Article
Pharmacology & Pharmacy
Yixin Han, Xiaoyu Zhang, Yuan Kang, Yuan Gao, Ximeng Li, Ruijuan Qi, Runlan Cai, Yun Qi
Summary: The study found that sophoraflavanone M (SFM) has anti-inflammatory effects, reducing the production of inflammatory mediators in vivo and in vitro. SFM acts on both NF-κB and JNK/AP-1 signaling pathways, indicating its potential as a natural candidate for alleviating inflammatory conditions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qian Lu, Chao Jiang, Jialong Hou, Hao Qian, Feifan Chu, Weiqi Zhang, Mengke Ye, Ziyi Chen, Jian Liu, Hanbing Yao, Jianfeng Zhang, Jiake Xu, Te Wang, Shunwu Fan, Qingqing Wang
Summary: The incidence of osteoporosis is increasing, especially in postmenopausal women. Patchouli alcohol (PA), a natural compound with anti-inflammatory effects, has shown inhibitory effects on osteoclasts and may be a potential treatment for osteoporosis in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Guibao Ke, Xueqin Chen, Ruyi Liao, Lixia Xu, Li Zhang, Hong Zhang, Sujuan Kuang, Yue Du, Juan Hu, Zhiwen Lian, Caoshuai Dou, Qianmei Zhang, Xingchen Zhao, Fengxia Zhang, Shuangshuang Zhu, Jianchao Ma, Zhuo Li, Sijia Li, Chaosheng He, Xia Chen, Yingzhen Wen, Zhonglin Feng, Minghao Zheng, Ting Lin, Ruizhao Li, Bohou Li, Wei Dong, Yuanhan Chen, Wenjian Wang, Zhiming Ye, Chunyu Deng, Houqin Xiao, Jie Xiao, Xinling Liang, Wei Shi, Shuangxin Liu
Summary: The expression of Receptor activator of NF-kappa B (RANK) is increased in podocytes of patients with diabetic nephropathy. Mouse models of podocyte-specific RANK depletion and overexpression showed that RANK depletion alleviated the development of kidney diseases, while RANK overexpression aggravated the condition. The findings suggest that RANK mediates the development of diabetic nephropathy by promoting glomerular oxidative stress and proinflammatory cytokine production.
KIDNEY INTERNATIONAL
(2021)
Article
Immunology
Yuan Gao, Zhenlu Xu, Ximeng Li, Zhuangzhuang Liu, Wenjing Li, Yuan Kang, Xiaoyu Zhang, Yun Qi
Summary: Resibufogenin (RBG), one of the major active components in toad venom, has significant anti-inflammatory activity by reducing inflammatory mediators and inhibiting NF-kappa B and AP-1 signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Huijiang Liu, Ronghe Gu, Qian Huang, Yun Liu, Chong Liu, Shijie Liao, Wenyu Feng, Tianyu Xie, Jinmin Zhao, Jiake Xu, Qian Liu, Xinli Zhan
Summary: This study found that isoliensinine can inhibit the differentiation of osteoclasts and reduce bone loss, showing great potential for treating osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eiichi Kusagawa, Chiharu Okuda, Rikako Yamaguchi, Kaori Nakano, Yasunobu Miyake, Takao Kataoka
Summary: Cucurbitacin B down-regulates TNF-alpha-induced ICAM-1 expression and inhibits the inflammatory response in lung adenocarcinoma cells by modulating the TNF-R1 expression in the NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Magdalena Kopytek, Michal Zabczyk, Piotr Mazur, Anetta Undas, Joanna Natorska
Summary: This study aimed to investigate the effect of LDL cholesterol on plasminogen activator inhibitor 1 (PAI-1) expression in aortic stenosis (AS). Results showed that PAI-1 expression in stenotic valves was correlated with lipid accumulation and AS severity, and co-expressed with nuclear factor-κB (NF-κB). In vitro experiments demonstrated that LDL stimulation increased PAI-1 levels and prolonged clot lysis time (CLT). Inhibition of PAI-1 activity or NF-κB pathway shortened CLT. These findings suggest that valvular PAI-1 overexpression driven by lipid accumulation contributes to hypofibrinolysis and AS severity in severe AS patients.
Article
Fisheries
Tong Zhang, Jiejie Sun, Liyan Wang, Hongsheng Yao, Zhicheng Guo, Wei Wu, Yinan Li, Lingling Wang, Linsheng Song
Summary: CgBCL10, a homologue identified in Pacific oysters, plays a crucial role in regulating the expression of inflammatory cytokines by activating MAPK kinase, and nuclear translocation of NF-KB/Rel and AP-1 to defend against pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Joanna Filipowska, Nagesha G. Kondegowda, Nancy Leon-Rivera, Sangeeta Dhawan, Rupangi C. Vasavada
Summary: LGR4 is a marker for intestinal crypt stem cells that binds R-spondins/Norrin and plays a crucial role in the enhancement of Wnt signaling. In addition to its role in development, LGR4 has been found to participate in the regulation of TGF beta and NF kappa B signaling, act as an alternative receptor for RANKL in bone cells, trigger anti-inflammatory responses in various tissues, regulate circadian rhythm, adipogenesis, and energy expenditure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Luodan Zhang, Fa Zeng, Minmin Jiang, Maozhen Han, Binbin Huang
Summary: This article reviews the potential role and therapeutic potential of osteoprotegerin in endocrine and metabolic diseases. It mainly focuses on the effects of osteoprotegerin through the RANKL/RANK/OPG system on various processes such as bone remodeling, vascular calcification, and beta-cell proliferation, providing a comprehensive understanding of osteoprotegerin as a potential drug for these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Mohamed Sadek Abdel-Bakky, Abdulmajeed Alqasoumi, Waleed Mohammad Altowayan, Elham Amin, Mostafa Assem Darwish
Summary: The study investigated the roles of ADAM10 and ADAM17 in T1DM, and the protective effects of SIM in STZ-induced T1DM. The results showed that SIM could reduce pancreatic inflammation and cell apoptosis, and decrease the expression of key proteins, alleviating the pathological damage of T1DM.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Biochemistry & Molecular Biology
Na Yang, Minxiu Wang, Ke Lin, Mengyang Wang, Diyun Xu, Xue Han, Xia Zhao, Yi Wang, Gaojun Wu, Wu Luo, Guang Liang, Peiren Shan
Summary: The study demonstrates that Dectin-1 plays a critical role in the pathogenesis of diabetic cardiomyopathy by regulating inflammation. Dectin-1 deficient mice are protected against diabetes-induced cardiac dysfunction, cardiomyocyte hypertrophy, tissue fibrosis, and inflammation. Dectin-1 may be a potential target for the treatment of diabetic cardiomyopathy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Chemistry, Applied
Jinyang Cai, Xin Li, Xing Wang, Chengfei Jiang, Dan Shen, Xianwei Cui, Kaipeng Xie, Chenbo Ji, Yan Cao
Summary: In this study, a novel peptide named BCCY-1 corresponding to human beta-casein sequence was identified in human milk, showing immunomodulatory activity by enhancing monocyte migration. BCCY-1 exerts its effects by activating NF-κB and MAPK signaling pathways.
Article
Endocrinology & Metabolism
Zahirrah BM. Rasheed, Yun S. S. Lee, Sung H. H. Kim, Tg Teoh, David A. A. MacIntyre, Phillip R. R. Bennett, Lynne Sykes
Summary: The study found that 15dPGJ2 has differential effects on inflammatory modulation depending on cell type, and is therefore unlikely to be a useful therapeutic agent for the prevention of preterm birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Stephan List, Christian Meinhardt, Julian Mueller, Thomas Deneke, Sebastian Barth, Christian Waechter, Ulrich Luesebrink, Albrecht Elsaesser, Alexander Arlt, Philipp Halbfass
Summary: The aim of this study was to evaluate the incidence of ablation-induced esophageal lesions and gastroparesis in patients undergoing high-power short-duration atrial fibrillation ablation using different target ablation index values. The results showed that 18.5% of patients had esophageal lesions or gastroparesis after ablation, and this was associated with higher ablation index values and lower body mass index.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Thilo Wedel, Marvin Heimke, Jordan Fletcher, Danilo Miskovic, Stefan Benz, Sigmar Stelzner, Tillmann Heinze
Summary: This study determined the optimal surgical dissection planes for right hemicolectomy with complete mesocolic excision (CME) based on anatomical studies. Using clear anatomical terms instead of confusing eponyms to describe the retrocolic fascial system and surgical planes for CME can improve surgical accuracy.
COLORECTAL DISEASE
(2023)
Letter
Gastroenterology & Hepatology
Thilo Wedel, Marcos Gomez Ruiz, Samson Tou, Sigmar Stelzner, Klaus E. Matzel
COLORECTAL DISEASE
(2023)
Article
Cell Biology
Claudia Geismann, Charlotte Hauser, Frauke Grohmann, Christian Schneeweis, Nico Boelter, Jan-Paul Gundlach, Gunter Schneider, Christoph Roecken, Christian Meinhardt, Heiner Schaefer, Stefan Schreiber, Alexander Arlt
Summary: The resistance to systemic therapies in PDAC remains a major challenge in clinical practice, and NF-kappa B activity plays a crucial role in this process. A20, identified as an NF-kappa B target gene, is associated with elevated RelA expression in PDAC patients. Elevated A20 expression leads to resistance to TRAIL-induced apoptosis but not to chemotherapeutic-induced cell death, mediated by its E3-ligase activity-mediating Zink finger domain. Additionally, p62 is found to be indispensable for the TRAIL-mediated apoptosis-inducing pathway affected by A20.
CELL DEATH & DISEASE
(2023)
Article
Genetics & Heredity
Jacqueline Moltzau Anderson, Tim Lachnit, Simone Lipinski, Maren Falk-Paulsen, Philip Rosenstiel
Summary: Viruses and bacteriophages have an impact on intestinal barrier function and bacterial communities. Changes in the fecal viral communities may be involved in human diseases such as inflammatory bowel disease. Antibiotics significantly affect the fecal viral communities. The composition of viral and bacterial communities are highly correlated, which may contribute to prolonged dysregulation of the bacterial composition.
G3-GENES GENOMES GENETICS
(2023)
Article
Surgery
Matthaus Felsenstein, Ann-Christin Amini, Sophie Dorfer, Mengwen Hu, Ruonan Wang, Lea Timmermann, Karl Herbert Hillebrandt, Christian Benzing, Uli Fehrenbach, Uwe Pelzer, Igor Maximillian Sauer, Johann Pratschke, Christian Juergensen, Thomas Malinka
Summary: This study presents a novel approach for the internal drainage of anastomotic leakage and peri-anastomotic fluid collections after pancreatic head resection. By retrospectively evaluating 531 patients, the study found that endoscopy-guided treatment demonstrated superior success rates and shorter hospital stays compared to other treatment modalities.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Ecology
Svenja Starke, Danielle M. M. Harris, Johannes Zimmermann, Sven Schuchardt, Mhmd Oumari, Derk Frank, Corinna Bang, Philip Rosenstiel, Stefan Schreiber, Norbert Frey, Andre Franke, Konrad Aden, Silvio Waschina
Summary: Amino acid auxotrophies are prevalent in the human gut microbiome, with tryptophan auxotrophy being the most common. Auxotrophy frequencies are higher for amino acids essential to the human host. The presence of auxotrophies is related to microbiome diversity and stability.
Article
Multidisciplinary Sciences
Emily Wood, Hinrich Schulenburg, Philip Rosenstiel, Tobias Bergmiller, Dyan Ankrett, Ivana Gudelj, Robert Beardmore
Summary: The mechanism by which antibiotics regulate population decline in bacteria during periods of low nutrient availability is poorly understood. The study finds that ribosome-binding antibiotics can prolong the lifespan of bacteria, while resistance mechanisms that increase growth rates can be detrimental during nutrient stresses. Ribosomal protection acts as a Trojan horse, providing protection from antibiotics but promoting bacterial demise during nutrient stresses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Camille Chauvin, Katarina Radulovic, Olivier Boulard, Myriam Delacre, Nadine Waldschmitt, Paul Regnier, Gauthier Legris, Clement Bouchez, Mohamed-Yassine Sleimi, Philip Rosenstiel, Guillaume Darrasse-Jeze, Mathias Chamaillard, Lionel F. Poulin
Summary: The study indicates that loss of Nod2 signaling in myeloid cells aids in tissue repair of the inflamed large intestine through lysozyme secretion, which may lead to new therapeutics to limit the inflammatory and tumorigenic functions of NOD2.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nourhane Ammar, Maya Hildebrandt, Claudia Geismann, Christian Roeder, Timo Gemoll, Susanne Sebens, Ania Trauzold, Heiner Schaefer
Summary: Pancreatic ductal adenocarcinoma (PDAC) cells adapt their metabolism to glutamine scarcity and develop resistance against anticancer treatments through the reverse Warburg phenotype and MCT1-mediated lactate uptake.
Article
Geriatrics & Gerontology
Roxana M. Pfefferkorn, Benedikt M. Mortzfeld, Christine Fink, Jakob von Frieling, Judith Bossen, Daniela Esser, Christoph Kaleta, Philip Rosenstiel, Holger Heine, Thomas Roeder
Summary: Severe protein restriction has effects on tumor growth and lifespan in a Drosophila model. Alternating periods of severe protein restriction with complete feeding can reduce tumor mass, restore gut functionality, and increase longevity. This diet also reduces chemotherapy-induced stem cell activity associated with tumor recurrence.
Meeting Abstract
Gastroenterology & Hepatology
Florian Tran, Raphael Brard, Klaus R. Flechsenhar, Konrad Aden, Philip Rosenstiel, Inoncent Agueusop, Stefan Schreiber
Meeting Abstract
Gastroenterology & Hepatology
Miriam Ecker, Olivia Coleman, Sandra Bierwirth, Adam Sorbie, Philipp Weber, Nikolai Kohler, Tim Kacprowski, Miriam Wimmer, Andreas Dunkel, Josch Pauling, Josef Ecker, Karin Kleigrewe, Jan Baumbach, Philip Rosenstiel, Katja Steiger, Moritz Jesinghaus, Klaus-Peter Janssen, Dirk Haller
Article
Immunology
Juan D. Matute, Jinzhi Duan, Magdalena B. Flak, Paul Griebel, Jose A. Tascon-Arcila, Shauni Doms, Thomas Hanley, Agne Antanaviciute, Jennifer Gundrum, Jessica L. Mark Welch, Brandon Sit, Shabnam Abtahi, Gwenny M. Fuhler, Joep Grootjans, Florian Tran, Stephanie T. Stengel, James R. White, Niklas Krupka, Dirk Haller, Simon Clare, Trevor D. Lawley, Arthur Kaser, Alison Simmons, Jonathan N. Glickman, Lynn Bry, Philip Rosenstiel, Gary Borisy, Matthew K. Waldor, John F. Baines, Jerrold R. Turner, Richard S. Blumberg
Summary: ITLN1, regulated by the unfolded protein response, coats certain microorganisms to thin the inner mucus layer and aggravates colitis. Its upregulation in UC patients is related to dysregulation of the unfolded protein response, affecting the composition of the inner mucus layer and increasing sensitivity to colitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
F. Wottawa, B. Becker, M. Bakr, J. Kugler, L. Mayr, S. Paludan, R. Blumberg, A. Kaser, T. Adolph, S. Schreiber, J. Meiser, P. Rosenstiel, K. Aden
JOURNAL OF CROHNS & COLITIS
(2022)