Article
Biochemistry & Molecular Biology
Rizwan Qaisar, Gavin Pharaoh, Shylesh Bhaskaran, Hongyang Xu, Rojina Ranjit, Jan Bian, Bumsoo Ahn, Constantin Georgescu, Jonathan D. Wren, Holly Van Remmen
Summary: The study showed that pharmacological activation of SERCA can mitigate sarcopenia phenotype in aging mice, reversing reductions in muscle mass and force generation, and preventing an increase in mitochondrial ROS production. These effects are mediated in part by enhanced cellular energetics through activation of PGC1-alpha, UCP1, HSF1, and APMK, as well as increased regenerative capacity by suppression of MEF2C and p38 MAPK signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Alexander Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev
Summary: This study found that in the areas of P-up-g(CaL) parametric space at the edge of system stability, rhythmic AP firing could be rescued by populating SAN tissue models with heterogeneous cells. The effect of cell heterogeneity was synergistic with respect to heterogeneity in g(CaL) and P-up, and the transitions between firing and non-firing states resembled phase transitions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Ashley N. Wirth, Kenta Tsutsui, Victor A. Maltsev, Edward G. Lakatta
Summary: This study reveals that adenosine exerts its excitatory effect on SANC not only by activating I-KAch,I-Ado, but also by affecting Ca2+ through the G(alpha i) signaling pathway, both of which decrease AP firing rate. Adenosine increases the mean APCL and APCL variability by reducing clock coupling and AP firing rate.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew J. Wleklinski, Dmytro O. Kryshtal, Kyungsoo Kim, Shan S. Parikh, Daniel J. Blackwell, Isabelle Marty, V. Ramesh Iyer, Bjorn C. Knollmann
Summary: CASQ2-K180R causes CPVT2 through impairing dynamic buffering of Ca within the SR, which is different from other CASQ2-related forms of CPVT2.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Maren E. Arnold, Wolfgang R. Dostmann, Jody Martin, Michael J. Previs, Bradley Palmer, Martin LeWinter, Markus Meyer
Summary: This study introduces a novel biosensor that can visualize the interaction between SERCA2a and phospholamban (PLB). The biosensor combines SERCA2a, a circularly permutated green fluorescent protein, and PLB into one recombinant protein (SGP). Activation of proteinkinase A leads to phosphorylation of the PLB domain, resulting in a significant increase in fluorescence yield for real-time monitoring of SERCA2a and PLB interactions in cells.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Noemi Toth, Axel Loewe, Jozefina Szlovak, Zsofia Kohajda, Gergo Bitay, Jouko Levijoki, Julius Gy Papp, Andras Varro, Norbert Nagy
Summary: Reverse Na+/Ca2+ exchanger plays a significant role in sinus node pacemaking by increasing intracellular Ca2+ concentration and heart rate.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Veronica Jimenez-Sabado, Sergi Casabella-Ramon, Anna Llach, Ignasi Gich, Sandra Casellas, Francisco Ciruela, S. R. Wayne Chen, Jose M. Guerra, Antonino Ginel, Raul Benitez, Juan Cinca, Carmen Tarifa, Leif Hove-Madsen
Summary: This study aimed to examine the impact of I3-blocker treatment on spontaneous calcium release events or transient inward currents (ITI) in patients with atrial fibrillation (AF). The results showed that I3-blocker treatment did not affect calcium current density, but it reduced ITI frequency and calcium spark frequency, as well as the levels of phosphorylated RyR2 and phospholamban.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Physiology
Molly E. E. Streiff, Andrea C. C. Corbin, Azmi A. A. Ahmad, Chris Hunter, Frank B. B. Sachse
Summary: Transient receptor potential canonical 1 (TRPC1) channels play a critical role in the physiological regulation of cardiac function and have implications in the development of cardiac diseases. This study reveals that TRPC1 channels are involved in the mechanosensitive modulation of sarcoplasmic reticulum Ca2+ concentration, highlighting their significance in cardiac physiology and potential as therapeutic targets for cardiac diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Molly E. Streiff, Frank B. Sachse
Summary: The regulation of Ca2+ concentrations in cardiomyocytes is crucial for various physiological processes. Two types of Ca2+ currents, background Ca2+ entry and Ca2+ leak from the sarcoplasmic reticulum, play important roles in the modulation of Ca2+ transients and Ca2+ load. Our study provides quantitative insights into the individual contributions of these Ca2+ currents and supports the hypothesis that TRP channels are involved in cardiac contractility modulation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biology
Lorenzo Donald, Edward G. Lakatta
Summary: Cardiovascular science has been studying the heartbeat even before the discovery of the sinoatrial node. The field became divided between electrophysiology and muscle contraction but was later reunited by the coupled-clock theory of pacemaker cell function. Recent discoveries have contextualized this theory into the complex world of sinoatrial node tissue, conceptualizing it as a brain-like structure composed of various types of cells and networks.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Sou Inagaki, Yoshiaki Suzuki, Keisuke Kawasaki, Rubii Kondo, Yuji Imaizumi, Hisao Yamamura
Summary: In this study, the role of mitochondrial fusion protein 2 (Mfn2) in the coupling of sarcoplasmic reticulum (SR) and mitochondria in vascular smooth muscle cells (VSMCs) was examined. It was found that Mfn2 is responsible for tethering mitochondria to SR, which regulates calcium signaling, ATP production, and cell proliferation in VSMCs.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Giampaolo Morciano, Alessandro Rimessi, Simone Patergnani, Veronica A. M. Vitto, Alberto Danese, Asrat Kahsay, Laura Palumbo, Massimo Bonora, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton
Summary: Intracellular calcium signaling is a universal language shared by various biological entities inside cells, regulating physiological functions like muscle contraction through calcium channels, pumps, and exchangers. Abnormal calcium homeostasis can lead to heart diseases, but can be corrected through chemical, peptide-based, and pharmacological modulators.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Weihong He, Charlotte S. McCarroll, Katrin Nather, Kristopher Ford, Kenneth Mangion, Alexandra Riddell, Dylan O'Toole, Ali Zaeri, David Corcoran, David Carrick, Mathew M. Y. Lee, Margaret McEntegart, Andrew Davie, Richard Good, Mitchell M. Lindsay, Hany Eteiba, Paul Rocchiccioli, Stuart Watkins, Stuart Hood, Aadil Shaukat, Lisa McArthur, Elspeth B. Elliott, John McClure, Catherine Hawksby, Tamara Martin, Mark C. Petrie, Keith G. Oldroyd, Godfrey L. Smith, Keith M. Channon, Colin Berry, Stuart A. Nicklin, Christopher M. Loughrey
Summary: The study identified that direct cardiac release of cathepsin-L in STEMI patients post-PPCI leads to elevated serum levels, and higher levels in the first 24 hours post-reperfusion are associated with reduced cardiac function and increased infarct size. Preclinical studies showed that inhibiting cathepsin-L release post-reperfusion injury can reduce infarct size and improve cardiac function by limiting abnormal calcium handling and apoptosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Cathrine R. Carlson, Jan Magnus Aronsen, Anna Bergan-Dahl, Marie Christine Moutty, Marianne Lunde, Per Kristian Lunde, Hilde Jarstadmarken, Pimthanya Wanichawan, Laetitia Pereira, Terje R. S. Kolstad, Bjorn Dalhus, Hariharan Subramanian, Susanne Hille, Geir Christensen, Oliver J. Mueller, Viacheslav Nikolaev, Donald M. Bers, Ivar Sjaastad, Xin Shen, William E. Louch, Enno Klussmann, Ole M. Sejersted
Summary: This study demonstrates that AKAP18 delta anchors and regulates CaMKII activity at the sarcoplasmic reticulum, contributing to the regulation of cardiac contraction and relaxation.
CIRCULATION RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Shanna Hamilton, Radmila Terentyeva, Richard T. Clements, Andriy E. Belevych, Dmitry Terentyev
Summary: This article reviews the major cause of sudden cardiac death due to ventricular tachyarrhythmias and the enhanced propensity to malignant cardiac arrhythmias associated with heart failure, diabetic cardiomyopathy, old age related cardiac dysfunction and inherited disorders. Defective mitochondrial function and abnormal intracellular Ca2+ homeostasis have been established as key contributing factors to pathophysiology and arrhythmogenesis in these conditions. The article also discusses the bidirectional control of ryanodine receptor-mediated sarcoplasmic reticulum Ca2+ release and mitochondrial function, and how defects in crosstalk between these organelles increase arrhythmic risk in cardiac disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Clinical Neurology
Jae-wook Chung, So-Ryoung Lee, Eue-Keun Choi, Sang-Hyeon Park, HuiJin Lee, JungMin Choi, Minju Han, Hyo-Jeong Ahn, Soonil Kwon, SeungWoo Lee, Kyungdo Han, Sunhwa Kim, Seil Oh, Gregory Y. H. Lip
Summary: This study examined the association between cumulative alcohol burden and the risk for stroke in young adults. The findings showed that young adults who engaged in moderate-to-heavy drinking had a higher risk for stroke, particularly hemorrhagic stroke. Therefore, reducing alcohol consumption should be emphasized as an important strategy for stroke prevention in young adults.
Article
Medicine, General & Internal
Hanjin Park, Hee Tae Yu, Tae-Hoon Kim, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jaemin Shim, Jin-Bae Kim, Jun Kim, Eue-Keun Choi, Hyung Wook Park, Young Soo Lee, Boyoung Joung
Summary: This study compared the safety and efficacy of DOAC with warfarin or no OAC in patients with advanced CKD or ESRD on dialysis who have atrial fibrillation. It found that DOAC was associated with a lower risk of bleeding and adverse clinical outcomes compared to warfarin or no OAC.
YONSEI MEDICAL JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Hyo-Jeong Ahn, So-Ryoung Lee, Eue-Keun Choi, Seung-Woo Lee, Kyung-Do Han, Soonil Kwon, Seil Oh, Gregory Y. H. Lip
Summary: This study investigated the association between metabolic syndrome (MetS) and the risk of ischemic stroke in atrial fibrillation (AF) patients without indication for oral anticoagulants. The findings showed that MetS was associated with an increased risk of ischemic stroke in this patient population.
Article
Cardiac & Cardiovascular Systems
So-Ryoung Lee, Eue-Keun Choi, Sang-Hyun Park, Kyung-Do Han, Seil Oh, Khaled Abdelgawwad, Gregory Y. H. Lip
Summary: The study found that rivaroxaban was associated with a lower risk of adverse renal outcomes compared with warfarin in Korean patients with atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Moonki Jung, Kyeongmin Byeon, Ki-Woon Kang, Wang-Soo Lee, Sang Wook Kim, Yae Min Park, You Mi Hwang, Sung Ho Lee, Eun-Sun Jin, Seung-Young Roh, Jin Seok Kim, Jinhee Ahn, So-Ryoung Lee, Eue-Keun Choi, Min-Soo Ahn, Eun Mi Lee, Hwan-Cheol Park, Ki Hong Lee, Min Kim, Joon Hyouk Choi, Jum Suk Ko, Jin Bae Kim, Changsoo Kim, Gregory Y. H. Lip, Seung Yong Shin
Summary: This multicenter cohort study evaluated the clinical outcomes of different antithrombotic treatments in atrial fibrillation patients with non-gender CHA(2)DS(2)-VASc score 0-1. The study found that among patients with ABCD score ≥1, non-VKA oral anticoagulants showed significant net clinical benefits compared to other treatments.
JOURNAL OF ARRHYTHMIA
(2023)
Article
Cardiac & Cardiovascular Systems
Eue-Keun Choi, Jong-Il Choi, Hyoung-Seob Park, Gyo-Seung Hwang, Boyoung Joung, Jong-Youn Kim, Dae-Hyeok Kim, Dong Gu Shin, Hyung Wook Park
Summary: The effectiveness and safety of edoxaban in Korean patients with atrial fibrillation (AF) were analyzed in this study. The outcomes were similar to the global AF population, indicating that edoxaban can be used effectively and safely in Korean AF patients, including the elderly.
JOURNAL OF ARRHYTHMIA
(2023)
Article
Cardiac & Cardiovascular Systems
Tae-Min Rhee, Kyung-Yeon Lee, Jungmin Choi, Eue-Keun Choi, Hyo-Jeong Ahn, So-Ryoung Lee, Seil Oh, Gregory Y. H. Lip
Summary: This study evaluated the association between neuroticism and long-term risk of sudden cardiac death (SCD). The results showed that a high neuroticism score was significantly associated with a lower risk of SCD, especially in women.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
So-Ryoung Lee, Hyoung-Seob Park, Soonil Kwon, Eue-Keun Choi, Seil Oh
Summary: This study aimed to evaluate the efficacy and safety of personalized Ablation Index (AI) strategy based on left atrial wall thickness (LAWT) assessed by cardiac computed tomography (CT) in pulmonary vein isolation (PVI) for atrial fibrillation (AF). The results showed that the personalized AI strategy can reduce acute pulmonary vein reconnection after PVI.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Ho-Gi Chung, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jaemin Shim, Jin-Bae Kim, Jun Kim, Eue-Keun Choi, Hyung Wook Park, Young Soo Lee, Boyoung Joung
Summary: This study investigated the relationship between rhythm control and cardiovascular outcomes in a contemporary atrial fibrillation (AF) registry. No difference in the risk of cardiovascular or cerebrovascular outcomes was found between the rhythm control and rate control groups. These findings suggest that early rhythm control should be considered to improve patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Soonil Kwon, So-Ryoung Lee, Eue-Keun Choi, Seung-Woo Lee, Jin-Hyung Jung, Kyung-Do Han, Hyo-Jeong Ahn, Seil Oh, Gregory Y. H. Lip
Summary: There is an association between metabolic syndrome components and the incidence of end-stage renal disease in patients with atrial fibrillation. The higher the metabolic score, the greater the risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yong-Soo Baek, Soonil Kwon, Seng Chan You, Kwang-No Lee, Hee Tae Yu, So-Ryung Lee, Seung-Young Roh, Dong-Hyeok Kim, Seung Yong Shin, Dae In Lee, Junbeom Park, Yae Min Park, Young Ju Suh, Eue-Keun Choi, Sang-Chul Lee, Boyoung Joung, Wonik Choi, Dae-Hyeok Kim, AIAFib Trial Investigators
Summary: This study aims to validate an existing artificial intelligence-enhanced ECG algorithm for predicting paroxysmal atrial fibrillation (PAF) and investigate its association with AF-related clinical outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
So-Ryoung Lee, Eue-Keun Choi, Seung-Woo Lee, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
Summary: This study compared the risk of recurrent stroke between early rhythm control therapy and usual care in patients with new-onset atrial fibrillation and a history of prior stroke, and found that early rhythm control was associated with a lower risk of recurrent stroke.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Kunwook Jo, Hoohyun Kim, Jongdoo Choi, Yun Kwan Kim, Lan-Mi Hwang, So-Ryong Lee, Eue-Keun Choi, Hee Seok Song
Summary: In this study, we propose a semantic segmentation-based method for detecting atrial fibrillation (AF) by learning and classifying the morphological characteristics of fibrillation waves (F-waves). The method outperforms existing methods in localizing the target shape, enabling accurate detection of AF occurrences. Two models were designed and tested: a binary classification model (BCM) for classifying F-waves and a multiclass classification model (MCM) for classifying P, QRS, and T information. The results indicate that the proposed method performs better in AF event detection and localization, with the MCM-based method slightly outperforming the BCM-based method.
2023 INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE IN INFORMATION AND COMMUNICATION, ICAIIC
(2023)
Article
Medicine, General & Internal
Tae -Min Rhee, Hyo-Jeong Ahn, Sunhwa Kim, So-Ryoung Lee, Eue-Keun Choi, Seil Oh
Summary: The electro-mechanical coupling index electromechanical window (EMW) can be used to predict fatal ventricular arrhythmias. The study found that EMW has an additive effect in predicting fatal ventricular arrhythmias in high-risk patients with implantable cardioverter-defibrillator (ICD) devices.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
So-Ryoung Lee, Jungmin Choi, Eue-Keun Choi, Huijin Lee, Minju Han, Hyo-Jeong Ahn, Soonil Kwon, Seung-Woo Lee, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
Summary: This observational cohort study evaluated the impact of early rhythm control on patients with T2DM and AF. The results showed that early rhythm control was associated with reduced risks of ischemic stroke, macrovascular and microvascular complications, and all-cause death.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)