations of carotenoids, particularly alpha-carotene and beta-carotene, have protective effects against cardiometabolic risk traits in both adults and children. Genetic influences play a significant role in determining the levels of these carotenoids in serum, and they show correlations with various cardiometabolic risk factors. Further research suggests that carotenoids may have differential effects on susceptibility to cardiometabolic diseases in children.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Victoria Ramirez, Francisco A. Montano, Regina J. Bautista, Srinivas Mummidi, Juan C. Alvarenga, Claudia J. Bautista
Summary: Breast milk is the best source of nutrition for newborns, providing a wide range of nutrients and supporting the development of the immune system. Abandoning breastfeeding for various reasons can have negative consequences on organ maturation and development in offspring.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Article
Cardiac & Cardiovascular Systems
Annayya R. Aroor, Srinivas Mummidi, Juan Carlos Lopez-Alvarenga, Nitin Das, Javad Habibi, Guanghong Jia, Guido Lastra, Bysani Chandrasekar, Vincent G. DeMarco
Summary: The combination therapy of sacubitril and valsartan showed better efficacy in improving cardiac diastolic dysfunction and arterial stiffness compared to valsartan monotherapy, suggesting it is a promising treatment for cardiovascular diseases associated with obesity-related prediabetes.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Medicine, General & Internal
Juan Carlos Lopez-Alvarenga, Dora A. Martinez, Alvaro Diaz-Badillo, Liza D. Morales, Rector Arya, Christopher P. Jenkinson, Joanne E. Curran, Donna M. Lehman, John Blangero, Ravindranath Duggirala, Srinivas Mummidi, Ruben D. Martinez
Summary: The Rio Grande Valley (RGV) in South Texas has a high prevalence of obesity and type 2 diabetes (T2D). Individuals with HIV in this area may develop T2D at younger ages independent of obesity. Rigorous longitudinal studies are needed to develop better treatment regimens for the high burden of T2D in these individuals.
FRONTIERS IN MEDICINE
(2021)
Article
Hematology
Patricia Snarski, Sergiy Sukhanov, Tadashi Yoshida, Yusuke Higashi, Svitlana Danchuk, Bysani Chandrasekar, Di Tian, Vikara Rivera-Lopez, Patrick Delafontaine
Summary: Macrophage-specific overexpression of IGF-1 led to a reduction in plaque macrophages, foam cells, and atherosclerotic burden, as well as an increase in features of stable atherosclerotic plaque. This effect was likely achieved through a decrease in CXCL12-mediated monocyte recruitment and an increase in ABCA1-dependent macrophage lipid efflux.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Nayely Garibay-Nieto, Brianda Areli Hernandez-Moran, Erendira Villanueva-Ortega, Maria Jose Garces-Hernandez, Karen Pedraza-Escudero, America Arroyo-Valerio, Cesar Pedraza-Helvert, Arturo Herrera-Rosas, Estibalitz Laresgoiti-Servitje, Mireya Leon-Hernandez, Neyla Baltazar-Lopez, Joselin Hernandez-Ruiz, Fabiola Serratos-Canales, Gloria Queipo-Garcia, Sarah Elizabeth Messiah, Srinivas Mummidi, Juan Carlos Lopez-Alvarenga
Summary: This study describes the effect size of age, obesity, and insulin sensitivity on carotid intima-media thickness and finds that children with obesity display similar abnormalities to obese adults. The polynomial shape of the model may predict cardiometabolic events during early adulthood.
ENDOCRINE PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Antoine H. Chaanine, LeeAnn Higgins, Todd Markowski, Jarrod Harman, Maureen Kachman, Charles Burant, L. Gabriel Navar, David Busija, Patrice Delafontaine
Summary: Metabolic remodeling plays a significant role in the pathophysiology of heart failure, and the crosstalk between PKA and AMPK signaling governs metabolic remodeling in myocardial remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Vettriselvi Venkatesan, Juan Carlos Lopez-Alvarenga, Rector Arya, Deepika Ramu, Teena Koshy, Umarani Ravichandran, Amaresh Reddy Ponnala, Surendra K. Sharma, Sailesh Lodha, Krishna K. Sharma, Mahaboob Vali Shaik, Roy G. Resendez, Priyanka Venugopal, R. Parthasarathy, Noelta Saju, Juliet A. Ezeilo, Cynthia Bejar, Gurpreet S. Wander, Sarju Ralhan, Jai Rup Singh, Narinder K. Mehra, Raghavendra Rao Vadlamudi, Marcio Almeida, Srinivas Mummidi, Chidambaram Natesan, John Blangero, Krishna M. Medicherla, Sadagopan Thanikachalam, Thyagarajan Sadras Panchatcharam, Dileep Kumar Kandregula, Rajeev Gupta, Dharambir K. Sanghera, Ravindranath Duggirala, Solomon F. D. Paul
Summary: This study assessed the burden and genetic profile of type 2 diabetes (T2D) in endogamous populations of India. The prevalence of T2D varied among different ethnic groups, and the genetic influences on T2D and related traits differed as well.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Antoine H. Chaanine, LeeAnn Higgins, Lothar Lauterboeck, Todd Markowski, Qinglin Yang, Patrice Delafontaine
Summary: The study utilizes a multiomics approach to uncover the molecular mechanisms of BNIP3 in the pathogenesis of HFrEF, revealing its role in modulating various pathobiological processes. The findings suggest that BNIP3 could be a potential therapeutic target for HFrEF.
Article
Cell & Tissue Engineering
Antje Anji, Briana Anderson, Feroz Akhtar, David A. Meekins, Takashi Ito, Srinivas Mummidi, Meena Kumari
Summary: Exosomes from P19 neurons can induce the differentiation of UD-P19 cells into P19 neurons, providing an alternative method for cellular differentiation of neurons. This finding is important for studying the pathways of neuron development and differentiation, as well as for developing new therapeutic strategies in neuroscience.
STEM CELL REVIEWS AND REPORTS
(2023)