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Biochemistry & Molecular Biology
Jose Alberto Molina-Tijeras, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Patricia Diez-Echave, Maria Jesus Rodriguez-Sojo, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Jose Perez del Palacio, Maria Reyes Gonzalez-Tejero, Maria Elena Rodriguez-Cabezas, Julio Galvez, Alba Rodriguez-Nogales, Teresa Vezza, Francesca Algieri
Summary: Obesity, a global public health problem, is increasing in prevalence rate. Plant-based treatments, such as Lavandula multifida extract (LME), have been gaining attention as a means to manage obesity and its comorbidities. In this study, LME was found to reduce weight gain, improve insulin sensitivity and glucose tolerance, decrease inflammation in the liver and adipose tissue, regulate gut permeability, and reduce oxidative stress. These findings suggest that LME may be a promising supplementary approach for managing obesity and its comorbidities.
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Medicine, Research & Experimental
Cho-Rong Bae, Young-Guen Kwon
Summary: The endothelial dysfunction blocker CU06-1004 was found to reduce lipid accumulation and improve insulin resistance and hepatic steatosis. This may make it a potential therapeutic agent for the prevention of obesity and obesity-related disorders.
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Biochemistry & Molecular Biology
Jinhui Bian, Yi Ding, Song Wang, Yefan Jiang, Mingyan Wang, Ke Wei, Linjie Si, Xin Zhao, Yongfeng Shao
Summary: This study investigated the role of celastrol in obesity-induced ferroptosis and cardiac injury. The results showed that celastrol alleviated ferroptosis and protected against cardiac injury through activation of the AKT/GSK38 signaling pathway and reduction of lipid peroxidation and mitochondrial ROS levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
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Cell Biology
Brandee Goo, Samah Ahmadieh, Abdalrahman Zarzour, Nicole K. H. Yiew, David Kim, Hong Shi, Jacob Greenway, Stephen Cave, Jenny Nguyen, Swetha Aribindi, Mark Wendolowski, Praneet Veerapaneni, Mourad Ogbi, Weiqin Chen, Yun Lei, Xin-Yun Lu, Ha Won Kim, Neal L. Weintraub
Summary: Obesity is a major risk factor for metabolic and cardiovascular diseases. Research has found that adipocyte-specific deletion of the HDAC9 gene can alleviate obesity and metabolic diseases in female mice, but the effect is less significant in male mice. These findings reveal sex-related differences in the contribution of HDAC9 to obesity-related metabolic diseases.
Article
Pharmacology & Pharmacy
Xiangxiang Li, Jing Zhou, Zhuozhou Hu, Liang Han, Wenyang Zhao, Tongyu Wu, Chun Li, Jingjing Liu, Jia Kang, Xinping Chen
Summary: Quinacrine has been found to attenuate obesity by activating the AMPK signaling pathway to suppress adipogenesis. In an obesity model with mice, quinacrine significantly reduced body weight and energy intake, improved glucose tolerance and lipid profile, and optimized the expression of AMPK signaling pathway related proteins in the liver and adipose tissues. Quinacrine shows potential as a novel treatment for obesity and its associated diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Rongya Tao, Oliver Stohr, Caixia Wang, Wei Qiu, Kyle D. Copps, Morris F. White
Summary: This study found that disruption of hepatic insulin signaling can reduce adipose mass and increase energy expenditure in mice, preventing obesity. Moreover, a protein called Fst produced by the liver was found to regulate energy expenditure through its effects on muscles, revealing the important communication between the liver and muscles in controlling energy balance and obesity.
MOLECULAR METABOLISM
(2023)
Article
Plant Sciences
Prabhakar Yellanur Konda, Vidyasagar Chennupati, Sreenivasulu Dasari, Nishesh Sharma, Muthukumaran Muthulingam, Ranjani Ramakrishnan, Ankanna Sade, Vigneshwari Jagadheeshkumar, Vijayakumar Natesan, Krishna Kumar Jaiswal
Summary: The study demonstrates that the supplementation of Syzygium paniculatum fruit extract can effectively improve hepatic insulin resistance induced by a high-fat diet, reducing body weight, blood sugar, insulin, lipid profiles, and liver enzymes in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
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Biochemistry & Molecular Biology
Ebru S. Selen, Michael J. Wolfgang
Summary: The study revealed that activation of mTORC1 by deleting TSC1 in the liver is not enough to suppress PPAR alpha signaling or ketogenesis after fasting.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nutrition & Dietetics
Siqi Li, Mengqian Wang, Chang Li, Qingjia Meng, Yantong Meng, Jian Ying, Shuqun Bai, Qun Shen, Yong Xue
Summary: This study found that partly milled highland barley (PHB) can regulate the serum glucose and lipid disorders of mice fed a high-fat diet (HFD) and has the potential to modulate gut microbiota. PHB supplementation reduced fasting blood glucose and improved oral glucose tolerance. PHB also prevented HFD-induced gut microbiota dysbiosis, enriching beneficial bacteria and reducing HFD-dependent taxa.
Article
Endocrinology & Metabolism
Caroline M. Ancel, Maggie C. Evans, Romy Kerbus, Elliot G. Wallace, Greg M. Anderson
Summary: Neuronal PTP1B deletion partially protects mice from HCD-induced obesity but does not significantly impact HCD-induced infertility.
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Plant Sciences
Rasidat O. Tijani, Jose Alberto Molina-Tijeras, Teresa Vezza, Antonio Jesus Ruiz-Malagon, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Oyindamola O. Abiodun, Julio Galvez
Summary: The methanol extract of Myrianthus arboreus leaf showed significant therapeutic effects in a mice model of metabolic syndrome induced by a high-fat diet, including reducing weight gain, improving blood sugar and insulin resistance, and enhancing lipid profile. Additionally, the extract demonstrated potential in treating metabolic disorders through modulation of inflammatory status and gene expression related to obesity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Meredith Krause-Hauch, Julia Fedorova, Linda Ines Zoungrana, Hao Wang, Mohammad Kasim Fatmi, Zehui Li, Migdalia Iglesias, Lily Slotabec, Ji Li
Summary: This study aims to explore the interconnection between Nrf2 and Sesn2 during obesity-related stress and its role in cardio-protection. The results showed that the overexpression of Sesn2 has cardio-protective effects on the obese heart by reducing ROS and fibrosis and improving cardiac function. Similar results were observed in human heart samples. However, there was no observable pattern of Sesn2/Nrf2 expression in mouse samples.
Article
Biochemistry & Molecular Biology
Sandip Mukherjee, Molee Chakraborty, Jake Haubner, Glen Ernst, Michael DePasquale, Danielle Carpenter, James C. Barrow, Anutosh Chakraborty
Summary: Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns. LI-2242, an inhibitor of the inositol pyrophosphate pathway, shows potential therapeutic effects in obesity and NAFLD by reducing body weight, improving glycemic parameters, and ameliorating hepatic steatosis. LI-2242 also enhances mitochondrial oxygen consumption rate and insulin signaling in adipocytes and hepatocytes in vitro.
Article
Biochemistry & Molecular Biology
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Bluher, Andre Kleinridders
Summary: The intake of high-fat diets leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium can protect against the development of diet-induced insulin resistance. However, selenium might not be able to attenuate insulin resistance in the presence of obesity.