mTORC1 activation is not sufficient to suppress hepatic PPARα signaling or ketogenesis

Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease

(2021) Ebru S. Selen et al.   JCI Insight

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

(2019) David A. Cappel et al.   Cell Metabolism

Maternal Lipid Metabolism Directs Fetal Liver Programming following Nutrient Stress

(2019) Caitlyn E. Bowman et al.   Cell Reports

mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion

(2017) William J. Quinn et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance

(2017) Jieun Lee et al.   Cell Reports

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

(2017) Alison Iroz et al.   Cell Reports

Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation

(2016) Jieun Lee et al.   Cell Reports

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity

(2016) Blanka Kucejova et al.   Cell Reports

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt

(2015) Heidi L. Kenerson et al.   PLoS One

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

(2014) David G. Cotter et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

(2014) M. Cornu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

(2012) S. Menon et al.   Science Signaling

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver

(2011) KyeongJin Kim et al.   HEPATOLOGY

Resistance to High-Fat Diet-Induced Obesity and Insulin Resistance in Mice with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency

(2010) Dongyan Zhang et al.   Cell Metabolism

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE